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Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.

https://arctichealth.org/en/permalink/ahliterature183926
Source
Am J Clin Nutr. 2003 Sep;78(3):485-92
Publication Type
Article
Date
Sep-2003
Author
Sulin Cheng
Frances Tylavsky
Heikki Kröger
Merja Kärkkäinen
Arja Lyytikäinen
Arvo Koistinen
Anitta Mahonen
Markku Alen
Jussi Halleen
Kalervo Väänänen
Christel Lamberg-Allardt
Author Affiliation
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland. cheng@sport.jyu.fi
Source
Am J Clin Nutr. 2003 Sep;78(3):485-92
Date
Sep-2003
Language
English
Publication Type
Article
Keywords
Acid Phosphatase - blood
Biological Markers - blood
Bone Density
Bone Resorption - diagnosis
Calcium - urine
Calcium, Dietary - administration & dosage
Child
Cross-Sectional Studies
Female
Finland - epidemiology
Humans
Hyperparathyroidism, Secondary - diagnosis - etiology - metabolism
Isoenzymes - blood
Parathyroid Hormone - blood
Puberty - metabolism
Seasons
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - complications - diagnosis - epidemiology - metabolism
Abstract
Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children.
We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls.
The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2, who reported a mean (+/- SD) dietary calcium intake of 733 +/- 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, areal BMD, and volumetric BMD were assessed by using different methods.
Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D
Notes
Erratum In: Am J Clin Nutr. 2006 Jan;83(1):174
PubMed ID
12936933 View in PubMed
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Relation of estrogen receptor-alpha gene polymorphism and hormone replacement therapy to fall risk and muscle strength in early postmenopausal women.

https://arctichealth.org/en/permalink/ahliterature190174
Source
Ann Med. 2002;34(1):64-72
Publication Type
Article
Date
2002
Author
Timo Salmén
Anna-Mari Heikkinen
Anitta Mahonen
Heikki Kröger
Marja Komulainen
Seppo Saarikoski
Risto Honkanen
Juhani Partanen
Pekka H Mäenpää
Author Affiliation
Department of Biochemistry, University of Kuopio, Finland.
Source
Ann Med. 2002;34(1):64-72
Date
2002
Language
English
Publication Type
Article
Keywords
Accidental Falls - prevention & control
Age Factors
Aged
Bone Density - genetics - physiology
Densitometry
Female
Finland
Fractures, Spontaneous - epidemiology - genetics
Hand Strength - physiology
Hormone Replacement Therapy - methods
Humans
Middle Aged
Osteoporosis, Postmenopausal - diagnosis - drug therapy - genetics
Polymorphism, Genetic
Probability
Receptors, Estrogen - analysis - genetics
Reference Values
Risk assessment
Risk factors
Sensitivity and specificity
Abstract
Several factors may increase fracture risk, among them reduced bone mineral density (BMD), increased bone resorption, microarchitectural deterioration of bone, increased fall risk, and decreased muscle strength. We have previously reported that PvuII polymorphism of the estrogen receptor-alpha (ER alpha) gene is associated with bone loss rate, fracture risk, and response to hormone replacement therapy (HRT) in early postmenopausal Finnish women.
We studied the influence of the ER alpha genotype on fall risk and muscle strength in a 5-year randomized HRT trial of 331 early postmenopausal women (subgroup of the population-based OSTPRE study, Kuopio, Finland). A 5-year postal inquiry in May 1994 included questions on falls during the previous 12 months. Grip strength was measured with dynamometer. The ER alpha gene polymorphism was analysed using PCR and PvuII restriction enzyme digestion. RESULTS. In all, 97 out of the 331 women reported falls. Half of those (56%) were slip falls, mostly during the winter season. In the HRT group, the ER alpha genotype was associated with fall risk (P = 0.002, logistic regression). The risk of falls (RR) was higher in women with the PP genotype than in those with the Pp (RR = 5.26, 95% CI 1.98-13.94, P = 0.001) or the pp (RR = 3.84, 95% CI 1.46-10.12, P = 0.007) genotype. When the falls were divided into slip (environment-related) and non-slip (endogenous) falls, the non-slip falls were associated with the genotype (P = 0.004), but the slip falls were not so clearly (P = 0.061). When all falls and non-slip falls were adjusted to the number of chronic health disorders and the variable time-since-menopause, the difference between the genotypes persisted (P = 0.003 and P = 0.010, respectively). In the non-HRT group, the ER alpha genotype was not associated with fall risk. The baseline or the 5-year grip strength values were not influenced by the ER alpha genotype. In conclusion, ER alpha polymorphism is associated with fall risk, especially with non-slip falls, in early postmenopausal Finnish women during the HRT. We have previously reported that, during HRT, women with the P allele have decreased fracture risk and that they may preferentially derive benefit from the positive effect of HRT on BMD. This suggests that the influence of ER alpha polymorphism may depend on the target tissue (bone versus the nervous system).
In these early postmenopausal, non-osteoporotic and relatively healthy women, the increased fall risk associated with the PP genotype was not associated with increased fracture risk, possibly due to improved bone strength during the HRT although falls generally predispose to fractures.
PubMed ID
12014437 View in PubMed
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Relation of PvuII site polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls.

