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Assessment of periodontal conditions and systemic disease in older subjects. I. Focus on osteoporosis.

https://arctichealth.org/en/permalink/ahliterature187844
Source
J Clin Periodontol. 2002 Sep;29(9):796-802
Publication Type
Article
Date
Sep-2002
Author
R E Persson
L G Hollender
L V Powell
M I MacEntee
C C L Wyatt
H A Kiyak
G R Persson
Author Affiliation
Department of Oral Medicine, University of Washington, Seattle, WA,USA. rper@u.washington.edu
Source
J Clin Periodontol. 2002 Sep;29(9):796-802
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Aged
Alveolar Bone Loss - complications - ethnology - radiography
Analysis of Variance
British Columbia - epidemiology
Chi-Square Distribution
China - ethnology
Ethnic Groups
Female
Geriatric Assessment
Humans
Male
Mandibular Diseases - complications - ethnology - radiography
Medical History Taking
Middle Aged
Odds Ratio
Osteoporosis - complications - ethnology - radiography
Periodontitis - complications - ethnology - radiography
Prevalence
ROC Curve
Radiography, Panoramic
Smoking
Statistics, nonparametric
Washington - epidemiology
Abstract
Osteoporosis (OPOR) is a common chronic disease, especially in older women. Patients are often unaware of the condition until they experience bone fractures. Studies have suggested that OPOR and periodontitis are associated diseases and exaggerated by cytokine activity. Panoramic radiography (PMX) allows studies of mandibular cortical index (MCI), which is potentially diagnostic for OPOR.
i). To study the prevalence of self-reported history of OPOR in an older, ethnically diverse population, ii). to assess the agreement between PMX/MCI findings and self-reported OPOR, and iii). to assess the likelihood of having both a self-reported history of OPOR and a diagnosis of periodontitis.
PMX and medical history were obtained from 1084 subjects aged 60-75 (mean age 67.6, SD +/- 4.7). Of the films, 90.3% were useful for analysis. PMXs were studied using MCI. The PMXs were used to grade subjects as not having periodontitis or with one of three grades of periodontitis severity.
A positive MCI was found in 38.9% of the subjects, in contrast to 8.2% self-reported OPOR. The intraclass correlation between MCI and self-reported OPOR was 0.20 (P
PubMed ID
12423291 View in PubMed
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Assessment of periodontal conditions and systemic disease in older subjects. II. Focus on cardiovascular diseases.

https://arctichealth.org/en/permalink/ahliterature187843
Source
J Clin Periodontol. 2002 Sep;29(9):803-10
Publication Type
Article
Date
Sep-2002
Author
R E Persson
L G Hollender
V L Powell
M. MacEntee
C C L Wyatt
H A Kiyak
G R Persson
Author Affiliation
Department of Oral Medicine, University of Washington, Seattle, WA, USA. rper@u.washington.edu
Source
J Clin Periodontol. 2002 Sep;29(9):803-10
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Aged
Alveolar Bone Loss - complications - epidemiology - radiography
British Columbia - epidemiology
Calcinosis - radiography
Carotid Artery Diseases - complications - epidemiology - radiography
Carotid Artery, Internal - radiography
Chi-Square Distribution
Ethnic Groups
Female
Geriatric Assessment
Humans
Linear Models
Male
Medical History Taking
Middle Aged
Myocardial Infarction - complications - epidemiology
Odds Ratio
Periodontitis - complications - epidemiology - radiography
Prevalence
Radiography, Panoramic
Statistics, nonparametric
Stroke - complications - epidemiology
Washington - epidemiology
Abstract
Panoramic radiographs (PMX)s may provide information about systemic health conditions.
i). To study clinical periodontal conditions and collect self-reported health status in a cohort of 1084 older subjects; ii). to study signs of alveolar bone loss and carotid calcification from panoramic radiographs obtained from these subjects; and iii). to study associations between study parameters.
PMXs from 1064 adults aged 60-75 (mean age 67.6, SD +/- 4.7) were studied. Signs of alveolar bone loss, vertical defects, and molar furcation radiolucencies defined periodontal status. Medical health histories were obtained via self-reports. Signs of carotid calcification were identified from panoramic radiographs.
The PMX allowed assessment of 53% of the films (Seattle 64.5% and Vancouver 48.4%). A self-reported history of a stroke was reported by 8.1% of men in Seattle and 2.9% of men in Vancouver (P
PubMed ID
12423292 View in PubMed
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Association of Endodontic Lesions with Coronary Artery Disease.

https://arctichealth.org/en/permalink/ahliterature282650
Source
J Dent Res. 2016 Nov;95(12):1358-1365
Publication Type
Article
Date
Nov-2016
Author
J M Liljestrand
P. Mäntylä
S. Paju
K. Buhlin
K A E Kopra
G R Persson
M. Hernandez
M S Nieminen
J. Sinisalo
L. Tjäderhane
P J Pussinen
Source
J Dent Res. 2016 Nov;95(12):1358-1365
Date
Nov-2016
Language
English
Publication Type
Article
Keywords
Acute Coronary Syndrome - diagnostic imaging - immunology - microbiology
Biomarkers - blood
Coronary Angiography
Coronary Artery Disease - diagnostic imaging - immunology - microbiology
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Finland
Humans
Immunoglobulin G - blood
Male
Middle Aged
Periapical Periodontitis - diagnostic imaging - immunology - microbiology
Porphyromonas endodontalis - isolation & purification
Radiography, Panoramic
Risk factors
Abstract
An endodontic lesion (EL) is a common manifestation of endodontic infection where Porphyromonas endodontalis is frequently encountered. EL may associate with increased risk for coronary artery disease (CAD) via similar pathways as marginal periodontitis. The aim of this cross-sectional study was to delineate the associations between EL and CAD. Subgingival P. endodontalis, its immune response, and serum lipopolysaccharide were examined as potential mediators between these 2 diseases. The Finnish Parogene study consists of 508 patients (mean age, 62 y) who underwent coronary angiography and extensive clinical and radiographic oral examination. The cardiovascular outcomes included no significant CAD ( n = 123), stable CAD ( n = 184), and acute coronary syndrome (ACS; n = 169). EL was determined from a panoramic tomography. We combined data of widened periapical spaces (WPSs) and apical rarefactions to a score of EL: 1, no EL ( n = 210); 2, =1 WPS per 1 apical rarefaction ( n = 222); 3, =2 apical rarefactions ( n = 76). Subgingival P. endodontalis was defined by checkerboard DNA-DNA hybridization analysis, and corresponding serum antibodies were determined by ELISA. In our population, 50.4% had WPSs, and 22.8% apical rarefactions. A total of 51.2% of all teeth with apical rarefactions had received endodontic procedures. Subgingival P. endodontalis levels and serum immunoglobulin G were associated with a higher EL score. In the multiadjusted model (age, sex, smoking, diabetes, body mass index, alveolar bone loss, and number of teeth), having WPSs associated with stable CAD (odds ratio [OR] = 1.94, 95% confidence interval [95% CI] = 1.13 to 3.32, P = 0.016) and highest EL score were associated with ACS (OR = 2.46, 95% CI = 1.09 to 5.54, P = 0.030). This association was especially notable in subjects with untreated teeth with apical rarefactions ( n = 59, OR = 2.72, 95% CI = 1.16 to 6.40, P = 0.022). Our findings support the hypothesis that ELs are independently associated with CAD and in particular with ACS. This is of high interest from a public health perspective, considering the high prevalence of ELs and CAD.
PubMed ID
27466397 View in PubMed
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