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Dust exposure and mortality in chrysotile mining, 1910-75.

https://arctichealth.org/en/permalink/ahliterature246109
Source
Br J Ind Med. 1980 Feb;37(1):11-24
Publication Type
Article
Date
Feb-1980
Author
J C McDonald
F D Liddell
G W Gibbs
G E Eyssen
A D McDonald
Source
Br J Ind Med. 1980 Feb;37(1):11-24
Date
Feb-1980
Language
English
Publication Type
Article
Keywords
Accidents
Aged
Asbestos - adverse effects
Asbestosis - mortality
Cerebrovascular Disorders - mortality
Dust
Employment
Environmental Exposure
Female
Follow-Up Studies
Heart Diseases - mortality
Humans
Lung Neoplasms - mortality
Male
Middle Aged
Mining
Neoplasms - mortality
Occupational Diseases - mortality
Quebec
Respiration Disorders - mortality
Smoking - complications
Time Factors
Abstract
We report a further follow-up of a birth cohort of 11 379 workers exposed to chrysotile. The cohort consisted of 10 939 men and 440 women, born 1891-1920, who had worked for at least a month in the mines and mills of Asbestos and Thetford Mines in Quebec. For all subjects, length of service and estimates of accumulated dust exposure were obtained, with a smoking history for the vast majority. Three methods of analysis, two based on the "man-years" methods, the other a "case-and-multiple-controls" approach, gave results consistent with one another and with previous analyses. By the end of 1975, 4463 men and 84 women had died. Among men, the overall excess mortality, 1926-75 was 2% at Asbestos and 10% at Thetford Mines, much the dustier region. The women, mostly employed at Asbestos, had a standardised mortality ratio (SMR) all causes, 1936-75) of 0.90. Analysis of deaths 20 years or more after first employment showed that in men with short service (less than five years) there was no discernible correlation with dust exposure. Among men employed at least 20 years, there were clear excesses in those exposed to the heaviest dust concentrations. Reanalysis in terms of exposure to age 45 showed definite and consistent trends for SMRs for total mortality, for lung cancer, and for pneumoconiosis to be higher the heavier the exposure. The response to increasing dose was effectively linear for lung cancer and for pneumoconiosis. Lung cancer deaths occurred in non-smokers, and showed a greater increase of incidence with increasing exposure than did lung cancer in smokers, but there was insufficient evidence to distinguish between multiplicative and additive risk models. There were no excess deaths from laryngeal cancer, but a clear association with smoking. Ten men and one woman died from pleural mesothelioma. If the only subjects studied had been the 1904 men with at least 20 years' employment in the lower dust concentrations, averaging 6.6 million particles per cubic foot (or about 20 fibres/cc), excess mortality would not have been considered statistically significant, except for pneumoconiosis. The inability of such a large epidemiological survey to detect increased risk at what, today, are considered unacceptable dust concentrations, and the consequent importance of exposure-response models are therefore emphasised.
Notes
Cites: Biometrics. 1969 Jun;25(2):339-555794104
Cites: Arch Environ Health. 1971 Jun;22(6):677-865574010
Cites: Arch Environ Health. 1972 Mar;24(3):189-975059627
Cites: Arch Environ Health. 1974 Feb;28(2):61-84809914
Cites: Arch Environ Health. 1974 Feb;28(2):69-714809915
Cites: Arch Environ Health. 1975 May;30(5):266-71130842
Cites: Br J Prev Soc Med. 1976 Dec;30(4):225-301009272
Cites: Int J Cancer. 1977 Sep 15;20(3):323-31903186
Cites: Prev Med. 1977 Sep;6(3):426-42333420
Cites: J Occup Med. 1977 Nov;19(11):737-40915568
Cites: Lancet. 1978 Mar 4;1(8062):484-976030
Cites: Br J Ind Med. 1964 Oct;21:304-714253230
PubMed ID
7370189 View in PubMed
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Dust exposure and mortality in chrysotile mining, 1910-75. 1980.

https://arctichealth.org/en/permalink/ahliterature219708
Source
Br J Ind Med. 1993 Dec;50(12):1058-72
Publication Type
Article
Date
Dec-1993
Author
J C McDonald
F D Liddell
G W Gibbs
G E Eyssen
A D McDonald
Source
Br J Ind Med. 1993 Dec;50(12):1058-72
Date
Dec-1993
Language
English
Publication Type
Article
Keywords
Asbestos, Serpentine
Asbestosis - history - mortality
Dust
History, 20th Century
Humans
Mining - history
Occupational Exposure - history
Quebec
Notes
Cites: Int J Cancer. 1977 Sep 15;20(3):323-31903186
Cites: Br J Prev Soc Med. 1976 Dec;30(4):225-301009272
Cites: Prev Med. 1977 Sep;6(3):426-42333420
Cites: J Occup Med. 1977 Nov;19(11):737-40915568
Cites: Lancet. 1978 Mar 4;1(8062):484-976030
Cites: Environ Res. 1978 Dec;17(3):340-6233818
Cites: Br J Ind Med. 1964 Oct;21:304-714253230
Cites: Biometrics. 1969 Jun;25(2):339-555794104
Cites: Arch Environ Health. 1971 Jun;22(6):677-865574010
Cites: Arch Environ Health. 1972 Mar;24(3):189-975059627
Cites: Arch Environ Health. 1974 Feb;28(2):61-84809914
Cites: Arch Environ Health. 1974 Feb;28(2):69-714809915
Cites: Arch Environ Health. 1975 May;30(5):266-71130842
Cites: N Engl J Med. 1976 Mar 25;294(13):687-9055969
Comment In: Occup Environ Med. 1994 Jun;51(6):4318044238
PubMed ID
8280637 View in PubMed
Less detail