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11 records – page 1 of 2.

[Surgical research is falling behind. Evaluation of new methods is too slow].

https://arctichealth.org/en/permalink/ahliterature210823
Source
Lakartidningen. 1996 Oct 16;93(42):3669-70
Publication Type
Article
Date
Oct-16-1996
Author
B. Jeppsson
Author Affiliation
kirurgiska kliniken, Universitetssjukhuset MAS, Malmö.
Source
Lakartidningen. 1996 Oct 16;93(42):3669-70
Date
Oct-16-1996
Language
Swedish
Publication Type
Article
Keywords
Clinical Trials as Topic
Humans
Randomized Controlled Trials as Topic
Research
Surgical Procedures, Operative
Sweden
PubMed ID
8965528 View in PubMed
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Quality of life and independence in activities of daily living preoperatively and at follow-up in patients with colorectal cancer.

https://arctichealth.org/en/permalink/ahliterature21934
Source
Support Care Cancer. 1997 Sep;5(5):402-9
Publication Type
Article
Date
Sep-1997
Author
K. Ulander
B. Jeppsson
G. Grahn
Author Affiliation
Department of Surgery, Lund University Hospital, Sweden.
Source
Support Care Cancer. 1997 Sep;5(5):402-9
Date
Sep-1997
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Adult
Age Factors
Aged
Aged, 80 and over
Colorectal Neoplasms - pathology - radiotherapy - surgery
Comparative Study
Confidence Intervals
Female
Follow-Up Studies
Humans
Male
Middle Aged
Postoperative Period
Preoperative Care
Prognosis
Quality of Life
Research Support, Non-U.S. Gov't
Sweden
Abstract
The aim of this exploratory study was to describe quality of life (QL) domains and independence in activities of daily living (ADL) in patients (n = 86) undergoing surgery for colorectal cancer. The patients were consecutively included, and two validated instruments, EORTC's QLQ-C30 and the Katz'/Hulter Asberg Index of Independence in ADL, were used preoperatively and at follow-up after 5-8 months. The findings were related to tumour localization, tumour burden according to Dukes' classification and to preoperative radiotherapy treatment. The results showed a significant improvement in the patients' scores for emotional functioning, appetite and global QL and a significant increase in financial impact at follow-up. The patients with colon cancer (n = 39) also had significantly less pain and less constipation at follow-up compared with preoperatively than did patients with rectal cancer (n = 47). The patients with rectal cancer, having undergone preoperative radiotherapy treatment, had significantly lower confidence intervals for means (95%) on the physical functioning and role functioning scales at follow-up versus preoperatively. Total ADL independence decreased from 70% of the patients preoperatively to 57% at follow-up, and independence in instrumental ADL decreased from 72% to 64% of the patients. No patient was dependent in personal ADL preoperatively, while 3% were dependent at follow-up. A lower mean score of global QL was found preoperatively and at follow-up for patients who were dependent in ADL than for patients who were independent in ADL. The instruments were found useful for evaluating individual patients in clinical practice.
PubMed ID
9322353 View in PubMed
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Mesocaval interposition shunting in the treatment of bleeding oesophageal varices.

https://arctichealth.org/en/permalink/ahliterature207789
Source
Eur J Surg. 1997 Aug;163(8):569-76
Publication Type
Article
Date
Aug-1997
Author
B. Isaksson
P. Hannesson
I. Rosén
B. Jeppsson
Author Affiliation
Department of Surgery, Lund University Hospital, Sweden.
Source
Eur J Surg. 1997 Aug;163(8):569-76
Date
Aug-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Blood Vessel Prosthesis - adverse effects - methods
Cause of Death
Chi-Square Distribution
Esophageal and Gastric Varices - mortality - surgery
Esophagoscopy
Female
Follow-Up Studies
Gastrointestinal Hemorrhage - mortality - surgery
Humans
Length of Stay
Male
Middle Aged
Polytetrafluoroethylene
Portacaval Shunt, Surgical - methods
Postoperative Complications
Prognosis
Retrospective Studies
Survival Rate
Sweden
Abstract
To assess the longterm results of mesocaval interposition shunt in the treatment of bleeding oesophageal varices.
Retrospective study.
University hospital, Sweden.
60 patients with bleeding oesophageal varices in all Child's classes. 20 of whom were operated on as emergencies, and 40 as elective cases.
A 14 mm polytetrafluoroethylene graft was used as an interposition shunt between the superior mesenteric vein and the vena cava.
Rebleeding rate, portal blood flow, hepatic encephalopathy, morbidity, mortality, and survival.
Rebleeding was rare and occurred mainly during the first 4 months after operation, (n = 5) in 10% of the patients, and at the 24 month follow-up, (n = 4) in 11% of the patients. Portal flow was measured preoperatively in 33 patients and in 22 (67%) it was hepatopetal. During follow-up it was reversed and after 24 months no patient had hepatopetal flow. Hepatic encephalopathy was present in 18 patients (20%) during follow-up. Shunts thrombosed in 9 patients (15%), 8 of which required reoperation. There was no operative mortality, but 4 patients (7%) died within 30 days of surgery. The main late cause of death (18/26) was liver failure. The 1 year survival was 80%, the 3 year survival 70% and the 5 year survival 60%.
The mesocaval interposition shunt gives good longterm results and can be recommended both as an emergency and an elective procedure for patients with portal hypertension and bleeding oesophageal varices that are unresponsive to sclerotherapy.
PubMed ID
9298909 View in PubMed
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[Organization of diagnosis, treatment, and further measures for patients with gastrointestinal cancer (author's transl)]

