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Association between low self-rated health and heterozygosity for -110A > C polymorphism in the promoter region of HSP70-1 in aged Danish twins.

https://arctichealth.org/en/permalink/ahliterature179751
Source
Biogerontology. 2004;5(3):169-76
Publication Type
Article
Date
2004
Author
Ripudaman Singh
Steen Kølvraa
Peter Bross
Niels Gregersen
Bjørn Andersen Nexø
Henrik Frederiksen
Kaare Christensen
Suresh I S Rattan
Author Affiliation
Department of Human Genetics, University of Aarhus, DK-8000, Aarhus-C, Denmark.
Source
Biogerontology. 2004;5(3):169-76
Date
2004
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Base Sequence
DNA Primers
Denmark
HSP70 Heat-Shock Proteins - genetics
Health status
Heterozygote
Humans
Polymorphism, Genetic
Promoter Regions, Genetic
Abstract
We have studied the possible association between the -110A > C polymorphism in the promoter region of one of the heat shock protein genes HSP70-1 with human longevity in a cohort of aged Danish twins. This cohort includes individuals aged between 70 and 91 years (mean = 75.6 years), who are categorized according to the presence or absence of various diseases and according to the various, age-related parameters for which a genetic component has already been defined. Four hundred DNA samples from the cohort were genotyped using real-time PCR. Aging phenotypes (diseases, physical and cognitive functioning) were compared with regard to genotype. Of all the aging phenotypes studied, self-rated health and relative self-rated health, which represent an individual's overall sense of physical well-being and which have been shown to be both predictors of survival at older ages and better indicators of future survival than objectively measured health status, were associated with the polymorphism. An association was found between low self-rated health and heterozygosity for -110A > C polymorphism in the promoter region of HSP70-1 in aged Danish twins.
PubMed ID
15190186 View in PubMed
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Effectiveness of anti-tumour necrosis factor-a therapy in Danish patients with inflammatory bowel diseases.

https://arctichealth.org/en/permalink/ahliterature268292
Source
Dan Med J. 2015 Mar;62(3)
Publication Type
Article
Date
Mar-2015
Author
Steffen Bank
Paal Skytt Andersen
Johan Burisch
Natalia Pedersen
Stine Roug
Julie Galsgaard
Stine Ydegaard Turino
Jacob Broder Brodersen
Shaista Rashid
Sara Avlund
Thomas Bastholm Olesen
Anders Green
Hans Jürgen Hoffmann
Marianne Kragh Thomsen
Vibeke Østergaard Thomsen
Bjørn Andersen Nexø
Ulla Vogel
Vibeke Andersen
Source
Dan Med J. 2015 Mar;62(3)
Date
Mar-2015
Language
English
Publication Type
Article
Keywords
Adalimumab - therapeutic use
Adolescent
Adult
Age Factors
Aged
Anti-Inflammatory Agents - therapeutic use
Child
Cohort Studies
Colitis, Ulcerative - drug therapy
Crohn Disease - drug therapy
Denmark
Female
Humans
Infliximab - therapeutic use
Male
Middle Aged
Odds Ratio
Registries
Retrospective Studies
Smoking - adverse effects
Treatment Outcome
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Young Adult
Abstract
The objective of this study was to evaluate the outcome of anti-tumour necrosis factor-a (anti-TNF) treatment in a large cohort of patients with inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) in clinical practice and to establish a cohort for future studies of genetic markers associated with treatment response.
A national, clinically based cohort of previously naïve anti-TNF treated patients from 18 medical departments was established. The patients were screened for tuberculosis prior to treatment initiation. By combining the unique personal identification number of Danish citizens (the CPR number) from blood samples with data from the National Patient Registry, patients with International Classification of Diseases, Version 10 (ICD-10) codes K50-K63 were identified. Treatment efficacy reflected the maximum response within 22 weeks.
Among 492 patients with CD and 267 patients with UC, 74%/13%/14% and 65%/12%/24% were responders, partial responders and non-responders to anti-TNF therapy, respectively. More patients with UC than with CD were non-responders (odds ratio (OR) = 1.96, 95% confidence interval (CI): 1.34-2.87, p = 0.001). Young age was associated with a beneficial response (p = 0.03), whereas smoking = 10 cigarettes/day was associated with non-response among patients with CD (OR = 2.33, 95% CI: 1.13-4.81, p = 0.03).
In this clinically based cohort of Danish patients with IBD treated with anti-TNF, high response rates were found. Heavy smoking was associated with non-response, whereas young age at treatment initiation was associated with a beneficial response among patients with CD. Thus, the results obtained in this cohort recruited from clinical practice were similar to those previously obtained in clinical trials.
The work was funded by Health Research Fund of Central Denmark Region, Colitis-Crohn Foreningen and the University of Aarhus (PhD grant).
Clinicaltrials NCT02322008.
PubMed ID
25748864 View in PubMed
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GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.

