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Mortiamides A-D, Cyclic Heptapeptides from a Novel Mortierella sp. Obtained from Frobisher Bay.

https://arctichealth.org/en/permalink/ahliterature285805
Source
J Nat Prod. 2017 Sep 18;
Publication Type
Article
Date
Sep-18-2017
Author
Alyssa L Grunwald
Fabrice Berrue
Andrew W Robertson
David P Overy
Russell G Kerr
Source
J Nat Prod. 2017 Sep 18;
Date
Sep-18-2017
Language
English
Publication Type
Article
Abstract
Four new cyclic heptapeptides, mortiamides A-D (1-4), were obtained from a novel Mortierella sp. isolate obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry. The absolute configurations of the amino acids were determined using Marfey's method. Localization of l and d amino acids within each compound was ascertained by retention time comparison of the partial hydrosylate products of each compound to synthesized dipeptide standards using LC-HRMS. Compounds 1-4 did not exhibit any significant antimicrobial or cytotoxic activity.
PubMed ID
28921982 View in PubMed
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