https://arctichealth.org/en/permalink/ahliterature27258
Source
Zentralbl Chir. 1981;106(19):1289-96
Publication Type
Article
Date
1981
Author
L. Hafström
S. Bengmark
I. Ihse
B. Jeppsson
Source
Zentralbl Chir. 1981;106(19):1289-96
Date
1981
Language
German
Publication Type
Article
Keywords
Antineoplastic Agents - therapeutic use
English Abstract
Fluorouracil - therapeutic use
Gastrointestinal Neoplasms - diagnosis - secondary - surgery
Humans
Infusions, Intra-Arterial
Liver Function Tests
Palliative Care - methods
Patient Care Planning
Patient care team
Prognosis
Sweden
Abstract
One third of the total surgical care at the Department of Surgery, University of Lund, Sweden, is for cancer patients. Gastrointestinal cancer occupies 9,000 of a total of 12,000 bed-days and this disease is usually handled by the team who cares for the specific organ in which the cancer is localized. A particularly important part of gastrointestinal care is endoscopy (gastroscopy and colo-sigmoideo-rectoscopy). These diagnostic procedures can sometimes be curative. The value of preoperative liver tests for diagnosing liver metastases in colorectal cancer is very low because of the low prevalence of liver metastases in this population. Palliative therapeutical procedures, such as Celestin-tubes for esophageal or cardia carcinoma and transhepatic endoprostheses for bile duct occlusive cancer, have been tested. Palliative cytostatic therapy is partly established, i.e., intraarterial infusion of 5-FU for recurrent rectal carcinoma in the lower pelvis. This type of treatment has a very good pain relief effect. Cytostatic therapy for tumour control in patients without symptoms e.g. primary or secondary liver carcinomas, has not yet been established. Most of the patients with cytostatic therapy are treated on an outpatient basis. The cytostatic therapist must always be properly protected when working with cytostatic drugs. It is very important that the patient who gets cytostatic therapy is followed in order to see if the drug has any growth-controlling effect. A cost-benefit analysis of the therapy should also be made.
PubMed ID
6172915 View in PubMed
Less detail
Source
Tijdschr Gastroenterol. 1978;21(6):431-44
Publication Type
Article
Date
1978
Author
S. Bengmark
P. Fredlund
L. Hafstrom
B. Jeppsson
Source
Tijdschr Gastroenterol. 1978;21(6):431-44
Date
1978
Language
English
Publication Type
Article
Keywords
Humans
Liver Neoplasms - mortality - surgery
Neoplasm Metastasis
Sweden
PubMed ID
756101 View in PubMed
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Multiple-system organ damage resulting from prolonged hepatic inflow interruption.

