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Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study.

https://arctichealth.org/en/permalink/ahliterature143206
Source
Cancer Causes Control. 2010 Oct;21(10):1533-44
Publication Type
Article
Date
Oct-2010
Author
Lena Maria Nilsson
Ingegerd Johansson
Per Lenner
Bernt Lindahl
Bethany Van Guelpen
Author Affiliation
Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden. lena.nilsson@nutrires.umu.se
Source
Cancer Causes Control. 2010 Oct;21(10):1533-44
Date
Oct-2010
Language
English
Publication Type
Article
Keywords
Coffee
Cohort Studies
Confidence Intervals
Cooking
Drinking
Female
Humans
Incidence
Life Style
Male
Middle Aged
Neoplasms - epidemiology
Prospective Studies
Questionnaires
Regression Analysis
Risk assessment
Risk factors
Sweden - epidemiology
Abstract
Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer.
Subjects were from the Västerbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15 years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression.
No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee =4 versus
PubMed ID
20512657 View in PubMed
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Diet and lifestyle of the Sami of southern Lapland in the 1930s-1950s and today.

https://arctichealth.org/en/permalink/ahliterature100980
Source
Int J Circumpolar Health. 2011 May 31;
Publication Type
Article
Date
May-31-2011
Author
Lena Maria Nilsson
Lars Dahlgren
Ingegerd Johansson
Magritt Brustad
Per Sjölander
Bethany Van Guelpen
Author Affiliation
Näringsforskning, Umeå universitet, SE-901 85, Umeå, Sweden. ena.nilsson@nutrires.umu.se.
Source
Int J Circumpolar Health. 2011 May 31;
Date
May-31-2011
Language
English
Publication Type
Article
Abstract
Objectives. To describe the lifestyle of the Sami of southern Lapland 50 to 70 years ago in relation to the present-day Sami and non-Sami populations and, thereby, to provide a basis for future studies of culturally related determinants of health and illness. Study design. A qualitative analysis, and a quantitative comparison of Sami and non-Sami groups. Methods. Semi-structured interviews were conducted with 20 elderly Sami concerning their parents' lifestyle and diet 50 to 70 years ago. Questionnaire data from 81 reindeer-herding Sami, 226 non-reindeer-herding Sami and 1,842 sex-, age- and geographically matched non-Sami from the population-based Västerbotten Intervention Project were analysed by non-parametric tests and partial least squares methodology. Results. Surprisingly, fatty fish may have been more important than reindeer meat for the Sami of southern Lapland in the 1930s to 1950s, and it is still consumed more frequently by reindeer-herding Sami than nonreindeer-herding Sami and non-Sami. Other dietary characteristics of the historical Sami and present-day reindeer-herding Sami were higher intakes of fat, blood and boiled coffee, and lower intakes of bread, fibre and cultivated vegetables, compared with present-day non-Sami. Physical activity was also a part of the daily life of the Sami to a greater extent in the 1930s to 1950s than today. Sami men often worked far from home, while the women were responsible for fishing, farming, gardening (which was introduced in the 1930-1950 period), as well as housework and childcare. Conclusions. For studies investigating characteristic lifestyle elements of specific ethnic groups, the elements of greatest acknowledged cultural importance today (in this case reindeer meat) may not be of the most objective importance traditionally.
PubMed ID
21631968 View in PubMed
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Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study.

https://arctichealth.org/en/permalink/ahliterature286526
Source
Nutr J. 2017 Apr 04;16(1):21
Publication Type
Article
Date
Apr-04-2017
Author
Stina Bodén
Maria Wennberg
Bethany Van Guelpen
Ingegerd Johansson
Bernt Lindahl
Jonas Andersson
Nitin Shivappa
James R Hebert
Lena Maria Nilsson
Source
Nutr J. 2017 Apr 04;16(1):21
Date
Apr-04-2017
Language
English
Publication Type
Article
Keywords
Biomarkers - blood
Body mass index
C-Reactive Protein - metabolism
Case-Control Studies
Diet
Exercise
Female
Follow-Up Studies
Humans
Inflammation - blood - epidemiology
Interleukin-6 - blood
Logistic Models
Male
Middle Aged
Myocardial Infarction - blood - epidemiology
Nutrition Assessment
Prospective Studies
Risk factors
Surveys and Questionnaires
Sweden - epidemiology
Abstract
Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up.
