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Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik.

https://arctichealth.org/en/permalink/ahliterature4455
Source
Environ Health Perspect. 2004 Oct;112(14):1359-65
Publication Type
Article
Date
Oct-2004
Author
Frédéric Dallaire
Eric Dewailly
Gina Muckle
Carole Vézina
Sandra W Jacobson
Joseph L Jacobson
Pierre Ayotte
Author Affiliation
Department of Social and Preventive Medicine, Laval University, and Public Health Research Unit, CHUQ-Laval University Medical Center, 945 Wolfe Street, Sainte-Foy, Québec G1V 5B3, Canada.
Source
Environ Health Perspect. 2004 Oct;112(14):1359-65
Date
Oct-2004
Language
English
Publication Type
Article
Keywords
Acute Disease
Adult
Cohort Studies
Dichlorodiphenyl Dichloroethylene - analysis - poisoning
Environmental Exposure
Environmental Pollutants - analysis - poisoning
Female
Gastrointestinal Diseases - epidemiology - etiology - microbiology
Humans
Infant
Infant, Newborn
Insecticides - analysis - poisoning
Inuits
Male
Otitis Media - epidemiology - etiology
Polychlorinated Biphenyls - analysis - poisoning
Pregnancy
Prenatal Exposure Delayed Effects
Quebec - epidemiology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Respiratory Tract Infections - epidemiology - etiology
Retrospective Studies
Abstract
The Inuit population of Nunavik (Canada) is exposed to immunotoxic organochlorines (OCs) mainly through the consumption of fish and marine mammal fat. We investigated the effect of perinatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) on the incidence of acute infections in Inuit infants. We reviewed the medical charts of a cohort of 199 Inuit infants during the first 12 months of life and evaluated the incidence rates of upper and lower respiratory tract infections (URTI and LRTIs, respectively), otitis media, and gastrointestinal (GI) infections. Maternal plasma during delivery and infant plasma at 7 months of age were sampled and assayed for PCBs and DDE. Compared to rates for infants in the first quartile of exposure to PCBs (least exposed), adjusted rate ratios for infants in higher quartiles ranged between 1.09 and 1.32 for URTIs, 0.99 and 1.39 for otitis, 1.52 and 1.89 for GI infections, and 1.16 and 1.68 for LRTIs during the first 6 months of follow-up. For all infections combined, the rate ratios ranged from 1.17 to 1.27. The effect size was similar for DDE exposure but was lower for the full 12-month follow-up. Globally, most rate ratios were > 1.0, but few were statistically significant (p
PubMed ID
15471725 View in PubMed
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Acylation stimulating protein is higher in Inuit from Nunavik compared to a southern Quebec population.

https://arctichealth.org/en/permalink/ahliterature98475
Source
Int J Circumpolar Health. 2009 Dec;68(5):421-32
Publication Type
Article
Date
Dec-2009
Author
Jessica D Smith
Katherine Cianflone
Eric Dewailly
Marie-Ludivine Château-Degat
Marie-Claude Vohl
Pierre Julien
Author Affiliation
Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y2186, 2725 Chemin Ste-foy, Ste-Foy G1V 4G5, Canada.
Source
Int J Circumpolar Health. 2009 Dec;68(5):421-32
Date
Dec-2009
Language
English
Geographic Location
Canada
Publication Type
Article
Keywords
Acylation
Adipokines - blood
Adult
Aged
Body Weights and Measures
Cross-Sectional Studies
European Continental Ancestry Group
Female
Humans
Intercellular Signaling Peptides and Proteins - blood
Inuits
Male
Metabolic Syndrome X - blood - ethnology
Middle Aged
Myocardial Ischemia - blood - ethnology
Quebec - epidemiology
Sex Factors
Vitamin A - blood
Abstract
OBJECTIVES: The Inuit of Nunavik in northern Quebec have a lower risk for ischemic heart disease (IHD) compared to Caucasian populations. Acylation stimulating protein (ASP), which is involved in the storage of dietary fat, may play a role. The objective of the study was to determine plasma concentration of ASP in an Inuit and a southern Quebec Caucasian population. STUDY DESIGN: This is a cross-sectional study evaluating the relationship between ASP and dietary factors, such as retinol, whose intake is higher in the Inuit. As well, concentrations of ASP were evaluated in relationship to components of the metabolic syndrome. METHODS: Medical history was collected via a questionnaire and anthropometric measurements and blood samples were collected. RESULTS: ASP was significantly higher in both the Inuit men and women compared to Caucasian men (66.1 +/- 4.1 nM vs 27.5 +/- 2.5 nM, p
Notes
RefSource: Int J Circumpolar Health. 2009 Dec;68(5):419-20
PubMed ID
20044961 View in PubMed
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Altered fine motor function at school age in Inuit children exposed to PCBs, methylmercury, and lead.

