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A retrospective cohort study of blood hemoglobin levels in blood donors and competitive rowers.

https://arctichealth.org/en/permalink/ahliterature158631
Source
Scand J Med Sci Sports. 2009 Feb;19(1):92-5
Publication Type
Article
Date
Feb-2009
Author
P I Johansson
H. Ullum
K. Jensen
N H Secher
Author Affiliation
Department of Clinical Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. per.johansson@rh.hosp.dk
Source
Scand J Med Sci Sports. 2009 Feb;19(1):92-5
Date
Feb-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Blood Donors
Cohort Studies
Competitive Behavior
Denmark
Female
Hemoglobins - analysis
Humans
Male
Middle Aged
Retrospective Studies
Ships
Young Adult
Abstract
To investigate the distribution of blood hemoglobin levels in healthy blood donors and elite athletes, a retrospective cohort study from 2001 to 2005 of candidate blood donors and elite rowers in Denmark was performed. Eighty-five thousand eight hundred and forty-six blood donors were identified (36 962 males), and 3.9% of the males had a blood hemoglobin above 10.5 mM, equalling a hematocrit of 51% and, 1.6% of the females had hemoglobin above 9.7 mM, corresponding to a hematocrit above 47%. One thousand four hundred and six rowers (1116 males) were investigated and 10.4% of the males and 8.3% of the females demonstrated values above the recommended limit for athletic competition. Thus, the prevalence of a high hemoglobin value was greater in the rowers, of both gender, than in the candidate blood donors (P
PubMed ID
18298615 View in PubMed
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The Danish Blood Donor Study: a large, prospective cohort and biobank for medical research.

https://arctichealth.org/en/permalink/ahliterature130792
Source
Vox Sang. 2012 Apr;102(3):271
Publication Type
Article
Date
Apr-2012

Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection.

https://arctichealth.org/en/permalink/ahliterature7476
Source
Blood. 2000 Dec 15;96(13):4091-5
Publication Type
Article
Date
Dec-15-2000
Author
N. Sidenius
C F Sier
H. Ullum
B K Pedersen
A C Lepri
F. Blasi
J. Eugen-Olsen
Author Affiliation
Department of Molecular Pathology and Medicine, Molecular Genetics Unit, DIBIT, San Raffaele Scientific Institute, Milan, Italy. nicolai.sidenius@hsr.it
Source
Blood. 2000 Dec 15;96(13):4091-5
Date
Dec-15-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Antiretroviral Therapy, Highly Active
Cohort Studies
Denmark - epidemiology
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections - blood - drug therapy - mortality
HIV-1
Humans
Life tables
Male
Middle Aged
Prognosis
Proportional Hazards Models
Receptors, Cell Surface - blood
Retrospective Studies
Severity of Illness Index
Solubility
Survival Analysis
Treatment Outcome
Abstract
Human immunodeficiency virus-1 (HIV-1) infection has been shown to result in up-regulation of the urokinase-type plasminogen activator receptor (uPAR/CD87) on leukocytes in vitro and in vivo. The objective of this study was to investigate whether this up-regulation is paralleled by higher serum levels of soluble uPAR (suPAR) in patients with advanced HIV-1 disease and whether the serum level of suPAR is predictive of clinical outcome. Using an enzyme-linked immunosorbent assay, the level of suPAR was measured retrospectively in serum samples from 314 patients with HIV-1 infection. By Kaplan-Meier and Cox regression analyses, the serum suPAR levels were correlated to survival with AIDS-related death as the end point. High levels of serum suPAR (greater than median) were associated with poor overall survival, and Kaplan-Meier analysis on patients stratified by suPAR level demonstrated a continuous increase in mortality rates with higher suPAR levels. After adjustment for accepted prognostic markers-including Centers for Disease Control and Prevention-defined clinical stages, CD4 counts, viral load, beta2-microglobulin, and age-the prognostic strength of suPAR remained highly significant, indicating that the serum suPAR level is a novel, strong, and independent predictor of survival in HIV-1 infection. This report is the first to demonstrate an important association between the plasminogen activator system and disease progression in HIV-1 infection.
PubMed ID
11110678 View in PubMed
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The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection.