We conducted a prospective case-control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores were derived from a validated food frequency questionnaire (FFQ) administered in 1986-2006. Multivariable conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI), using quartile 1 (most anti-inflammatory diet) as the reference category. For validation, general linear models were used to estimate the association between the DII scores and two inflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) in a subset (n?=?605) of the study population.
Male participants with the most pro-inflammatory DII scores had an increased risk of MI [ORQ4vsQ1?=?1.57 (95% CI 1.21-2.02) P trend?=?0.02], which was essentially unchanged after adjustment for potential confounders, including cardiovascular risk factors [ORQ4vsQ1?=?1.50 (95% CI 1.14-1.99), P trend?=?0.10]. No association was found between DII and MI in women. An increase of one DII score unit was associated with 9% higher hsCRP (95% CI 0.03-0.14) and 6% higher IL-6 (95% CI 0.02-0.11) in 605 controls with biomarker data available.
A pro-inflammatory diet was associated with an elevated risk of first myocardial infarction in men; whereas for women the relationship was null. Consideration of the inflammatory impact of diet could improve prevention of cardiovascular disease.
Notes
Cites: Int J Epidemiol. 1995 Apr;24(2):389-987635601
Cites: Scand J Prim Health Care. 1998 Sep;16(3):171-69800231
Cites: Ann Epidemiol. 2015 Jun;25(6):398-40525900255
Cites: Prev Med. 2012 May;54 Suppl:S29-3722178471
Cites: Scand J Public Health Suppl. 2003;61:18-2414660243
Cites: Public Health Nutr. 2014 Aug;17 (8):1825-3324107546
Cites: Eur J Clin Nutr. 2011 Jul;65(7):800-721468094
Cites: Eur J Prev Cardiol. 2016 Jan;23 (2):194-20525416041
Cites: Nutr J. 2012 Jun 11;11:4022686621
Cites: J Intern Med. 2011 Oct;270(4):365-7621443679
Cites: Adv Nutr. 2015 Nov 13;6(6):738-4726567198
Cites: J Clin Chem Clin Biochem. 1984 Dec;22(12):895-9046396369
Cites: Public Health Nutr. 2002 Jun;5(3):487-9612003662
Cites: Glob Health Action. 2010 Mar 22;3:null20339479
Cites: Scand J Public Health Suppl. 2003;61:9-1714660242
Cites: Lancet. 2009 Sep 5;374(9692):767-919733769
Cites: Br J Nutr. 2011 Dec;106 Suppl 3:S5-7822133051
Cites: J Nutr. 2015 Mar;145(3):532-4025733469
Cites: Public Health Nutr. 2014 Aug;17 (8):1689-9623941862
Cites: Epidemiology. 1992 Sep;3(5):452-61391139
Cites: Am J Clin Nutr. 2006 Jun;83(6):1369-7916762949
Cites: PLoS Med. 2008 Apr 8;5(4):e7818399716
Cites: Obes Rev. 2010 Feb;11(2):137-4919656309
Cites: Eur J Nutr. 2017 Mar;56(2):683-69226644215
Cites: Br J Nutr. 2012 Oct 28;108(8):1428-3422221517
Cites: Nutrients. 2015 May 29;7(6):4124-3826035241
Cites: Nutr J. 2014 Nov 22;13:10725416917
Cites: Ann Epidemiol. 2002 Nov;12 (8):577-8612495831
Cites: Circulation. 2003 Jan 28;107(3):499-51112551878
Cites: Ann Epidemiol. 2001 Aug;11(6):417-2711454501
Cites: Nutr Res. 2014 Dec;34(12):1058-6525190219
Cites: PLoS One. 2015 Sep 04;10 (9):e013522126340022
Cites: Nutr Res. 2016 May;36(5):391-40127101757
Cites: Circulation. 1994 Jul;90(1):583-6128026046
Cites: J Nutr. 2007 Apr;137(4):992-817374666
Cites: Nature. 2002 Dec 19-26;420(6917):868-7412490960
Cites: Public Health Nutr. 2009 Sep;12(9):1477-8419144238
Cites: Am J Cardiol. 2003 Dec 1;92(11):1335-914636916
Cites: Atherosclerosis. 2016 Oct;253:164-17027498398
Cites: Cent Eur J Immunol. 2015;40(3):380-626648785
Cites: Eur J Clin Nutr. 2010 Aug;64(8):905-1320502473
Cites: Am J Epidemiol. 1997 Dec 15;146(12):1046-559420529
Cites: Am J Clin Nutr. 2016 Mar;103(3):878-8526864363
Cites: Eur J Cardiovasc Prev Rehabil. 2006 Dec;13(6):924-3017143124
Cites: Am J Cardiol. 2003 Jul 3;92(1A):10i-8i12867250
Cites: Public Health Nutr. 2001 Aug;4(4):919-2711527517
Cites: Br J Nutr. 2015 Dec 28;114(12):2074-8226450630
Cites: Atherosclerosis. 2015 Jan;238(1):38-4425437888
Cites: BMJ Open. 2015 Dec 18;5(12):e00965126685034
PubMed ID
28376792 View in PubMed
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Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake.

