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Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome.

https://arctichealth.org/en/permalink/ahliterature166831
Source
Fertil Steril. 2007 Mar;87(3):603-6
Publication Type
Article
Date
Mar-2007
Author
Erja Kerkelä
Heli Skottman
Barbro Friden
Kerstin Bjuresten
Juha Kere
Outi Hovatta
Author Affiliation
Department of Biosciences, Novum, Karolinska Institutet, Huddinge, Sweden.
Source
Fertil Steril. 2007 Mar;87(3):603-6
Date
Mar-2007
Language
English
Publication Type
Article
Keywords
Adult
Exons - genetics
Female
Gene Frequency
Humans
Iatrogenic Disease
Ovarian Hyperstimulation Syndrome - genetics
Polymorphism, Genetic
Receptors, FSH - genetics
Receptors, LH - genetics
Sweden
Abstract
To sequence the coding regions of the luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) genes to find out if polymorphisms in them are responsible for the severe form of ovarian hyperstimulation syndrome (OHSS) in Swedish patients.
A mutation analysis of gonadotropin receptor genes from women undergoing gonadotropin treatment.
The Fertility Unit of Karolinska University Hospital Huddinge, Stockholm, Sweden.
A set of 10 well-characterized patients with severe OHSS, and 10 control women who did not develop OHSS after FSH stimulation. An additional 11 patients and 41 control women were screened for a two-amino-acid insertion in the first exon of the LHR gene.
None.
Changes in the sequence of the receptor genes between patients and controls.
No association was found between polymorphisms of the coding region of LHR or FSHR genes and the development of OHSS. Incidence of the two-amino-acid insertion in the first exon of the LHR gene was slightly higher in patients than in controls, but no statistically significant difference was seen.
LHR and FSHR coding polymorphisms are not a major cause of severe OHSS in Swedish patients.
PubMed ID
17074323 View in PubMed
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