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23 records – page 1 of 3.

Arterial pressure, left ventricular mass, and aldosterone in essential hypertension.

https://arctichealth.org/en/permalink/ahliterature195409
Source
Hypertension. 2001 Mar;37(3):845-50
Publication Type
Article
Date
Mar-2001
Author
A H El-Gharbawy
V S Nadig
J M Kotchen
C E Grim
K B Sagar
M. Kaldunski
P. Hamet
Z. Pausova
D. Gaudet
F. Gossard
T A Kotchen
Author Affiliation
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Source
Hypertension. 2001 Mar;37(3):845-50
Date
Mar-2001
Language
English
Publication Type
Article
Keywords
Adult
African Continental Ancestry Group
Aldosterone - blood
Blood pressure
Body mass index
Canada
Circadian Rhythm
Electrocardiography
European Continental Ancestry Group
Female
France - ethnology
Humans
Hypertension - blood - physiopathology
Hypertrophy, Left Ventricular - physiopathology
Male
Middle Aged
Obesity - blood - physiopathology
Potassium - blood
Renin - blood
United States
Abstract
The purpose of the present study was to evaluate the relationship of aldosterone to blood pressure and left ventricular size in black American (n=109) and white French Canadian (n=73) patients with essential hypertension. Measurements were obtained with patients off antihypertensive medications and included 24-hour blood pressure monitoring, plasma renin activity and aldosterone, and an echocardiogram. Compared with the French Canadians, the black Americans had higher body mass indexes, higher systolic blood pressures, attenuated nighttime reduction of blood pressure, and lower serum potassium concentrations (P:
PubMed ID
11244006 View in PubMed
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Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia.

https://arctichealth.org/en/permalink/ahliterature205337
Source
Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):1007-12
Publication Type
Article
Date
Jun-1998
Author
P. Couture
L D Brun
F. Szots
M. Lelièvre
D. Gaudet
J P Després
J. Simard
P J Lupien
C. Gagné
Author Affiliation
Department of Medicine, CHUL Research Center and Laval University, Québec, Canada.
Source
Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):1007-12
Date
Jun-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Anticholesteremic Agents - pharmacology
Apolipoproteins B - blood
Canada
Child
Cholesterol, LDL - blood
Double-Blind Method
Female
Heterozygote
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Hyperlipoproteinemia Type II - blood - drug therapy - genetics
Lipoproteins - blood
Male
Point Mutation
Receptors, LDL - genetics
Simvastatin - pharmacology
Abstract
In familial hypercholesterolemia (FH), the efficacy of the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase shows considerable interindividual variation, and several genetic and environmental factors can contribute to explaining this variability. A randomized, double-blind, placebo-controlled clinical trial with simvastatin, an HMG-CoA reductase inhibitor, was conducted in 63 children and adolescents with heterozygous FH. The patients were grouped according to known LDL receptor genotype. After 6 weeks of treatment with 20 mg/d simvastatin, the mean reduction in plasma LDL cholesterol in patients with the W66G mutation (n=14) was 31%, whereas in the deletion>15 kb (n=23) and the C646Y mutation groups (n=10), it was 38% and 42%, respectively (P
PubMed ID
9633944 View in PubMed
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Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.

https://arctichealth.org/en/permalink/ahliterature164054
Source
Diabetologia. 2007 Jun;50(6):1209-17
Publication Type
Article
Date
Jun-2007
Author
J C Florez
M. Sjögren
C M Agapakis
N P Burtt
P. Almgren
U. Lindblad
G. Berglund
T. Tuomi
D. Gaudet
M J Daly
K G Ardlie
J N Hirschhorn
D. Altshuler
L. Groop
Author Affiliation
Simches Research Building-CPZN 6820, Diabetes Unit/Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA. jcflorez@partners.org
Source
Diabetologia. 2007 Jun;50(6):1209-17
Date
Jun-2007
Language
English
Publication Type
Article
Keywords
Aged
Body mass index
Case-Control Studies
Diabetes Mellitus, Type 2 - genetics
European Continental Ancestry Group - genetics
Female
Genetic Variation
Glucose Tolerance Test
Humans
Insulin - physiology
Insulin Receptor Substrate Proteins
Male
Middle Aged
Phosphoproteins - genetics
Poland - ethnology
Polymorphism, Single Nucleotide
Signal Transduction
Sweden - ethnology
United States
Abstract
Activation of the insulin receptor substrate-1 (IRS1) is a key initial step in the insulin signalling pathway. Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabetes, we and others have not observed this association in well-powered samples. However, other nearby variants might account for the putative association signal.
We characterised the haplotype map of IRS1 and selected 20 markers designed to capture common variations in the region. We genotyped this comprehensive set of markers in several family-based and case-control samples of European descent totalling 12,129 subjects.
In an initial sample of 2,235 North American and Polish case-control pairs, the minor allele of the rs934167 polymorphism showed nominal evidence of association with type 2 diabetes (odds ratio [OR] 1.25, 95% CI 1.03-1.51, p = 0.03). This association showed a trend in the same direction in 7,659 Scandinavian samples (OR 1.16, 95% CI 0.96-1.39, p = 0.059). The combined OR was 1.20 (p = 0.008), but statistical correction for the number of variants examined yielded a p value of 0.086. We detected no differences across rs934167 genotypes in insulin-related quantitative traits.
Our data do not support an association of common variants in IRS1 with type 2 diabetes in populations of European descent.
PubMed ID
17443311 View in PubMed
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CANNT: supporting the Canadian nephrology experience.