https://arctichealth.org/en/permalink/ahliterature275653
Source
Environ Int. 2016 Aug 26;
Publication Type
Article
Date
Aug-26-2016
Author
Olivier Boucher
Gina Muckle
Pierre Ayotte
Eric Dewailly
Sandra W Jacobson
Joseph L Jacobson
Source
Environ Int. 2016 Aug 26;
Date
Aug-26-2016
Language
English
Publication Type
Article
Abstract
Motor deficits have frequently been reported in methylmercury (MeHg) poisoning in adults. However, whether exposure to neurotoxic contaminants from environmental sources early in life is associated with neuromotor impairments has received relatively little attention. This study examines the relation of developmental exposure to MeHg, polychlorinated biphenyls (PCBs), and lead to motor function in school-age Inuit children exposed through their traditional diet.
In a prospective study in Nunavik, children (mean age=11.3years) were assessed on a battery of fine motor tasks, namely the Stanford-Binet Copying subtest (N=262), the Santa Ana Form Board, and the Finger Tapping Test (N=215). The relation of mercury (Hg; as an index of MeHg exposure), PCB congener 153 (PCB153), and lead concentrations in cord and current blood samples to task performance was examined using linear regression analyses.
After adjustment for potential confounders and control for the other contaminants, higher current PCB concentrations were associated with poorer Santa Ana Form Board and Finger Tapping performance. Results were virtually identical when PCB153 was replaced by other PCB congeners. Higher current Hg levels were independently associated with poorer Finger Tapping performance.
This is the first prospective longitudinal study in children to provide evidence of neuromotor impairments associated with postnatal exposure to seafood contaminants from environmental sources. Fine motor speed appears particularly sensitive to the effects of postnatal PCB exposure, which is unusually high in this population. Results with postnatal MeHg are concordant with previous cross-sectional studies with children and adults.
PubMed ID
27575364 View in PubMed
Less detail

An examination of traditional foods and cigarette smoking as cadmium sources among the nine First Nations of Eeyou Istchee, Northern Quebec, Canada.

https://arctichealth.org/en/permalink/ahliterature104372
Source
Environ Sci Process Impacts. 2014 May 28;16(6):1422-33
Publication Type
Article
Date
May-28-2014
Author
Nadia A Charania
Leonard J S Tsuji
Ian D Martin
Eric N Liberda
Suzanne Coté
Pierre Ayotte
Eric Dewailly
Evert Nieboer
Author Affiliation
Environment and Resource Studies, University of Waterloo, Waterloo, ON, Canada.
Source
Environ Sci Process Impacts. 2014 May 28;16(6):1422-33
Date
May-28-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cadmium - blood
Child
Environmental Exposure - analysis - statistics & numerical data
Environmental monitoring
Environmental pollutants - blood
Food Contamination - analysis - statistics & numerical data
Humans
Indians, North American
Male
Middle Aged
Quebec - epidemiology
Smoking - epidemiology
Young Adult
Abstract
Cadmium (Cd), a nonessential toxic metal present in the environment, accumulates in the organs of herbivorous mammals which typically are consumed by Aboriginal populations. The relative contribution of this potential exposure source to concentrations of blood Cd was investigated in 1429 participants (age >7 years) residing in the nine Cree First Nations communities of Eeyou Istchee, northern Quebec, Canada. Analysis of variance identified significant Cd concentration differences between communities, sex, and age groups, although these were complicated by significant 2-way interactions. The percentage of participants with Cd concentrations within the adopted health-based guideline categories of 'acceptable', 'concern' and 'action' pertaining to kidney damage was 56.2%, 38.3%, and 5.5%, respectively. Partial correlations (controlling for age as a continuous variable) did not show a significant association between consumption of traditional foods and Cd concentrations (r = 0.014, df = 105, p = 0.883). A significant and positive partial correlation (r = 0.390, df = 105, p
PubMed ID
24781002 View in PubMed
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Arctic berry extracts target the gut-liver axis to alleviate metabolic endotoxaemia, insulin resistance and hepatic steatosis in diet-induced obese mice.

