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34 records – page 1 of 4.

6-Locus HLA allele and haplotype frequencies in a population of 1075 Russians from Karelia.

https://arctichealth.org/en/permalink/ahliterature295799
Source
Hum Immunol. 2018 Nov 02; :
Publication Type
Journal Article
Date
Nov-02-2018
Author
Yvonne Hagenlocher
Beatrix Willburger
Geoffrey A Behrens
Alexander H Schmidt
Yuri Ioffe
Jürgen Sauter
Author Affiliation
DKMS German Bone Marrow Donor Center, Tübingen, Germany.
Source
Hum Immunol. 2018 Nov 02; :
Date
Nov-02-2018
Language
English
Publication Type
Journal Article
Abstract
A total of 1075 Russians from the Russian part of Karelia were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next generation sequencing methods. The haplotypic and allelic profiles as well as Hardy-Weinberg proportions of this population sample were evaluated. As the most frequent 6-locus haplotype, A*03:01?g?~?B*07:02?g?~?C*07:02?g?~?DRB1*15:01?g?~?DQB1*06:02?g?~?DPB1*04:01?g was identified with an estimated frequency of 3.5%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Russia Karelia" and the identifier AFN3430.
PubMed ID
30391501 View in PubMed
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6-Locus HLA allele and haplotype frequencies in a population of 1075 Russians from Karelia.

https://arctichealth.org/en/permalink/ahliterature301335
Source
Hum Immunol. 2019 Feb; 80(2):95-96
Publication Type
Journal Article
Date
Feb-2019
Author
Yvonne Hagenlocher
Beatrix Willburger
Geoffrey A Behrens
Alexander H Schmidt
Yuri Ioffe
Jürgen Sauter
Author Affiliation
DKMS German Bone Marrow Donor Center, Tübingen, Germany.
Source
Hum Immunol. 2019 Feb; 80(2):95-96
Date
Feb-2019
Language
English
Publication Type
Journal Article
Keywords
Alleles
Gene Frequency
Genetic Loci
Genetics, Population
Genotype
HLA Antigens - genetics
Haplotypes
Humans
Population Groups
Russia - ethnology
Abstract
A total of 1075 Russians from the Russian part of Karelia were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next generation sequencing methods. The haplotypic and allelic profiles as well as Hardy-Weinberg proportions of this population sample were evaluated. As the most frequent 6-locus haplotype, A*03:01?g?~?B*07:02?g?~?C*07:02?g?~?DRB1*15:01?g?~?DQB1*06:02?g?~?DPB1*04:01?g was identified with an estimated frequency of 3.5%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Russia Karelia" and the identifier AFN3430.
PubMed ID
30391501 View in PubMed
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AG 85, a major secretion protein of Mycobacterium tuberculosis, can be identified in ancient bone.

https://arctichealth.org/en/permalink/ahliterature271332
Source
Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S87-92
Publication Type
Article
Date
Jun-2015
Author
Tyede H Schmidt-Schultz
Michael Schultz
Source
Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S87-92
Date
Jun-2015
Language
English
Publication Type
Article
Keywords
Adult
Aged
Biomarkers - analysis
Blotting, Western
Case-Control Studies
Female
Germany
History, Ancient
History, Medieval
Humans
Indoles - analysis
Male
Microscopy - methods
Middle Aged
Mycobacterium tuberculosis
Paleopathology - methods
Siberia
Tuberculosis, Osteoarticular - diagnosis - history
Young Adult
Abstract
For the confirmation of Ag 85 in ancient and recent ECM of native macerated human bone, five cases were investigated. In three individuals, highly positive results for Ag 85 were identified in Western blot: 1) a male from Arzhan, South Siberia, dating from the 7th century BC, 2) a male from Kirchberg in Hesse, Germany, dating from the 10th - 12th century AD and 3) a recent female with a proven diagnosis of TB. As a negative control, a recent male is presented who did not suffer from TB. In another recent male, Ag 85 could be identified only very weakly. From cases in the literature it is well-known that highly positive results for Ag 85 indicate active TB, however, weakly positive results indicate a silent initial infection with Mtb. Thus, apparently, also in ancient individuals, it might well be possible to differentiate between diseased persons and disease carriers using paleoproteomic techniques.
PubMed ID
25890594 View in PubMed
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An epidemic of syphilis among homosexuals and bisexuals.

