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An outbreak of serogroup B:15:P1.16 meningococcal disease, Frederiksborg County, Denmark, 1987-9.

https://arctichealth.org/en/permalink/ahliterature36826
Source
Epidemiol Infect. 1992 Feb;108(1):19-30
Publication Type
Article
Date
Feb-1992
Author
S. Samuelsson
P. Ege
L. Berthelsen
I. Lind
Author Affiliation
Neisseria Department, Statens Seruminstitut, Copenhagen, Denmark.
Source
Epidemiol Infect. 1992 Feb;108(1):19-30
Date
Feb-1992
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Bacteremia - epidemiology - mortality - prevention & control
Child
Child, Preschool
Cluster analysis
Denmark - epidemiology
Disease Outbreaks - statistics & numerical data
Female
Humans
Infant
Male
Meningitis, Meningococcal - epidemiology - mortality - prevention & control
Meningococcal Infections - epidemiology - mortality - prevention & control
Neisseria meningitidis - classification - isolation & purification
Prevalence
Rifampin - therapeutic use
Seasons
Serotyping
Sex Factors
Suburban Population
Abstract
Epidemiological features of an outbreak of group B:15:P1.16 meningococcal disease (MD) in Frederiksborg county, Denmark, 1987-9, were investigated. The study comprised 149 cases notified during the outbreak and the two preceding years; 115 were confirmed by the isolation of Neisseria meningitidis. In 1989 the incidence had increased to 14.1 per 100,000 population. Among group B strains, B:15:P1.16 accounted for 80% (77/97). The overall mortality rate was 10% (15/149). Regarding cases due to group B:15:P1.16 strains a significant time-space clustering, which exclusively occurred within the 10-19 years age group, was demonstrated. The link between cases within clusters was indirect or unknown, except for ten patients with contact to one particular school. The prophylactic measures used included administration of rifampicin to household contacts. During the outbreak the proportion of secondary cases was high (6-15%). All secondary cases occurred outside the household indicating that the household had been protected.
PubMed ID
1547836 View in PubMed
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Antimicrobial susceptibility of Neisseria gonorrhoeae strains isolated in Nuuk, Greenland during 1998-1999.

https://arctichealth.org/en/permalink/ahliterature31166
Source
Int J STD AIDS. 2002 Dec;13(12):826-8
Publication Type
Article
Date
Dec-2002
Author
D. Dragsted
P. Poulsen
C. Nørgaard
I. Lind
Author Affiliation
WHO Collaborating Centrefor Reference and Research in Gonococci, Neisseria Unit, Department of Respiratory Infections, Meningitis and STIs, Statens Serum Institut, Artillerivei 5, DK-2300 Copenhagen S, Denmark. dmd@ssi.dk
Source
Int J STD AIDS. 2002 Dec;13(12):826-8
Date
Dec-2002
Language
English
Geographic Location
Greenland
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Anti-Infective Agents - pharmacology - therapeutic use
Child
Ciprofloxacin - pharmacology - therapeutic use
Drug Resistance, Microbial
Female
Gonorrhea - drug therapy
Greenland - epidemiology
Humans
Male
Microbial Sensitivity Tests - methods
Middle Aged
Neisseria gonorrhoeae - classification - drug effects - isolation & purification
Penicillins - pharmacology - therapeutic use
Abstract
Sixty-one gonococcal strains isolated in Greenland during 1998-1999 were tested locally for susceptibility to penicillin and ciprofloxacin by a disc diffusion method (Rosco) and at the reference laboratory in Copenhagen by the agar dilution method and the E-test, showed that more than 60% of the strains were less susceptible or resistant to penicillin (minimum inhibitory concentration [MIC] > or = 0.25 mg/L), indicating that penicillin should not be used as a first line drug for the treatment of gonorrhoea in Greenland. The Rosco disc diffusion method only identified 8% of strains as less susceptible to penicillin. Ciprofloxacin can still be used as a first line drug for treatment of gonorrhoea in Greenland since decreased susceptibility was only seen in one imported strain. However, the decreased susceptibility in this strain was not identified by the Rosco disc diffusion test, therefore the future local surveillance of antibiotic resistance in Neisseria gonorrhoeae will be based on MIC determinations.
PubMed ID
12537735 View in PubMed
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Characterization of Neisseria meningitidis isolates and clinical features of meningococcal conjunctivitis in ten patients.