https://arctichealth.org/en/permalink/ahliterature22702
Source
Arch Surg. 1996 Apr;131(4):442-7
Publication Type
Article
Date
Apr-1996
Author
D L Liu
B. Jeppsson
C H Hakansson
R. Odselius
Author Affiliation
Department of Surgery, Lund University, Sweden.
Source
Arch Surg. 1996 Apr;131(4):442-7
Date
Apr-1996
Language
English
Publication Type
Article
Keywords
Animals
Blood Transfusion
Hepatectomy
Intestines - ultrastructure
Liver - blood supply - ultrastructure
Lung - ultrastructure
Multiple Organ Failure - pathology
Myocardium - ultrastructure
Random Allocation
Rats
Rats, Sprague-Dawley
Reperfusion Injury - pathology
Time Factors
Abstract
BACKGROUND: It has been reported that patients undergoing major hepatectomy tolerated 90 and 127 minutes of continuous hepatic inflow interruption with no evidence of permanent damage to the liver. We questioned the safety and feasibility of the interruption beyond 90 minutes in normothermic human beings. We also postulated that, besides injury to the liver per se, extended continuous hepatic inflow interruption would cause extrahepatic multiple-system organ damage in subjects exposed to continuous hepatic inflow interruption for 90 or 120 minutes. DESIGN: Fifty Sprague-Dawley rats were divided into three groups. Group 1 served as controls that had only laparotomy. Group 2 underwent continuous hepatic inflow interruption for 90 minutes, and group 3 was subjected to continuous hepatic inflow interruption for 120 minutes. Scanning electron microscopy and transmission electron microscopy were used to evaluate ultrastructural alterations in the liver, lung, heart, and intestine. SETTING: Lund (Sweden) University Hospital and Top Cancer Institute, Lund. INTERVENTIONS: Intraoperative and postoperative infusion and blood transfusion were given in all experimental animals. MAIN OUTCOME MEASURES: Animal survival and manifestations of multiple-system organ failure. RESULTS: In rats with continuous hepatic inflow interruption for 90 or 120 minutes, scanning electron microscopy showed a necrotic surface of the liver cells together with fibrin exudation. Hepatic sinusoids and intrahepatic nerves also had severe injury. Destruction of pulmonary structures and breakdown of microcirculation in the lung were characterized by thinned and ruptured walls of alveoli and a greatly decreased number of capillaries in the damaged alveolar wall. Transmission electron microscopy showed four types of ultrastructural changes, ie, necrosis of epithelial cells, extremely swollen mitochondria in intestinal cells, death of mucosal cells, and increased permeability of vessels in the injured intestine. The affected heart manifested highly enlarged mitochondria in myocardial cells, thickened vascular walls, and scattered necrotic lesions in myocardial tissue. CONCLUSIONS: Multiple-system organ failure resulting from ischemia-reperfusion injury and obstacle of portal hemodynamics in a subject subjected to an extended continuous hepatic inflow interruption is an unrecognized new disorder that may cause a high mortality rate. Our preliminary results indicated that animals subjected to continuous hepatic inflow interruption for 90 or 120 minutes developed various injuries to the liver, lung, heart, and gut. Therefore, we believe that continuous hepatic inflow interruption exceeding 90 minutes could also be hazardous in human beings.
PubMed ID
8615734 View in PubMed
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Compliance and findings in a Swedish population screened for colorectal cancer with sigmoidoscopy.

https://arctichealth.org/en/permalink/ahliterature18739
Source
Eur J Surg Oncol. 2002 Dec;28(8):827-31
Publication Type
Article
Date
Dec-2002
Author
J. Blom
A. Lidén
B. Jeppsson
L. Holmberg
L. Påhlman
Author Affiliation
Department of Surgery at University Hospital South Hospital, Stockholm, Sweden. johannes.blom@kirurg.sos.sll.se
Source
Eur J Surg Oncol. 2002 Dec;28(8):827-31
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adenoma - epidemiology - pathology - prevention & control
Age Distribution
Colonic Polyps - epidemiology - pathology - prevention & control
Colorectal Neoplasms - epidemiology - pathology - prevention & control
Comparative Study
Female
Humans
Incidence
Male
Mass Screening - methods
Middle Aged
Patient Compliance - statistics & numerical data
Probability
Research Support, Non-U.S. Gov't
Risk factors
Sex Distribution
Sigmoidoscopy - methods
Sweden - epidemiology
Abstract
AIM: The aim of this study was to evaluate the patterns of compliance and the frequency of adenomas and neoplasms in a Swedish population. METHODS: In 1996, 2000 men and women born in 1935 or 1936 were selected at random from the population registers of Uppsala and Malmö/Lund. All subjects were invited by mail to participate. In a randomised study design, subjects were either called up by a nurse to schedule the appointment for sigmoidoscopy or instructed to call themselves. At sigmoidoscopy subjects with a cancer, an adenoma (neoplastic polyp) or more than three hyperplastic polyps were scheduled for a complete colonoscopy. RESULTS: Thirty-nine percent (770/1988) of all the invited subjects had a sigmoidoscopy. The participation differed between the two centres, 47% at the Uppsala centre and 30% at the Malmö/Lund centre (P
PubMed ID
12477473 View in PubMed
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[Of what importance are the resources of the large hospital in colo-rectal cancer?]