https://arctichealth.org/en/permalink/ahliterature239664
Source
Acta Derm Venereol Suppl (Stockh). 1985;120:65-7
Publication Type
Article
Date
1985
Author
H. Schmidt
A S Jørgensen
H O Petersen
Source
Acta Derm Venereol Suppl (Stockh). 1985;120:65-7
Date
1985
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cytomegalovirus Infections - epidemiology
Denmark
Disease Outbreaks - epidemiology
Female
Herpes Simplex - epidemiology
Homosexuality
Humans
Male
Middle Aged
Sexual Behavior
Syphilis - epidemiology
Abstract
22 cases of syphilis were diagnosed in the last part of 1982 in the Department of Dermatology and Venereology. Out of them 21 were male cases and 16 were homo- or bisexuals. Most cases were in the secondary stage and Herxheimer reaction only developed in these. Serological titers to both lipoidal and treponemal antigens were extremely high. All bisexual males were positive in herpes and CMV complement fixation test. Two of the homosexuals appeared with iridocyclitis and motile treponemes were isolated from the anterior chamber in one case.
PubMed ID
3010617 View in PubMed
Less detail
Source
Home Healthc Nurse. 1997 Oct;15(10):706-12
Publication Type
Article
Date
Oct-1997
Author
H. Schmidt
Source
Home Healthc Nurse. 1997 Oct;15(10):706-12
Date
Oct-1997
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Community Health Nursing - standards
Fatal Outcome
Home Care Services
Humans
Male
Norway
Nurse-Patient Relations
Abstract
This article, written by a home care nurse from Norway, won the World Health Organization's Balint Prize for the field of health and nursing care in 1996. The author shares a compelling client situation illustrating that home care nurses throughout the world share many attributes, but the main one is caring.
PubMed ID
9369590 View in PubMed
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[Breaking the smoking habit in general practice]

https://arctichealth.org/en/permalink/ahliterature67913
Source
Ugeskr Laeger. 1990 Aug 6;152(32):2302-3
Publication Type
Article
Date
Aug-6-1990
Author
J G Hansen
H. Schmidt
Source
Ugeskr Laeger. 1990 Aug 6;152(32):2302-3
Date
Aug-6-1990
Language
Danish
Publication Type
Article
Keywords
Adolescent
Adult
Denmark
English Abstract
Family Practice
Female
Humans
Lung Diseases, Obstructive - etiology
Male
Middle Aged
Patient Education
Research Support, Non-U.S. Gov't
Respiratory Function Tests
Smoking - adverse effects - physiopathology - prevention & control
Abstract
A total of 1,022 adult smokers were questioned about smoking habits and were submitted to pulmonary function tests with spirometry. These patients were subdivided into two groups depending on whether investigation of pulmonary function showed obstruction or normal findings. All of the patients were given the pamphlet: "Important information about smoking" published by the Danish Anticancer League and they were given standardized warnings about smoking and information about the result of the pulmonary function tests. Twelve months later, the patients were questioned about their current smoking habits. 9% with obstruction and 11% without obstruction, respectively, had stopped smoking.
PubMed ID
2399617 View in PubMed
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The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.

https://arctichealth.org/en/permalink/ahliterature159483
Source
Digestion. 2007;76(3-4):196-202
Publication Type
Article
Date
2007
Author
Daniel C Baumgart
Carsten Buning
Lars Geerdts
Hartmut H Schmidt
Janine Genschel
Thomas Fiedler
Enno Gentz
Tomas Molnar
Ferenc Nagy
Janos Lonovics
Herbert Lochs
Bertram Wiedenmann
Renate Nickel
Heiko Witt
Axel Dignass
Author Affiliation
Division of Gastroenterology and Hepatology, Department of Medicine, Charité Medical School, Humboldt University of Berlin, Berlin, Germany. daniel.baumgart@charite.de
Source
Digestion. 2007;76(3-4):196-202
Date
2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Antigens, CD14 - genetics
Cohort Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Inflammatory Bowel Diseases - genetics
Male
Phenotype
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Retrospective Studies
Toll-Like Receptor 4 - genetics
Abstract
Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest.
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (CD) (n = 379; German n = 235, Hungarian n = 144) and ulcerative colitis (UC) (n = 263; German n = 145, Hungarian n = 118) and healthy controls (n = 605; German n = 403, Hungarian n = 202) were genotyped for the presence of the CD14 c.1-260C>T promoter variant and the TLR4 c.896A>G (p.D299G) variant by melting curve analysis using fluorescence resonance energy transfer probes. Data were stratified according to the presence of NOD2 (CARD15) mutations and a detailed genotype-phenotype analysis was performed.
In the German cohort the CD14 single-nucleotide polymorphism was associated with UC, but not CD (UC p = 0.016 vs. CD p = 0.190), while the opposite was found in the Hungarian cohort (UC p = 0.083 vs. CD p = 0.019). No association of IBD with the TLR4 single-nucleotide polymorphism was found in either cohort (UC p = 0.430, CD p = 0.783 vs. UC p = 0.745, CD p = 0.383).
IBD appears to be associated with the CD14 c.1-260C>T promoter variant in Germans and Hungarians, but not with the TLR4 c.896A>G (p.D299G) variant.
PubMed ID
18174680 View in PubMed
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Climate sensitivity of reproduction in a mast-seeding boreal conifer across its distributional range from lowland to treeline forests.