https://arctichealth.org/en/permalink/ahliterature61482
Source
Stroke. 2005 Jul;36(7):1426-31
Publication Type
Article
Date
Jul-2005
Author
Bethany Van Guelpen
Johan Hultdin
Ingegerd Johansson
Birgitta Stegmayr
Göran Hallmans
Torbjörn K Nilsson
Lars Weinehall
Cornelia Witthöft
Richard Palmqvist
Anna Winkvist
Author Affiliation
Department of Medical Biosciences, Umeå University Hospital, Umeå, Sweden. Bethany.Van.Guelpen@nutrires.umu.se
Source
Stroke. 2005 Jul;36(7):1426-31
Date
Jul-2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Brain Ischemia - etiology - pathology
Case-Control Studies
Cerebrovascular Accident - etiology - pathology
Cohort Studies
Diet
Female
Folic Acid - blood - pharmacology
Hemorrhage - blood
Homocysteine - blood
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Multivariate Analysis
Nutritional Status
Odds Ratio
Polymorphism, Genetic
Prospective Studies
Registries
Research Support, Non-U.S. Gov't
Risk
Sweden
Vitamin B 12 - pharmacology
Abstract
BACKGROUND AND PURPOSE: Folate metabolism has been implicated in stroke. However, the possibility of a role for folate and vitamin B12, independent of their effects on homocysteine status, remains to be explored. The aim of this prospective, nested case-referent study was to relate plasma and dietary intake levels of folate and vitamin B12 to risk of stroke, taking into consideration plasma homocysteine concentrations and methylenetetrahydrofolate reductase polymorphisms. METHODS: Subjects were 334 ischemic and 62 hemorrhagic stroke cases and matched double referents from the population-based Northern Sweden Health and Disease Cohort. RESULTS: Plasma folate was statistically significantly associated with risk of hemorrhagic stroke in an inverse linear manner, both in univariate analysis and after adjustment for conventional risk factors including hypertension (odds ratio [OR] for highest versus lowest quartile 0.21 (95% confidence interval [CI], 0.06 to 0.71; P for trend=0.008)). Risk estimates were attenuated by inclusion of homocysteine in the model (OR, 0.34; 95% CI, 0.08 to 1.40; P for trend=0.088). A similar pattern was observed for increasing folate intake (multivariate OR, 0.07; 95% CI, 0.01 to 0.55; P for trend=0.031 without homocysteine, and OR, 0.16, 95% CI, 0.02 to 1.23; P for trend=0.118 with homocysteine in the analysis). We found little evidence of an association between plasma or dietary folate and risk of ischemic stroke. Neither plasma nor dietary vitamin B12 was associated with risk of either stroke subtype. CONCLUSIONS: The results of this study suggest a protective role for folate, possibly in addition to its effects on homocysteine status, in hemorrhagic but not ischemic stroke.
PubMed ID
15933256 View in PubMed
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Longitudinal study of body mass index, dyslipidemia, hyperglycemia, and hypertension in 60,000 men and women in Sweden and Austria.

