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[Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations].

https://arctichealth.org/en/permalink/ahliterature140492
Source
Mol Biol (Mosk). 2010 Jul-Aug;44(4):620-6
Publication Type
Article
Author
S A Golenkina
A Iu Gol'tsov
I L Kuznetsova
A P Grigorenko
T V Andreeva
D A Reshetov
S S Kunizheva
L I Shagam
I Iu Morozova
I V Goldenkova-Pavlova
Kh Shimshilashvili
A O Viacheslavova
G. Faskhutdinova
A É Gareeva
A G Zainullina
É K Khusnutdinova
V P Puzyrev
V A Stepanov
A V Kolotvin
L M Samokhodskaia
N D Selezneva
S I Gavrilova
E I Rogaev
Source
Mol Biol (Mosk). 2010 Jul-Aug;44(4):620-6
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alleles
Alzheimer Disease - epidemiology - genetics
Clusterin - genetics
Cohort Studies
Female
Gene Frequency - genetics
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Genetic - genetics
Russia - epidemiology
Abstract
Three genes mutations in which cause familial forms of Alzheimer's disease are known to date:PSEN1, PSEN2 and APP; and APOE gene polymorphism is a strong risk factor for Alzheimer's disease. We have evaluated allele and genotype frequency distribution of rs11136000 polymorphism in clusterin (CLU) gene (or apolipoprotein J, APOJ) in populations of three Russian regions and i nAlzheimhner's diseasepatients. Genome-wideassociation studies in samples from several European populations have recently revealed highly significant association o fCLU gene with AD (p = 8.5 x 10(-10)). We found no differences in allele and genotype frequencies of rs11136000 between populations from Moscow, Ural and Siberia regions. The allele frequencies are close to those in European populations. The genetic association analysis in cohort of Alzheimer's disease patients and normal individuals (>500 individuals ineach group) revealed no significant association of the rs11136000 polymorphism in CLU with Alzheimer's disease in Russian populations. Although our resultsdo not confirm the role of CLU gene as a majorgenetic factor forcommon form of Alzheimer's disease, the data do not rule out the possibility of modest effect of CLU and interaction between CLU and APOE genotypes in etiology of Alzheimer's disease.
PubMed ID
20873220 View in PubMed
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[Association of NAT2 polymorphism with risks to develop psoriasis and various dermatological diseases in Moscow population].

https://arctichealth.org/en/permalink/ahliterature151763
Source
Mol Biol (Mosk). 2009 Jan-Feb;43(1):62-76
Publication Type
Article
Author
Zh M Kozhekbaeva
O A Gra
V S Fadeev
I V Goldenkova-Pavlova
I M Korsunskaia
S A Bruskin
E E Agafonova
An L Piruzian
S A Surzhikov
T V Nasedkina
Source
Mol Biol (Mosk). 2009 Jan-Feb;43(1):62-76
Language
Russian
Publication Type
Article
Keywords
Adult
Alcoholic Beverages - adverse effects
Arylamine N-Acetyltransferase - genetics
Female
Genotype
Humans
Male
Middle Aged
Moscow
Polymorphism, Single Nucleotide
Psoriasis - epidemiology - genetics
Risk factors
Smoking - adverse effects - epidemiology
Abstract
Ruacetyltransferase 2 (NAT2) is one of key enzymes of the second phase of biotransformation that metabolize genotoxic compounds such as carcinogens and mutagens in different types of cells. There is a correlation between the decreasing activity of NAT2 gene product and the sensitivity to harmful environmental factors that increase the risk of occurrence of different multifactorial diseases, including dermatological ones like psoriasis. We developed the NAT2-biochip for 17 SNPs. The biochip was been tested on 279 clinical DNA samples from 180 patients with psoriasis and 99 healthy individuals, residents of Moscow. We found only six SNPs that were significant for European populations (282C > T, 341T > C, 481C > T, 590G > A, 803A > G and 857G > A). The analysis in psoriasis group did not show any genotype association. The increase in frequency of a slow acetylation phenotype in group of patients with type II psoriasis and in group of patients with normosthenic constitution, in comparison with control group (OR = 1.76,p = 0.177 and OR = 2.07,p = 0.050, respectively) has been revealed. The results for patients smoking one or more pack of cigarettes per day, and daily alcohol drinking in comparison with the control showed an increase in frequency for the genotype 341C/C, 481T/T, 803G/G (OR = 7.42, p = 0.008 and OR = 106.11, p = 0.003, respectively). We also found an increase of frequency of genotype 341T/T, 481C/C, 590A/-, 803A/A in patients with side reactions to medical products comparing with group of healthy donors (OR = 2.05, p = 0.099). Thus, the present data show that the certain NAT2 genotypes and some styles of life can be considered as risk factors of psoriasis development in this muscovite population.
PubMed ID
19334527 View in PubMed
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[Association of xenobiotic-metabolizing gene polymorphisms with childhood atopic diseases in Russian patients from the Republic of Bashkortostan].

