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Confidentiality and the compulsory reporting of child abuse.

https://arctichealth.org/en/permalink/ahliterature243551
Source
Health Law Can. 1981;2(1):15-6, 23
Publication Type
Article
Date
1981
Author
J G Thomson
Source
Health Law Can. 1981;2(1):15-6, 23
Date
1981
Language
English
Publication Type
Article
Keywords
Canada
Child
Child Abuse - legislation & jurisprudence
Confidentiality
Humans
PubMed ID
10309515 View in PubMed
Less detail

D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature46954
Source
Diabetologia. 2005 Dec;48(12):2540-3
Publication Type
Article
Date
Dec-2005
Author
A M Valdes
G. Thomson
J. Graham
M. Zarghami
B. McNeney
I. Kockum
A. Smith
M. Lathrop
A R Steenkiste
J S Dorman
J A Noble
J A Hansen
A. Pugliese
A. Lernmark
Author Affiliation
Department of Integrative Biology, University of California, Berkeley, CA, USA.
Source
Diabetologia. 2005 Dec;48(12):2540-3
Date
Dec-2005
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Case-Control Studies
Chromosome Mapping
Cohort Studies
Diabetes Mellitus, Type 1 - epidemiology - genetics - prevention & control
Female
Genetic Predisposition to Disease
HLA-DQ Antigens - genetics
HLA-DR Antigens - genetics
Haplotypes - genetics
Humans
Male
Membrane Glycoproteins - genetics
Microsatellite Repeats
Middle Aged
Odds Ratio
Predictive value of tests
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Risk
Sweden - epidemiology
Abstract
AIMS/HYPOTHESIS: The HLA class II DQB1*0602 allele confers strong dominant protection against type 1 diabetes but protection is not absolute. The aim of this study was to identify markers within the HLA region that differentiate DQB1*0602 haplotypes and show different associations with disease risk. METHODS: We defined alleles at eight microsatellite markers spanning the HLA region in a case-control cohort from Sweden. RESULTS: We found that allele 15 at marker D6S265 (109 kb centromeric of HLA-A) was over-represented among patients carrying DRB1*15, DQB1*0602. A detailed haplotype analysis showed that DRB1*15, DQB1*0602 haplotypes carrying D6S265*15 have a ten-fold higher odds ratio (OR) than those carrying other alleles and thus confer reduced protection [OR D6S265*15=0.186 (95% CI 0.074, 0.472) vs OR D6S265*15-=0.017 (95% CI 0.005, 0.062), p
PubMed ID
16320082 View in PubMed
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HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients.

https://arctichealth.org/en/permalink/ahliterature14532
Source
Arthritis Rheum. 1989 Sep;32(9):1135-41
Publication Type
Article
Date
Sep-1989
Author
W P Robinson
S M van der Linden
M A Khan
H U Rentsch
A. Cats
A. Russell
G. Thomson
Author Affiliation
Department of Genetics, University of California, Berkeley 94720.
Source
Arthritis Rheum. 1989 Sep;32(9):1135-41
Date
Sep-1989
Language
English
Publication Type
Article
Keywords
Alleles
Canada
Comparative Study
Disease Susceptibility
Genotype
HLA-B Antigens - genetics
HLA-B27 Antigen
Haplotypes
Humans
Netherlands
Norway
Phenotype
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Spondylitis, Ankylosing - genetics
Switzerland
United States
Abstract
We examined the distribution of non-B27 alleles of the HLA-B locus among B27+ patients with ankylosing spondylitis (AS), to detect any additional HLA-B locus allele(s) that may act in conjunction with B27 to increase susceptibility to AS. HLA-Bw60 (or B40 when the Bw60,61 split of B40 was not typed for) was shown to be increased among B27+ AS patients in each of 5 independent data sets. This increase was statistically significant in 4 of the 5 data sets studied, and the overall significance was P less than 0.00001. Susceptibility to AS in B27+ individuals was further increased by a factor of approximately 3 when Bw60 was also present. The distribution of HLA-A alleles on the B27-bearing haplotypes in AS patients was not significantly different from that in normal controls. On the other hand, the distribution of HLA-A alleles on Bw60-bearing haplotypes was significantly different from the distribution of A alleles on Bw60 haplotypes in the general population (P less than 0.0005). Bw60 was not increased in B27- patients with AS. A dominant mode of inheritance generally fits AS; however, our sib pair analysis indicates that the B27,Bw60 disease subgroup follows a more recessive mode of inheritance.
Notes
Comment In: Arthritis Rheum. 1991 Feb;34(2):247-81994928
PubMed ID
2789045 View in PubMed
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Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease.

