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Electrocardiographic unrecognized myocardial infarction does not improve prediction of cardiovascular events beyond traditional risk factors. The Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature294322
Source
Eur J Prev Cardiol. 2018 01; 25(1):78-86
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
01-2018
Author
Andrea Milde Øhrn
Henrik Schirmer
Inger Njølstad
Ellisiv B Mathiesen
Anne E Eggen
Maja-Lisa Løchen
Tom Wilsgaard
Haakon Lindekleiv
Author Affiliation
1 Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Source
Eur J Prev Cardiol. 2018 01; 25(1):78-86
Date
01-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Aged
Aged, 80 and over
Cause of Death
Electrocardiography
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction - diagnosis - epidemiology - mortality
Norway
Predictive value of tests
Prevalence
Prognosis
Proportional Hazards Models
Prospective Studies
Recurrence
Risk factors
Stroke - diagnosis - epidemiology
Time Factors
Abstract
Background Unrecognized myocardial infarction (MI) is a frequent and intriguing entity associated with a similar risk of death as recognized MI. Previous studies have not fully addressed whether the poor prognosis is explained by traditional cardiovascular risk factors. We investigated whether electrocardiographically detected unrecognized MI was independently associated with cardiovascular events and death and whether it improved prediction for future MI in a general population. Design Prospective cohort study. Methods We studied 5686 women and men without clinically recognized MI at baseline in 2007-2008. We assessed the risk of future MI, stroke and all-cause mortality in persons with unrecognized MI compared with persons with no MI during 31,051 person-years of follow-up. Results In the unadjusted analyses, unrecognized MI was associated with increased risk of future recognized MI (hazard ratio 1.84, 95% confidence interval (CI) 1.15-2.96) and all-cause mortality (hazard ratio 1.78, 95% CI 1.21-2.61), but not stroke (hazard ratio 1.09, 95% CI 0.56-2.17). The associations did not remain significant after adjustment for traditional risk factors (hazard ratio 1.25, 95% CI 0.76-2.06 and hazard ratio 1.38, 95% CI 0.93-2.05) for MI and all-cause mortality respectively. Unrecognized MI did not improve risk prediction for future recognized MI using the Framingham Risk Score ( p?=?0.96) or the European Systematic COronary Risk Evaluation ( p?=?0.65). There was no significant sex interaction regarding any of the endpoints. Conclusion Electrocardiographic unrecognized MI was not significantly associated with future risk of MI, stroke or all-cause mortality in the general population after adjustment for the traditional cardiovascular risk factors, and it did not improve prediction of future MI.
Notes
CommentIn: Eur J Prev Cardiol. 2018 Jan;25(1):76-77 PMID 29067850
PubMed ID
29048217 View in PubMed
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Electrocardiographic unrecognized myocardial infarction does not improve prediction of cardiovascular events beyond traditional risk factors. The Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature286473
Source
Eur J Prev Cardiol. 2017 Jan 01;:2047487317736826
Publication Type
Article
Date
Jan-01-2017
Author
Andrea Milde Øhrn
Henrik Schirmer
Inger Njølstad
Ellisiv B Mathiesen
Anne E Eggen
Maja-Lisa Løchen
Tom Wilsgaard
Haakon Lindekleiv
Source
Eur J Prev Cardiol. 2017 Jan 01;:2047487317736826
Date
Jan-01-2017
Language
English
Publication Type
Article
Abstract
Background Unrecognized myocardial infarction (MI) is a frequent and intriguing entity associated with a similar risk of death as recognized MI. Previous studies have not fully addressed whether the poor prognosis is explained by traditional cardiovascular risk factors. We investigated whether electrocardiographically detected unrecognized MI was independently associated with cardiovascular events and death and whether it improved prediction for future MI in a general population. Design Prospective cohort study. Methods We studied 5686 women and men without clinically recognized MI at baseline in 2007-2008. We assessed the risk of future MI, stroke and all-cause mortality in persons with unrecognized MI compared with persons with no MI during 31,051 person-years of follow-up. Results In the unadjusted analyses, unrecognized MI was associated with increased risk of future recognized MI (hazard ratio 1.84, 95% confidence interval (CI) 1.15-2.96) and all-cause mortality (hazard ratio 1.78, 95% CI 1.21-2.61), but not stroke (hazard ratio 1.09, 95% CI 0.56-2.17). The associations did not remain significant after adjustment for traditional risk factors (hazard ratio 1.25, 95% CI 0.76-2.06 and hazard ratio 1.38, 95% CI 0.93-2.05) for MI and all-cause mortality respectively. Unrecognized MI did not improve risk prediction for future recognized MI using the Framingham Risk Score ( p?=?0.96) or the European Systematic COronary Risk Evaluation ( p?=?0.65). There was no significant sex interaction regarding any of the endpoints. Conclusion Electrocardiographic unrecognized MI was not significantly associated with future risk of MI, stroke or all-cause mortality in the general population after adjustment for the traditional cardiovascular risk factors, and it did not improve prediction of future MI.