https://arctichealth.org/en/permalink/ahliterature296582
Source
PLoS One. 2018; 13(6):e0197830
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
2018
Author
Mieke Van Hemelrijck
Hanno Ulmer
Gabriele Nagel
Raphael Simon Peter
Josef Fritz
Robin Myte
Bethany van Guelpen
Bernhard Föger
Hans Concin
Christel Häggström
Pär Stattin
Tanja Stocks
Author Affiliation
King's College London, Division of Cancer Studies, Translational Oncology & Urology Research, London, United Kingdom.
Source
PLoS One. 2018; 13(6):e0197830
Date
2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Austria - epidemiology
Body mass index
Dyslipidemias - epidemiology
Female
Humans
Hyperglycemia - epidemiology
Hypertension - epidemiology
Longitudinal Studies
Male
Middle Aged
Sweden - epidemiology
Abstract
Obesity is suggested to underlie development of other metabolic aberrations, but longitudinal relationships between metabolic factors at various ages has not been studied in detail.
Data from 27,379 men and 32,275 women with in total 122,940 health examinations in the Västerbotten Intervention Project, Sweden and the Vorarlberg Health Monitoring and Prevention Programme, Austria were used to investigate body mass index (BMI), mid-blood pressure, and fasting levels of glucose, triglycerides, and total cholesterol at baseline in relation to 10-year changes of these factors and weight. We included paired examinations performed 10±2 years apart and used them for longitudinal analysis with linear regression of changes between the ages 30 and 40, 40 and 50, or 50 and 60 years.
Higher levels of BMI were associated with increases in glucose and mid-blood pressure as well as triglycerides levels, and, to a lesser extent, decreases in cholesterol levels. For instance, per 5 kg/m2 higher BMI at age 40, glucose at age 50 increased by 0.24 mmol/l (95%CI: 0.22-0.26) and mid-blood pressure increased by 1.54 mm Hg (95%CI: 1.35-1.74). The strongest association observed was between BMI at age 30 and mid-blood pressure, which was 2.12 mm Hg (95% CI: 1.79-2.45) increase over ten years per 5 kg/m2 higher BMI level. This association was observed at an age when blood pressure levels on average remained stable. Other associations than those with BMI at baseline were much weaker. However, triglyceride levels were associated with future glucose changes among individuals with elevated BMI, particularly in the two older age groups.
BMI was most indicative of long-term changes in metabolic factors, and the strongest impact was observed for increases in blood pressure between 30 and 40 years of age. Our study supports that lifestyle interventions preventing metabolic aberrations should focus on avoiding weight increases.
PubMed ID
29897925 View in PubMed
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Low-carbohydrate, high-protein diet score and risk of incident cancer; a prospective cohort study.

https://arctichealth.org/en/permalink/ahliterature261486
Source
Nutr J. 2013;12:58
Publication Type
Article
Date
2013
Author
Lena Maria Nilsson
Anna Winkvist
Ingegerd Johansson
Bernt Lindahl
Göran Hallmans
Per Lenner
Bethany Van Guelpen
Source
Nutr J. 2013;12:58
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Diet, Carbohydrate-Restricted
Dietary Fats - administration & dosage
Dietary Proteins - administration & dosage
Energy intake
Fatty Acids - administration & dosage - adverse effects
Female
Follow-Up Studies
Food Habits
Humans
Incidence
Male
Middle Aged
Neoplasms - epidemiology
Proportional Hazards Models
Prospective Studies
Questionnaires
Risk factors
Sweden - epidemiology
Abstract
Although carbohydrate reduction of varying degrees is a popular and controversial dietary trend, potential long-term effects for health, and cancer in specific, are largely unknown.
We studied a previously established low-carbohydrate, high-protein (LCHP) score in relation to the incidence of cancer and specific cancer types in a population-based cohort in northern Sweden. Participants were 62,582 men and women with up to 17.8 years of follow-up (median 9.7), including 3,059 prospective cancer cases. Cox regression analyses were performed for a LCHP score based on the sum of energy-adjusted deciles of carbohydrate (descending) and protein (ascending) intake labeled 1 to 10, with higher scores representing a diet lower in carbohydrates and higher in protein. Important potential confounders were accounted for, and the role of metabolic risk profile, macronutrient quality including saturated fat intake, and adequacy of energy intake reporting was explored.