https://arctichealth.org/en/permalink/ahliterature7647
Source
AIDS. 1998 Sep 10;12(13):1639-43
Publication Type
Article
Date
Sep-10-1998
Author
A. Cozzi Lepri
T L Katzenstein
H. Ullum
A N Phillips
P. Skinhøj
J. Gerstoft
B K Pedersen
Author Affiliation
Royal Free Centre for HIV Medicine & Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, UK.
Source
AIDS. 1998 Sep 10;12(13):1639-43
Date
Sep-10-1998
Language
English
Publication Type
Article
Keywords
Adult
Aged
Biological Markers
CD4 Lymphocyte Count
Cohort Studies
Female
Follow-Up Studies
HIV - genetics
HIV Infections - immunology - physiopathology
Humans
Male
Middle Aged
Prognosis
Proportional Hazards Models
RNA, Viral - blood
Research Support, Non-U.S. Gov't
Viral Load
Abstract
OBJECTIVE: It has been suggested that the plasma HIV RNA level is a better predictor of AIDS and death than the CD4 lymphocyte count. We assessed whether the prognostic value of plasma virus levels was different according to the CD4 count. DESIGN: Prospective cohort study of HIV-infected patients followed for a median of 2.91 years (range, 0.02-4.54). SETTING: Department of Infectious Diseases at Rigshospitalet, Copenhagen, Denmark. PARTICIPANTS: A group of 255 HIV-infected individuals with an initial measurement of CD4 lymphocyte count and plasma HIV RNA. MAIN OUTCOME MEASURE: Survival time. RESULTS: The plasma HIV RNA (median 101410 copies/ml; range (range 200-7200000) and the CD4 lymphocyte count (median 250 cells x 10(6)/l; range 1-1247) were negatively correlated (Pearson r = -0.53; P
PubMed ID
9764783 View in PubMed
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Prevalence and prognostic significance of infection with TT virus in patients infected with human immunodeficiency virus.

https://arctichealth.org/en/permalink/ahliterature7532
Source
J Infect Dis. 2000 May;181(5):1796-9
Publication Type
Article
Date
May-2000
Author
J K Christensen
J. Eugen-Olsen
M. SLrensen
H. Ullum
S B Gjedde
B K Pedersen
J O Nielsen
K. Krogsgaard
Author Affiliation
Clinical Research Unit 441, Copenhagen University Hospitals, Hvidovre Hospital, Hvidovre, Denmark.
Source
J Infect Dis. 2000 May;181(5):1796-9
Date
May-2000
Language
English
Publication Type
Article
Keywords
AIDS-Related Opportunistic Infections - epidemiology - mortality - virology
Adolescent
Adult
Aged
Blood Donors
Comparative Study
DNA Virus Infections - epidemiology - mortality
DNA Viruses - isolation & purification
Denmark - epidemiology
Female
Humans
Male
Middle Aged
Predictive value of tests
Prevalence
Prognosis
Survival Rate
Time Factors
Abstract
No clear association between human disease and TT virus (TTV) has been documented. A possible pathogenic role of TTV was investigated in patients infected with human immunodeficiency virus (HIV). TTV serum concentrations were estimated in 185 HIV-infected patients by dilution polymerase chain reaction. Of these, 149 (76%) were TTV-positive, compared with 18 (7%) of 252 Danish blood donors (P/=5 times the highest concentration observed among blood donors, i.e., >/=3.5x105 TTV/mL of serum). High TTV viremia was associated with decreased survival (P
PubMed ID
10823787 View in PubMed
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Shift work at young age is associated with increased risk of multiple sclerosis in a Danish population.