https://arctichealth.org/en/permalink/ahliterature230126
Source
Am J Hum Genet. 1989 Oct;45(4):541-6
Publication Type
Article
Date
Oct-1989
Author
H. Payami
S. Joe
N R Farid
V. Stenszky
S H Chan
P P Yeo
J S Cheah
G. Thomson
Author Affiliation
Department of Medical Genetics, Oregon Health Sciences University, Portland 97201.
Source
Am J Hum Genet. 1989 Oct;45(4):541-6
Date
Oct-1989
Language
English
Publication Type
Article
Keywords
Alleles
Eye Diseases - complications - genetics - immunology
Genetic markers
Genetic Predisposition to Disease
Graves Disease - complications - genetics - immunology
HLA-DR Antigens - genetics
Heterozygote Detection
Humans
Newfoundland and Labrador
Abstract
A method is described to reveal the relative predispositional effects (RPEs) (predisposing, protective, or neutral) of the HLA alleles or of any other marker system that is associated with a disease. When the disease is associated with two or more alleles of a locus, the RPE method identifies the associations sequentially according to their strength; thus the problem that a strong association with one allele can create misleading deviations in the frequencies of other alleles is alleviated. Using this method, we have examined the relative effects of HLA-DR alleles in susceptibility to Graves disease in the Caucasian population. The well-established positive association with DR3 was confirmed as the strongest effect. In addition, a negative association was found between DR5 and Graves disease. The reduced frequency of DR5 among patients is statistically significant and is not a result of the increase in DR3. Finally, when patients were divided according to the presence or absence of eye disease, the latter showed a significant increase in the frequency of DR4. With family data, linkage to HLA of Graves disease was established in both Caucasian and Chinese families by the sib-pair method.
Notes
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PubMed ID
2491013 View in PubMed
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Unrecognized ocular problems associated with port-wine stain of the face in children.

https://arctichealth.org/en/permalink/ahliterature252983
Source
Can Med Assoc J. 1974 Nov 2;111(9):953-4
Publication Type
Article
Date
Nov-2-1974
Author
R F Stevenson
H G Thomson
J D Morin
Source
Can Med Assoc J. 1974 Nov 2;111(9):953-4
Date
Nov-2-1974
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Child
Child, Preschool
Face - innervation
Facial Neoplasms - complications
Female
Glaucoma - diagnosis - epidemiology - etiology
Hemangioma - complications
Humans
Infant
Intraocular Pressure
Male
Maxillary Nerve
Ontario
Ophthalmic Nerve
Abstract
The port-wine stain, a relatively rare subgroup of capillary hemangiomas, usually involves the face and in children it may be associated with glaucoma. A series of 50 patients with facial port-wine stains had ocular examination at The Hospital for Sick Children, Toronto. When the facial areas supplied by both the ophthalmic and maxillary divisions of the sensory branch of the trigeminal nerve were involved (26 patients) there was about a 45% chance of diagnosing glaucoma, either as "true" glaucoma (with visual loss and raised intraocular pressure) or as "glaucoma suspect" (without visual loss). Involvement of the area supplied by either division alone was not associated with glaucoma.
Notes
Cites: Arch Neurol. 1969 Nov;21(5):554-64899082
Cites: Plast Reconstr Surg. 1971 Aug;48(2):113-205561889
PubMed ID
4418401 View in PubMed
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6 records – page 1 of 1.