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Does gallium uptake in the pulmonary hila predict involvement by non-Hodgkin's lymphoma?

https://arctichealth.org/en/permalink/ahliterature222935
Source
Nucl Med Commun. 1992 Oct;13(10):730-7
Publication Type
Article
Date
Oct-1992
Author
P E Champion
D. Groshar
H R Hooper
M. Palmer
Z. Catz
A. Belch
A. McEwan
Author Affiliation
Department of Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada.
Source
Nucl Med Commun. 1992 Oct;13(10):730-7
Date
Oct-1992
Language
English
Publication Type
Article
Keywords
Alberta - epidemiology
Gallium Radioisotopes - diagnostic use - pharmacokinetics
Humans
Lung - metabolism
Lung Neoplasms - epidemiology - radionuclide imaging
Lymphoma, Non-Hodgkin - epidemiology - radionuclide imaging
Prognosis
Retrospective Studies
Tomography, Emission-Computed, Single-Photon
Abstract
67Ga imaging of non-Hodgkin's lymphoma is useful for evaluating the presence of viable tumour in a residual mass after treatment. However, we have frequently seen gallium uptake in the pulmonary hila without other evidence of lymphoma. To study the significance of this finding, 79 patients with intermediate grade non-Hodgkin's lymphoma were reviewed. Thirty-seven (47%) had abnormal hilar gallium uptake. Twenty-three of these could be fully evaluated, and only five (22%) had hilar lymphoma. A pattern of bilateral, symmetric hilar uptake was seen in 19 patients, but only one had evidence of lymphoma. In 15 cases, this pattern was seen only on single photon emission computed tomography (SPECT). The aetiology of this uptake remains unknown. It is not treatment related, as 12 patients had hilar gallium uptake prior to chemotherapy. Unless confirmed by other methods, hilar gallium uptake should not be attributed to lymphoma, and should not influence patient management.
PubMed ID
1491837 View in PubMed
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