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Determinants of duration of untreated psychosis among first-episode psychosis patients in Denmark: A nationwide register-based study.

https://arctichealth.org/en/permalink/ahliterature295757
Source
Schizophr Res. 2018 02; 192:154-158
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-2018
Author
Lene Halling Hastrup
Ulrik Helt Haahr
Jens Einar Jansen
Erik Simonsen
Author Affiliation
Psychiatric Research Unit, Region Zealand Psychiatry, Denmark. Electronic address: lhhs@regionsjaelland.dk.
Source
Schizophr Res. 2018 02; 192:154-158
Date
02-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Adult
Age of Onset
Awareness
Demography
Denmark - epidemiology
Early Intervention (Education)
Female
Humans
Male
Psychiatric Status Rating Scales
Psychotic Disorders - diagnosis - epidemiology - psychology
Registries
Young Adult
Abstract
Information on determinants of duration of untreated psychosis (DUP) is still needed to inform campaigns targeting people with first episode psychosis (FEP). This nation-wide study analysed the association between demographic factors (age, sex, ethnicity, marital status, and geographic area), premorbid and illness-related factors (global functional level, substance misuse, and contact to police), healthcare factors (referral source and first FEP contact) and DUP.
The study population of 1266 patients aged 15-25years diagnosed with FEP (ICD10 F20.0-F20.99) was drawn from the Danish National Indicator Project during 2009-2011. The study population was combined with data from national administrative registers. A multinomial regression model was estimated to analyse the impact of demographic, premorbid and illness-related, and healthcare factors on DUP.
One third of the population had a DUP below 6months. DUP longer than 12months was associated with older age at onset, being female, having cannabis misuse, and living in peripheral municipalities. Being charged by the criminal authorities during one year before FEP was associated with a DUP over 6months.
DUP is related to a number of demographic, premorbid and healthcare factors. These findings suggest that future information campaigns should focus on increasing the awareness of early signs of psychosis not only among mental health professionals but also other professionals in contact with adolescents such as the police. It may also be useful to consider how to target information campaigns towards persons living in peripheral areas.
PubMed ID
28578812 View in PubMed
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Childhood adversity specificity and dose-response effect in non-affective first-episode psychosis.

https://arctichealth.org/en/permalink/ahliterature269845
Source
Schizophr Res. 2015 Jun;165(1):52-9
Publication Type
Article
Date
Jun-2015
Author
Anne Marie Trauelsen
Sarah Bendall
Jens Einar Jansen
Hanne-Grethe Lyse Nielsen
Marlene Buch Pedersen
Christopher Høier Trier
Ulrik H Haahr
Erik Simonsen
Source
Schizophr Res. 2015 Jun;165(1):52-9
Date
Jun-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Case-Control Studies
Child Abuse - psychology
Denmark
Female
Humans
International Classification of Diseases
Logistic Models
Male
Psychopathology
Psychotic Disorders - diagnosis - epidemiology - psychology
Reproducibility of Results
Surveys and Questionnaires
Young Adult
Abstract
Reviews conclude that childhood and adolescence sexual, physical, emotional abuse and emotional and physical neglect are all risk factors for psychosis. However, studies suggest only some adversities are associated with psychosis. Dose-response effects of several adversities on risk of psychosis have not been consistently found. The current study aimed to explore adversity specificity and dose-response effects of adversities on risk of psychosis.
Participants were 101 persons with first-episode psychosis (FEP) diagnosed with ICD-10 F20 - F29 (except F21) and 101 non-clinical control persons matched by gender, age and parents' socio-economic status. Assessment included the Childhood Trauma Questionnaire and parts of the Childhood Experience of Care and Abuse Questionnaire.
Eighty-nine percent of the FEP group reported one or more adversities compared to 37% of the control group. Childhood and adolescent sexual, physical, emotional abuse, and physical and emotional neglect, separation and institutionalization were about four to 17 times higher for the FEP group (all p
PubMed ID
25868932 View in PubMed
Less detail