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The 1 alpha-hydroxylase locus is not linked to calcium stone formation or calciuric phenotypes in French-Canadian families.

https://arctichealth.org/en/permalink/ahliterature206213
Source
J Am Soc Nephrol. 1998 Mar;9(3):425-32
Publication Type
Article
Date
Mar-1998
Author
P. Scott
D. Ouimet
Y. Proulx
M L Trouvé
G. Guay
B. Gagnon
L. Valiquette
A. Bonnardeaux
Author Affiliation
Service de Néphrologie, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
Source
J Am Soc Nephrol. 1998 Mar;9(3):425-32
Date
Mar-1998
Language
English
Publication Type
Article
Keywords
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics - metabolism
Adult
Calcium - urine
Canada
European Continental Ancestry Group - genetics
Family Health
Female
France - ethnology
Genetic Linkage
Genetic Markers - genetics
Humans
Kidney Calculi - enzymology - genetics
Male
Middle Aged
Nuclear Family
Pedigree
Phenotype
Vitamin D - blood
Abstract
Calcium urolithiasis is often associated with increased intestinal absorption and urine excretion of calcium, and has been suggested to result from increased vitamin D production. The role of the enzyme 1 alpha-hydroxylase, the rate-limiting step in active vitamin D production, was evaluated in 36 families, including 28 sibships with at least a pair of affected sibs, using qualitative and quantitative trait linkage analyses. Sibs with a verified calcium urolithiasis passage (n = 117) had higher 24-h calciuria (P = 0.03), oxaluria (P = 0.02), fasting and postcalcium loading urine calcium/creatinine (Ca/cr) ratios (P = 0.008 and P = 0.002, respectively), and serum 1,25(OH)2 vitamin D levels (P = 0.02) compared with nonstone-forming sibs (n = 120). Markers from a 9-centiMorgan interval encompassing the VDD1 locus on chromosome 12q13-14 (putative 1 alpha-hydroxylase) were analyzed in 28 sibships (146 sib pairs) of single and recurrent stone formers and in 14 sibships (65 sib pairs) with recurrent-only (> or = 3 episodes) stone-forming sibs. Two-point and multipoint analyses did not reveal excess in alleles shared among affected sibs at the VDD1 locus. Linkage of stone formation to the VDD1 locus could be excluded, respectively, with a lambda d of 2.0 (single and recurrent stone formers) and 3.25 (recurrent stone formers). Quantitative trait analyses revealed no evidence for linkage to 24-h calciuria and oxaluria, serum 1,25(OH)2 vitamin D levels, and Ca/cr ratios. This study shows absence of linkage of the putative 1 alpha-hydroxylase locus to calcium stone formation or to quantitative traits associated with idiopathic hypercalciuria. In addition, there is coaggregation of calciuric and oxaluric phenotypes with stone formation.
PubMed ID
9513904 View in PubMed
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Edmonton Regional Palliative Care Program: impact on patterns of terminal cancer care.

https://arctichealth.org/en/permalink/ahliterature201060
Source
CMAJ. 1999 Aug 10;161(3):290-3
Publication Type
Article
Date
Aug-10-1999
Author
E. Bruera
C M Neumann
B. Gagnon
C. Brenneis
P. Kneisler
P. Selmser
J. Hanson
Author Affiliation
Edmonton Regional Palliative Care Program, University of Alberta, Alta.
Source
CMAJ. 1999 Aug 10;161(3):290-3
Date
Aug-10-1999
Language
English
Publication Type
Article
Keywords
Alberta
Health Care Surveys
Health Services - utilization
Health Services Accessibility - statistics & numerical data
Humans
Neoplasms - mortality
Palliative Care
Physician's Practice Patterns - statistics & numerical data - trends
Terminal Care - trends
Abstract
The Edmonton Regional Palliative Care Program was established in July 1995 to measure the access of patients with terminal cancer to palliative care services, decrease the number of cancer-related deaths in acute care facilities and increase the participation of family physicians in the care of terminally ill patients. In this retrospective study the authors compared the pattern of care and site of deaths before establishment of the program (1992/93) and during its second year of operation (1996/97). Significantly more cancer-related deaths occurred in acute care facilities in 1992/93 than in 1996/97 (86% [1119/1304] v. 49% [633/1279]) (p
Notes
Cites: Cancer. 1984 May 15;53(10 Suppl):2250-76704913
Cites: J Pain Symptom Manage. 1997 Dec;14(6):332-429409098
Cites: Acta Oncol. 1989;28(2):177-822472159
Cites: Pain. 1989 May;37(2):203-92748193
Cites: J Pain Symptom Manage. 1990 Apr;5(2):78-822348091
Cites: J Pain Symptom Manage. 1990 Apr;5(2):83-932348092
Cites: J Palliat Care. 1991 Spring;7(1):5-112045996
Cites: J Palliat Care. 1991 Summer;7(2):6-91714502
Cites: Aust N Z J Med. 1993 Jun;23(3):245-517688953
Cites: N Engl J Med. 1994 Mar 3;330(9):592-67508092
Cites: Lancet. 1994 Aug 6;344(8919):4097519713
Cites: CMAJ. 1995 Feb 1;152(3):361-77530164
Cites: J Pain Symptom Manage. 1995 Jul;10(5):348-557673767
Cites: J Pain Symptom Manage. 1995 Nov;10(8):599-6038594120
Cites: Palliat Med. 1996 Jul;10(3):251-78817597
Cites: J Pain Symptom Manage. 1997 Jan;13(1):10-99029857
Cites: Palliat Med. 1997 Mar;11(2):93-1009156104
Cites: Can Fam Physician. 1997 Nov;43:1983-6, 1989-929386885
Cites: J Pain Symptom Manage. 1997 Dec;14(6):328-319409097
Cites: South Med J. 1987 Sep;80(9):1120-43629316
PubMed ID
10463053 View in PubMed
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Increasing maternal participation in the hospitalization of young children.

https://arctichealth.org/en/permalink/ahliterature248321
Source
Med Care. 1978 Sep;16(9):765-77
Publication Type
Article
Date
Sep-1978
Author
E. Roskies
M. Mongeon
B. Gagnon-Lefebvre
Source
Med Care. 1978 Sep;16(9):765-77
Date
Sep-1978
Language
English
Publication Type
Article
Keywords
Adult
Canada
Child
Child Psychology
Child, Hospitalized
Consumer Participation
Female
Hospitals, Pediatric
Humans
Infant
Mother-Child Relations
Parents - education
Patient Admission
Pediatric Nursing
Visitors to Patients
Abstract
In an attempt to reduce the harmful emotional effects of separation for young children, hospitals in recent years have liberalized visiting hours, but parents have not taken advantage of their new privileges. The study described here sought to increase mothers' participation in their children's hospitalization by overcoming some of the psychological barriers believed to exist. The mothers of 48 children aged 1 to 5, to be admitted for elective surgery to a large, metropolitan pediatric hospital, constituted the primary sample and were divided into experimental and control groups. Mothers in the experimental group had an extra half-hour session in a pre-admission interview focusing on visiting, and specific suggestions were made about frequency and timing of visits, as well as the role of the mother during her visits. During the experimental period weekly meetings were held with the nursing staff to enlist their support for this change in visiting patterns. Results indicate that duration of visits, timing of visits, and behavior during them were all significantly modified for the experimental group of mothers. In contrast, the nurses did not significantly change their relationship with the mothers or the children. Clinical possibilities and limitations of such a program are discussed.
PubMed ID
682711 View in PubMed
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