Skip header and navigation

2 records – page 1 of 1.

Associations between polymorphisms related to calcium metabolism and human height: the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature126446
Source
Ann Hum Genet. 2012 May;76(3):200-10
Publication Type
Article
Date
May-2012
Author
Rolf Jorde
Johan Svartberg
Ragnar Martin Joakimsen
Guri Grimnes
Author Affiliation
Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, Norway. rolf.jorde@unn.no
Source
Ann Hum Genet. 2012 May;76(3):200-10
Date
May-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Body Height - genetics
Calcium - blood - metabolism
Female
Humans
Male
Middle Aged
Parathyroid Hormone - blood
Phosphates - blood
Polymorphism, Single Nucleotide
Receptors, Calcitriol - genetics
Vitamin D - analogs & derivatives - blood
Abstract
A number of single nucleotide polymorphisms (SNPs) related to height have been detected. Calcium metabolism is important for the skeleton and accordingly also for adult height. Therefore, in the present study, nine SNPs related to the vitamin D receptor (VDR) gene and serum levels of 25-hydroxyvitamin D (25(OH)D), calcium, phosphate and parathyroid hormone (PTH) were related to height in 9471 subjects. Relation with height was evaluated with linear regression for trend across SNP genotypes with age and gender as covariates. After correcting for multiple testing, significant associations with height were found for two SNPs related to the VDR gene (rs1544410 (Bsml) and rs7975232 (Apal)), one SNP related to serum 25(OH)D (rs3829251 at the DHCR7/NADSYN1 gene), one SNP related to serum calcium (rs1459015 at the PTH gene) and one SNP related to serum phosphate (rs1697421 at the ALPL gene). For rs3829251, the mean differences in height between major and minor homozygotes were 1.5-2.0 cm (P
PubMed ID
22390397 View in PubMed
Less detail

The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction, and body height: the Tromsø study.

https://arctichealth.org/en/permalink/ahliterature257647
Source
Thyroid. 2014 Feb;24(2):215-22
Publication Type
Article
Date
Feb-2014
Author
Rolf Jorde
Henrik Schirmer
Tom Wilsgaard
Ragnar Martin Joakimsen
Ellisiv Bøgeberg Mathiesen
Inger Njølstad
Maja-Lisa Løchen
Yngve Figenschau
Johan Svartberg
Moira Strand Hutchinson
Marie Kjærgaard
Lone Jørgensen
Guri Grimnes
Author Affiliation
1 Tromsø Endocrine Research Group, University of Tromsø , Tromsø, Norway .
Source
Thyroid. 2014 Feb;24(2):215-22
Date
Feb-2014
Language
English
Publication Type
Article
Keywords
3',5'-Cyclic-AMP Phosphodiesterases - genetics
Adult
Aged
Body Height
Cardiovascular Diseases - etiology
Diabetes Mellitus, Type 2 - genetics
Female
Genotype
Humans
Male
Middle Aged
Myocardial Infarction - etiology
Neoplasms - genetics
Polymorphism, Single Nucleotide
Risk
Thyroid Diseases - physiopathology
Thyroid Gland - physiopathology
Thyroxine - blood
Triiodothyronine - blood
Abstract
High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is causal, one could also expect rs4704397 genotypes to predict CVD and possibly health in general.
DNA was prepared and genotyping performed for rs4704397 in subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints myocardial infarction (MI), type 2 diabetes (T2DM), cancer, or death, as well as a randomly selected control group. Similarly, genotyping was performed in subjects who had participated in clinical trials where serum TSH, free T4 (fT4), and free T3 (fT3) were measured.
From the Tromsø Study, 8938 subjects without thyroid disease or thyroid medication were successfully genotyped for rs4704397. Among these, 2098 were registered with MI, 1025 with T2DM, 2748 with cancer, and 3592 had died. The minor homozygote genotype (A:A) had a median serum TSH level that was 0.29?mIU/L higher than in the major homozygote genotype (G:G). The A:A genotype had a significantly increased risk of MI as compared to the G:G genotype (1.14 [1.00-1.29], hazard ratio [confidence interval], Cox regression with adjustment for age, sex, and body mass index). No significant associations were seen with the other endpoints or CVD risk factors. Furthermore, subjects with the G:G genotype were significantly taller than subjects with the A:A genotype (mean difference 1.5?cm). In 584 subjects with serum TSH, fT4, and fT3 measurements, the subjects with the A:A genotype had significantly higher serum TSH and nonsignificantly lower serum fT3 (mean difference 0.15?pmol/L) levels than subjects with the G:G genotype.
rs4704397 is associated with thyroid function, risk of MI, and body height. However, confirmation in other cohorts is needed before firm conclusions can be drawn.
PubMed ID
23941514 View in PubMed
Less detail