https://arctichealth.org/en/permalink/ahliterature35810
Source
Eur J Clin Microbiol Infect Dis. 1994 May;13(5):388-93
Publication Type
Article
Date
May-1994
Author
J. Anderson
I. Lind
Author Affiliation
Neisseria Department, Statens Seruminstitut, Copenhagen S, Denmark.
Source
Eur J Clin Microbiol Infect Dis. 1994 May;13(5):388-93
Date
May-1994
Language
English
Publication Type
Article
Keywords
Child
Child, Preschool
Conjunctivitis, Bacterial - epidemiology - microbiology - physiopathology
Denmark - epidemiology
Female
Humans
Infant
Infant, Newborn
Male
Meningococcal Infections - epidemiology - microbiology - physiopathology
Neisseria meningitidis - classification - isolation & purification
Retrospective Studies
Serotyping
Abstract
Cases of meningococcal conjunctivitis occurring in Denmark in the period 1982-1991 were reviewed. In a survey of laboratory reports, ten cases were identified. The meningococcal strains were characterized by serological grouping, typing and subtyping, and by antimicrobial susceptibility testing. Five cases were caused by serogroup B meningococci (B:15:P1.16, B:15:P1.6, B:4:P1.15) and five cases by serogroup C meningococci (C:2a:P1.2 (4 strains), C:14:NST). The median age of the patients was 12.5 months (range 7 days to 9 years). Signs of conjunctivitis were predominant; in addition, five of the patients had fever and general malaise. In one patient the same strain was recovered from blood and eye secretions. None of the patients had signs of meningitis. All meningococcal strains isolated from patients with meningococcal conjunctivitis were assumed to be virulent and had the same characteristics as strains causing meningococcal disease in Denmark within the same period.
PubMed ID
8070451 View in PubMed
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Comparative studies on pharyngeal carriage of Neisseria meningitidis during a localized outbreak of serogroup C meningococcal disease.

https://arctichealth.org/en/permalink/ahliterature222162
Source
Scand J Infect Dis. 1993;25(3):331-9
Publication Type
Article
Date
1993
Author
T. Rønne
L. Berthelsen
L H Buhl
I. Lind
Author Affiliation
Department of Epidemiology, Statens Seruminstitut, Copenhagen, Denmark.
Source
Scand J Infect Dis. 1993;25(3):331-9
Date
1993
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Carrier State - epidemiology - microbiology
Cluster analysis
Denmark - epidemiology
Disease Outbreaks
Female
Humans
Incidence
Male
Meningococcal Infections - epidemiology - microbiology
Neisseria meningitidis - isolation & purification
Pharynx - microbiology
Abstract
An outbreak involving 20 cases of serogroup C meningococcal disease, predominantly among teenagers, occurred over a 7-month period in the Randers area of Denmark. The cases were caused by serogroup C:2a:P1.2 sulphonamide-resistant strains. The available evidence was against the transmission being related to particular schools. The outbreak was experienced as 3 clusters. At 2 schools involved in the first and the third cluster of the outbreak, 351 students were examined regarding pharyngeal carriage of meningococci, 282 of whom were tested again 17 weeks later; 308 students attending two similar schools in a nearby area were examined once. The majority of strains isolated from group C carriers in the high-risk area were serologically indistinguishable from the outbreak strain (13/14 = 95%), but less often sulphonamide-resistant (5/13 = 38%). In both areas, the overall rate (30%), the overall group C rate (3%), the carrier rate for the outbreak strain (1%) were the same. The attack rate for the outbreak strain differed significantly: 1/40 in the high-risk area versus 1/2,500 in the normal risk area. No conditions that might explain this difference were revealed. Immediately after recognition of the first and the third cluster, 780 and 13,300 students, respectively, were vaccinated with meningococcal polysaccharide vaccine A+C. It was concluded that the definition of target groups for vaccination should be liberal, because the "at risk" population may be difficult to recognize at the onset of an outbreak.
PubMed ID
8362229 View in PubMed
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Cool tadpoles from Arctic environments waste less nutrients - High gross growth efficiencies lead to low consumer-mediated nutrient recycling in the North.