https://arctichealth.org/en/permalink/ahliterature287743
Source
Diabetologia. 2017 Dec 21;
Publication Type
Article
Date
Dec-21-2017
Author
Fernando F Anhê
Thibault V Varin
Mélanie Le Barz
Geneviève Pilon
Stéphanie Dudonné
Jocelyn Trottier
Philippe St-Pierre
Cory S Harris
Michel Lucas
Mélanie Lemire
Éric Dewailly
Olivier Barbier
Yves Desjardins
Denis Roy
André Marette
Source
Diabetologia. 2017 Dec 21;
Date
Dec-21-2017
Language
English
Publication Type
Article
Abstract
There is growing evidence that fruit polyphenols exert beneficial effects on the metabolic syndrome, but the underlying mechanisms remain poorly understood. In the present study, we aimed to analyse the effects of polyphenolic extracts from five types of Arctic berries in a model of diet-induced obesity.
Male C57BL/6 J mice were fed a high-fat/high-sucrose (HFHS) diet and orally treated with extracts of bog blueberry (BBE), cloudberry (CLE), crowberry (CRE), alpine bearberry (ABE), lingonberry (LGE) or vehicle (HFHS) for 8 weeks. An additional group of standard-chow-fed, vehicle-treated mice was included as a reference control for diet-induced obesity. OGTTs and insulin tolerance tests were conducted, and both plasma insulin and C-peptide were assessed throughout the OGTT. Quantitative PCR, western blot analysis and ELISAs were used to assess enterohepatic immunometabolic features. Faecal DNA was extracted and 16S rRNA gene-based analysis was used to profile the gut microbiota.
Treatment with CLE, ABE and LGE, but not with BBE or CRE, prevented both fasting hyperinsulinaemia (mean ± SEM [pmol/l]: chow 67.2?±?12.3, HFHS 153.9?±?19.3, BBE 114.4?±?14.3, CLE 82.5?±?13.0, CRE 152.3?±?24.4, ABE 90.6?±?18.0, LGE 95.4?±?10.5) and postprandial hyperinsulinaemia (mean ± SEM AUC [pmol/l?×?min]: chow 14.3?±?1.4, HFHS 31.4?±?3.1, BBE 27.2?±?4.0, CLE 17.7?±?2.2, CRE 32.6?±?6.3, ABE 22.7?±?18.0, LGE 23.9?±?2.5). None of the berry extracts affected C-peptide levels or body weight gain. Levels of hepatic serine phosphorylated Akt were 1.6-, 1.5- and 1.2-fold higher with CLE, ABE and LGE treatment, respectively, and hepatic carcinoembryonic antigen-related cell adhesion molecule (CEACAM)-1 tyrosine phosphorylation was 0.6-, 0.7- and 0.9-fold increased in these mice vs vehicle-treated, HFHS-fed mice. These changes were associated with reduced liver triacylglycerol deposition, lower circulating endotoxins, alleviated hepatic and intestinal inflammation, and major gut microbial alterations (e.g. bloom of Akkermansia muciniphila, Turicibacter and Oscillibacter) in CLE-, ABE- and LGE-treated mice.
Our findings reveal novel mechanisms by which polyphenolic extracts from ABE, LGE and especially CLE target the gut-liver axis to protect diet-induced obese mice against metabolic endotoxaemia, insulin resistance and hepatic steatosis, which importantly improves hepatic insulin clearance. These results support the potential benefits of these Arctic berries and their integration into health programmes to help attenuate obesity-related chronic inflammation and metabolic disorders.
All raw sequences have been deposited in the public European Nucleotide Archive server under accession number PRJEB19783 ( https://www.ebi.ac.uk/ena/data/view/PRJEB19783 ).
PubMed ID
29270816 View in PubMed
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Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort Study.

