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Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study.

https://arctichealth.org/en/permalink/ahliterature53319
Source
Eur J Clin Nutr. 2004 Jul;58(7):1062-70
Publication Type
Article
Date
Jul-2004
Author
J. Dyerberg
D C Eskesen
P W Andersen
A. Astrup
B. Buemann
J H Christensen
P. Clausen
B F Rasmussen
E B Schmidt
T. Tholstrup
E. Toft
S. Toubro
S. Stender
Author Affiliation
Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. jdcon@post4.tele.dk
Source
Eur J Clin Nutr. 2004 Jul;58(7):1062-70
Date
Jul-2004
Language
English
Publication Type
Article
Keywords
Adult
Biological Markers - blood
Cardiovascular Diseases - blood - prevention & control
Cholesterol - blood
Double-Blind Method
Fatty Acids, Omega-3 - administration & dosage - pharmacology
Heart Rate - drug effects - physiology
Humans
Lipoproteins - blood
Lipoproteins, HDL Cholesterol - blood
Lipoproteins, LDL Cholesterol - blood
Male
Middle Aged
Research Support, Non-U.S. Gov't
Risk factors
Trans Fatty Acids - administration & dosage - pharmacology
Triglycerides - blood
Abstract
BACKGROUND: Studies of long-term intake of industrially produced trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (PUFA) suggest opposite effects on cardiovascular disease risk. Common mechanisms of action are probable. OBJECTIVE: To examine the effects on cardiovascular risk markers of dietary enrichment with TFA or n-3 PUFA. DESIGN: Randomized, double-blind, parallel intervention trial. SETTING: Department of Human Nutrition, The Royal Veterinary and Agricultural University. SUBJECTS: In all, 87 healthy males included, 79 completed. INTERVENTION: Subjects were randomly assigned to 8 weeks of a daily intake of 33 g of experimental fats from either partially hydrogenated soy oil containing 20 g of TFA, 12 g of fish oil with approximately 4 g of n-3 PUFA and 21 g of control fat, or 33 g of control fat. The experimental fats were incorporated into bakery products. Plasma lipids, blood pressure, heart rate variability (HRV), arterial dilatory capacity, compliance, and distensibility were recorded before and after intervention and at follow-up 12 weeks after the intervention. RESULTS: High-density lipoprotein cholesterol (HDL-C) decreased in the TFA group and triglycerides and mean arterial blood pressure decreased in the n-3 PUFA group compared to the control group. HRV, arterial dilatory capacity, compliance, and distensibility were unchanged. CONCLUSION: The results indicate that the association between coronary heart disease risk and intake of TFA and n-3 PUFA relates only modestly to changes in traditional risk markers. SPONSORSHIP: Danish Medical Research Council (Grant no. 22-01-0390), Center of Advanced Food Research (Copenhagen, Denmark) (Grant no. KVL-R-2001-107), the Danish Heart Association (Grant no. 99-2-3-45-22748), Novozymes (Bagsvaerd, Denmark), Aarhus Olie (Aarhus, Denmark), and from private sources. The experimental fats were provided by Pronova Biocare (Aalesund, Norway) and Aarhus Olie (Aarhus, Denmark).
PubMed ID
15220949 View in PubMed
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N-3 fatty acids and cardiac function after myocardial infarction in Denmark.

https://arctichealth.org/en/permalink/ahliterature53849
Source
Int J Circumpolar Health. 2001 Aug;60(3):360-5
Publication Type
Article
Date
Aug-2001
Author
H A Skou
E. Toft
J H Christensen
J B Hansen
J. Dyerberg
E B Schmidt
Author Affiliation
Department of Medicine, Hjørring Hospital, Denmark. helleskou@hotmail.com
Source
Int J Circumpolar Health. 2001 Aug;60(3):360-5
Date
Aug-2001
Language
English
Publication Type
Article
Keywords
Aged
Comparative Study
Dietary Supplements
Double-Blind Method
Drug Administration Schedule
Echocardiography
Fatty Acids, Omega-3 - therapeutic use
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction - complications - diagnosis - drug therapy
Probability
Reference Values
Statistics, nonparametric
Treatment Outcome
Ventricular Dysfunction, Left - diagnosis - drug therapy - etiology
Abstract
In order to evaluate the effect of marine n-3 polyunsaturated fatty acids (n-3 PUFA) on systolic left ventricular function, we investigated the effect of daily supplementation with 5.2 g n-3 PUFA for 12 weeks in 55 patients with a recent myocardial infarction in a double blind placebo-controlled design. Left ventricular function was assessed by transthoracal echo-cardiography and plasma concentration of proANP and N-terminal proANP. No effect of n-3 PUFA could be demonstrated on these indices of left ventricular function.
PubMed ID
11590875 View in PubMed
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N-3 fatty acids from fish and coronary artery disease: implications for public health.

https://arctichealth.org/en/permalink/ahliterature54106
Source
Public Health Nutr. 2000 Mar;3(1):91-8
Publication Type
Article
Date
Mar-2000
Author
E B Schmidt
H A Skou
J H Christensen
J. Dyerberg
Author Affiliation
Department of Medicine, Hjørring/Brønderslev Hospital, Hjørring, Denmark. ebs@dadlnet.dk
Source
Public Health Nutr. 2000 Mar;3(1):91-8
Date
Mar-2000
Language
English
Publication Type
Article
Keywords
Coronary Disease - diet therapy - epidemiology - prevention & control
Death, Sudden, Cardiac - prevention & control
Denmark - epidemiology
Dietary Fats - administration & dosage
Fatty Acids, Omega-3 - administration & dosage
Fish Oils - administration & dosage
Humans
Public Health
Research Support, Non-U.S. Gov't
Risk factors
Abstract
OBJECTIVE: To review and discuss the effect of n-3 polyunsaturated fatty acids (PUFA) from fish in the prevention and, primarily, in the treatment of coronary artery disease (CAD). DESIGN: Overview of the literature. SETTING: Denmark. RESULTS: There is good evidence that fish consumption may reduce the risk of CAD. CONCLUSIONS: Fish can be recommended to reduce the risk of CAD both in healthy subjects and in patients with a high risk of CAD or with documented CAD. The use of fish oil concentrates can not be recommended in general, but may be considered in patients after a myocardial infarction or in patients with hypertriglyceridaemia. An increased intake of n-3 polyunsaturated fatty acids from fish may have substantial implications for public health and health economy by decreasing the risk of coronary events and sudden cardiac death.
PubMed ID
10786728 View in PubMed
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