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Cerebral abscesses among Danish patients with hereditary haemorrhagic telangiectasia.

https://arctichealth.org/en/permalink/ahliterature256387
Source
Acta Neurol Scand. 2014 Mar;129(3):192-7
Publication Type
Article
Date
Mar-2014
Author
A D Kjeldsen
P M Tørring
H. Nissen
P E Andersen
Author Affiliation
Department of Otorhinolaryngology, Odense University Hospital, Odense, Denmark.
Source
Acta Neurol Scand. 2014 Mar;129(3):192-7
Date
Mar-2014
Language
English
Publication Type
Article
Keywords
Activin Receptors, Type II - genetics
Adult
Angiography
Antigens, CD - genetics
Arteriovenous Fistula - diagnosis - epidemiology
Brain Abscess - epidemiology
DNA Mutational Analysis
Denmark
Echocardiography
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Mutation - genetics
Pulmonary Artery - abnormalities
Pulmonary Veins - abnormalities
Receptors, Cell Surface - genetics
Retrospective Studies
Telangiectasia, Hereditary Hemorrhagic - epidemiology
Young Adult
Abstract
Hereditary haemorrhagic telangiectasia (HHT) is a dominantly inherited disease characterized by a wide variety of clinical manifestations, including pulmonary arteriovenous malformations (PAVMs), which due to paradoxical embolization may cause cerebral abscess.
To estimate the risk of cerebral abscess among patients with HHT.
All patients with HHT included in the Danish HHT data base, between January 1995 and October 2012, have been clinically evaluated for the presence of neurological symptoms and history of previous cerebral abscess.
A total of 337 patients with HHT have been included in the Danish database. Of these, 264 were screened for the presence of PAVM. In 117 patients, a PAVM was diagnosed; among these, we identified nine patients with a history of cerebral abscess. The prevalence of cerebral abscess among patients with HHT and PAVM was therefore 7.8%. The patients with a history of cerebral abscess were genetically evaluated, and seven had ENG mutations, one had an ALK1 mutation, and in one case, a mutation could not be identified.
Patients with untreated PAVM have a considerable risk of sustaining cerebral abscesses. A cerebral abscess may be the first symptom leading to an HHT diagnosis. Patients with unexplained cerebral abscess should be evaluated for HHT and PAVM.
PubMed ID
23962120 View in PubMed
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Detection of a single base deletion in codon 424 of the low density lipoprotein receptor gene in a Danish family with familial hypercholesterolemia.

https://arctichealth.org/en/permalink/ahliterature35587
Source
Atherosclerosis. 1994 Dec;111(2):209-15
Publication Type
Article
Date
Dec-1994
Author
H. Nissen
A B Hansen
P. Guldberg
N E Petersen
M L Larsen
T. Haghfelt
K. Kristiansen
M. Hørder
Author Affiliation
Department of Clinical Chemistry, Odense University Hospital, Denmark.
Source
Atherosclerosis. 1994 Dec;111(2):209-15
Date
Dec-1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Amino Acid Sequence
Base Sequence
Child
Child, Preschool
Codon
Denmark
Electrophoresis, Gel, Two-Dimensional
Female
Humans
Hypercholesterolemia, Familial - genetics - mortality
Male
Middle Aged
Molecular Sequence Data
Mutation
Myocardial Ischemia - genetics - mortality
Pedigree
Polymerase Chain Reaction
Receptors, LDL - genetics
Research Support, Non-U.S. Gov't
Survivors
Abstract
We performed a screening of exon 9 of the low density lipoprotein receptor (LDLR) gene in 14 Danish families with familial hypercholesterolemia (FH) using the denaturing gradient gel electrophoresis (DGGE) technique. In one of the probands from these families an abnormal band pattern in the gradient gel was detected. Subsequent DGGE analysis of the family of this index patient revealed that the DGGE pattern cosegregated with the disease in this family. Sequencing of the exon showed a deletion of a C in codon 424 of the LDLR gene resulting in a frame shift with the introduction of a stop codon 5 codons further downstream. The mutation is referred to as FH-Odense. The predicted truncated receptor protein consists of the 428 amino terminal amino acids. Consequently, the cytosolic and membrane spanning parts of the mature LDL receptor, which normally secure the receptor in the plasma membrane, are missing. The FH-Odense mutation results in severe premature coronary atherosclerosis as shown by the clinical expression in 5 generations of the affected family.
PubMed ID
7718023 View in PubMed
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Development of a high-resolution melting genotyping assay for the angiotensin I converting enzyme insertion/deletion polymorphism and establishment of genotype-specific reference intervals in a Danish population.