For the lowest to highest LCHP scores, 2 to 20, carbohydrate intakes ranged from median 60.9 to 38.9% of total energy intake. Both protein (primarily animal sources) and particularly fat (both saturated and unsaturated) intakes increased with increasing LCHP scores. LCHP score was not related to cancer risk, except for a non-dose-dependent, positive association for respiratory tract cancer that was statistically significant in men. The multivariate hazard ratio for medium (9-13) versus low (2-8) LCHP scores was 1.84 (95% confidence interval: 1.05-3.23; p-trend?=?0.38). Other analyses were largely consistent with the main results, although LCHP score was associated with colorectal cancer risk inversely in women with high saturated fat intakes, and positively in men with higher LCHP scores based on vegetable protein.
These largely null results provide important information concerning the long-term safety of moderate carbohydrate reduction and consequent increases in protein and, in this cohort, especially fat intakes. In order to determine the effects of stricter carbohydrate restriction, further studies encompassing a wider range of macronutrient intakes are warranted.
Notes
Cites: Eur J Clin Nutr. 2010 Aug;64(8):905-1320502473
Cites: Am J Pathol. 2006 Nov;169(5):1505-2217071576
Cites: Am J Clin Nutr. 2010 Oct;92(4):967-7420826627
Cites: Exp Oncol. 2010 Sep;32(3):137-4221403607
Cites: Ann Intern Med. 2010 Sep 7;153(5):289-9820820038
Cites: N Engl J Med. 2006 Nov 9;355(19):1991-200217093250
Cites: J Intern Med. 2007 Apr;261(4):366-7417391111
Cites: Acta Oncol. 2007;46(3):286-30717450464
Cites: Eur J Clin Nutr. 2007 May;61(5):575-8117136037
Cites: J Am Coll Nutr. 2007 Apr;26(2):163-917536128
Cites: J Clin Endocrinol Metab. 2007 Nov;92(11):4480-417785367
Cites: J Am Diet Assoc. 2008 Jan;108(1):91-10018155993
Cites: Am J Clin Nutr. 2008 May;87(5):1571S-1575S18469290
Cites: Lakartidningen. 2008 Jun 11-24;105(24-25):1864-618619014
Cites: Br J Nutr. 2008 Nov;100(5):942-618377685
Cites: Obes Rev. 2009 Jan;10(1):36-5018700873
Cites: N Engl J Med. 2009 Feb 26;360(9):859-7319246357
Cites: N Engl J Med. 2009 Feb 26;360(9):923-519246365
Cites: Nutr J. 2009;8:1219228378
Cites: Public Health Nutr. 2009 Sep;12(9):1477-8419144238
Cites: Lancet. 2009 Sep 5;374(9692):767-919733769
Cites: Am J Clin Nutr. 2011 May;93(5):1062-7221389180
Cites: Am J Epidemiol. 2011 Sep 15;174(6):652-6021832271
Cites: Glob Health Action. 2012;5. doi: 10.3402/gha.v5i0.1036722468143
Cites: Eur J Clin Nutr. 2012 Jun;66(6):694-70022333874
Cites: BMJ. 2012;344:e402622735105
Cites: JAMA. 2012 Jun 27;307(24):2627-3422735432
Cites: Oncogene. 2012 Sep 6;31(36):3999-401122231450
Cites: Int J Immunopathol Pharmacol. 2012 Jul-Sep;25(3):573-8123058007
Cites: Nutr J. 2012;11:4022686621
Cites: Scand J Public Health Suppl. 2001;56:13-2011681559
Cites: Public Health Nutr. 2002 Jun;5(3):487-9612003662
Cites: N Engl J Med. 2003 May 22;348(21):2074-8112761364
Cites: Cancer. 1984 Oct 1;54(7):1435-86467164
Cites: Am J Epidemiol. 1986 Jul;124(1):17-273521261
Cites: Scand J Prim Health Care. 1998 Sep;16(3):171-69800231
Cites: J Epidemiol Community Health. 1999 Apr;53(4):243-5010396552
Cites: Am J Epidemiol. 2005 Feb 1;161(3):239-4915671256
Cites: Nutr Rev. 2010 Apr;68(4):214-3120416018
PubMed ID
23651548 View in PubMed
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One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study.