https://arctichealth.org/en/permalink/ahliterature176171
Source
CANNT J. 1999;9(3):17-9
Publication Type
Article
Date
1999
Author
D. Gaudet
Author Affiliation
Dr Geogre-L Dumont Regional Hospital, Beaséjour Hospital Corporation, Moncton, New Brunswick.
Source
CANNT J. 1999;9(3):17-9
Date
1999
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Certification
Evidence-Based Medicine
Humans
Kidney Failure, Chronic - epidemiology - therapy
Nephrology - education
Nurse Clinicians
Nursing Research
Personnel Staffing and Scheduling - organization & administration
Registries
Renal Replacement Therapy - nursing
Social Support
Specialties, Nursing - education - organization & administration
Tissue and Organ Procurement - organization & administration
Abstract
The Canadian Organ Replacement Register annual report (1998) provides insightful trends in renal replacement treatment modalities, comparing data from 1981 to 1996. The purpose of reviewing this report was to look at the scope of change over time in the distribution of treatment modalities and Canadian patient demographics: age, gender, dwelling (alternate care facilities, home and in-hospital), and medical conditions (vascular access, communicable diseases, diagnosis, and cause of death). Discussion focuses on the impact of these and other changes in the practice setting and describes the Canadian Association of Nephrology Nurses and Technologists' (CANNT) initiatives to support nephrology nurses and technologists.
PubMed ID
15712468 View in PubMed
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Comparison of the effect of two low-density lipoprotein receptor class mutations on coronary heart disease among French-Canadian patients heterozygous for familial hypercholesterolaemia.

https://arctichealth.org/en/permalink/ahliterature208571
Source
Eur J Clin Invest. 1997 May;27(5):366-73
Publication Type
Article
Date
May-1997
Author
M C Vohl
D. Gaudet
S. Moorjani
G. Tremblay
P. Perron
C. Gagné
D. Lesiège
J. Bergeron
P J Lupien
J P Després
Author Affiliation
Lipid Research Center, Laval University Hospital, Sainte-Foy, Québec, Canada.
Source
Eur J Clin Invest. 1997 May;27(5):366-73
Date
May-1997
Language
English
Publication Type
Article
Keywords
Adult
Aging
Angioplasty, Balloon, Coronary
Body constitution
Body mass index
Coronary Angiography
Coronary Artery Bypass
Coronary Disease - genetics
Female
Heterozygote
Humans
Hyperlipoproteinemia Type II - genetics
Lipoprotein(a) - blood
Male
Middle Aged
Mutation
Quebec
Receptors, LDL - genetics - physiology
Abstract
The aim of this study was to compare the age at first elective coronary angiogram and the age at first revascularization (coronary artery bypass grafting or percutaneous transluminal coronary angioplasty) in 102 patients without familial hypercholesterolaemia (FH), who were matched for age and sex with 76 heterozygous FH patients carrying a defective allele at the low-density lipoprotein (LDL) receptor gene (LDL-R) and 26 heterozygous FH patients bearing a null mutation at the LDL-R. The prevalence of diabetes was significantly higher in the non-FH group than in the two FH groups (P 50% stenosis was higher in null allele carriers than in non-FH patients and tended to be higher than among defective allele carriers (P
PubMed ID
9179542 View in PubMed
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Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Qu├ębec population.