https://arctichealth.org/en/permalink/ahliterature4473
Source
Environ Health Perspect. 2003 Jul;111(9):1253-8
Publication Type
Article
Date
Jul-2003
Author
Pierre Ayotte
Gina Muckle
Joseph L Jacobson
Sandra W Jacobson
Eric Dewailly
Author Affiliation
Department of Social and Preventive Medicine, Laval University and Public Health Research Unit, CHUQ-Laval University Medical Centre, Québec, Québec, Canada. pierre.ayotte@inspq.qc.ca
Source
Environ Health Perspect. 2003 Jul;111(9):1253-8
Date
Jul-2003
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Biological Markers - analysis
Breast Feeding
Chromatography, Gas
Cohort Studies
Environmental Exposure
Environmental Pollutants - analysis - blood
Epidemiologic Studies
Female
Fetal Blood - chemistry
Forecasting
Humans
Indians, North American
Infant
Infant, Newborn
Maternal-Fetal Exchange
Milk, human - chemistry
Models, Theoretical
Polychlorinated Biphenyls - analysis - blood
Pregnancy
Quebec - epidemiology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Abstract
Polychlorinated biphenyls (PCBs) are food-chain contaminants that have been shown to induce adverse developmental effects in humans. In the course of an epidemiologic study established to investigate neurodevelopmental deficits induced by environmental PCB exposure in the Inuit population of northern Québec (Nunavik, Canada), we compared three biomarkers of prenatal exposure and models to predict PCB plasma concentration at 6 months postpartum. Concentrations of 14 PCB congeners were measured by high-resolution gas chromatography with electron capture detection in lipids extracted from maternal plasma, cord plasma, breast milk (collected at approximately 1 month postpartum), and 6-month-old infant plasma samples. Similar congener profiles were observed in all biologic samples, and PCB-153, the most abundant and persistent PCB congener, was strongly correlated with other frequently detected PCB congeners in all biologic media. When expressed on a lipid basis, maternal plasma, cord plasma, and milk concentrations of this congener were strongly intercorrelated, indicating that PCB concentration in any of these biologic media is a good indicator of prenatal exposure to PCBs. A multivariate model that included maternal PCB-153 plasma lipid concentration, breast-feeding duration, and the sum of two skin-fold thicknesses (an index of infant body fat mass) explained 72% of PCB-153 plasma concentration variance at 6 months postpartum (p
PubMed ID
12842782 View in PubMed
Less detail

Association between methylmercury and cardiovascular risk factors in a native population of Quebec (Canada): a retrospective evaluation.

https://arctichealth.org/en/permalink/ahliterature120888
Source
Environ Res. 2013 Jan;120:102-8
Publication Type
Article
Date
Jan-2013
Author
Beatriz Valera
Eric Dewailly
Paul Poirier
Author Affiliation
Axe santé des populations et environnementale, Centre de recherche du CHUQ, Édifice Delta 2, 2875, boulevard Laurier, 6e étage, Sainte-Foy, Québec, Canada G1V 2M2. beatriz.valera@crchul.ulaval.ca
Source
Environ Res. 2013 Jan;120:102-8
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Blood pressure
Environmental Exposure - adverse effects
Female
Heart rate
Humans
Hypertension - chemically induced
Male
Methylmercury Compounds - adverse effects - blood
Middle Aged
Quebec
Retrospective Studies
Risk factors
Young Adult
Abstract
Epidemiological evidence suggests a negative impact of methylmercury (MeHg) on cardiovascular risk factors such as blood pressure (BP) and heart rate (HR). This issue is of concern in Arctic populations such as in the Inuit of Nunavik since this contaminant is accumulated in fish and marine mammals, which still represent the subsistence diet of this population.
We examined the associations between MeHg and BP and resting HR among Inuit adults.
The "Santé Quebec" health survey was conducted in 1992 in the 14 villages of Nunavik and a complete set of data was obtained for 313 Inuit adults=18 years. Blood samples were collected in order to determine total mercury, lead, total polychlorinated biphenyls (PCBs), n-3 polyunsaturated fatty acids (PUFAs), fasting glucose and lipid profile while socio-demographic variables were obtained through questionnaires. Anthropometric measurements as well as BP and resting HR were obtained using standardised protocols. Pulse pressure (PP: systolic BP minus diastolic BP) was also calculated. Multiple linear regression was used in order to determine the change in the dependent variables associated with the quartiles of MeHg concentration, taking the quartile 1 as reference.
The mean age of the participants was 38±14 years and the sample was composed of 132 men (42.2%) and 181 women (57.8%). MeHg geometric mean was 15.4 µg/L (95%CI: 13.9-17.0) and levels ranged from 0.8 to 112.0 µg/L. Resting HR increased linearly across quartiles of blood MeHg concentration after adjusting for confounders (p for trend=0.02). An increase of 6.9 beats per minute (bpm) between the 4th and 1st quartile was observed after adjusting for confounders. No significant association was observed between blood MeHg and systolic BP, diastolic BP or PP.
MeHg was associated with increasing resting HR after considering traditional risk factors as well as other contaminants (lead and total PCBs) and n-3 PUFAs. In contrast, no significant association with blood pressure was observed in this study.
PubMed ID
22959488 View in PubMed
Less detail

Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik.

https://arctichealth.org/en/permalink/ahliterature108571
Source
Environ Int. 2013 Sep;59:282-9
Publication Type
Article
Date
Sep-2013
Author
Beatriz Valera
Pierre Ayotte
Paul Poirier
Eric Dewailly
Author Affiliation
Axe santé publique et pratiques optimales en santé, Centre de recherche du CHU de Québec, Canada. beatriz.valera@crchul.ulaval.ca
Source
Environ Int. 2013 Sep;59:282-9
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Animals
Arctic Regions
Blood Pressure - drug effects
Dichlorodiphenyl Dichloroethylene - blood
Diet
Dioxins - blood
Environmental Exposure
Environmental pollutants - blood
Fatty Acids, Omega-3 - blood
Female
Fishes
Humans
Hydrocarbons, Chlorinated - blood
Hypertension - chemically induced - epidemiology
Inuits
Lindane - blood
Male
Mercury - blood
Middle Aged
Pesticides - blood
Polychlorinated biphenyls - blood
Quebec - epidemiology
Tetrachlorodibenzodioxin - blood
Young Adult
Abstract
Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, which represent the traditional diet of these populations.
We examined the associations between polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides and hypertension among Inuit from Nunavik (Quebec, Canada).
A complete set of data was obtained for 315 Inuit=18years who participated in the "Santé Québec" health survey that was conducted in the 14 villages of Nunavik in 1992. Fourteen polychlorinated biphenyls (PCBs) and 8 OC pesticides or their metabolites were measured in plasma samples using gas chromatography with electron capture detection. Blood pressure (BP) was measured using a standardized protocol and information regarding anti-hypertensive medication was obtained through questionnaires. The associations between log-transformed POPs and hypertension (systolic BP=140mmHg, diastolic BP=90mmHg or anti-hypertensive medication) were analyzed using multiple logistic regressions.
Total PCBs as well as the sum of non-dioxin-like PCBs were significantly associated with higher risk of hypertension. Furthermore, the risk of hypertension increased with higher plasma concentrations of congeners 101, 105, 138 and 187. Models adjusted for BP risk factors became significant after including n-3 polyunsaturated fatty acids (PUFAs) and further adjustment for lead and mercury did not change the results. Regarding OC pesticides, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was associated with increased risk of hypertension while inverse associations were observed with p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT), ß-hexachlorocyclohexane (HCH) and oxychlordane.
Some PCB congeners were associated with higher risk of hypertension in this highly exposed population. Most associations became significant after including n-3 PUFAs in the models. However, the analyses of OC pesticides revealed divergent results, which need to be confirmed in further cohort and experimental studies.
PubMed ID
23872387 View in PubMed
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Associations between prenatal cigarette smoke exposure and externalized behaviors at school age among Inuit children exposed to environmental contaminants.