https://arctichealth.org/en/permalink/ahliterature99464
Source
Cancer Causes Control. 2010 Apr;21(4):557-66
Publication Type
Article
Date
Apr-2010
Author
Bethany Van Guelpen
Anna M Dahlin
Johan Hultdin
Vincy Eklöf
Ingegerd Johansson
Maria L Henriksson
Inger Cullman
Göran Hallmans
Richard Palmqvist
Author Affiliation
Department of Medical Biosciences, Pathology, Umeå University, Building 6M, 2nd Floor, 90185 Umeå, Sweden. bethany.van.guelpen@medbio.umu.se
Source
Cancer Causes Control. 2010 Apr;21(4):557-66
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Aged
Carbon - metabolism
Case-Control Studies
Colorectal Neoplasms - epidemiology - genetics - metabolism
CpG Islands - genetics
DNA Methylation
Female
Folic Acid - blood
Genetic Predisposition to Disease
Homocysteine - blood
Humans
Incidence
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Multivariate Analysis
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide
Risk factors
Sweden - epidemiology
Vitamin B 12 - blood
Abstract
OBJECTIVE: We related prediagnostic plasma folate, vitamin B12, and total homocysteine concentrations, and the MTHFR 677C>T and 1298A>C polymorphisms, to the risk of colorectal cancer with and without the CpG island methylator phenotype (CIMP). METHODS: This was a nested case-referent study of 190 cases and double, matched referents from the large, population-based Northern Sweden Health and Disease Study. Using archival tumor tissue, promoter methylation in an eight-gene panel was analyzed by MethyLight. RESULTS: A reduced risk of CIMP-low/CIMP-high CRC (> or =1 gene methylated) was observed in subjects with very low plasma folate concentrations [multivariate odds ratio 2.96 (95% CI 1.24-7.08) for quintiles two to five versus one (lowest)]. With the exception of a reduced risk in MTHFR 677 TT-homozygotes, none of the other one-carbon variables were associated with the risk of CIMP-low/CIMP-high CRC. For CIMP-negative CRC, only the MTHFR polymorphisms were statistically significantly related to risk, inversely for 677C>T and positively for 1298A>C, but a tendency toward a reduced risk was observed in subjects with an adequate methyl availability, combining the plasma variables [multivariate odds ratio 0.61 (95% CI 0.32-1.15)]. CONCLUSION: Though limited by low power, these findings suggest the possibility of different roles for one-carbon metabolism in different pathways of colorectal tumorigenesis.
PubMed ID
20012180 View in PubMed
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Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.

https://arctichealth.org/en/permalink/ahliterature17418
Source
Int J Cancer. 2005 Feb 20;113(5):819-24
Publication Type
Article
Date
Feb-20-2005
Author
Johan Hultdin
Bethany Van Guelpen
Anders Bergh
Göran Hallmans
Pär Stattin
Author Affiliation
Department of Medical Biosciences, Clinical Chemistry, Umeå University Hospital, Umeå, Sweden.
Source
Int J Cancer. 2005 Feb 20;113(5):819-24
Date
Feb-20-2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Bone Neoplasms - blood - etiology - secondary
Case-Control Studies
Comparative Study
Folic Acid - blood
Homocysteine - blood
Humans
Lymphatic Metastasis
Male
Middle Aged
Prospective Studies
Prostatic Neoplasms - blood - epidemiology - etiology
Research Support, Non-U.S. Gov't
Risk factors
Sweden - epidemiology
Vitamin B 12 - blood
Abstract
The role of folate metabolism in cancer development is a topic of much current interest, with maintenance of adequate folate status tending to show a protective effect. Aberrant methylation, primarily hypermethylation of certain genes including tumor suppressors, has been implicated in prostate cancer development. Folate, vitamin B12 and homocysteine are essential for methyl group metabolism and thus also for DNA methylation. We related plasma levels of these factors to prostate cancer risk in a prospective study of 254 case subjects and 514 matched control subjects. Increasing plasma levels of folate and vitamin B12 were statistically significantly associated with increased prostate cancer risk, with an odds ratio of 1.60 (95% CI = 1.03-2.49; p(trend) = 0.02) for folate and 2.63 (95% CI = 1.61-4.29; p(trend)
PubMed ID
15499634 View in PubMed
Less detail

Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke.