https://arctichealth.org/en/permalink/ahliterature265490
Source
Ann Clin Biochem. 2015 Jan;52(Pt 1):105-12
Publication Type
Article
Date
Jan-2015
Author
Peter H Nissen
Nina Buntzen Campbell
Carsten S Højskov
Andreas Fløe
Hans Jürgen Hoffmann
Ole Hilberg
Søren A Ladefoged
Holger J Møller
Source
Ann Clin Biochem. 2015 Jan;52(Pt 1):105-12
Date
Jan-2015
Language
English
Publication Type
Article
Keywords
Biological Assay - standards
Blood Donors
Denmark
Female
Gene Frequency
Genotype
Genotyping Techniques
Humans
INDEL Mutation
Male
Nucleic Acid Denaturation
Peptidyl-Dipeptidase A - blood - genetics
Polymorphism, Genetic
Real-Time Polymerase Chain Reaction
Reference Values
Sarcoidosis - blood - diagnosis - genetics
Abstract
The serum-angiotensin I converting enzyme (s-ACE) activity is influenced by a genetic insertion/deletion (I/D) polymorphism in the ACE gene, and the resulting large interindividual variation in s-ACE limits the use of normal reference intervals in the evaluation of sarcoidosis. In this study, we developed a new method for genotyping the I/D polymorphism in ACE and established genotype-specific reference intervals in order to improve the diagnostic accuracy and the value for treatment of sarcoidosis.
The new genotyping assay is based on high-resolution melting (HRM) using LCGreen?+?and was used to genotype 400 healthy Danish individuals. The assay was compared to a real-time polymerase chain reaction (RT-PCR) assay in a validation set of 86 samples. Enzyme activity in serum was measured using the Infinity™ ACE Liquid Stable Reagent from Thermo adapted for the ABX Pentra analyzer.
There was full concordance between genotyping assays. The three genotypes II, ID and DD were present with a frequency of 0.23, 0.51 and 0.26. The distribution of s-ACE values in the total population was non-Gaussian (non-parametric 95% reference interval 12.0-60.0 U/L). The median activities of the genotypes differed significantly (P
PubMed ID
24696153 View in PubMed
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[Endocarditis--clinical picture of native valve infection]

https://arctichealth.org/en/permalink/ahliterature54871
Source
Ugeskr Laeger. 1994 Aug 8;156(32):4576-9
Publication Type
Article
Date
Aug-8-1994
Author
H. Nissen
P F Nielsen
M. Frederiksen
C. Helleberg
J S Nielsen
Author Affiliation
Odense Universitetshospital, kardiologisk afdeling B.
Source
Ugeskr Laeger. 1994 Aug 8;156(32):4576-9
Date
Aug-8-1994
Language
Danish
Publication Type
Article
Keywords
Adult
Denmark - epidemiology
Diagnosis, Differential
Endocarditis, Bacterial - diagnosis - microbiology - mortality
English Abstract
Female
Heart Valves - microbiology
Humans
Male
Middle Aged
Retrospective Studies
Abstract
In a population of 930,000 inhabitants all records of native valve infective endocarditis diagnosed in the decade 1980-89 were reviewed. One hundred and thirty-two cases were found, of whom 23 were not diagnosed until postmortem. Median prehospital duration of symptoms was 20 days (range 0-180) and median in-hospital diagnostic delay five days (range 0-54). Known cardiac disease was found in 42%, possible portal of entry in 33%, but in 36% no predisposing factors were found. During the clinical course 55% experienced cardiac failure and 17% embolic episodes. Surgery was required in 19 patients. Of 111 culture positive cases, streptococci were found in 61 and staphylococci in 45 cases. Overall mortality was 33% with a mortality of clinically diagnosed cases of 18%. Native valve endocarditis is thus associated with a significant mortality in part due to significant diagnostic delays and a large number of post-mortem diagnosed cases. Only by securing a high level of alertness towards endocarditis can we expect a reduced mortality.
PubMed ID
7992392 View in PubMed
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Familial hypercholesterolaemia in Finland: common, rare and mild mutations of the LDL receptor and their clinical consequences. Finnish FH-group.