https://arctichealth.org/en/permalink/ahliterature265104
Source
J Anim Ecol. 2015 Aug 3;
Publication Type
Article
Date
Aug-3-2015
Author
A. Liess
J. Guo
M I Lind
O. Rowe
Source
J Anim Ecol. 2015 Aug 3;
Date
Aug-3-2015
Language
English
Publication Type
Article
Abstract
Endothermic organisms can adapt to short growing seasons, low temperatures, and nutrient limitation by developing high growth rates and high gross growth efficiencies (GGEs). Animals with high GGEs are better at assimilating limiting nutrients and thus should recycle (or loose) fewer nutrients. Longer guts in relation to body mass may facilitate higher GGE under resource limitation. Within the context of ecological stoichiometry theory, this study combines ecology with evolution by relating latitudinal life history adaptations in GGE, mediated by gut length, to its ecosystem consequences, such as consumer-mediated nutrient recycling. In common garden experiments, we raised Rana temporaria tadpoles from two regions (Arctic/ Boreal) under two temperature regimes (18/ 23°C) crossed with two food quality treatments (high/ low nitrogen content). We measured tadpole GGEs, total nutrient loss (excretion + egestion) rates, and gut length during ontogeny. In order to maintain their elemental balance, tadpoles fed low-nitrogen (N) food had lower N excretion rates and higher total phosphorous (P) loss rates than tadpoles fed high quality food. In accordance with expectations, Arctic tadpoles had higher GGEs and lower N-loss rates than their low latitude conspecifics, especially when fed low-N food, but only in ambient temperature treatments. Arctic tadpoles also had relatively longer guts than Boreal tadpoles during early development. That temperature and food quality interacted with tadpole region of origin in affecting tadpole GGEs, nutrient loss rates and relative gut length, suggests evolved adaptation to temperature and resource differences. With future climate change, mean annual temperatures will increase. Additionally, species and genotypes will migrate north. This will change the functioning of Boreal and Arctic ecosystems by affecting consumer-mediated nutrient recycling and thus affect nutrient dynamics in general. Our study shows that evolved latitudinal adaption can change key ecosystem functions. This article is protected by copyright. All rights reserved.
PubMed ID
26239271 View in PubMed
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Dynamics of the meningococcal carrier state and characteristics of the carrier strains: a longitudinal study within three cohorts of military recruits.