https://arctichealth.org/en/permalink/ahliterature184882
Source
Physiol Genomics. 2003 Aug 15;14(3):217-24
Publication Type
Article
Date
Aug-15-2003
Author
Miia Suuriniemi
Anitta Mahonen
Vuokko Kovanen
Markku Alén
Sulin Cheng
Author Affiliation
Department of Cell Biology, University of Jyväskylä, Finland.
Source
Physiol Genomics. 2003 Aug 15;14(3):217-24
Date
Aug-15-2003
Language
English
Publication Type
Article
Keywords
Binding Sites - genetics
Bone Density - genetics
Bone Remodeling - genetics
Child
Collagen - genetics
Collagen Type I
Deoxyribonucleases, Type II Site-Specific - genetics
Female
Finland - epidemiology
Fractures, Bone - epidemiology - genetics
Genetic Predisposition to Disease - genetics
Humans
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide
Puberty - genetics
Retrospective Studies
Risk factors
Abstract
Genetic susceptibility to fractures may be detectable in early childhood. We evaluated the associations between the polymorphic PvuII site of the COL1A2 gene and bone properties assessed by different modalities (dual-energy X-ray absorptiometry; peripheral quantitative computed tomography; gel coupling scanning quantitative ultrasonometry; ultrasound bone sonometry), bone turnover markers, and the occurrence of fractures in 244 prepubertal Finnish girls. Tanner stage and physical characteristics did not differ significantly among girls with different COL1A2 genotypes. The polymorphism was not significantly associated with different bone properties or any of the bone turnover markers when girls at Tanner stage I (prepuberty) and stage II (early puberty) were considered together, but there was a significant association with spine bone mineral content (BMC) and bone mineral density (BMD), as well as with speed of sound (SOS) (P
PubMed ID
12813128 View in PubMed
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Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children.

https://arctichealth.org/en/permalink/ahliterature297403
Source
J Clin Endocrinol Metab. 2018 07 01; 103(7):2670-2679
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
07-01-2018
Author
Sonja Soininen
Aino-Maija Eloranta
Anna Viitasalo
Geneviève Dion
Arja Erkkilä
Virpi Sidoroff
Virpi Lindi
Anitta Mahonen
Timo A Lakka
Author Affiliation
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Source
J Clin Endocrinol Metab. 2018 07 01; 103(7):2670-2679
Date
07-01-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adiposity
Child
Cholestanetriol 26-Monooxygenase - blood
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cross-Sectional Studies
Cytochrome P450 Family 2 - blood
Exercise
Female
Finland
Genetic Variation
Humans
Lipids - blood
Male
Sedentary Behavior
Triglycerides - blood
Vitamin D - analogs & derivatives - blood
Vitamin D-Binding Protein - blood
Abstract
The associations of serum 25-hydroxyvitamin D [25(OH)D] with plasma lipids remain controversial in children.
To examine the associations and interactions of 25(OH)D and related gene variants with lipids in children.
Cross-sectional.
Kuopio, Finland.
Population sample of 419 prepubertal white children aged 6 to 8 years.
25(OH)D, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides.
Serum 25(OH)D was negatively associated with total cholesterol (ß = -0.141, P = 0.004), LDL cholesterol (ß = -0.112, P = 0.023), HDL cholesterol (ß = -0.150, P = 0.002), and triglycerides (ß = -0.104, P = 0.035) adjusted for age and sex. Associations of 25(OH)D with total cholesterol, LDL cholesterol, and HDL cholesterol remained after adjustment for adiposity, physical activity, sedentary behavior, diet, daylight time, and parental education. Children in the highest quartile of 25(OH)D had the lowest total cholesterol (P = 0.022) and LDL cholesterol (P = 0.026) adjusted for age and sex. Cytochrome P450 family 2 subfamily R member 1 (CYP2R1) rs12794714, CYP2R1 rs10741657, and vitamin D binding protein (DBP) rs2282679 were associated with 25(OH)D adjusted for age and sex. CYP2R1 rs12794714 was associated with total cholesterol and LDL cholesterol and C10orf88 rs6599638 with HDL cholesterol adjusted for age, sex, and 25(OH)D. The gene variants did not explain or modify the associations of 25(OH)D with lipids.
25(OH)D was independently and inversely associated with total cholesterol, LDL cholesterol, and HDL cholesterol. CYP2R1 rs12794714, CYP2R1 rs10741657, and DBP rs2282679 were associated with 25(OH)D. CYP2R1 rs12794714 was associated with total cholesterol and LDL cholesterol and chromosome 10 open reading frame 88 (C10orf88) rs6599638 with HDL cholesterol independent of 25(OH)D. None of the gene variants modified the associations of 25(OH)D with lipids. Further studies are needed to detect the mechanisms for the associations of 25(OH)D with lipids.
PubMed ID
29750416 View in PubMed
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6 records – page 1 of 1.