https://arctichealth.org/en/permalink/ahliterature161123
Source
Community Genet. 2007;10(4):218-26
Publication Type
Article
Date
2007
Author
A-M Madore
L. Houde
H. Vézina
M-C Vohl
L. Pérusse
N. Mior
P W Connelly
C. Laberge
D. Gaudet
C. Laprise
Author Affiliation
University of Montreal Community Genomic Medicine Center, Chicoutimi University Hospital, Chicoutimi, Canada.
Source
Community Genet. 2007;10(4):218-26
Date
2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Alleles
Asthma - epidemiology - genetics
Cardiovascular Diseases - epidemiology - genetics
Chi-Square Distribution
Chronic Disease
Cluster analysis
Female
Gene Frequency
Genetic Predisposition to Disease
Genetics, Population
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Quebec - epidemiology
Abstract
The purpose of this project was to evaluate the potential of the downward hierarchical clustering analysis (DHCA) for studying genetic heterogeneity, i.e. differences in allele frequency in subpopulations, such as the 15 public health regions of the province of Québec (Canada).
The study relied on an anonymized sample of 1,680 individuals who had participated in the Québec Heart Health Survey in 1990-1991. The genotyping of 11 variants in 8 candidate genes known to be involved in chronic inflammatory diseases, namely asthma and cardiovascular diseases, was performed using the amplification refractory mutation system and restriction fragment length polymorphism techniques. Only variants showing an allelic frequency >2% in the Québec Heart Health Survey (n = 8) were selected. DHCA techniques were then applied to model the geographical distribution of these 8 genetic variants in 15 Québec public health regions and to study genetic heterogeneity.
The DHCA allowed to group public health regions and gene variants on the basis of genetic variability. For both asthma and cardiovascular diseases, 3 significant clusters of public health regions and 1 cluster of gene variants were identified.
This study suggests that DHCA might be useful in studying genetic heterogeneity at the population level and for public health activities.
PubMed ID
17895627 View in PubMed
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Contribution of receptor negative versus receptor defective mutations in the LDL-receptor gene to angiographically assessed coronary artery disease among young (25-49 years) versus middle-aged (50-64 years) men.

https://arctichealth.org/en/permalink/ahliterature202384
Source
Atherosclerosis. 1999 Mar;143(1):153-61
Publication Type
Article
Date
Mar-1999
Author
D. Gaudet
M C Vohl
P. Couture
S. Moorjani
G. Tremblay
P. Perron
C. Gagné
J P Després
Author Affiliation
Chicoutimi Hospital Lipid Clinic, Quebec, Canada. dgaudet@saglac.qc.ca
Source
Atherosclerosis. 1999 Mar;143(1):153-61
Date
Mar-1999
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Coronary Angiography
Coronary Disease - blood - complications - genetics - radiography
France - ethnology
Heterozygote
Humans
Hyperlipoproteinemia Type II - complications - genetics
Lipids - blood
Lipoproteins - blood
Logistic Models
Male
Middle Aged
Mutation
Quebec
Receptors, LDL - genetics
Risk factors
Abstract
Elevated plasma LDL-cholesterol (LDL-C) levels are associated with an increased risk of coronary artery disease (CAD). Familial hypercholesterolemia (FH), a monogenic trait due to mutations in the LDL-receptor (R) gene is characterized by raised plasma LDL-C levels and premature CAD. The aim of the present investigation, derived from the study of a population of 1465 unrelated men aged 25 to 64 years, was to compare the expression of CAD assessed by coronary angiography in young (aged 25-49 years) versus middle-aged (50-64 years) heterozygous FH patients of French Canadian descent. Furthermore, the relationship of binding-defective versus receptor negative mutations in the LDL-R to premature CAD ( 15 kb or point mutations Y468X or R329X) whereas 64 were carriers of a receptor defective mutation (W66G, E207K or C646Y). As expected, in both age groups (25-49 years vs. 50-64 years), carriers of a receptor negative mutation had higher plasma cholesterol and LDL-C levels than carriers of a defective allele or men with a normal plasma lipoprotein-lipid profile. In addition, the mean number of diseased vessels (with > 50% stenosis) was higher in men aged 50-64 years compared to those aged 25 49 years. In the two age groups, FH patients were characterized by a higher number of stenosed coronary vessels than the normal phenotype group. Within each group (either receptor negative, receptor defective or normal phenotype) plasma cholesterol, LDL-C, HDL-C, triglyceride and apolipoprotein B levels were similar irrespective of age (25 49 years vs. 50-64 years). Finally, multiple logistic regression analyses revealed that compared to non-FH men, the relative odds of being affected by CAD before the age of 50 years was 7.3-fold higher for carriers of a receptor negative mutation and 2.7-fold higher for men with a receptor defective mutation at the LDL-R locus. These results suggest that CAD could be an earlier event among heterozygous FH subjects bearing a receptor negative mutation compared to LDL-R defective patients. It also suggest that the selective screening for mutations in the LDL-R gene may allow a better assessment of the individual risk and facilitate the development of family-based preventive strategies or intervention programs in FH.
PubMed ID
10208490 View in PubMed
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[Dyslipoproteinemias in Quebec: primary deficit in lipoprotein lipase and familial hypercholesterolemia].

