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Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome.

https://arctichealth.org/en/permalink/ahliterature126256
Source
Am J Psychiatry. 2012 Apr;169(4):374-80
Publication Type
Article
Date
Apr-2012
Author
Wenche Ten Velden Hegelstad
Tor K Larsen
Bjørn Auestad
Julie Evensen
Ulrik Haahr
Inge Joa
Jan O Johannesen
Johannes Langeveld
Ingrid Melle
Stein Opjordsmoen
Jan Ivar Rossberg
Bjørn Rishovd Rund
Erik Simonsen
Kjetil Sundet
Per Vaglum
Svein Friis
Thomas McGlashan
Author Affiliation
Division of Psychiatry, Stavanger University Hospital, Regional Center for Clinical Research in Psychosis, Health West, Norway. wenchetenvelden@me.com
Source
Am J Psychiatry. 2012 Apr;169(4):374-80
Date
Apr-2012
Language
English
Publication Type
Article
Keywords
Adult
Denmark
Early Diagnosis
Female
Follow-Up Studies
Humans
Male
Norway
Outcome and Process Assessment (Health Care) - statistics & numerical data
Prognosis
Psychotic Disorders - diagnosis
Abstract
Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, and 5 years, but longitudinal effects are unknown. The authors investigated the differences in symptoms and recovery after 10 years between regional health care sectors with and without a comprehensive program for the early detection of psychosis.
The authors evaluated 281 patients (early detection, N=141) 18 to 65 years old with a first episode of nonaffective psychosis between 1997 and 2001. Of these, 101 patients in the early-detection area and 73 patients in the usual-detection area were followed up at 10 years, and the authors compared their symptoms and recovery.
A significantly higher percentage of early-detection patients had recovered at the 10-year follow-up relative to usual-detection patients. This held true despite more severely ill patients dropping out of the study in the usual-detection area. Except for higher levels of excitative symptoms in the early-detection area, there were no symptom differences between the groups. Early-detection recovery rates were higher largely because of higher employment rates for patients in this group.
Early detection of first-episode psychosis appears to increase the chances of milder deficits and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over 10 years may indicate that a prognostic link exists between the timing of intervention and outcome that deserves additional study.
Notes
Comment In: Am J Psychiatry. 2012 Sep;169(9):992; author reply 992-322952080
Comment In: Am J Psychiatry. 2012 Apr;169(4):345-722476671
PubMed ID
22407080 View in PubMed
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