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5HTR2A gene polymorphism and personality traits in patients with major psychoses.

https://arctichealth.org/en/permalink/ahliterature190821
Source
Eur Psychiatry. 2002 Mar;17(1):24-8
Publication Type
Article
Date
Mar-2002
Author
V E Golimbet
M V Alfimova
K K Manandyan
N G Mitushina
L I Abramova
V G Kaleda
I V Oleichik
YuB Yurov
V I Trubnikov
Author Affiliation
Laboratory of Preventive Genetics, Research Mental Health Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, Moscow, Russia 113152. golimbet@mail.ru
Source
Eur Psychiatry. 2002 Mar;17(1):24-8
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Female
Humans
Male
Moscow
Personality - genetics
Personality Inventory
Polymorphism, Genetic - genetics
Psychiatric Status Rating Scales
Psychotic Disorders - genetics
Receptors, Serotonin - genetics
Abstract
Serotonin receptor (5HTR2A) gene polymorphism has been reported to be associated with clinical phenotypes in schizophrenia. The current study attempted to investigate a relationship between 5HTR2A 102T/C polymorphism and personality traits as well as clinical symptoms in patients with ICD-10 diagnoses of schizophrenia and affective disorders. 5HTR2A genotyping, clinical and psychological assessment were administered to 375 patients, 104 first-degree healthy relatives of the patients and 157 controls. In the patients an association was observed between the 2/2 5HTR2A genotype and scores on the Hypochondriasis scale (MMPI) (ANOVA, F = 4.56; P = 0.011) and trait anxiety (F = 4.21; P = 0.002). A significant difference between 1/1 and 2/2 genotypes has been also found for Neuroticism scores (EPI) (t = 2.18; P = 0.0031). No significant differences by 5HTR2A genotype were observed in either the control or first-degree relatives group for all scales studied. Positive, negative and psychopathological symptoms emerged higher in the 2/2 genotype patients compared to other genotype carriers. Therefore, the 2/2 genotype may contribute to produce the phenotype, with specific clinical and pathological features in common, regardless of nosologic heterogeneity of psychoses.
PubMed ID
11918989 View in PubMed
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Assessing depression in Russian psychiatric patients: validity of MMPI and Rorschach.

https://arctichealth.org/en/permalink/ahliterature191967
Source
Assessment. 2001 Dec;8(4):373-89
Publication Type
Article
Date
Dec-2001
Author
J B Ritsher
E B Slivko-Kolchik
I V Oleichik
Author Affiliation
University of Maryland, USA. jennifer@ritsher.net
Source
Assessment. 2001 Dec;8(4):373-89
Date
Dec-2001
Language
English
Publication Type
Article
Keywords
Catchment Area (Health)
Culture
Depressive Disorder, Major - diagnosis - epidemiology - psychology
Humans
MMPI
Mental Disorders - psychology
Reproducibility of Results
Rorschach test
Russia - epidemiology
Abstract
We tested the criterion, concurrent, and content validity of depression indicators in 180 Russian psychiatric patients. Indicators from the Exner Rorschach (DEPI, CDI) and the Russian MMPI (Berezin Scale 2, Wiggins depression content) were compared to Hamilton (HRSD) scores and 3 types of diagnosis: traditional Russian, contemporary Western (ICD-10), and a mixed version. The MMPI scales had significant associations with each other and each criterion. The Rorschach indexes were unrelated to all other variables, even when their affective, cognitive, and interpersonal components were analyzed separately, response styles were taken into account, or the 2 indexes were used in combination. Nevertheless, sample means on 107 variables were roughly similar to Exner's norms. The study represents an initial step towards establishing the validity of instruments commonly used in Russia and North America for assessing depression among Russians.
PubMed ID
11785582 View in PubMed
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