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13 records – page 1 of 2.

[A complex approach to evaluation of human genome instability].

https://arctichealth.org/en/permalink/ahliterature168018
Source
Vestn Ross Akad Med Nauk. 2006;(4):36-41
Publication Type
Article
Date
2006
Author
Iu A Revazova
L V Khripach
I E Sidorova
V V Iurchenko
I E Zykova
Source
Vestn Ross Akad Med Nauk. 2006;(4):36-41
Date
2006
Language
Russian
Publication Type
Article
Keywords
Genome, Human - genetics
Human Genome Project
Humans
Mutagenesis - genetics
Occupational Diseases - genetics
Occupational Exposure
Oxidative Stress - physiology
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Russia
Abstract
In this study, evaluation of genome instability in individuals exposed to chemical compounds included detection of the genetic polymorphism of some xenobiotic metabolic enzymes (CYP1A1, CYP1E1, PON1, GSTM1, GSTT1), as well as measurement of oxidative state chemiluminescent variables and the level of cytogenetic damage. According to the study, the level of chromosomal aberrations in peripheral blood lymphocytes shows a strong correlation with PON54 left allele and GSTM1 null genotype, and can be described by the polynomial function of blood plasma luminol-dependent chemiluminescence. The frequencies of micronuclei in buccal epithelium displayed a weak association with GSTT1 null genotype.
PubMed ID
16889354 View in PubMed
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[A methodological scheme for examination of the urban population, by making multilevel assessments of exposure to ambient air pollutants].

https://arctichealth.org/en/permalink/ahliterature159936
Source
Gig Sanit. 2007 Sep-Oct;(5):65-7
Publication Type
Article
Author
L V Khripach
T D Kniazeva
N S Skvortsova
I M Korsunskaia
V M Rozental'
I E Zykova
Iu A Revazova
S M Novikov
Source
Gig Sanit. 2007 Sep-Oct;(5):65-7
Language
Russian
Publication Type
Article
Keywords
Air Pollutants - adverse effects
Biological Markers - analysis
Child
Environmental Illness - diagnosis - epidemiology - metabolism
Humans
Pilot Projects
Risk Assessment - methods
Russia - epidemiology
Urban health
Urban Population
Abstract
A novel methodological design comprising multilevel assessments of exposures of examinees to controlled ambient air pollution according to the data of route stations was developed to examine the population of large towns. The design was tested in 4 surveys of Moscow residents (apparently healthy and outpatients with a number of chronic diseases). The findings indicate the fundamental possibility of altering the traditional differential design of biomedical surveys of the population, by introducing more evidence-based regression analyses and dividing the contributions of individual chemicals to the observed changes in health indices.
PubMed ID
18062018 View in PubMed
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[Approaches to assessing the human risk of mutagens].

https://arctichealth.org/en/permalink/ahliterature166698
Source
Gig Sanit. 2006 Sep-Oct;(5):23-4
Publication Type
Article
Author
V S Zhurkov
L P Sycheva
Iu A Revazova
S M Novikova
Source
Gig Sanit. 2006 Sep-Oct;(5):23-4
Language
Russian
Publication Type
Article
Keywords
Animals
Environmental Exposure - adverse effects
Environmental Illness - chemically induced - epidemiology
Humans
Mutagens - adverse effects
Prevalence
Risk assessment
Risk factors
Russia - epidemiology
Abstract
The assessment of the human risk of mutagens is a constituent of the general assessment of the risk of environment-pollutant chemicals to the population's health. An algorithm of assessing the risk of mutagens is proposed. Stage 1 (hazard identification) is to provide an expert analytical characterization of the mutagenic potential of the chemicals polluting the study object. Stage 2 (hazard characterization) is to analyze the quantitative dependences of the effect of mutagens in gametes and somatic cells of man and mammals. Stage 3 (effect evaluation) is to characterize the sources of pollution and the doses of mutagens affecting the population. Stage 4 (risk characterization) is to calculate the risk of mutagens to the population and individuals.
PubMed ID
17087204 View in PubMed
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[Dioxins and medical-genetic indices of health of residents of the town of Chapayevsk].