https://arctichealth.org/en/permalink/ahliterature16967
Source
Cancer Lett. 2005 Nov 8;229(1):85-91
Publication Type
Article
Date
Nov-8-2005
Author
Rikke Hansen
Mona Saebø
Camilla Furu Skjelbred
Bjørn Andersen Nexø
Per Christian Hagen
Günther Bock
Inger Marie Bowitz Lothe
Egil Johnson
Steinar Aase
Inger-Lise Hansteen
Ulla Vogel
Elin H Kure
Author Affiliation
National Institute of Occupational Health, Copenhagen, Denmark.
Source
Cancer Lett. 2005 Nov 8;229(1):85-91
Date
Nov-8-2005
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - etiology - genetics
Adenoma - etiology - genetics
Aged
Case-Control Studies
Colorectal Neoplasms - etiology - genetics
DNA Damage
DNA Glycosylases - genetics
DNA Repair - genetics
Female
Genetic Predisposition to Disease
Glutathione Peroxidase - genetics
Humans
Male
Middle Aged
Norway
Oxidative Stress
Polymorphism, Genetic
Research Support, Non-U.S. Gov't
Risk factors
Abstract
Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited from the Norwegian cohort NORCCAP. No associations were found between the polymorphism GPX Pro198Leu and risk of colorectal adenomas or carcinomas. Carriers of the variant allele OGG1 Ser326Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma.
PubMed ID
15946795 View in PubMed
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Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3: linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients.

https://arctichealth.org/en/permalink/ahliterature18541
Source
Biochem Genet. 2003 Feb;41(1-2):27-37
Publication Type
Article
Date
Feb-2003
Author
Jiaoyang Yin
Ulla Vogel
Lars Ulrik Gerdes
Marianne Dybdahl
Lars Bolund
Bjørn Andersen Nexø
Author Affiliation
Institute of Human Genetics, University of Aarhus, Aarhus C DK-8000, Denmark.
Source
Biochem Genet. 2003 Feb;41(1-2):27-37
Date
Feb-2003
Language
English
Publication Type
Article
Keywords
Adult
Carcinoma, Basal Cell - etiology - genetics
Chromosomes, Human, Pair 19
DNA Helicases
DNA Mutational Analysis
DNA Repair - genetics
DNA-Binding Proteins
Denmark
Endonucleases
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Proteins - genetics
Psoriasis - complications - genetics
Research Support, Non-U.S. Gov't
Skin Neoplasms - etiology - genetics
Transcription Factors
Xeroderma Pigmentosum Group D Protein
Abstract
The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4 (Odds ratio 12;95% Confidence Interval 1.17-124; p(chi2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06). This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al. (in press) Carcinogenesis; Yin et al. (manuscript submitted for publication). Cancer Epidemiol. Biomarkers Prev), which places two highly influential markers between these two genes. The analysis also confirmed that considerable linkage disequilibrium exists between SNPs both within genes and between genes in this region. The combined studies suggest that genetic variation in nucleotide excision repair is of importance for the development of BCC.
PubMed ID
12645871 View in PubMed
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6 records – page 1 of 1.