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15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia.

https://arctichealth.org/en/permalink/ahliterature287813
Source
Transl Psychiatry. 2017 Apr 25;7(4):e1109
Publication Type
Article
Date
Apr-25-2017
Author
M O Ulfarsson
G B Walters
O. Gustafsson
S. Steinberg
A. Silva
O M Doyle
M. Brammer
D F Gudbjartsson
S. Arnarsdottir
G A Jonsdottir
R S Gisladottir
G. Bjornsdottir
H. Helgason
L M Ellingsen
J G Halldorsson
E. Saemundsen
B. Stefansdottir
L. Jonsson
V K Eiriksdottir
G R Eiriksdottir
G H Johannesdottir
U. Unnsteinsdottir
B. Jonsdottir
B B Magnusdottir
P. Sulem
U. Thorsteinsdottir
E. Sigurdsson
D. Brandeis
A. Meyer-Lindenberg
H. Stefansson
K. Stefansson
Source
Transl Psychiatry. 2017 Apr 25;7(4):e1109
Date
Apr-25-2017
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 15 - genetics
Cognition - physiology
DNA Copy Number Variations - genetics
Developmental Disabilities - genetics
Dyscalculia - genetics
Dyslexia - genetics
Female
Functional Neuroimaging - methods - standards
Heterozygote
Humans
Iceland - epidemiology
Intellectual Disability - genetics
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neuropsychological Tests - standards
Phenotype
Temporal Lobe - anatomy & histology - diagnostic imaging
Young Adult
Abstract
Several copy number variants have been associated with neuropsychiatric disorders and these variants have been shown to also influence cognitive abilities in carriers unaffected by psychiatric disorders. Previously, we associated the 15q11.2(BP1-BP2) deletion with specific learning disabilities and a larger corpus callosum. Here we investigate, in a much larger sample, the effect of the 15q11.2(BP1-BP2) deletion on cognitive, structural and functional correlates of dyslexia and dyscalculia. We report that the deletion confers greatest risk of the combined phenotype of dyslexia and dyscalculia. We also show that the deletion associates with a smaller left fusiform gyrus. Moreover, tailored functional magnetic resonance imaging experiments using phonological lexical decision and multiplication verification tasks demonstrate altered activation in the left fusiform and the left angular gyri in carriers. Thus, by using convergent evidence from neuropsychological testing, and structural and functional neuroimaging, we show that the 15q11.2(BP1-BP2) deletion affects cognitive, structural and functional correlates of both dyslexia and dyscalculia.
Notes
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PubMed ID
28440815 View in PubMed
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Biliary tract malignancies: a population-based study on incidence, prognosis and management of patients.

https://arctichealth.org/en/permalink/ahliterature285119
Source
Scand J Gastroenterol. 2016 Dec;51(12):1520-1525
Publication Type
Article
Date
Dec-2016
Author
Gunnar Juliusson
Jon Gunnlaugur Jonasson
Sara B Jonsdottir
Henrik G Garcia
Elinborg Olafsdottir
Pall Helgi Möller
Einar S Björnsson
Source
Scand J Gastroenterol. 2016 Dec;51(12):1520-1525
Date
Dec-2016
Language
English
Publication Type
Article
Keywords
Aged
Ampulla of Vater - pathology
Biliary Tract Neoplasms - epidemiology - mortality - therapy
Biliary Tract Surgical Procedures
Cholangiocarcinoma - epidemiology - mortality - therapy
Drug Therapy
Female
Humans
Iceland - epidemiology
Incidence
Kaplan-Meier Estimate
Male
Prognosis
Registries
Sex Distribution
Survival Rate
Abstract
Biliary tract malignancies are uncommon and few population-based studies are available.
This nationwide population-based study in Iceland included all patients diagnosed with intra- and extrahepatic cholangiocarcinoma, gallbladder and ampullary cancer from 1984 to 2012. Patients were identified through the Icelandic Cancer Registry. Clinical information was obtained from patient records.
Overall 245 patients were identified: 38 had intrahepatic cholangiocarcinoma, 66 extrahepatic cholangiocarcinoma, 73 gallbladder cancer (GBC) and 68 ampullary cancer. Overall incidence for bile tract malignancies was 1-3 per 100,000 person-years and less than 1 by sub-type. The overall bile tract malignancies in males increased from 1.3 (95% CI 0.8-1.8) to 2.5 (1.9-3.1) per 100,000 inhabitants. The incidence of GBC among females decreased from 1.1 (0.7-1.5) to 0.5 (0.2-0.7). Surgery decreased for extrahepatic cholangiocarcinoma (56 to 23%, p?=?.027), ampullary cancer (80 to 48%, p?=?.03) and overall bile tract cancer (61 to 32%, p?
PubMed ID
27553174 View in PubMed
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Incidence, diagnostic, treatment and outcome of patients diagnosed with cancer of the pancreas during 1986-2009: a population-based study.