https://arctichealth.org/en/permalink/ahliterature214350
Source
Union Med Can. 1995 Sep;124(2):61-7
Publication Type
Article
Date
Sep-1995
Author
C. Gagné
D. Gaudet
Author Affiliation
Département de médecine, Centre hospitalier de l'Université Laval.
Source
Union Med Can. 1995 Sep;124(2):61-7
Date
Sep-1995
Language
French
Publication Type
Article
Keywords
Gene Frequency
Humans
Hyperlipoproteinemia Type I - epidemiology - genetics - metabolism
Hyperlipoproteinemia Type II - epidemiology - genetics - metabolism
Mutation
Phenotype
Population Surveillance
Quebec - epidemiology
PubMed ID
8846259 View in PubMed
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Evaluation of test media for routine monitoring of Escherichia coli in nonpotable waters.

https://arctichealth.org/en/permalink/ahliterature210783
Source
Appl Environ Microbiol. 1996 Nov;62(11):4032-5
Publication Type
Article
Date
Nov-1996
Author
I D Gaudet
L Z Florence
R N Coleman
Author Affiliation
Alberta Environmental Centre, Vegreville, Canada. irene@aec.arc.ab.ca
Source
Appl Environ Microbiol. 1996 Nov;62(11):4032-5
Date
Nov-1996
Language
English
Publication Type
Article
Keywords
Bacteriological Techniques - standards - statistics & numerical data
Biometry
Canada
Colony Count, Microbial - methods - standards - statistics & numerical data
Culture Media - standards
Escherichia coli - isolation & purification
Evaluation Studies as Topic
Feces - microbiology
Fresh Water - microbiology
Humans
Public Health
Reference Standards
Sewage - microbiology
Water Microbiology
Abstract
Six test media, m-TEC, m-TEC with 4-methylumbelliferyl-beta-D-glucuronide (MUG), lauryl tryptose agar (LTA) with MUG, LTA with 5-bromo-4-chloro-3-indolyl-beta-D-glucuronide (X-Glue), EC medium with MUG, and lauryl tryptose broth with MUG, were evaluated for their usefulness in enumerating Escherichia coli in nonpotable waters on a routine basis. The media were chosen for their case of interpretation of target colonies, ability to allow enumeration at low and high concentrations, and ability to inhibit nontarget microorganisms. The recoveries on the test media were compared with those on three reference media, R2A, m-FC, and m-Endo, by analysis of spiked samples of filter-sterilized waters. The test media were then further tested for their ability to differentiate nontarget but closely related microorganisms. Statistical analysis indicated that the best recoveries were obtained with lauryl tryptose agar with added MUG and X-Gluc. The media were then tested with surface waters that could be expected to have high levels of total and fecal coliforms along with Escherichia coli.
Notes
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Cites: Appl Environ Microbiol. 1989 Apr;55(4):1003-82658802
Cites: J Appl Bacteriol. 1989 Sep;67(3):343-62693426
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Cites: Appl Environ Microbiol. 1991 May;57(5):1528-341854205
Cites: Appl Environ Microbiol. 1988 Jun;54(6):1595-6013046490
Cites: Appl Environ Microbiol. 1981 May;41(5):1152-87020592
Cites: J Clin Microbiol. 1984 Feb;19(2):172-46365956
Cites: Appl Environ Microbiol. 1986 May;51(5):1007-123524452
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PubMed ID
8899994 View in PubMed
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[Familial hypercholesterolemia in eastern Quebec: a public health problem? The experience of the hyperlipidemia clinic of Chicoutimi].

https://arctichealth.org/en/permalink/ahliterature214351
Source
Union Med Can. 1995 Sep;124(2):54-60
Publication Type
Article
Date
Sep-1995

23 records – page 1 of 3.