https://arctichealth.org/en/permalink/ahliterature204520
Source
Epidemiol Infect. 1998 Aug;121(1):85-94
Publication Type
Article
Date
Aug-1998
Author
J. Andersen
L. Berthelsen
B. Bech Jensen
I. Lind
Author Affiliation
Neisseria Department, Statens Serum Institut, Copenhagen S, Denmark.
Source
Epidemiol Infect. 1998 Aug;121(1):85-94
Date
Aug-1998
Language
English
Publication Type
Article
Keywords
Carrier State - epidemiology
Denmark - epidemiology
Drug Resistance, Microbial
Humans
Longitudinal Studies
Male
Meningococcal Infections - epidemiology - microbiology
Microbial Sensitivity Tests
Military Personnel
Neisseria meningitidis - classification - drug effects - isolation & purification
Pharynx - microbiology
Phenotype
Seasons
Serotyping
Abstract
Three cohorts of Danish male military recruits (n = 1069) were studied for pharyngeal meningococcal carriage during 3 months at different seasons: 39-47% of entrants were meningococcal carriers and the carriage rate remained constant over time and season. However, individual changes in the carrier state occurred frequently, and after 3 months 34% had changed carrier state on one or more occasions. Initially, a loss of carriage predominated; on the other hand almost 20% of non-carriers had acquisition of meningococci within the first month. The serological phenotypes of the 670 carrier strains were compared with those of 261 invasive strains recovered concurrently from patients with meningococcal disease country-wide. Both carrier strains and invasive strains were phenotypically heterogeneous. Almost 60% of the invasive strains belonged to three phenotypes: B:15:P1.7, 16, C:2a:P1.2, 5 and C:2b:P1.2, 5. In contrast, these phenotypes only amounted to 3.2% of the carrier strains, among which no phenotype was found with a prevalence above 4.9%. However, 30% of the carrier strains had serological phenotypes identical to those of 80% of the invasive strains. Our results indicated that the transmission rate of potential pathogenic carrier strains did not differ from that of other carrier strains.
PubMed ID
9747759 View in PubMed
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Epidemiology of meningococcal disease in Denmark 1974-1999: contribution of the laboratory surveillance system.

https://arctichealth.org/en/permalink/ahliterature175383
Source
Epidemiol Infect. 2005 Apr;133(2):205-15
Publication Type
Article
Date
Apr-2005
Author
I. Lind
L. Berthelsen
Author Affiliation
Neisseria Unit, Department of Respiratory Infections, Meningitis and Sexually Transmitted Infections, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen, Denmark. il@ssi.dk
Source
Epidemiol Infect. 2005 Apr;133(2):205-15
Date
Apr-2005
Language
English
Publication Type
Article
Keywords
DNA, Bacterial
Denmark - epidemiology
Disease Outbreaks
Drug Resistance, Bacterial
Enzyme-Linked Immunosorbent Assay
Epidemiologic Studies
Humans
Laboratories - standards
Meningococcal Infections - epidemiology
Neisseria meningitidis - genetics - isolation & purification - pathogenicity
Phenotype
Population Surveillance
Retrospective Studies
Abstract
The Danish meningococcal disease laboratory surveillance system was established in 1974, based on close collaboration between local Departments of Clinical Microbiology and the Reference Laboratory at Statens Serum Institut. The completeness of the clinical notification system integrated with the laboratory surveillance system has been estimated to be more than 95%. Overall 4257 (79%) of 5356 cases of meningococcal disease notified during 1974-1999 were confirmed by culture of Neisseria meningitidis. The proportion of culture-confirmed cases ranged from 70% in 1989 to 89% in 1980. Only 26 patients (0.6%) with culture-confirmed meningococcal disease were not notified. Serological phenotype and susceptibility to penicillin and sulphonamide were determined for all isolates. Multilocus enzyme electrophoresis and/or DNA-based analyses were used for the assessment of clusters and outbreaks. Meningococcal antibody tests and counter-immunoelectrophoresis were used for the ascertainment of suspected cases. These combined systems allowed timely and reliable management of outbreaks and identification of clusters.
PubMed ID
15816145 View in PubMed
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The epidemiology of Neisseria gonorrhoeae isolates in Greenland 1979-1990: the emergence, spread and disappearance of non-PPNG strains carrying the conjugative 38.9 kb plasmid.