https://arctichealth.org/en/permalink/ahliterature100984
Source
Clin Chem Lab Med. 2011 Jun 2;
Publication Type
Article
Date
Jun-2-2011
Author
Johan Hultdin
Bethany Van Guelpen
Anna Winkvist
Göran Hallmans
Lars Weinehall
Birgitta Stegmayr
Torbjörn K Nilsson
Author Affiliation
Clinical Chemistry, Department of Medical Biosciences, Umeå University, Umeå, Sweden.
Source
Clin Chem Lab Med. 2011 Jun 2;
Date
Jun-2-2011
Language
English
Publication Type
Article
Abstract
Abstract Background: Abnormalities in homocysteine metabolism have been suggested as risk factors for stroke. The aim of this prospective study was to examine whether total plasma homocysteine concentration (tHcy) and its main genetic determinant, methylene tetrahydrofolate reductase (MTHFR) polymorphisms, were associated with first ischemic or hemorrhagic stroke. Methods: This was a nested case-referent study of 321 ischemic and 60 hemorrhagic stroke cases, defined by WHO MONICA criteria and each matched with two event-free referents for sex, age, cohort, recruitment date and geographical area. All subjects were from the population-based Northern Sweden Health and Disease Study cohorts. Odds ratios were determined by conditional logistic regression. Results: The mean follow-up time was 4.2 years. Both tHcy and MTHFR were independent predictors of hemorrhagic stroke in multivariate models including body mass index, hypertension and, for MTHFR, tHcy [OR for the highest vs. lowest tHcy quartile 8.13 (95% CI 1.83-36.1), p(trend)=0.002; OR for MTHFR 677TT vs. 677CC genotype 3.62 (95% CI 0.77-17.0), p(trend)=0.040]. Haplotype analyses confirmed that the MTHFR 677T-1298A haplotype was positively associated with hemorrhagic stroke [OR 1.81 (95% CI 1.09-3.00), p=0.022], whereas the MTHFR 677C-1298C haplotype was not significantly related to either hemorrhagic or ischemic stroke. Neither tHcy nor the MTHFR polymorphisms were significant predictors of ischemic stroke. Conclusion: Both elevated plasma homocysteine levels and the MTHFR 677T allele are indicators of increased risk of hemorrhagic stroke in the northern Swedish population.
PubMed ID
21631392 View in PubMed
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A traditional Sami diet score as a determinant of mortality in a general northern Swedish population.

https://arctichealth.org/en/permalink/ahliterature124404
Source
Int J Circumpolar Health. 2012;71(0):1-12
Publication Type
Article
Date
2012
Author
Lena Maria Nilsson
Anna Winkvist
Magritt Brustad
Jan-Håkan Jansson
Ingegerd Johansson
Per Lenner
Bernt Lindahl
Bethany Van Guelpen
Author Affiliation
Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden. lena.nilsson@nutrires.umu.se
Source
Int J Circumpolar Health. 2012;71(0):1-12
Date
2012
Language
English
Publication Type
Article
Keywords
Adult
Cardiovascular Diseases - mortality
Cause of Death
Cohort Studies
Diet - ethnology
Diet Surveys
Ethnic Groups
Female
Follow-Up Studies
Food Habits - ethnology
Humans
Life expectancy
Life Style
Male
Middle Aged
Mortality
Neoplasms - mortality
Population Groups - statistics & numerical data
Sweden - epidemiology
Abstract
To examine the relationship between "traditional Sami" dietary pattern and mortality in a general northern Swedish population.
Population-based cohort study.
We examined 77,319 subjects from the Västerbotten Intervention Program (VIP) cohort. A traditional Sami diet score was constructed by adding 1 point for intake above the median level of red meat, fatty fish, total fat, berries and boiled coffee, and 1 point for intake below the median of vegetables, bread and fibre. Hazard ratios (HR) for mortality were calculated by Cox regression.