https://arctichealth.org/en/permalink/ahliterature193072
Source
Ann Med. 2001 Sep;33(6):410-21
Publication Type
Article
Date
Sep-2001
Author
A F Vuorio
K. Aalto-Setälä
U M Koivisto
H. Turtola
H. Nissen
P T Kovanen
T A Miettinen
H. Gylling
H. Oksanen
K. Kontula
Author Affiliation
Department of Medicine, University of Helsinki, Finland.
Source
Ann Med. 2001 Sep;33(6):410-21
Date
Sep-2001
Language
English
Publication Type
Article
Keywords
Age of Onset
Chromosome Deletion
Coronary Disease - epidemiology - genetics
DNA Mutational Analysis
Finland - epidemiology
Genotype
Humans
Hyperlipoproteinemia Type II - genetics
Molecular Epidemiology
Pedigree
Phenotype
Point Mutation
Receptors, LDL - genetics
Abstract
Familial hypercholesterolaemia (FH) is an autosomal co-dominantly inherited condition resulting from mutations of the low-density lipoprotein (LDL) receptor which occur in heterozygous form in approximately one in 500 individuals. Clinically, FH is characterized by 2-3-fold elevation of serum LDL cholesterol levels, accelerated development of atherosclerotic vascular disease, and, if untreated, shortened lifespan. The Finnish population, which represents a genetic isolate, offers exceptional possibilities for genetic-epidemiological studies on FH, as a handful of founder gene mutations account for the majority of FH cases in Finland. This review summarizes data from our FH studies carried out since 1985. We wish to emphasize the continuum of genotype-phenotype relationships, the importance of molecular diagnosis, the detection of novel risk factors of vascular disease, and innovations inhibiting cholesterol absorption for the modern treatment of FH.
PubMed ID
11585102 View in PubMed
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Familial hypercholesterolemia in St-Petersburg: the known and novel mutations found in the low density lipoprotein receptor gene in Russia.

https://arctichealth.org/en/permalink/ahliterature176250
Source
BMC Med Genet. 2005 Feb 8;6:6
Publication Type
Article
Date
Feb-8-2005
Author
Faina M Zakharova
Dorte Damgaard
Michail Y Mandelshtam
Valery I Golubkov
Peter H Nissen
Gitte G Nilsen
Anette Stenderup
Boris M Lipovetsky
Vladimir O Konstantinov
Alexander D Denisenko
Vadim B Vasilyev
Ole Faergeman
Author Affiliation
Department of Molecular Genetics, Institute of Experimental Medicine, St-Petersburg, Russia. f.zakharova@vz5518.spb.edu
Source
BMC Med Genet. 2005 Feb 8;6:6
Date
Feb-8-2005
Language
English
Publication Type
Article
Keywords
Apolipoproteins B - genetics
Base Sequence
Codon, Nonsense
DNA - chemistry - genetics
DNA Mutational Analysis
Female
Frameshift Mutation
Genetic Testing
Humans
Hyperlipoproteinemia Type II - diagnosis - genetics
Male
Mutation
Mutation, Missense
Pedigree
Polymorphism, Single-Stranded Conformational
Receptors, LDL - genetics
Russia
Abstract
Familial hypercholesterolemia is a human monogenic disease caused by population-specific mutations in the low density lipoprotein (LDL) receptor gene. Despite thirteen different mutations of the LDL receptor gene were reported from Russia prior to 2003, the whole spectrum of disease-causing gene alterations in this country is poorly known and requires further investigation provided by the current study.
Forty-five patients with clinical diagnosis of FH were tested for the apolipoprotein B (apoB) mutation R3500Q by restriction fragment length analysis. After exclusion of R3500Q mutation high-sensitive fluorescent single-strand conformation polymorphism (SSCP) analysis and automatic DNA sequencing were used to search for mutations in the LDL receptor gene.
We found twenty one rare sequence variations of the LDL receptor gene. Nineteen were probably pathogenic mutations, and two (P518P, T705I) were considered as neutral ones. Among the mutations likely to be pathogenic, eight were novel (c.670-671insG, C249X, c.936-940del5, c.1291-1331del41, W422X, c.1855-1856insA, D601N, C646S), and eleven (Q12X, IVS3+1G>A, c.651-653del3, E207X, c.925-931del7, C308Y, L380H, c.1302delG, IVS9+1G>A, V776M, V806I) have already been described in other populations. None of the patients had the R3500Q mutation in the apoB gene.
Nineteen pathogenic mutations in the LDL receptor gene in 23 probands were identified. Two mutations c.925-931del7 and L380H are shared by St.-Petersburg population with neighbouring Finland and several other mutations with Norway, Sweden or Denmark, i.e. countries from the Baltic Sea region. Only four mutations (c.313+1G>A, c.651-653del3, C308Y and W422X) were recurrent as all those were found in two unrelated families. By this study the number of known mutations in the LDL receptor gene in St.-Petersburg area was increased nearly threefold. Analysis of all 34 low density lipoprotein receptor gene mutations found in St.-Petersburg argues against strong founder effect in Russian familial hypercholesterolemia.
Notes
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PubMed ID
15701167 View in PubMed
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Genomic characterization of five deletions in the LDL receptor gene in Danish Familial Hypercholesterolemic subjects.