https://arctichealth.org/en/permalink/ahliterature280589
Source
Mult Scler Relat Disord. 2016 Sep;9:104-9
Publication Type
Article
Date
Sep-2016
Author
S. Gustavsen
H B Søndergaard
D B Oturai
B. Laursen
J H Laursen
M. Magyari
H. Ullum
M H Larsen
F. Sellebjerg
A B Oturai
Source
Mult Scler Relat Disord. 2016 Sep;9:104-9
Date
Sep-2016
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Case-Control Studies
Denmark - epidemiology
Employment
Female
Humans
Logistic Models
Male
Multiple Sclerosis - epidemiology
Odds Ratio
Risk factors
Abstract
Epidemiological studies suggest an important role for environmental factors in developing multiple sclerosis (MS). Furthermore several studies have indicated that the effect of environmental factors may be especially pronounced in adolescents. Recently only one study investigated and found that shift work at young age is associated with an increased risk of developing MS. In this study we focused on the effect of shift work in the vulnerable period between 15-19 years.
The aim of this study was to investigate the association between shift work at young age and the risk of developing MS.
We performed a large case-control study including 1723 patients diagnosed with MS and 4067 controls. MS patients were recruited from the Danish Multiple Sclerosis Biobank and controls from The Danish Blood Donor Study. Information on working patterns and lifestyle factors was obtained using a comprehensive lifestyle-environmental factor questionnaire with participants enrolled between 2009 and 2014. Logistic regression models were used to investigate the association between shift work at age 15-19 years and the subsequent risk of MS and were controlled for effects due to established MS risk factors.
We found a statistically significant association when total numbers of night shifts were compared with non-shift workers. For every additional 100 night shifts the odds ratio (OR) for MS was 1.20 (95% confidence interval (CI), 1.08-1.34, p=0.001). Increasing intensity of shift work also increased MS risk. For every additional night per month the OR was 1.04 (95% CI, 1.01-1.06, p=0.002). Duration of shift work in years was not associated with risk of MS.
This study supports a statistically significant association between shift work at age 15-19 years and MS risk.
PubMed ID
27645354 View in PubMed
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Digital questionnaire platform in the Danish Blood Donor Study.

https://arctichealth.org/en/permalink/ahliterature280970
Source
Comput Methods Programs Biomed. 2016 Oct;135:101-4
Publication Type
Article
Date
Oct-2016
Author
K S Burgdorf
N. Felsted
S. Mikkelsen
M H Nielsen
L W Thørner
O B Pedersen
E. Sørensen
K R Nielsen
M T Bruun
T. Werge
C. Erikstrup
T. Hansen
H. Ullum
Source
Comput Methods Programs Biomed. 2016 Oct;135:101-4
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Blood Donors
Denmark
Female
Humans
Male
Surveys and Questionnaires
Abstract
The Danish Blood Donor Study (DBDS) is a prospective, population-based study and biobank. Since 2010, 100,000 Danish blood donors have been included in the study. Prior to July 2015 all participating donors had to complete a paper-based questionnaire. Here we describe the establishment of a digital tablet-based questionnaire platform implemented in blood bank sites across Denmark.
The digital questionnaire was developed using the open source survey software tool LimeSurvey. The participants accesses the questionnaire online with a standard SSL encrypted HTTP connection using their personal civil registration numbers. The questionnaire is placed at a front-end web server and a collection server retrieves the completed questionnaires. Data from blood samples, register data, genetic data and verification of signed informed consent are then transferred to and merged with the questionnaire data in the DBDS database.
The digital platform enables personalized questionnaires, presenting only questions relevant to the specific donor by hiding unneeded follow-up questions on screening question results. New versions of questionnaires are immediately available at all blood collection facilities when new projects are initiated.
The digital platform is a faster, cost-effective and more flexible solution to collect valid data from participating donors compared to paper-based questionnaires. The overall system can be used around the world by the use of Internet connection, but the level of security depends on the sensitivity of the data to be collected.
PubMed ID
27586483 View in PubMed
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8 records – page 1 of 1.