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Appearance of Fim3 and ptxP3-Bordetella pertussis strains, in two regions of Sweden with different vaccination programs.

https://arctichealth.org/en/permalink/ahliterature101795
Source
Vaccine. 2011 Apr 18;29(18):3438-42
Publication Type
Article
Date
Apr-18-2011
Author
Abdolreza Advani
Lennart Gustafsson
Christina Ahrén
Frits R Mooi
Hans O Hallander
Author Affiliation
Swedish Institute for Communicable Disease Control, SE-171 82 Solna, Sweden. reza.advani@smi.se
Source
Vaccine. 2011 Apr 18;29(18):3438-42
Date
Apr-18-2011
Language
English
Publication Type
Article
Keywords
Antigens, Bacterial - genetics
Bacterial Typing Techniques
Bordetella Infections - epidemiology - microbiology
Bordetella pertussis - classification - genetics
Child
Fimbriae Proteins - genetics
Gene Frequency
Genotype
Humans
Immunization Programs
Pertussis Toxin - genetics
Pertussis Vaccine - administration & dosage - genetics
Sweden - epidemiology
Virulence Factors, Bordetella - genetics
Abstract
After introduction of a mono-component vaccine, containing only pertussis toxoid (PT), the incidence of pertussis was significantly higher in the Gothenburg area among children during the period October 1, 1997 until end of 2006 compared to the Rest of Sweden where a vaccine containing PT and two other pertussis antigens was used. To investigate a possible cause of this difference, the Bordetella pertussis populations in both regions were compared by determining the fimbrial serotype (Fim), the PFGE-type and the pertussis toxin promoter allele type (ptxP). Strains with the ptxP1 allele were successively replaced by ptxP3 strains producing more pertussis toxin. In Gothenburg compared to the Rest of Sweden, Fim3 and ptxP3 strains were observed earlier and reached higher frequencies in the studied period. Since ptxP3 strains have been shown to be more virulent, their higher prevalence may have contributed to the higher incidence of pertussis in the Gothenburg area. In addition we found a high degree of linkage between PFGE-profile and ptxP3. Our results highlight the importance of strain typing to gain insight into the mechanisms of immunity-associated selection of microbial subtypes and the causes of changes in incidences of infectious diseases.
PubMed ID
21396900 View in PubMed
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Bordetella pertussis isolates, Finland.

https://arctichealth.org/en/permalink/ahliterature176145
Source
Emerg Infect Dis. 2005 Jan;11(1):183-4
Publication Type
Article
Date
Jan-2005
Author
Johanna Mäkinen
Jussi Mertsola
Frits R Mooi
Shirley Van Amersfoorth
Heikki Arvilommi
Matti K Viljanen
Quishui He
Source
Emerg Infect Dis. 2005 Jan;11(1):183-4
Date
Jan-2005
Language
English
Publication Type
Article
Keywords
Adult
Bordetella pertussis - classification - genetics - isolation & purification
Child
DNA Fingerprinting - methods
Disease Outbreaks
Electrophoresis, Gel, Pulsed-Field
Finland - epidemiology
Humans
Schools
Urban Population
Whooping Cough - epidemiology - microbiology - transmission
Notes
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PubMed ID
15714669 View in PubMed
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