Increasing traditional Sami diet scores were associated with slightly elevated all-cause mortality in men [Multivariate HR per 1-point increase in score 1.04 (95% CI 1.01-1.07), p=0.018], but not for women [Multivariate HR 1.03 (95% CI 0.99-1.07), p=0.130]. This increased risk was approximately equally attributable to cardiovascular disease and cancer, though somewhat more apparent for cardiovascular disease mortality in men free from diabetes, hypertension and obesity at baseline [Multivariate HR 1.10 (95% CI 1.01-1.20), p=0.023].
A weak increased all-cause mortality was observed in men with higher traditional Sami diet scores. However, due to the complexity in defining a "traditional Sami" diet, and the limitations of our questionnaire for this purpose, the study should be considered exploratory, a first attempt to relate a "traditional Sami" dietary pattern to health endpoints. Further investigation of cohorts with more detailed information on dietary and lifestyle items relevant for traditional Sami culture is warranted.
Notes
Cites: JAMA. 2002 Nov 27;288(20):2569-7812444864
Cites: Public Health Nutr. 2002 Jun;5(3):487-9612003662
Cites: Int J Epidemiol. 2003 Aug;32(4):486-812913011
Cites: Hum Nutr Clin Nutr. 1985;39 Suppl 1:5-414044297
Cites: Am J Epidemiol. 1986 Jul;124(1):17-273521261
Cites: Arctic Med Res. 1991 Jan;50(1):3-72021395
Cites: Arctic Med Res. 1991;Suppl:741-61365287
Cites: Anthropol Anz. 1997 Dec;55(3-4):281-79468755
Cites: Scand J Prim Health Care. 1998 Sep;16(3):171-69800231
Cites: Sven Lakartidn. 1962 Oct 4;59:2829-4413952700
Cites: Radiol Health Data Rep. 1964 Feb;5:83-9714118397
Cites: Int J Epidemiol. 2005 Jun;34(3):623-915737965
Cites: Croat Med J. 2006 Aug;47(4):553-6516909452
Cites: JAMA. 2006 Oct 18;296(15):1885-9917047219
Cites: Eur J Clin Nutr. 2007 Mar;61(3):431-316900081
Cites: Acta Oncol. 2007;46(3):286-30717450464
Cites: Scand J Public Health. 2008 Jan;36(1):84-9118426788
Cites: Int J Circumpolar Health. 2008 Feb;67(1):27-4218468257
Cites: Int J Circumpolar Health. 2008 Feb;67(1):56-6618468259
Cites: Int J Circumpolar Health. 2008 Feb;67(1):82-9618468261
Cites: Int J Obes (Lond). 2008 Jun;32(6):1031-318392036
Cites: BMJ. 2008;337:a134418786971
Cites: Int J Clin Pract. 2008 Sep;62(9):1306-1218643931
Cites: Diabetes Res Clin Pract. 2008 Oct;82(1):1-1718768236
Cites: Public Health Nutr. 2009 Jan;12(1):91-618339225
Cites: Int J Circumpolar Health. 2008 Dec;67(5):421-3219186763
Cites: Nutr J. 2009;8:1219228378
Cites: Lancet. 2009 Jul 4;374(9683):65-7519577695
Cites: Public Health Nutr. 2009 Sep;12(9):1477-8419144238
Cites: Int J Circumpolar Health. 2009 Sep;68(4):372-8519917189
Cites: Eur J Clin Nutr. 2010 Aug;64(8):905-1320502473
Cites: Cancer Causes Control. 2010 Oct;21(10):1533-4420512657
Cites: Public Health Nutr. 2010 Nov;13(11):1818-2520338083
Cites: Am J Clin Nutr. 2011 Jan;93(1):27-3621048056
Cites: J Nutr. 2011 Apr 1;141(4):639-4421346102
Cites: Int J Circumpolar Health. 2011 Jun;70(3):301-1821631968
Cites: Glob Health Action. 2011;4. doi: 10.3402/gha.v4i0.845722007156
Cites: Int J Circumpolar Health. 2012;71:1799722456051
Cites: Int J Obes Relat Metab Disord. 2000 Sep;24(9):1119-3011033980
Cites: J Intern Med. 2003 Jun;253(6):653-912755961
PubMed ID
22584519 View in PubMed
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