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11 records – page 1 of 2.

Cancer risk in patients on dialysis and after renal transplantation.

https://arctichealth.org/en/permalink/ahliterature20380
Source
Lancet. 2000 May 27;355(9218):1886-7
Publication Type
Article
Date
May-27-2000
Author
S A Birkeland
H. Løkkegaard
H H Storm
Source
Lancet. 2000 May 27;355(9218):1886-7
Date
May-27-2000
Language
English
Publication Type
Article
Keywords
Adult
Denmark - epidemiology
Female
Humans
Kidney Transplantation - adverse effects
Male
Middle Aged
Neoplasms - epidemiology - etiology
Registries
Renal Dialysis - adverse effects
Retrospective Studies
Risk factors
Abstract
The increased risk of cancer in patients who have had kidney transplants has mainly been attributed to immunosuppressive therapy; however, the prior period of uraemia and dialysis has also been postulated as a cofactor. We analysed cancer risk retrospectively in a cohort of 4178 patients undergoing renal replacement therapy, of whom 3592 were treated with dialysis alone and 1821 later had transplants. We found that excess cancer risk in such patients occurred after transplantation and not during dialysis.
PubMed ID
10866449 View in PubMed
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The epidemiology and prognosis of glomerulonephritis in Denmark 1985-1997.

https://arctichealth.org/en/permalink/ahliterature201065
Source
Nephrol Dial Transplant. 1999 Aug;14(8):1889-97
Publication Type
Article
Date
Aug-1999
Author
J. Heaf
H. Løkkegaard
S. Larsen
Author Affiliation
Department of Nephrology, Herlev Hospital, University of Copenhagen, Denmark.
Source
Nephrol Dial Transplant. 1999 Aug;14(8):1889-97
Date
Aug-1999
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Biopsy
Denmark - epidemiology
Glomerulonephritis - complications - epidemiology - pathology - physiopathology
Humans
Kidney - pathology
Kidney Diseases - etiology
Middle Aged
Mortality
Multivariate Analysis
Prognosis
Abstract
The existence of a national renal biopsy register and a national terminal uraemia status register in Denmark provides an opportunity to study the prognosis of glomerulonephritis (GN), and factors influencing prognosis.
Multivariate analysis of 2380 renal biopsies with GN performed between 1985 and 1997 was done to determine the influence of clinical and histological factors on prognosis.
The incidence of GN (39/mo/year) and individual diagnoses did not change during the period. After 10 years, 32%, were dead, 13% terminally uraemic, 5%, uraemic and 50% well. Older age increased mortality, but not the incidence of renal failure after the first year. Male sex increased both mortality and incidence of renal failure (34 vs 24% at 10 years, P
PubMed ID
10462267 View in PubMed
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HLA-DR typing in cadaver kidney donors and recipients in Copenhagen.

https://arctichealth.org/en/permalink/ahliterature48955
Source
Scand J Urol Nephrol Suppl. 1981;64:79-86
Publication Type
Article
Date
1981
Author
M. Thomsen
L. Astrup
B. Jakobsen
N. Morling
P. Platz
L P Ryder
A. Svejgaard
H. Løkkegaard
J. Ladefoged
J H Thaysen
Source
Scand J Urol Nephrol Suppl. 1981;64:79-86
Date
1981
Language
English
Publication Type
Article
Keywords
Blood Transfusion
Cadaver
Denmark
Diabetic Nephropathies - complications - therapy
Genes, MHC Class II
Graft Survival
HLA-DR Antigens
Histocompatibility Antigens Class II - analysis - immunology
Histocompatibility testing
Humans
Kidney Failure, Chronic - complications - epidemiology - therapy
Kidney Transplantation
Preoperative Care
Research Support, Non-U.S. Gov't
Tissue Donors
Abstract
Among 224 cadaver kidney transplantations performed since Spring 1977, successful DR typing of both donor and recipient could be done in 149 cases. Assessment of DR match grade and clinical data was done independently. The minimum observation time was 3 months and the time of follow up was 1 December, 1980. There was an effect of DR matching which became significant when only 1. transplants were considered and high risk recipients (i.e. diabetics) excluded. Transfusions were of minor importance on graft survival and the difference was only obvious in the first year after transplantation. Matching for HLA-A, B antigen had no obvious effect on graft survival in this material.
PubMed ID
6815796 View in PubMed
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Kidney transplantation activity and outcome in Denmark 1990-1999.