PubMed ID
29048217 View in PubMed
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Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature280888
Source
BMC Cardiovasc Disord. 2017 Mar 14;17(1):79
Publication Type
Article
Date
Mar-14-2017
Author
Jon V Norvik
Henrik Schirmer
Kirsti Ytrehus
Trond G Jenssen
Svetlana N Zykova
Anne E Eggen
Bjørn O Eriksen
Marit D Solbu
Source
BMC Cardiovasc Disord. 2017 Mar 14;17(1):79
Date
Mar-14-2017
Language
English
Publication Type
Article
Abstract
Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent.
We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomial regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest.
Decreased adiponectin was associated with higher odds of average tissue Doppler e'?
Notes
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PubMed ID
28292262 View in PubMed
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Obesity and Staphylococcus aureus nasal colonization among women and men in a general population.

https://arctichealth.org/en/permalink/ahliterature113946
Source
PLoS One. 2013;8(5):e63716
Publication Type
Article
Date
2013
Author
Karina Olsen
Kjersti Danielsen
Tom Wilsgaard
Maria Sangvik
Johanna U E Sollid
Inger Thune
Anne E Eggen
Gunnar S Simonsen
Anne-Sofie Furberg
Author Affiliation
Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway. karina.olsen@unn.no
Source
PLoS One. 2013;8(5):e63716
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Body mass index
Colony Count, Microbial
Female
Humans
Male
Middle Aged
Norway - epidemiology
Nose - microbiology
Obesity - epidemiology - microbiology
Odds Ratio
Probability
Staphylococcus aureus - growth & development
Waist Circumference
Abstract
Obesity and diabetes mellitus (DM) have been linked to increased risk of infections, and Staphylococcus aureus nasal colonization is a major risk factor for developing infections with the microbe. We therefore sought to find whether body mass index (BMI) and waist circumference (WC) could be associated with S. aureus colonization independent of DM.
S. aureus colonization was assessed by nasal swab cultures among 2,169 women and 1,709 men, aged 30-87 years, in the population-based Tromsø Staph and Skin Study in 2007-08. Height (cm), weight (kg), WC (cm), and glycated haemoglobin (HbA1c,%) were measured. Multivariable logistic regression analyses including information on DM, HbA1c, hormonal contraceptive use and other potential confounders were used.
In the female population, each 2.5 kg/m(2) increase in BMI was associated with a 7% higher odds of S. aureus nasal colonization (P?=?0.01). When comparing obese and lean women aged 30-43 years, we observed that BMI =32.5 versus
Notes
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PubMed ID
23667661 View in PubMed
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Perceived barriers to consumption of fish among Norwegian women.

https://arctichealth.org/en/permalink/ahliterature71192
Source
Appetite. 2003 Dec;41(3):301-14
Publication Type
Article
Date
Dec-2003
Author
Torbjørn Trondsen
Joachim Scholderer
Eiliv Lund
Anne E Eggen
Author Affiliation
Norwegian College of Fishery Science, University of Tromsø, Breivika 9037 Tromsø, Norway. torbjorn@nfh.uit.no
Source
Appetite. 2003 Dec;41(3):301-14
Date
Dec-2003
Language
English
Publication Type
Article
Keywords
Aged
Animals
Diet Surveys
Family Characteristics
Female
Fish Products - standards - supply & distribution
Fishes
Food Habits - psychology
Food Supply
Health Knowledge, Attitudes, Practice
Health status
Humans
Logistic Models
Middle Aged
Norway
Perception
Questionnaires
Research Support, Non-U.S. Gov't
Seafood - standards - supply & distribution
Social Class
Abstract
This study aimed to characterize constraints on consumption of fish perceived by consumers in Norway. A random sample of Norwegian women aged 45-69 years answered a self-administered mail questionnaire in 1996 about eating habits, perceived barriers to fish consumption, socioeconomic status, and questions related to health. Altogether, 9407 women answered the questionnaire (response rate: 52.5%). Data were analyzed by means of logistic regression. Limited supply of fish products that satisfy children's wishes reduce at-home fish consumption. People with health problems and those who wish to lose weight are dissatisfied with the range of products offered in the marketplace. Satisfaction with quality and availability of wild lean codfish, especially in inland regions, is lower than for aqua-cultured fat salmon. Neither income nor education or health factors were significantly associated with consumption levels among those who would like to eat more fish. Higher education and income were associated with increased dissatisfaction about fish consumption, but also with reduced perception of most barriers. It is concluded that improvements in the supply of high-quality fresh and processed fish products that satisfy (a) children's wishes, (b) health-oriented family members, and (c) convenience-oriented consumers, will significantly increase at-home consumption of fish.