https://arctichealth.org/en/permalink/ahliterature258359
Source
Neurotoxicol Teratol. 2013 Sep-Oct;39:84-90
Publication Type
Article
Author
Caroline Desrosiers
Olivier Boucher
Nadine Forget-Dubois
Eric Dewailly
Pierre Ayotte
Sandra W Jacobson
Joseph L Jacobson
Gina Muckle
Author Affiliation
Université Laval, Québec City, Québec, Canada; Centre de recherche du Centre Hospitalier Universitaire de Québec, Québec City, Québec, Canada.
Source
Neurotoxicol Teratol. 2013 Sep-Oct;39:84-90
Language
English
Publication Type
Article
Keywords
Attention - drug effects
Attention Deficit Disorder with Hyperactivity - chemically induced - epidemiology - psychology
Attention Deficit and Disruptive Behavior Disorders - chemically induced - psychology
Child
Drug Interactions
Environmental Pollutants - analysis - toxicity
Female
Fetal Blood - chemistry
Humans
Inuits - psychology
Lead Poisoning, Nervous System, Childhood - blood - psychology
Male
Mercury Poisoning, Nervous System - blood - psychology
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - psychology
Prevalence
Quebec - epidemiology
Tobacco Smoke Pollution - adverse effects
Abstract
Smoking during pregnancy is common among Inuit women from the Canadian Arctic. Yet prenatal cigarette smoke exposure (PCSE) is seen as a major risk factor for childhood behavior problems. Recent data also suggest that co-exposure to neurotoxic environmental contaminants can exacerbate the effects of PCSE on behavior. This study examined the association between PCSE and behavior at school age in a sample of Inuit children from Nunavik, Qu?bec, where co-exposure to environmental contaminants is also an important issue. Interactions with lead (Pb) and mercury (Hg), two contaminants associated with behavioral problems, were also explored.
Participants were 271 children (mean age=11.3years) involved in a prospective birth-cohort study. PCSE was assessed through maternal recall. Assessment of child behavior was obtained from the child's classroom teacher on the Teacher Report Form (TRF) and the Disruptive Behavior Disorders Rating Scale (DBD). Exposure to contaminants was assessed from umbilical cord and child blood samples. Other confounders were documented by maternal interview.
After control for contaminants and confounders, PCSE was associated with increased externalizing behaviors and attention problems on the TRF and higher prevalence of attention deficit hyperactivity disorder (ADHD) assessed on the DBD. No interactions were found with contaminants.
This study extends the existing empirical evidence linking PCSE to behavioral problems in school-aged children by reporting these effects in a population where tobacco use is normative rather than marginal. Co-exposure to Pb and Hg do not appear to exacerbate tobacco effects, suggesting that these substances act independently.
Notes
Cites: J Am Acad Child Adolesc Psychiatry. 2003 Jul;42(7):826-3312819442
Cites: Environ Health Perspect. 2000 Nov;108(11):1079-8311102300
Cites: Environ Health Perspect. 2003 Oct;111(13):1660-414527847
Cites: Early Hum Dev. 2003 Dec;75(1-2):21-3314652157
Cites: J Clin Psychol. 2004 Jun;60(6):689-9315141400
Cites: Nicotine Tob Res. 2004 Apr;6 Suppl 2:S125-4015203816
Cites: Arch Gen Psychiatry. 2004 Aug;61(8):836-4315289282
Cites: J Am Acad Child Adolesc Psychiatry. 1992 Mar;31(2):210-81564021
Cites: Psychol Bull. 1993 Sep;114(2):376-908416037
Cites: Neurotoxicol Teratol. 2005 May-Jun;27(3):395-40615939200
Cites: Biol Psychiatry. 2005 Jun 1;57(11):1377-8415950011
Cites: Pediatrics. 2005 Aug;116(2):462-716061604
Cites: Arch Gen Psychiatry. 2005 Oct;62(10):1142-716203959
Cites: Hum Mol Genet. 2006 Jul 15;15(14):2276-8416774975
Cites: J Clin Psychiatry. 2006;67 Suppl 8:7-1216961424
Cites: Acta Paediatr. 2007 Mar;96(3):377-8217407460
Cites: Environ Health Perspect. 2001 Dec;109(12):1291-911748038
Cites: Biol Psychiatry. 2003 Jan 15;53(2):130-512547468
Cites: Ann Epidemiol. 2007 Jan;17(1):27-3517027287
Cites: Am J Addict. 2006 Nov-Dec;15(6):450-617182447
Cites: Neuropsychopharmacology. 2007 Mar;32(3):693-916554741
Cites: J Am Acad Child Adolesc Psychiatry. 2007 Mar;46(3):362-917314722
Cites: Biol Psychiatry. 2007 Jun 15;61(12):1320-817157268
Cites: Arch Pediatr Adolesc Med. 2007 Sep;161(9):857-6417768285
Cites: Child Psychiatry Hum Dev. 2007 Dec;38(4):255-6917520361
Cites: Dev Psychopathol. 2008 Winter;20(1):139-6418211732
Cites: Nicotine Tob Res. 2008 Feb;10(2):267-7818236291
Cites: Environ Health Perspect. 2008 Jul;116(7):956-6218629321
Cites: Neurotoxicology. 2008 Sep;29(5):783-80118652843
Cites: Vital Health Stat 10. 2008 Jul;(237):1-1418998276
Cites: Int J Epidemiol. 2009 Jun;38(3):698-70518250076
Cites: Int J Epidemiol. 2009 Jun;38(3):680-918775874
Cites: Nicotine Tob Res. 2009 Oct;11(10):1166-7419640836
Cites: Pediatrics. 2009 Dec;124(6):e1054-6319933729
Cites: Acta Paediatr. 2010 Jan;99(1):106-1119793315
Cites: Environ Health Perspect. 2010 Jan;118(1):150-420056582
Cites: Prev Med. 2010 Jan-Feb;50(1-2):13-820026103
Cites: J Epidemiol Community Health. 2010 Jul;64(7):622-919703906
Cites: Pediatrics. 2010 Oct;126(4):705-1120855396
Cites: J Psychiatr Res. 2010 Nov;44(15):1058-6220413131
Cites: Neurotoxicol Teratol. 2011 Jan-Feb;33(1):137-4421256428
Cites: Am J Clin Nutr. 2011 May;93(5):1025-3721389181
Cites: CMAJ. 2011 May 17;183(8):E480-621555383
Cites: Alcohol Clin Exp Res. 2011 Jun;35(6):1081-9121332531
Cites: Environ Res. 2011 Nov;111(8):1173-921764051
Cites: Am J Clin Nutr. 2011 Dec;94(6):1592-922071708
Cites: Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):289-9722259195
Cites: Psychopharmacology (Berl). 2012 Oct;223(4):401-1522562524
Cites: Environ Health Perspect. 2012 Oct;120(10):1456-6123008274
Cites: J Pediatr. 2003 Jul;143(1):104-1012915833
PubMed ID
23916943 View in PubMed
Less detail