https://arctichealth.org/en/permalink/ahliterature220020
Source
Sex Transm Dis. 1993 Nov-Dec;20(6):338-43
Publication Type
Article
Author
K. Reimann
I. Kallings
I. Lind
Author Affiliation
Neisseria Department, Statens Seruminstitut, Copenhagen, Denmark.
Source
Sex Transm Dis. 1993 Nov-Dec;20(6):338-43
Language
English
Publication Type
Article
Keywords
Conjugation, Genetic
Drug Resistance, Microbial - genetics
Gonorrhea - epidemiology - microbiology
Greenland - epidemiology
Humans
Microbial Sensitivity Tests
Neisseria gonorrhoeae - classification - drug effects - enzymology - genetics
Penicillin Resistance - genetics
Penicillinase - biosynthesis
Prevalence
Prospective Studies
R Factors
Retrospective Studies
Serotyping
Streptomycin - pharmacology
Abstract
In 1990, Greenland was one of the few areas in the world in which endemic occurrence of PPNG had not been reported. However, between 1982 and 1988 an increase in the prevalence of strains with chromosomally mediated resistance to penicillin had been noticed. The standard treatment regimen was changed early in 1983.
To determine the prevalence of the 38.9 kb plasmid in gonococcal strains isolated in Greenland 1979-1990.
Retrospective (1979-1984) and prospective (1985-1990) studies of antimicrobial susceptibility and plasmid profile of consecutive N. gonorrhoeae isolates from patients attending the STD clinic in Nuuk, Greenland; selected strains from 1982-1984 were subjected to serotyping and auxotyping.
Before 1982, N. gonorrhoeae strains harboring the 38.9 kb conjugative plasmid were rare; in 1982, a sudden increase in the prevalence of these strains was strongly associated with the emergence of streptomycin-resistant strains with high-level chromosomally mediated resistance to penicillin, 70% of which carried the 38.9 kb plasmid. Determination of antimicrobial susceptibility pattern, auxotype and serovar supported the assumption of an epidemic spread of a single clone. The predominance of this clone was transient, but the 38.9 kb plasmid spread to penicillin-susceptible as well as to other clones of penicillin-resistant strains.
The emergence of the 38.9 kb plasmid in 1982 was linked to a single clone of strains, but the subsequent spread of the plasmid was independent of the presence of other plasmids, and its disappearance was not associated with a change in standard treatment regimen.
PubMed ID
8108757 View in PubMed
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[Gonococcal complement fixation reaction in patients with lung diseases in Greenland].

https://arctichealth.org/en/permalink/ahliterature111950
Source
Ugeskr Laeger. 1966 Apr 7;128(14):409-15
Publication Type
Article
Date
Apr-7-1966
Author
P K Lange
A. Reyn
M W Bentzon
I. Lind
Source
Ugeskr Laeger. 1966 Apr 7;128(14):409-15
Date
Apr-7-1966
Language
Danish
Publication Type
Article
Keywords
Complement Fixation Tests
Gonorrhea - diagnosis
Greenland
Humans
Lung Diseases - complications
PubMed ID
5915764 View in PubMed
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Incidence of gonorrhoea in Denmark, 1957-1971.

https://arctichealth.org/en/permalink/ahliterature254351
Source
Br J Vener Dis. 1973 Oct;49(5):454-9
Publication Type
Article
Date
Oct-1973
Author
I. Lind
Source
Br J Vener Dis. 1973 Oct;49(5):454-9
Date
Oct-1973
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Denmark
Female
Gonorrhea - epidemiology - microbiology
Homosexuality
Humans
Male
Neisseria gonorrhoeae - isolation & purification
Registries
Sex Factors
Notes
Cites: Bull World Health Organ. 1969;40(2):245-554979391
Cites: Lakartidningen. 1971 Feb 3;68(6):569-715101470
Cites: Br Med J. 1971 Dec 11;4(5788):660-15002598
Cites: Postgrad Med J. 1972 Jan;48:Suppl 1:7-114622555
Cites: JAMA. 1972 Jun 5;220(10):1315-84623385
Cites: Br J Vener Dis. 1972 Jun;48(3):182-35069605
Cites: Br J Vener Dis. 1972 Oct;48(5):363-84345591
PubMed ID
4201246 View in PubMed
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35 records – page 1 of 4.