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Cardiac resynchronization therapy and bone marrow cell transplantation in patients with ischemic heart failure and electromechanical dyssynchrony: a randomized pilot study.

https://arctichealth.org/en/permalink/ahliterature134723
Source
J Cardiovasc Transl Res. 2011 Dec;4(6):767-78
Publication Type
Article
Date
Dec-2011
Author
Evgeny Pokushalov
Alexander Romanov
Giorgio Corbucci
Darya Prohorova
Alexander Chernyavsky
Petr Larionov
Igor Terekhov
Sergey Artyomenko
Elena Kliver
Natalya Shirokova
Alexander Karaskov
Nabil Dib
Author Affiliation
State Research Institute of Circulation Pathology, Novosibirsk, Russia. E.Pokushalov@gmail.com
Source
J Cardiovasc Transl Res. 2011 Dec;4(6):767-78
Date
Dec-2011
Language
English
Publication Type
Article
Keywords
Aged
Bone Marrow Transplantation - adverse effects
Bundle-Branch Block - diagnosis - etiology - physiopathology - therapy
Cardiac Resynchronization Therapy - adverse effects
Chi-Square Distribution
Combined Modality Therapy
Coronary Circulation
Cross-Over Studies
Echocardiography, Doppler
Exercise Test
Female
Heart Failure - diagnosis - etiology - physiopathology - therapy
Humans
Male
Middle Aged
Myocardial Ischemia - complications - diagnosis - physiopathology - therapy
Myocardial Perfusion Imaging - methods
Pilot Projects
Predictive value of tests
Quality of Life
Questionnaires
Recovery of Function
Russia
Single-Blind Method
Stroke Volume
Time Factors
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Ventricular Dysfunction, Left - diagnosis - etiology - physiopathology - therapy
Ventricular Function, Left
Abstract
Most studies have confirmed the beneficial effects of autologous bone marrow mononuclear cell (BMMC) transplantation on angina, myocardial perfusion, regional wall motion, and LV ejection fraction (LVEF). Cardiac resynchronization therapy (CRT) has also shown a beneficial effect in patients with heart failure (HF) and electrical/mechanical dyssynchrony. However, the relative contribution of BMMC and CRT in patients with ischemic HF and electromechanical dyssynchrony has never been investigated. The aim of this study was to evaluate the benefit of combining BMMC transplantation with CRT in patients with severe ischemic HF, left bundle branch block (LBBB), and mechanical dyssynchrony. Patients with ischemic HF, LVEF?
PubMed ID
21547598 View in PubMed
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