Skip header and navigation

Refine By

4 records – page 1 of 1.

Ancient human genome sequence of an extinct Palaeo-Eskimo.

https://arctichealth.org/en/permalink/ahliterature98088
Source
Nature. 2010 Feb 11;463(7282):757-62
Publication Type
Article
Date
Feb-11-2010
Author
Morten Rasmussen
Yingrui Li
Stinus Lindgreen
Jakob Skou Pedersen
Anders Albrechtsen
Ida Moltke
Mait Metspalu
Ene Metspalu
Toomas Kivisild
Ramneek Gupta
Marcelo Bertalan
Kasper Nielsen
M Thomas P Gilbert
Yong Wang
Maanasa Raghavan
Paula F Campos
Hanne Munkholm Kamp
Andrew S Wilson
Andrew Gledhill
Silvana Tridico
Michael Bunce
Eline D Lorenzen
Jonas Binladen
Xiaosen Guo
Jing Zhao
Xiuqing Zhang
Hao Zhang
Zhuo Li
Minfeng Chen
Ludovic Orlando
Karsten Kristiansen
Mads Bak
Niels Tommerup
Christian Bendixen
Tracey L Pierre
Bjarne Grønnow
Morten Meldgaard
Claus Andreasen
Sardana A Fedorova
Ludmila P Osipova
Thomas F G Higham
Christopher Bronk Ramsey
Thomas V O Hansen
Finn C Nielsen
Michael H Crawford
Søren Brunak
Thomas Sicheritz-Pontén
Richard Villems
Rasmus Nielsen
Anders Krogh
Jun Wang
Eske Willerslev
Author Affiliation
Centre for GeoGenetics, Natural History Museum of Denmark and Department of Biology, University of Copenhagen, Universitetsparken 15, DK-2100 Copenhagen, Denmark.
Source
Nature. 2010 Feb 11;463(7282):757-62
Date
Feb-11-2010
Language
English
Geographic Location
Russia
Publication Type
Article
Keywords
Cryopreservation
Emigration and Immigration - history
Extinction, Biological
Genetics, Population
Genome, Human - genetics
Genomics
Genotype
Greenland
Hair
History, Ancient
Humans
Inuits - genetics
Male
Phenotype
Phylogeny
Polymorphism, Single Nucleotide - genetics
Sequence Analysis, DNA
Siberia - ethnology
Abstract
We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
Notes
RefSource: Nature. 2010 Feb 11;463(7282):739-40
PubMed ID
20148029 View in PubMed
Less detail

Genome-wide association study identifies four loci associated with eruption of permanent teeth.