Blood pressure among the Inuit (Eskimo) populations in the Arctic.

https://arctichealth.org/en/permalink/ahliterature3453
Source
Scand J Public Health. 2003;31(2):92-9
Publication Type
Article
Date
2003
Author
Peter Bjerregaard
Eric Dewailly
T Kue Young
Carole Blanchet
Robert A Hegele
Sven E O Ebbesson
Patricia M Risica
Gert Mulvad
Author Affiliation
National Institute of Public Health, Svanemollevej 25, DK-2100 Copenhagen, Denmark. p.bjerregaard@dadlnet.dk
Source
Scand J Public Health. 2003;31(2):92-9
Date
2003
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Alaska - epidemiology
Antihypertensive Agents - therapeutic use
Arctic Regions - epidemiology
Blood Pressure - physiology
Female
Greenland - epidemiology
Humans
Hypertension - drug therapy - ethnology - physiopathology
Inuits - genetics - statistics & numerical data
Male
Middle Aged
Obesity - complications - ethnology
Quebec - epidemiology
Risk factors
Sex Factors
Smoking - adverse effects - ethnology
World Health
Abstract
AIMS: Studies of blood pressure among various Inuit (Eskimo) populations in the Arctic have given inconsistent results. Most studies reported lower blood pressure among the Inuit as compared with the predominantly white national populations. This has been attributed to traditional subsistence practices and lifestyle. This study compared the blood pressure among the major Inuit population groups with other populations and examined the associations with factors like age, gender, obesity and smoking. METHODS: The study comprised four Inuit populations from Alaska, Canada, and Greenland with participation rates ranging from 51% to 73%. In a cross-sectional design, 2,509 randomly selected adults from 31 villages were examined. Blood pressure, anthropometric measurements, smoking, and medication were recorded. RESULTS: Mean systolic blood pressures ranged from 116 to 124 mm Hg among men and 110 to 118 among women in the four populations. Mean diastolic blood pressures ranged from 75 to 78 mm Hg among men and from 71 to 73 among women. Systolic blood pressure increased with age. Male gender, obesity, being a non-smoker, and being on anti-hypertensive treatment were associated with high systolic and diastolic blood pressure. Adjusted for age, body mass index, smoking, and anti-hypertensive treatment, blood pressure differed among the populations (p
PubMed ID
12745758 View in PubMed
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