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6 records – page 1 of 1.

Source
Tidsskr Nor Laegeforen. 2016 Dec;136(23-24):1968-1969
Publication Type
Article
Date
Dec-2016
Author
Øystein Buer
Mary Kalfoss
Lars Weisæth
Bjørn Bendz
Source
Tidsskr Nor Laegeforen. 2016 Dec;136(23-24):1968-1969
Date
Dec-2016
Language
English
Norwegian
Publication Type
Article
Keywords
Critical Illness
Death
Humans
Norway
Surveys and Questionnaires
Translations
PubMed ID
28004543 View in PubMed
Less detail

[Prehospital ECG reduces time to treatment with percutaneous coronary interventions]

https://arctichealth.org/en/permalink/ahliterature53529
Source
Tidsskr Nor Laegeforen. 2003 May 15;123(10):1353-4
Publication Type
Article
Date
May-15-2003

The terminal part of the QT interval (T peak to T end): a predictor of mortality after acute myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature124898
Source
Ann Noninvasive Electrocardiol. 2012 Apr;17(2):85-94
Publication Type
Article
Date
Apr-2012
Author
Gunnar Erikssen
Knut Liestøl
Lars Gullestad
Kristina H Haugaa
Bjørn Bendz
Jan P Amlie
Author Affiliation
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Norway. gunnar.erikssen@rikshospitalet.no
Source
Ann Noninvasive Electrocardiol. 2012 Apr;17(2):85-94
Date
Apr-2012
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Aged, 80 and over
Biological Markers - blood
Coronary Angiography
Coronary Disease - physiopathology
Creatinine - blood
Electrocardiography
Female
Heart Conduction System - physiopathology
Heart Failure - physiopathology
Heart Rate - physiology
Humans
Male
Middle Aged
Myocardial Infarction - complications - mortality - physiopathology
Norway - epidemiology
Predictive value of tests
Proportional Hazards Models
Prospective Studies
ROC Curve
Risk factors
Survival Rate
Tachycardia, Ventricular - physiopathology
Abstract
The terminal part of the QT interval (T peak to T end; Tp-e)-an index for dispersion of cardiac repolarization-is often prolonged in patients experiencing malignant ventricular arrhythmias after acute myocardial infarction (AMI). We wanted to explore whether high Tp-e might predict mortality or fatal arrhythmia post-AMI.
Tp-e was measured prospectively in 1359/1384 (98.2%) consecutive patients with ST elevation (n = 525) or non-ST elevation (n = 859) myocardial infarction (STEMI or NSTEMI) admitted for coronary angiography.
Tp-e was significantly correlated with age, heart rate (HR), heart failure, LVEF, creatinine, three-vessel disease, previous AMI and QRS and QT duration. During a mean follow-up of 1.3 years (range 0.4-2.3),109 patients (7.9%) died; 25, 45, and 39 from cardiac arrhythmia, nonarrhythmic cardiac causes and other causes, respectively. Long Tp-e was strongly associated with increased risk of death, and Tp-e remained a significant predictor of death in multivariable Cox analyses (RR 1.5, 95% CI[1.3-1.7]). HR-corrected Tp-e (cTp-e) was the strongest predictor of death (RR 1.6 [1.4-1.9]). Tp-e and cTp-e were particularly strong predictors of fatal cardiac arrhythmia (RR 1.6 [1.2-2.1] and RR 1.8 [1.4-2.4]). Findings were similar in STEMI and NSTEMI. When comparing two methods for measuring Tp-e, one including the tail of the T wave and one not, the former had markedly higher predictive power (P
PubMed ID
22537325 View in PubMed
Less detail

Health-related quality of life in older patients with acute coronary syndrome randomised to an invasive or conservative strategy. The After Eighty randomised controlled trial.

https://arctichealth.org/en/permalink/ahliterature294203
Source
Age Ageing. 2018 Jan 01; 47(1):42-47
Publication Type
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Date
Jan-01-2018
Author
Nicolai Tegn
Michael Abdelnoor
Lars Aaberge
Anette Hylen Ranhoff
Knut Endresen
Erik Gjertsen
Rita Skårdal
Lars Gullestad
Bjørn Bendz
Author Affiliation
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Source
Age Ageing. 2018 Jan 01; 47(1):42-47
Date
Jan-01-2018
Language
English
Publication Type
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Keywords
Acute Coronary Syndrome - diagnostic imaging - psychology - therapy
Age Factors
Aged, 80 and over
Angina, Unstable - diagnostic imaging - psychology - therapy
Conservative Treatment - adverse effects
Coronary Angiography
Coronary Artery Bypass - adverse effects
Female
Humans
Male
Non-ST Elevated Myocardial Infarction - diagnostic imaging - psychology - therapy
Norway
Percutaneous Coronary Intervention - adverse effects
Prospective Studies
Quality of Life
Risk factors
Surveys and Questionnaires
Time Factors
Treatment Outcome
Abstract
in the After Eighty study (ClinicalTrials.gov.number, NCT01255540), patients aged 80 years or more, with non-ST-elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UAP), were randomised to either an invasive or conservative management approach. We sought to compare the effects of these management strategies on health related quality of life (HRQOL) after 1 year.
the After Eighty study was a prospective randomised controlled multicenter trial. In total, 457 patients aged 80 or over, with NSTEMI or UAP, were randomised to either an invasive strategy (n = 229, mean age: 84.7 years), involving early coronary angiography, with immediate evaluation for percutaneous coronary intervention, coronary artery bypass graft, optimal medical therapy, or to a conservative strategy (n = 228, mean age: 84.9 years). The Short Form 36 health survey (SF-36) was used to assess HRQOL at baseline, and at the 1-year follow-up.
baseline SF-36 completion was achieved for 208 and 216 patients in the invasive and conservative groups, respectively. A total of 137 in the invasive group and 136 patients in the conservative group completed the SF-36 form at follow-up. When comparing the changes from follow-up to baseline (delta) no significant changes in quality-of-life scores were observed between the two strategies in any of the domains, expect for a small but statistically significant difference in bodily pain. This difference in only one of the SF-36 subscales may not necessarily be clinically significant.
from baseline to the 1 year follow-up, only minor differences in change of HRQOL as measured by SF-36 were seen by comparing an invasive and conservative strategy.
NCT01255540.
PubMed ID
28985265 View in PubMed
Less detail

Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain.

https://arctichealth.org/en/permalink/ahliterature270674
Source
Int J Cardiovasc Imaging. 2015 Jun;31(5):967-73
Publication Type
Article
Date
Jun-2015
Author
Marit Kristine Smedsrud
Jørgen Gravning
Torbjørn Omland
Christian Eek
Lars Mørkrid
Helge Skulstad
Lars Aaberge
Bjørn Bendz
John Kjekshus
Thor Edvardsen
Source
Int J Cardiovasc Imaging. 2015 Jun;31(5):967-73
Date
Jun-2015
Language
English
Publication Type
Article
Keywords
Aged
Biomarkers - blood
Biomechanical Phenomena
Coronary Angiography
Coronary Artery Disease - blood - diagnosis - physiopathology - therapy
Echocardiography
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Myocardial Contraction
Myocardial Infarction - blood - diagnosis - physiopathology - therapy
Myocardial Revascularization
Myocardium - pathology
Natriuretic Peptide, Brain - blood
Necrosis
Norway
Peptide Fragments - blood
Predictive value of tests
Prospective Studies
Stress, mechanical
Time Factors
Treatment Outcome
Troponin I - blood
Troponin T - blood
Ventricular Function, Left
Ventricular Remodeling
Abstract
N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponins (cTns) measured with sensitive assays provide strong prognostic information in patients with stable coronary artery disease. However, the relationship between these biomarkers and myocardial contractile function, as well as infarct size, in this patient group, remains to be defined. The study population consisted of 160 patients referred to a follow-up echocardiography scheduled 1 year after coronary revascularization. Concentrations of NT-proBNP, high-sensitive cTnT (hs-cTnT) and sensitive cTnI assays were assessed. Left ventricular function was measured as global peak systolic longitudinal strain by speckle tracking echocardiography and infarct size was assessed by late-enhancement MRI. NT-proBNP and sensitive cTnI levels were significantly associated with left ventricular function by peak systolic strain (R-values 0.243 and 0.228, p = 0.002 and 0.004) as well as infarct size (R-values 0.343 and 0.366, p = 0.014 and p = 0.008). In contrast, hs-cTnT did not correlate with left ventricular function (R = 0.095, p = 0.231) and only marginally with infarct size (R = 0.237, p = 0.094). NT-proBNP and sensitive cTnI levels correlate with left ventricular function and infarct size in patients with stable coronary artery disease after revascularization. As opposed to hs-cTnT, NT-proBNP and cTnI seem to be indicators of incipient myocardial dysfunction and the extent of myocardial necrosis.
PubMed ID
25788439 View in PubMed
Less detail

Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial.

https://arctichealth.org/en/permalink/ahliterature133675
Source
Transplantation. 2011 Jul 27;92(2):235-43
Publication Type
Article
Date
Jul-27-2011
Author
Satish Arora
Thor Ueland
Bertil Wennerblom
Vilborg Sigurdadottir
Hans Eiskjær
Hans E Bøtker
Bjorn Ekmehag
Kjell Jansson
Svend-Aage Mortensen
Kari Saunamaki
Svein Simonsen
Einar Gude
Bjørn Bendz
Dag Solbu
Pål Aukrust
Lars Gullestad
Author Affiliation
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Source
Transplantation. 2011 Jul 27;92(2):235-43
Date
Jul-27-2011
Language
English
Publication Type
Article
Keywords
Aged
Azathioprine - therapeutic use
C-Reactive Protein - metabolism
Calcineurin - antagonists & inhibitors
Disease Progression
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Follow-Up Studies
Heart Transplantation - immunology
Humans
Immunosuppressive Agents - therapeutic use
Incidence
Male
Middle Aged
Mycophenolic Acid - analogs & derivatives - therapeutic use
Risk factors
Scandinavia
Sirolimus - analogs & derivatives - therapeutic use
Ultrasonography, Interventional
Vascular Cell Adhesion Molecule-1 - blood
Vascular Diseases - epidemiology - prevention & control - ultrasonography
von Willebrand Factor - metabolism
Abstract
Everolimus reduces the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant (HTx) recipients, but the influence on established CAV is unknown.
In this Nordic Certican Trial in Heart and lung Transplantation substudy, 111 maintenance HTx recipients (time post-HTx 5.8 ± 4.3 years) randomized to everolimus+reduced calcineurin inhibitor (CNI) or standard CNI had matching (intravascular ultrasound) examinations at baseline and 12 months allowing accurate assessment of CAV progression.
No significant difference in CAV progression was evident between the treatment groups (P = 0.30). When considering patients receiving concomitant azathioprine (AZA) therapy (n = 39), CAV progression was attenuated with everolimus versus standard CNI (?maximal intimal thickness 0.00 ± 0.04 and 0.04 ± 0.04 mm, ?percent atheroma volume 0.2% ± 3.0% and 2.6% ± 2.5%, and ?total atheroma volume 0.25 ± 14.1 and 19.8 ± 20.4 mm(3), respectively [P
Notes
Comment In: Transplantation. 2011 Jul 27;92(2):127-821555972
PubMed ID
21677600 View in PubMed
Less detail

6 records – page 1 of 1.