https://arctichealth.org/en/permalink/ahliterature257147
Source
Oecologia. 2014 Mar;174(3):665-77
Publication Type
Article
Date
Mar-2014
Author
Carl A Roland
Joshua H Schmidt
Jill F Johnstone
Author Affiliation
National Park Service, Central Alaska Network, 4175 Geist Road, Fairbanks, AK, 99709, USA, carl_roland@nps.gov.
Source
Oecologia. 2014 Mar;174(3):665-77
Date
Mar-2014
Language
English
Publication Type
Article
Keywords
Alaska
Altitude
Bayes Theorem
Climate
Climate change
Droughts
Ecosystem
Picea - physiology
Reproduction
Seeds - physiology
Temperature
Trees - physiology
Abstract
Mast-seeding conifers such as Picea glauca exhibit synchronous production of large seed crops over wide areas, suggesting climate factors as possible triggers for episodic high seed production. Rapidly changing climatic conditions may thus alter the tempo and spatial pattern of masting of dominant species with potentially far-reaching ecological consequences. Understanding the future reproductive dynamics of ecosystems including boreal forests, which may be dominated by mast-seeding species, requires identifying the specific cues that drive variation in reproductive output across landscape gradients and among years. Here we used annual data collected at three sites spanning an elevation gradient in interior Alaska, USA between 1986 and 2011 to produce the first quantitative models for climate controls over both seedfall and seed viability in P. glauca, a dominant boreal conifer. We identified positive associations between seedfall and increased summer precipitation and decreased summer warmth in all years except for the year prior to seedfall. Seed viability showed a contrasting response, with positive correlations to summer warmth in all years analyzed except for one, and an especially positive response to warm and wet conditions in the seedfall year. Finally, we found substantial reductions in reproductive potential of P. glauca at high elevation due to significantly reduced seed viability there. Our results indicate that major variation in the reproductive potential of this species may occur in different landscape positions in response to warming, with decreasing reproductive success in areas prone to drought stress contrasted with increasing success in higher elevation areas currently limited by cool summer temperatures.
PubMed ID
24213628 View in PubMed
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[Diagnosis and treatment of acute sinusitis by Danish general practitioners].

https://arctichealth.org/en/permalink/ahliterature218567
Source
Ugeskr Laeger. 1994 Mar 28;156(13):1934-5, 1938-40
Publication Type
Article
Date
Mar-28-1994
Author
J G Hansen
H. Schmidt
Source
Ugeskr Laeger. 1994 Mar 28;156(13):1934-5, 1938-40
Date
Mar-28-1994
Language
Danish
Publication Type
Article
Keywords
Acute Disease
Adult
Denmark - epidemiology
Family Practice - statistics & numerical data
Humans
Nasal Decongestants - therapeutic use
Penicillins - therapeutic use
Questionnaires
Sinusitis - diagnosis - drug therapy - epidemiology
Abstract
We studied Danish general practitioners' (GP) weighting of symptoms, clinical findings and use of paraclinical investigations when diagnosing acute sinusitis in adults. Questionnaires were sent to 300 representative GPs. Sixty-seven percent answered the questionnaire. The GPs weighted pain and tenderness on application of pressure over the sinuses as the most important symptom and finding. Only a few used paraclinical investigations. The GPs estimated their own diagnostic certainty as being 70%. Detumescent nose-drops were prescribed in 95% of the cases, and antibiotic treatment was given in 50%, most frequently as V-penicillin.
Notes
Comment In: Ugeskr Laeger. 1994 Sep 5;156(36):5136-77941057
PubMed ID
7516592 View in PubMed
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[Diagnosis and treatment of bacterial vaginosis by general practitioners]

https://arctichealth.org/en/permalink/ahliterature73016
Source
Ugeskr Laeger. 1995 Aug 7;157(32):4459-62
Publication Type
Article
Date
Aug-7-1995
Author
H. Schmidt
J G Hansen
Source
Ugeskr Laeger. 1995 Aug 7;157(32):4459-62
Date
Aug-7-1995
Language
Danish
Publication Type
Article
Keywords
Denmark
English Abstract
Female
Health Knowledge, Attitudes, Practice
Humans
Physicians, Family
Questionnaires
Vaginosis, Bacterial - diagnosis - drug therapy
Abstract
In order to evaluate which diagnostic procedures and treatments general practitioners (GP) used for bacterial vaginosis, and to describe their knowledge of the disease, all the GPs in two counties were asked to fill in a questionnaire. Two hundred and sixty-six (59%) answered. The GP used the criteria of Amsel in 9%, the wet smear criteria in 12%, clue cells in 6%, the amine test in 30%, culture of Gardnerella vaginalis in 29%, 8% only used clinical examination and 6% did not use any criteria. Many examinations were carried out unnecessarily. Sixty-six percent stated that they had a sufficient knowledge of bacterial vaginosis, 36% had knowledge of the criteria of Amsel, 78% of the definition of clue cells and 58% considered culture of Gardnerella vaginalis as being diagnostically useful. Seventy-one percent used metronidazole for treatment. Treatment of the sexual partner was carried out in 33%. In conclusion, we recommend introduction of a more simple criterion than the criteria of Amsel.
PubMed ID
7483026 View in PubMed
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34 records – page 1 of 4.