https://arctichealth.org/en/permalink/ahliterature131166
Source
PLoS Genet. 2011 Sep;7(9):e1002275
Publication Type
Article
Date
Sep-2011
Author
Frank Geller
Bjarke Feenstra
Hao Zhang
John R Shaffer
Thomas Hansen
Ann-Louise Esserlind
Heather A Boyd
Ellen A Nohr
Nicholas J Timpson
Ghazaleh Fatemifar
Lavinia Paternoster
David M Evans
Robert J Weyant
Steven M Levy
Mark Lathrop
George Davey Smith
Jeffrey C Murray
Jes Olesen
Thomas Werge
Mary L Marazita
Thorkild I A Sørensen
Mads Melbye
Author Affiliation
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. fge@ssi.dk
Source
PLoS Genet. 2011 Sep;7(9):e1002275
Date
Sep-2011
Language
English
Publication Type
Article
Keywords
Adolescent
Alleles
Child
Cohort Studies
Denmark
Female
Genome-Wide Association Study
Genotype
HMGA2 Protein - genetics
Humans
Male
Membrane Proteins - genetics
Polymorphism, Single Nucleotide - genetics
Tooth Eruption - genetics
Tooth, Deciduous - physiology
United States
Abstract
The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P
Notes
Cites: Pediatr Dent. 2004 Jan-Feb;26(1):87-9215080365
Cites: PLoS One. 2007;2(9):e87317849003
Cites: Community Dent Oral Epidemiol. 1973;1(1):3-84153462
Cites: Community Dent Oral Epidemiol. 1974;2(3):122-94528826
Cites: Hum Hered. 1978;28(2):89-95621091
Cites: Angle Orthod. 1985 Apr;55(2):93-1073860029
Cites: Am J Orthod. 1985 Nov;88(5):433-83864376
Cites: J Dent Res. 1997 Jul;76(7):1337-409207765
Cites: ASDC J Dent Child. 1965;32:39-4414249344
Cites: Am J Med Sci. 2005 Feb;329(2):66-7015711422
Cites: Hum Mutat. 2009 Apr;30(4):590-819191329
Cites: Pediatrics. 2008 May;121(5):e1139-4318450858
Cites: Am J Epidemiol. 2005 Oct 1;162(7):623-3216107566
Cites: Nat Genet. 2009 May;41(5):579-8419330030
Cites: BMC Med Genet. 2009;10:10419825159
Cites: Arch Oral Biol. 2009 Dec;54 Suppl 1:S45-5118715551
Cites: PLoS One. 2009;4(12):e844420041193
Cites: PLoS Genet. 2010 Feb;6(2):e100085620195514
Cites: Genet Epidemiol. 2010 May;34(4):364-7220091798
Cites: Nat Genet. 2010 Jun;42(6):504-720453838
Cites: PLoS One. 2010;5(5):e1069320502693
Cites: Caries Res. 2010;44(3):277-8420516689
Cites: Bioinformatics. 2010 Sep 1;26(17):2190-120616382
Cites: Bioinformatics. 2010 Sep 15;26(18):2336-720634204
Cites: Nat Genet. 2010 Oct;42(10):869-7320802479
Cites: Nat Genet. 2010 Oct;42(10):885-9220852631
Cites: Nature. 2010 Oct 14;467(7317):832-820881960
Cites: Genet Epidemiol. 2010 Nov;34(7):665-7320839289
Cites: Genet Epidemiol. 2010 Dec;34(8):816-3421058334
Cites: Nat Genet. 2010 Dec;42(12):1077-8521102462
Cites: J Natl Cancer Inst. 2011 Mar 2;103(5):425-3521263130
Cites: Breast Cancer Res Treat. 2011 Apr;126(3):717-2720872241
Cites: Angle Orthod. 1999 Dec;69(6):529-3310593443
Cites: Eur J Oral Sci. 2000 Jun;108(3):184-810872987
Cites: Community Dent Oral Epidemiol. 2001 Apr;29(2):92-811300177
Cites: Scand J Public Health. 2001 Dec;29(4):300-711775787
Cites: Nat Genet. 2007 Oct;39(10):1245-5017767157
Cites: J Dent Res. 2007 Dec;86(12):1160-518037648
Cites: Community Dent Oral Epidemiol. 2008 Apr;36(2):179-8918333882
Cites: Thyroid. 2004 Mar;14(3):187-9015072700
Cites: J Public Health Dent. 2002 Spring;62(2):109-1411989205
Cites: Community Dent Oral Epidemiol. 2003 Feb;31(1):30-912542430
Cites: Eur J Oral Sci. 2003 Apr;111(2):106-1012648261
Cites: Pediatrics. 2003 Sep;112(3 Pt 1):e184-9112949310
Cites: J Public Health Dent. 2003 Fall;63(4):211-2014682644
Cites: J Forensic Sci. 2005 Sep;50(5):1164-7416225225
Cites: Am J Hum Genet. 2006 Jan;78(1):78-8816385451
Cites: Dan Med Bull. 2006 Nov;53(4):441-917150149
Cites: Food Nutr Bull. 2006 Dec;27(4 Suppl Growth Standard):S244-5617361661
Cites: Nat Genet. 2007 Jul;39(7):870-417529973
Cites: Nat Genet. 2007 Jul;39(7):865-917529974
Cites: Nature. 2007 Jun 28;447(7148):1087-9317529967
Cites: Am J Hum Genet. 2007 Sep;81(3):559-7517701901
Cites: Am J Orthod Dentofacial Orthop. 2004 Oct;126(4):432-4515470346
PubMed ID
21931568 View in PubMed
Less detail

[Meta-analysis of association between pentachlorophenol exposure and cancer risk].