https://arctichealth.org/en/permalink/ahliterature168674
Source
BMC Med Genet. 2006;7:55
Publication Type
Article
Date
2006
Author
Peter H Nissen
Dorte Damgaard
Anette Stenderup
Gitte G Nielsen
Mogens L Larsen
Ole Faergeman
Author Affiliation
Department of Clinical Biochemistry, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark. sci08phn@as.aaa.dk
Source
BMC Med Genet. 2006;7:55
Date
2006
Language
English
Publication Type
Article
Keywords
Alu Elements
Chromosome Breakage
Computational Biology
Denmark
Exons
Genome, Human
Genomics
Humans
Hyperlipoproteinemia Type II - diagnosis - genetics
Polymerase Chain Reaction
Promoter Regions, Genetic
Receptors, LDL - genetics
Sequence Deletion
Abstract
Familial Hypercholesterolemia is a common autosomal dominantly inherited disease that is most frequently caused by mutations in the gene encoding the receptor for low density lipoproteins (LDLR). Deletions and other major structural rearrangements of the LDLR gene account for approximately 5% of the mutations in many populations.
Five genomic deletions in the LDLR gene were characterized by amplification of mutated alleles and sequencing to identify genomic breakpoints. A diagnostic assay based on duplex PCR for the exon 7-8 deletion was developed to discriminate between heterozygotes and normals, and bioinformatic analyses were used to identify interspersed repeats flanking the deletions.
In one case 15 bp had been inserted at the site of the deleted DNA, and, in all five cases, Alu elements flanked the sites where deletions had occurred. An assay developed to discriminate the wildtype and the deletion allele in a simple duplex PCR detected three FH patients as heterozygotes, and two individuals with normal lipid values were detected as normal homozygotes.
The identification of the breakpoints should make it possible to develop specific tests for these mutations, and the data provide further evidence for the role of Alu repeats in intragenic deletions.
Notes
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PubMed ID
16796766 View in PubMed
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[Investigation and diagnosis of familial hypocalciuric hypercalcemia in Denmark].

https://arctichealth.org/en/permalink/ahliterature175576
Source
Ugeskr Laeger. 2005 Feb 21;167(8):905-10
Publication Type
Article
Date
Feb-21-2005
Author
Signe Engkjaer Christensen
Peter H Nissen
Peter Schwarz
Author Affiliation
Arhus Universitetshospital, Arhus Sygehus, Medicinsk-endokrinologisk Afdeling C. SEC@aas.auh.dk
Source
Ugeskr Laeger. 2005 Feb 21;167(8):905-10
Date
Feb-21-2005
Language
Danish
Publication Type
Article
Keywords
Calcium - urine
Denmark - epidemiology
Diagnosis, Differential
Humans
Hypercalcemia - diagnosis - epidemiology - genetics
Prevalence
Receptors, Calcium-Sensing - genetics
PubMed ID
15789846 View in PubMed
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[Mammographic screening in the municipality of Copenhagen. Results of the first screening round]