https://arctichealth.org/en/permalink/ahliterature145977
Source
Mol Biol (Mosk). 2009 Nov-Dec;43(6):1032-9
Publication Type
Article
Author
Iu Iu Fedorova
O A Gra
A S Karunas
A Kh Khuzina
N N Ramazanova
A A Iuldasheva
A R Biktasheva
E I Etkina
T V Nasedkina
I V Goldenkova-Pavlova
E K Khusnutdinova
Source
Mol Biol (Mosk). 2009 Nov-Dec;43(6):1032-9
Language
Russian
Publication Type
Article
Keywords
Adolescent
Alleles
Bashkiria
Child
Child, Preschool
Environmental Exposure - adverse effects
Female
Gene Frequency - genetics
Humans
Infant
Male
Oxidoreductases - genetics
Polymorphism, Genetic
Rhinitis, Allergic, Perennial - chemically induced - enzymology - genetics
Sex Factors
Xenobiotics - adverse effects
Abstract
Enzymes of biotransformation system involved in the metabolism of exogenous and endogenous compounds are effective mechanism of protection from negative environmental factors. Decreasing activity or insufficient synthesis of biotransformation system enzymes caused by genetic polymorphism form the risk of various complex diseases, including atopic. Using allele-specific hybridization on the biochip the frequencies of xenobiotic-metabolizing gene polymorphisms in Russian children with bronchial asthma, allergic rhinitisand healthy donors from the Republic of Bashkortostan have been determined. The analysis of polymorphisms in CYP1A1, GSTT1, GSTM1, NAT2, MTHFR, CYP2C9 and CYP2C19 genes didn't reveal any association with atopic diseases. The frequencies of CYP2D6*1934G/G genotype and CYP2D6*1934G allele were significantly higher among boys with rhinitis symptoms than in control group.
PubMed ID
20088379 View in PubMed
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[Population analysis and determination of the ethnic background are necessary in the study of multifactorial diseases: a study using the Dagestan population as a model].

https://arctichealth.org/en/permalink/ahliterature167149
Source
Genetika. 2006 Aug;42(8):1137-42
Publication Type
Article
Date
Aug-2006
Author
I V Goldenkova-Pavlova
An L Piruzian
R M Abdeev
L V Khripach
M O Radzhabov
L A Piruzian
Source
Genetika. 2006 Aug;42(8):1137-42
Date
Aug-2006
Language
Russian
Publication Type
Article
Keywords
Dagestan
Ethnic Groups - genetics
Genetic Predisposition to Disease
Genetics, Population - methods
Humans
Models, Genetic
Multifactorial Inheritance - genetics
Psoriasis - ethnology - genetics
Abstract
Psoriasis, a multifactorial disease with genetic predisposition, has been used as an example to study the role of the ethnic background in multifactorial diseases in the Dagestan population. The individual information card (IIC) is proposed as the main tool for correct collection and processing of information. The results of the study demonstrate that the Dagestan population is a convenient and adequate model population for studying multifactorial diseases, such as psoriasis, and may serve as an object for studying the role of heredity in the etiologies and pathogeneses of this and other multifactorial diseases.
PubMed ID
17025165 View in PubMed
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