https://arctichealth.org/en/permalink/ahliterature32022
Source
Clin Transpl. 2000;:357-8
Publication Type
Article
Date
2000
Author
M. Madsen
B. Jespersen
H. Løkkegaard
J. Ladefoged
Source
Clin Transpl. 2000;:357-8
Date
2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Child, Preschool
Denmark - epidemiology
Graft Survival
HLA Antigens
Humans
Kidney Transplantation - mortality - statistics & numerical data
Living Donors
Middle Aged
Registries
Survival Rate
Abstract
1. During the period 1990-1999, 1,715 renal transplants were performed in Denmark, corresponding to 31.8 per million population per year. Seventy-five per cent were cadaver donor transplants; in 25%, a living donor kidney was used. 2. Living donors of 437 kidneys were mainly parents (54%) and siblings (36%). In 20 transplants, a kidney from a living-unrelated donor was used. 3. The overall actuarial patient survival rates at one and 5 years were 91.0% and 78.2%, respectively. The major causes of recipient death were cardiovascular disease and infection. 4. The overall actuarial graft survival rates at one and 5 years were 81.4% and 62.0%, respectively. The major single causes of graft loss were rejection (41%) and recipient death (32%). Graft survival has improved during the decade.
PubMed ID
11512333 View in PubMed
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[Living-donor kidney transplantation].

https://arctichealth.org/en/permalink/ahliterature195911
Source
Ugeskr Laeger. 2000 Nov 27;162(48):6527-32
Publication Type
Article
Date
Nov-27-2000
Author
A L Kamper
H. Løkkegaard
F. Rasmussen
Author Affiliation
Nefrologisk afdeling B og urologisk afdeling H, Amtssygehuset i Herlev.
Source
Ugeskr Laeger. 2000 Nov 27;162(48):6527-32
Date
Nov-27-2000
Language
Danish
Publication Type
Article
Keywords
Denmark
Ethics, Medical
Graft Survival
Histocompatibility testing
Humans
Immunosuppressive Agents - administration & dosage
Kidney Transplantation - methods - statistics & numerical data
Nephrectomy - adverse effects
Postoperative Complications - diagnosis
Prognosis
Tissue Donors - psychology - statistics & numerical data
Tissue and Organ Procurement
Abstract
In recent years transplantation from living donors has accounted for 25-30% of all kidney transplants in Denmark corresponding to 40-45 per year. Most of these living donors are parents or siblings, although internationally an increasing number are unrelated donors. Donor nephrectomy is associated with only few complications. The long-term outcome for kidney donors is good without increase in mortality or risk for development of hypertension and renal failure; proteinuria may be seen. Living kidney transplantation is the optimal treatment of end-stage renal disease with better graft survival than in cadaver transplantation. The ethical and psychological aspects related to transplantation from a living donor are complex and need to be carefully evaluated when this treatment is offered to the patients.
PubMed ID
11187219 View in PubMed
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[Peritonitis in continuous ambulatory peritoneal dialysis. Experiences after 7 years].

https://arctichealth.org/en/permalink/ahliterature231237
Source
Ugeskr Laeger. 1989 Feb 27;151(9):563-6
Publication Type
Article
Date
Feb-27-1989
Author
E. Ejlersen
H D Christiansen
H. Løkkegaard
Source
Ugeskr Laeger. 1989 Feb 27;151(9):563-6
Date
Feb-27-1989
Language
Danish
Publication Type
Article
Keywords
Denmark
Female
Humans
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory - adverse effects
Peritonitis - epidemiology - etiology
Retrospective Studies
Abstract
A retrospective study of CAPD-related peritonitis revealed a frequency of 1.7 episodes per treatment year among 121 patients during a period of 7 years. Life-table methodology estimated a 44% probability of still remaining peritonitis-free after six months on CAPD, with no differences between subgroup populations according to sex, age (younger/older than 60 years) and primary disease (diabetic/non-diabetic). A marked improvement in probability of remaining peritonitis-free was evident in the last calendar period (1983-86). The predominant etiological microorganisms in peritonitis episodes were staphylococci. In 25% of the episodes, no microorganism could be isolated. One patient died from peritonitis; lethality 0.7% per year. Ten patients (8%) were transferred from CAPD because of either repeated episodes of peritonitis or a single complicated episode.
PubMed ID
2922866 View in PubMed
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Predicting future trends in the number of patients on renal replacement therapy in Denmark.