https://arctichealth.org/en/permalink/ahliterature156427
Source
Wei Sheng Yan Jiu. 2008 Mar;37(2):151-4
Publication Type
Article
Date
Mar-2008
Author
Weiwei Zheng
Ying Zhou
Weidong Qu
Hao Zhang
et al
Author Affiliation
Key Laboratory of the Public Health and Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Source
Wei Sheng Yan Jiu. 2008 Mar;37(2):151-4
Date
Mar-2008
Language
Chinese
Publication Type
Article
Keywords
Canada - epidemiology
Colorectal Neoplasms - epidemiology - mortality
Environmental Exposure - adverse effects
Humans
Kidney Neoplasms - epidemiology - mortality
Neoplasms - epidemiology - mortality
Pentachlorophenol - toxicity
Risk factors
United States - epidemiology
Abstract
The epidemiological data based on the exposure of pentachlorophenol (PCP) and cancer incidence and mortality were analyzed to study the relationship between PCP exposure and cancer risk.
According to the online search of relevant literatures, Poisson regression was used to analyze mortality rates for major cancer sites and fixed-effect model was employed to assess cancer SMR. The dose-response relationship between PCP exposure and cancer risk was also analyzed.
Major cancer mortality rates of exposure populations researched in American and Canadian studies were approximate to or lower than national male cancer mortality rates respectively. The incidence rate of colorectal cancer in occupational exposure population was over 16.4 times in comparison with the population exposed from to drinking water and food. The pooled SMR value of kidney cancer was 1.34 (95% CI 1.02-1.77). The pooled RR for major cancer mortality increased with the rise of PCP exposure level.
A potential dose-response relationship between PCP exposure and cancer risk could exist. In comparison with to the population to exposed from the drinking water and food, the risk of colorectal cancer in occupational exposure population was higher. PCP may be one of the risk factors of the kidney cancer in occupational exposure population.
PubMed ID
18589595 View in PubMed
Less detail

Trends in overweight and obesity in Danish children and adolescents: 2000-2008--exploring changes according to parental education.

https://arctichealth.org/en/permalink/ahliterature269682
Source
Scand J Public Health. 2014 Jun;42(4):385-92
Publication Type
Article
Date
Jun-2014
Author
Jeppe Matthiessen
Anders Stockmarr
Anja Biltoft-Jensen
Sisse Fagt
Hao Zhang
Margit Velsing Groth
Source
Scand J Public Health. 2014 Jun;42(4):385-92
Date
Jun-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Child, Preschool
Cross-Sectional Studies
Denmark - epidemiology
Educational Status
Female
Health Status Disparities
Humans
Male
Overweight - epidemiology
Parents
Pediatric Obesity - epidemiology
Prevalence
Sex Distribution
Abstract
To examine the hypotheses that an overall levelling off in the prevalence of overweight and obesity during the period 2000-2008 has occurred, and that increasing social inequality in overweight and obesity exists in a nationally representative sample of Danish children and adolescents.
The population comprised a random sample of 1849 children aged 4-14 years who participated in the Danish National Survey of Diet and Physical Activity in 2000-2002, 2003-2004 and 2005-2008. Parental education was chosen as an indicator of children's socioeconomic status. Body mass index (BMI) was calculated from parent-reported weight and height. Subjects were classified as overweight and obese according to the International Obesity Task Force age- and gender-specific BMI cut-off values. Crude prevalence estimates and logistic regression models were used to analyse trends in overweight and obesity as the main outcome measures.
An increase was found in the crude prevalence of overweight (including obesity) in boys (12.8-21.7%, p = 0.0006), but not in girls (17.6-15.9%, p = 0.56), between 2000-2002 and 2005-2008. The prevalence of overweight increased significantly in boys of parents with low educational level only. A strong inverse social gradient in overweight and obesity was documented for boys and girls during the whole survey period.
The present study showed an increase in the prevalence of overweight in Danish boys, but not in girls. This increase was due to increasing social inequality in overweight among boys. Public health initiatives aimed at preventing and reducing overweight and obesity should consider gender difference and especially target boys with parents of low educational level.
PubMed ID
24516062 View in PubMed
Less detail