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Ability of vaccine strain induced antibodies to neutralize field isolates of caliciviruses from Swedish cats.

https://arctichealth.org/en/permalink/ahliterature276779
Source
Acta Vet Scand. 2015 Dec 12;57:86
Publication Type
Article
Date
Dec-12-2015
Author
Jonas Johansson Wensman
Ayman Samman
Anna Lindhe
Jean-Christophe Thibault
Louise Treiberg Berndtsson
Margaret J Hosie
Source
Acta Vet Scand. 2015 Dec 12;57:86
Date
Dec-12-2015
Language
English
Publication Type
Article
Keywords
Animals - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Antibodies, Viral - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Caliciviridae Infections - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Calicivirus, Feline - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Cat Diseases - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Cats - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Neutralization Tests - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Sweden - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Viral Vaccines - immunology - immunology - veterinary - virology - immunology - immunology - virology - veterinary - immunology
Abstract
Feline calicivirus (FCV) is a common cause of upper respiratory tract disease in cats worldwide. Its characteristically high mutation rate leads to escape from the humoral immune response induced by natural infection and/or vaccination and consequently vaccines are not always effective against field isolates. Thus, there is a need to continuously investigate the ability of FCV vaccine strain-induced antibodies to neutralize field isolates.
Seventy-eight field isolates of FCV isolated during the years 2008-2012 from Swedish cats displaying clinical signs of upper respiratory tract disease were examined in this study. The field isolates were tested for cross-neutralization using a panel of eight anti-sera raised in four pairs of cats following infection with four vaccine strains (F9, 255, G1 and 431).
The anti-sera raised against F9 and 255 neutralised 20.5 and 11.5 %, and 47.4 and 64.1 % of field isolates tested, respectively. The anti-sera against the more recently introduced vaccine strains G1 and 431 neutralized 33.3 and 55.1 % (strain G1) or 69.2 and 89.7 % (strain 431) of the field isolates with titres =5. [corrected]. Dual vaccine strains displayed a higher cross-neutralization.
This study confirms previous observations that more recently introduced vaccine strains induce antibodies with a higher neutralizing capacity compared to vaccine strains that have been used extensively over a long period of time. This study also suggests that dual FCV vaccine strains might neutralize more field isolates compared to single vaccine strains. Vaccine strains should ideally be selected based on updated knowledge on the antigenic properties of field isolates in the local setting, and there is thus a need for continuously studying the evolution of FCV together with the neutralizing capacity of vaccine strain induced antibodies against field isolates at a national and/or regional level.
Notes
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Erratum In: Acta Vet Scand. 2016;58:1426888695
PubMed ID
26655039 View in PubMed
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