https://arctichealth.org/en/permalink/ahliterature191814
Source
Gig Sanit. 2001 Nov-Dec;(6):11-6
Publication Type
Article
Author
Iu A Revazova
V S Zhurkov
N A Zhuchenko
I A Ivanova
L D Katosova
V I Platonova
B A Revich
L P Sycheva
V V Iurchenko
Source
Gig Sanit. 2001 Nov-Dec;(6):11-6
Language
Russian
Publication Type
Article
Keywords
Adult
Chemical Industry
Chromosome Aberrations
Congenital Abnormalities - epidemiology
Cytogenetics
Dioxins - adverse effects
Environmental Pollutants - adverse effects
Female
Health Surveys
Humans
Incidence
Infant, Newborn
Male
Micronucleus Tests
Mutation
Risk factors
Russia - epidemiology
Urban Population
Abstract
The paper presents the results of an integrated medical genetic survey carried out in the town of Chapayevsk. The survey included an estimation of the incidence of congenital malformations (CMF), congenital morphogenetic options (CMGO), evaluation of the frequency of chromosomal mutations of various types and micronuclei in human somatic cells. The incidence of CMF among newborn infants corresponds to that in Russia, but such forms of CMF as congenital hydrocephalus and agenesia and disgenesis of the kidney were more common in the town. The study ascertained that the average number of CMGO per child was on the increase. Cytogenetic findings unambiguously demonstrate that there was a spatial gradient within the town (from the plant to remote districts), higher rates of chromosomal aberrations. Further studies of the effects of dioxins on genetic health are required to assess the actual genetic risk due to its human contact.
PubMed ID
11810895 View in PubMed
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[Phenotypic polymorphism of biomedical parameters of the health status in hygienic studies].

https://arctichealth.org/en/permalink/ahliterature128613
Source
Gig Sanit. 2011 Sep-Oct;(5):32-6
Publication Type
Article
Author
L V Khripach
D A Grishin
A V Kirillov
O B Kozlova
N V Solntseva
E V Kruglova
I E Zykova
Iu A Revazova
E V Zhelezniak
A K Makovetskaia
V N Fedoseeva
Source
Gig Sanit. 2011 Sep-Oct;(5):32-6
Language
Russian
Publication Type
Article
Keywords
Biological Markers - blood
Catalase - blood - genetics
Catecholamines - blood
Environmental Exposure - analysis - statistics & numerical data
Erythrocytes - enzymology
Genotype
Glutathione Transferase - blood - genetics
Health Status Indicators
Humans
Hygiene
Moscow
Oxidative Stress - genetics
Phenotype
Polymorphism, Genetic
Tumor Necrosis Factor-alpha - blood - genetics
Abstract
The paper presents the results of investigating the phenotypic polymorphism of a number of biochemical and immunological parameters (the values of oxidative stress, the activity of catalase and glutathione-S-transferase in red blood cells, the serum levels of catecholamines, tumor-necrosis factor-?, and IgG antibody subclasses) in the authors' hygienic studies of genotypic and nongenotypic population samples.
PubMed ID
22184998 View in PubMed
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[Results of the population and genetic study in the Republic of Tatarstan].

https://arctichealth.org/en/permalink/ahliterature261192
Source
Genetika. 2014 May;50(5):619-24
Publication Type
Article
Date
May-2014
Author
G I El'chinova
T A Vasil'eva
L A El'kanova
Iu A Revazova
N V Petrova
E E Timkovskaia
R A Zinchenko
Source
Genetika. 2014 May;50(5):619-24
Date
May-2014
Language
Russian
Publication Type
Article
Keywords
Asian Continental Ancestry Group - classification - genetics
Consanguinity
Genetics, Population
Humans
Marriage
Tatarstan
Abstract
Using data on the distribution of frequent surnames, the Crow index and its components, and nine polymorphic DNA loci, it was shown that the Tatar population of the Republic of Tatarstan is divided into subethnic groups (Mishars, Teptyars, and Kazan Tatars). No subdivision within each of these groups was found.
PubMed ID
25715478 View in PubMed
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13 records – page 1 of 2.