https://arctichealth.org/en/permalink/ahliterature22755
Source
Ugeskr Laeger. 1996 Feb 26;158(9):1212-7
Publication Type
Article
Date
Feb-26-1996
Author
T. Jørgensen
L B Jensen
S. Duun
F R Hirsch
H T Mouridsen
M. Blichert-Toft
F E Rank
L H Christensen
A G Hansen
F H Nissen
Author Affiliation
Kirugisk afdeling K, røntgenafdelingen, patologisk instiut, Bispebjerg Hospital, København.
Source
Ugeskr Laeger. 1996 Feb 26;158(9):1212-7
Date
Feb-26-1996
Language
Danish
Publication Type
Article
Keywords
Aged
Biopsy
Breast Neoplasms - epidemiology - pathology - radiography
Carcinoma in Situ - epidemiology - pathology - radiography
Comparative Study
Denmark - epidemiology
English Abstract
Europe - epidemiology
Female
Humans
Mammography
Mass Screening
Middle Aged
Neoplasm Invasiveness
Prevalence
Abstract
The aim of the study was to evaluate the results from the prevalence round of the mammography screening programme in the Municipality of Copenhagen. All women who by 1 April 1991 were 50-69 years old, and who lived in the Municipality of Copenhagen, were during the period 1 April 1991-24 April 1993 offered a mammography. Those with suspect findings were recalled for further examination and possible biopsy. Women with breast cancer were offered treatment according to the standard national protocols (DBCCG). The participation rate was 71% (30,416/43,087). Among these 2043 (6.7%) were re-examined and 592 (1.9%) underwent surgical biopsy. Breast cancer was revealed in 359 (1.2%) women, of whom 88% had an invasive breast cancer. Prevalence of breast cancer increased significantly with increasing age. The positive predictive value for breast cancer among those re-examined was 18% and for those who had a surgical biopsy 61%. Among women with an invasive breast cancer 41% had a tumour of 10 mm or less, 80% had negative lymph node status and 56% had breast conserving surgery. During the following 12 months 14 women with a normal mammogram at the screening round developed breast cancer giving a sensitivity of 96%. It is concluded that the first mammography screening in Denmark showed the highest breast cancer prevalence published so far. A possible explanation could be a high sensitivity of the screening method, indicated by a relatively high frequency of small cancers. The screening programme was fully comparable with international standards.
Notes
Comment On: Ugeskr Laeger. 1996 Feb 26;158(9):1218-218644426
PubMed ID
8644425 View in PubMed
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Measurements of nitrogen dioxide in Greenland using Palmes diffusion tubes.

https://arctichealth.org/en/permalink/ahliterature195358
Source
J Environ Monit. 2001 Feb;3(1):139-45
Publication Type
Article
Date
Feb-2001
Author
T S Hansen
M. Kruse
H. Nissen
M. Glasius
C. Lohse
Author Affiliation
University of Southern Denmark, Department of Chemistry, Odense M. tsh@chem.sdu.dk
Source
J Environ Monit. 2001 Feb;3(1):139-45
Date
Feb-2001
Language
English
Publication Type
Article
Keywords
Air Pollution - analysis
Diffusion
Environmental monitoring
Greenland
Humans
Motor Vehicles
Nitrogen Dioxide - analysis
Urban Population
Abstract
Measurements of nitrogen dioxide using the Palmes diffusion tubes in Uummannaq, Aasiaat, and Nuuk. all located along the west-coast of Greenland, have demonstrated that the levels of pollution at the most heavily impacted sites are comparable to levels in much larger towns in Denmark. The highest concentrations were, in general, observed near sites influenced by car traffic (peak concentrations of up to 16 ppbv), medium concentrations were observed in the residential areas (2 6 ppbv), and very low levels were found at the background locations in the town outskirts (1-2 ppbv). Observations of nitrogen dioxide concentrations less than 0.1 ppbv at a remote site, Akia, 25 km from Nuuk, indicate that, compared to local sources, long-range transport of nitrogen dioxide is not important in western Greenland.
PubMed ID
11253007 View in PubMed
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20 records – page 1 of 2.