https://arctichealth.org/en/permalink/ahliterature27543
Source
Lakartidningen. 1978 Sep 20;75(38):3297-8
Publication Type
Article
Date
Sep-20-1978

[Predicting local recurrence after surgery for rectal cancer]

https://arctichealth.org/en/permalink/ahliterature23122
Source
Lakartidningen. 1995 Aug 23;92(34):2982
Publication Type
Article
Date
Aug-23-1995

Administration of different Lactobacillus strains in fermented oatmeal soup: in vivo colonization of human intestinal mucosa and effect on the indigenous flora.

https://arctichealth.org/en/permalink/ahliterature222069
Source
Appl Environ Microbiol. 1993 Jan;59(1):15-20
Publication Type
Article
Date
Jan-1993
Author
M L Johansson
G. Molin
B. Jeppsson
S. Nobaek
S. Ahrné
S. Bengmark
Author Affiliation
Department of Food Technology, Lund University, Sweden.
Source
Appl Environ Microbiol. 1993 Jan;59(1):15-20
Date
Jan-1993
Language
English
Publication Type
Article
Keywords
Adult
Cereals - microbiology
Female
Fermentation
Food Microbiology
Genotype
Humans
Intestinal Mucosa - microbiology
Lactobacillus - genetics - growth & development - isolation & purification
Male
Middle Aged
Phenotype
Species Specificity
Abstract
In vivo colonization by different Lactobacillus strains on human intestinal mucosa of healthy volunteers was studied together with the effect of Lactobacillus administration on different groups of indigenous bacteria. A total of 19 test strains were administered in fermented oatmeal soup containing 5 x 10(6) CFU of each strain per ml by using a dose of 100 ml of soup per day for 10 days. Biopsies were taken from both the upper jejunum and the rectum 1 day before administration was started and 1 and 11 days after administration was terminated. The administration significantly increased the Lactobacillus counts on the jejunum mucosa, and high levels remained 11 days after administration was terminated. The levels of streptococci increased by 10- to 100-fold in two persons, and the levels of sulfite-reducing clostridia in the jejunum decreased by 10- to 100-fold in three of the volunteers 1 day after administration was terminated. In recta, the anaerobic bacterium counts and the gram-negative anaerobic bacterium counts decreased significantly by the end of administration. Furthermore, a decrease in the number of members of the Enterobacteriaceae by 1,000-fold was observed on the rectal mucosa of two persons. Randomly picked Lactobacillus isolates were identified phenotypically by API 50CH tests and genotypically by the plasmid profiles of strains and by restriction endonuclease analysis of chromosomal DNAs.(ABSTRACT TRUNCATED AT 250 WORDS)
Notes
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Cites: Antonie Van Leeuwenhoek. 1992 Apr;61(3):175-831325752
Cites: Annu Rev Microbiol. 1977;31:107-33334036
Cites: N Engl J Med. 1978 Mar 9;298(10):531-4625309
Cites: Am J Hosp Pharm. 1979 Jun;36(6):754-7111546
Cites: J Antimicrob Chemother. 1979 Sep;5(5):531-7115830
Cites: Scand J Infect Dis. 1979;11(3):233-42118526
Cites: Surg Clin North Am. 1980 Feb;60(1):197-2127361222
Cites: J Appl Bacteriol. 1979 Oct;47(2):197-208120356
Cites: J Dairy Sci. 1980 Mar;63(3):353-76768778
Cites: Eur J Pediatr. 1982 Sep;139(1):18-216816601
Cites: Scand J Infect Dis. 1987;19(5):531-73122316
Cites: Surgery. 1988 Aug;104(2):185-903135625
Cites: Surgery. 1988 Nov;104(5):917-233055397
Cites: Infection. 1988;16(6):329-363146551
Cites: World J Surg. 1990 Mar-Apr;14(2):191-52183481
Cites: Ann Med. 1990 Feb;22(1):57-92184848
Cites: Br J Surg. 1992 Jul;79(7):614-231643468
Cites: Antonie Van Leeuwenhoek. 1992 Apr;61(3):167-731519914
Cites: J Bacteriol. 1976 Sep;127(3):1576-8821936
PubMed ID
8439146 View in PubMed
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11 records – page 1 of 2.