https://arctichealth.org/en/permalink/ahliterature207413
Source
Nephrol Dial Transplant. 1997 Oct;12(10):2117-23
Publication Type
Article
Date
Oct-1997
Author
P. Vestergaard
H. Løkkegaard
Author Affiliation
Danish National Registry, Danish Society of Nephrology.
Source
Nephrol Dial Transplant. 1997 Oct;12(10):2117-23
Date
Oct-1997
Language
English
Publication Type
Article
Keywords
Adult
Denmark
Forecasting
Humans
Kidney Transplantation
Middle Aged
Models, Theoretical
Prognosis
Renal Replacement Therapy - trends
Stochastic Processes
Uremia - therapy
Abstract
To predict the future prevalence of patients on renal replacement therapy due to chronic renal failure in Denmark.
Four thousand and nine terminal uraemic patients (median age 50.0 years, 15.2% diabetic) were treated in Denmark with renal replacement therapy in the period 1 January 1991 to 31 December 1995. Incidence rates and rates of transition between the treatment modalities (haemodialysis, peritoneal dialysis, and renal transplantation) were calculated. The prediction was made using a Markov model in three ways: (1) using the average rates (deterministic model), (2) using rates simulated with pseudorandom numbers based on the average rates (stochastic model), and (3) using increasing incidence rates in a deterministic model.
Using present rates both model types predicted a significant increase in the prevalence of renal transplant recipients or = 60 years (from 456 in 1995 to about 903 in 2006) while the prevalence of other treatment modalities would change less dramatically. The overall prevalence proportion would increase from 539 patients per million population (p.m.p.) in 1995 to about 777 p.m.p. in 2006. The stochastic model clearly demonstrated the uncertainties linked to the prognosis in contrast to the deterministic model. The deterministic model with increasing rates predicted a prevalence proportion of 1162 p.m.p. in 2006.
Even with present rates the prevalence of haemodialysis patients in Denmark will continue to increase. Mathematical models offers a good tool to study future trends and to plan future capacity.
PubMed ID
9351075 View in PubMed
Less detail

[Predicting the number of patients on dialysis and renal transplant recipients in Denmark].

https://arctichealth.org/en/permalink/ahliterature204869
Source
Ugeskr Laeger. 1998 Jul 27;160(31):4520-3
Publication Type
Article
Date
Jul-27-1998
Author
P. Vestergaard
H. Løkkegaard
Author Affiliation
Afdeling 900, Arhus Amtssygehus, Arhus Universitetshospital.
Source
Ugeskr Laeger. 1998 Jul 27;160(31):4520-3
Date
Jul-27-1998
Language
Danish
Publication Type
Article
Keywords
Adult
Denmark - epidemiology
Female
Humans
Kidney Failure, Chronic - epidemiology - surgery - therapy
Kidney Transplantation - statistics & numerical data - trends
Male
Middle Aged
Models, Statistical
Peritoneal Dialysis - statistics & numerical data - trends
Prevalence
Renal Dialysis - statistics & numerical data - trends
Abstract
A Markov model was applied in three ways: 1) a deterministic model with fixed rates, 2) a stochastic model using simulated varying rates and 3) a deterministic model with increasing rates. With present rates an increase in the prevalence of renal transplant recipients
PubMed ID
9700307 View in PubMed
Less detail

[Prognosis for patients admitted to intensive care units with acute renal failure requiring dialysis].

https://arctichealth.org/en/permalink/ahliterature215172
Source
Ugeskr Laeger. 1995 May 1;157(18):2564-9
Publication Type
Article
Date
May-1-1995
Author
M B Jensen
E. Ejlersen
K R Eliasen
H. Løkkegaard
Author Affiliation
Nefrologisk afdeling, Amtssygehuset i Herlev.
Source
Ugeskr Laeger. 1995 May 1;157(18):2564-9
Date
May-1-1995
Language
Danish
Publication Type
Article
Keywords
Acute Kidney Injury - diagnosis - mortality - therapy
Adolescent
Adult
Aged
Coronary Care Units
Denmark - epidemiology
Female
Humans
Male
Middle Aged
Multiple Organ Failure
Patient Admission
Prognosis
Renal Dialysis
Retrospective Studies
Abstract
The mortality of critically ill patients who develop acute renal failure (ARF) is persistingly high. We reviewed all patients who developed ARF that required dialysis in a single intensive care unit (n = 167) during the period 1977 to 1989, in order to identify variables with possible influence on outcome. Overall mortality within hospital was 75%. Age above 60 (p
PubMed ID
7778240 View in PubMed
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11 records – page 1 of 2.