To elucidate factors associated with an established marker of occlusive atherosclerosis of lower extremities - low ankle-brachial index (ABI) - in patients with diabetes mellitus or prediabetes.
We examined 182 patients with diabetes (n=158), impaired glucose tolerance (n=17), or impaired fasting glucose (n=7). We analyzed history, demographic parameters, anthropometric data (body mass index [BMI], waist circumference), levels of plasma high and low density lipoprotein cholesterol, triglycerides, degree of glycemic control, and presence of signs of atherosclerosis of other localizations.
ABI was 0.9, respectively, p=0.006). Factors independently related to ABI
Data of about 50 consecutive patients with acute coronary syndromes aged at least 18 years admitted to 59 hospitals in different Russian cities were collected from November 2000 to July 2001. In 1412 patients included into registry presumably ischemic symptoms within previous 24 hours were associated with ST-segment elevation or left bundle branch block on ECG. Demographics, history, characteristics of acute coronary syndrome, management and outcomes during hospitalization as well as diagnoses at presentation and discharge were analyzed. Markers of myocardial necrosis were measured in 61% of patients. Rates of interventions that may improve outcome appeared to be low. In acute phase aspirin was used in 79% (contraindications were reported in 6.2%). Within 12 hours of symptoms onset thrombolysis was performed in 12.9%, coronary angioplasty in 1.2%. In patients hospitalized within 12 hours of symptoms onset these rates were 21.3 and 1.9%, respectively. Beta-blockers were prescribed no more than in 60% of cases (fist dose intravenously in 4.3%). Lipid lowering drugs were recommended at discharge to 12.3% of patients (to 21.1% of those with known hypercholesterolemia). ACE inhibitors during hospitalization were used in 68.1% of patients. After acute phase of the disease coronary angioplasty was performed in 5 patients, CABG in 1. However hospital mortality appeared to be not high (8.5% in general, 10.1% in patients with overt acute myocardial infarction at presentation). Reinfaction rate in this registry was impossible to assess, angina recurrences were registered in every fifth patient.
Data from about 50 consecutive patients with acute coronary syndromes aged > or =18 years admitted to 59 hospitals in different Russian cities were collected between November 2000 and July 2001. In addition to presumably ischemic symptoms within previous 24 hours they were to have ischemic ECG changes, documented coronary heart disease or positive markers of myocardial necrosis. Of 2806 patients included into registry 1394 (49.7%) had non-ST elevation acute coronary syndrome. Markers of myocardial necrosis (mainly CK activity) were evaluated in 59.5% of them. Frequency of interventions known to improve outcome was rather low: aspirin in acute phase was used in 73% (contraindications were reported just in 6%), thyenopyridines - in few cases, unfractionated heparin intravenously only with APTT control - in 11.8%, low-molecular weight heparins - in 7.4% of patients. Beta-blockers were prescribed in 55.6% of cases (with fist dose intravenously in 2.9%). Lipid lowering drugs were recommended on discharge to 15% of patients (to 20% with known hypercholesterolemia). Coronary angiography and revascularization procedures were performed in 25 (1.8%) and 11 (0.8%) patients, respectively. However hospital mortality appeared to be relatively low (3.8%). Meanwhile rates of (re)infactions and angina recurrences during hospitalization were high - 16.5 and 25.1% of cases, respectively.