https://arctichealth.org/en/permalink/ahliterature293483
Source
Scand J Gastroenterol. 2018 Jan; 53(1):100-106
Publication Type
Journal Article
Date
Jan-2018
Author
Sara B Jonsdottir
Gunnar Juliusson
Jon Ö Kristinsson
Johann P Hreinsson
Jon G Jonasson
Einar S Björnsson
Author Affiliation
a Department of Internal Medicine, Division of Gastroenterology and Hepatology , Landspitali University Hospital , Reykjavik , Iceland.
Source
Scand J Gastroenterol. 2018 Jan; 53(1):100-106
Date
Jan-2018
Language
English
Publication Type
Journal Article
Keywords
Adenocarcinoma - diagnosis - mortality - therapy
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Humans
Iceland - epidemiology
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Pancreas - pathology
Pancreatic Neoplasms - diagnosis - mortality - therapy
Registries
Retrospective Studies
Sex Distribution
Survival Rate
Time Factors
Treatment Outcome
Young Adult
Abstract
Limited data exist on the changes in the epidemiology of pancreatic cancer and outcomes over the last decades in population-based cohorts. We aimed to compare the incidence of pancreatic cancer, diagnostic, treatment and survival among patients diagnosed over the period 1986-2009.
A retrospective, nationwide, population-based study. All patients diagnosed with pancreatic cancer in Iceland in two periods, 1986-1997 (P1) and 1998-2009 (P2) were identified through the Icelandic Cancer Registry and relevant clinical information obtained from medical records.
A total of 645 patients were identified, 296 in P1 and 349 in P2 (NS). The incidence during P1 was 6.8 per 100,000 inhabitants and 6.2 during P2 (NS). Among biopsy-proven cancers, adenocarcinoma was diagnosed in 89% of the cases in P1 and in P2 in 93% of the cases. Overall 38 (14%) in P1 underwent resection and 22 (7%) in P2 (p?
PubMed ID
29058490 View in PubMed
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Skin-to-skin care in neonatal intensive care units in the Nordic countries: a survey of attitudes and practices.

https://arctichealth.org/en/permalink/ahliterature122100
Source
Acta Paediatr. 2012 Nov;101(11):1140-6
Publication Type
Article
Date
Nov-2012
Author
Emma Olsson
Randi D Andersen
Anna Axelin
Rakel B Jonsdottir
Ragnhild Maastrup
Mats Eriksson
Author Affiliation
Department of Paediatrics, Örebro University Hospital, Sweden. miniemma@hotmail.com
Source
Acta Paediatr. 2012 Nov;101(11):1140-6
Date
Nov-2012
Language
English
Publication Type
Article
Keywords
Adult
Attitude of Health Personnel
Female
Finland
Health Care Surveys
Humans
Iceland
Infant, Newborn
Intensive Care Units, Neonatal - statistics & numerical data
Intensive Care, Neonatal - methods - psychology - statistics & numerical data
Kangaroo-Mother Care Method - psychology - utilization
Male
Middle Aged
Nurse's Practice Patterns - statistics & numerical data
Physician's Practice Patterns - statistics & numerical data
Practice Guidelines as Topic
Questionnaires
Scandinavia
Abstract
To investigate the application of skin-to-skin care (SSC) in the Nordic countries, the existence of guidelines for SSC and the attitudes of neonatal staff towards SSC.
One questionnaire was distributed at unit level and one at staff level in all Nordic neonatal intensive care units (n = 109).
The unit questionnaire was answered by 95 (87%) units and the staff questionnaire by 1446 staff members (72%). All units offered SSC to various degrees, but guidelines only existed at 47% of them. Units in Denmark, Norway and Sweden seemed to use SSC earlier, longer and in more medically complicated situations than units in Finland and Iceland. Seventy-seven per cent of the units had private rooms where parents and infants could stay together, still the physical environment of the units limited the use of SSC. Medical risks were considered the main barrier for further implementation of SSC, while general development and early interaction were the most frequently mentioned benefits.
Skin-to-skin care is implemented in all Nordic neonatal units, but offered to various degrees, to various populations and to varying extents. Danish, Norwegian and Swedish units are offering SSC more extensively than units in Finland and Iceland.
PubMed ID
22849363 View in PubMed
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