PubMed ID
14637329 View in PubMed
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Secular and longitudinal trends in cardiovascular risk in a general population using a national risk model: The Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature298176
Source
Eur J Prev Cardiol. 2019 Feb 12; :2047487319830806
Publication Type
Journal Article
Date
Feb-12-2019
Author
Amalie Nilsen
Tove A Hanssen
Knut T Lappegård
Anne E Eggen
Maja-Lisa Løchen
Inger Njølstad
Tom Wilsgaard
Laila Hopstock
Author Affiliation
1 Department of Medicine, Nordland Hospital, Bodø, Norway.
Source
Eur J Prev Cardiol. 2019 Feb 12; :2047487319830806
Date
Feb-12-2019
Language
English
Publication Type
Journal Article
Abstract
Primary prevention guidelines promote the use of risk assessment tools to estimate total cardiovascular risk. We aimed to study trends in cardiovascular risk and contribution of single risk factors, using the newly developed NORRISK 2 risk score, which estimates 10-year risk of fatal and non-fatal cardiovascular events.
Prospective population-based study.
We included women and men aged 45-74 years attending the sixth and seventh survey of the Tromsø Study (Tromsø 6, 2007-2008, n?=?7284 and Tromsø 7, 2015-2016, n?=?14,858) to study secular trends in NORRISK 2 score. To study longitudinal trends, we followed participants born 1941-1962 attending both surveys ( n?=?4534). We calculated NORRISK 2 score and used linear regression models to study the relative contribution (% R2) of each single risk factor to the total score.
Mean NORRISK 2 score decreased and distribution in risk categories moved from higher to lower risk in both sexes and all age-groups between the first and second surveys ( p?
PubMed ID
30755014 View in PubMed
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Tinnitus and associations with chronic pain: The population-based Tromsø Study (2015-2016).

https://arctichealth.org/en/permalink/ahliterature303468
Source
PLoS One. 2021; 16(3):e0247880
Publication Type
Journal Article
Date
2021
Author
Jannike H-L Ausland
Bo Engdahl
Bente Oftedal
Ólöf A Steingrímsdóttir
Christopher S Nielsen
Laila A Hopstock
Magnar Johnsen
Oddgeir Friborg
Jan H Rosenvinge
Anne E Eggen
Norun H Krog
Author Affiliation
Department of Environmental Health, Norwegian Institute of Public Health, Skøyen, Oslo, Norway.
Source
PLoS One. 2021; 16(3):e0247880
Date
2021
Language
English
Publication Type
Journal Article
Abstract
Tinnitus and pain have many similarities. Both are subjective sensations that may turn chronic, they are often accompanied by hypersensitivity in their respective sensory system, and overlapping brain changes have been observed. Since no population study has examined the empirical association between chronic pain and tinnitus, the present study aimed to explore the relationship in a general adult population. We used data from the seventh survey of the Tromsø Study (2015-2016). Participants (aged =40) responded to questions about pain and tinnitus. Using multiple logistic regression, we analysed the adjusted relationship between chronic pain and tinnitus in the full sample (n = 19,039), using several tinnitus definitions ranging from tinnitus >5 minutes within the past 12 months (broadest definition) to at least weekly and highly bothersome tinnitus (strictest definition). We also analysed relationships between number of body regions with pain, pain intensity and bothering, and tinnitus >5 minutes, among participants with chronic pain (n = 11,589). We found an association between chronic pain and tinnitus that was present irrespective of tinnitus definition, but was stronger with more bothersome tinnitus. With chronic pain, the odds of tinnitus >5 minutes was 64% higher, while odds of at least weekly, highly bothersome tinnitus was 144% higher than without chronic pain. Among participants with chronic pain, the number of pain regions was the pain variable most strongly associated with tinnitus >5 minutes (OR = 1.17 (95% CI: 1.14-1.20) for an increase of one region), whereas the other pain variables (intensity and bothering) showed weaker associations. All chronic pain variables had significant interactions with age, with the strongest associations for the youngest individuals (40-54 years). Our findings support the existence of an association between chronic pain and tinnitus and emphasises the importance of examining for comorbid pain in tinnitus patients to provide a more comprehensive treatment of tinnitus.
PubMed ID
33651844 View in PubMed
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