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Trace elements in early phase type 2 diabetes mellitus-A population-based study. The HUNT study in Norway.

https://arctichealth.org/en/permalink/ahliterature283515
Source
J Trace Elem Med Biol. 2017 Mar;40:46-53
Publication Type
Article
Date
Mar-2017
Author
Ailin Falkmo Hansen
Anica Simic
Bjørn Olav Åsvold
Pål Richard Romundstad
Kristian Midthjell
Tore Syversen
Trond Peder Flaten
Source
J Trace Elem Med Biol. 2017 Mar;40:46-53
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Aged
Diabetes Mellitus, Type 2 - blood - epidemiology
Female
Humans
Male
Middle Aged
Norway - epidemiology
Trace Elements - blood
Abstract
Differences in trace elements levels between individuals with type 2 diabetes and controls have been reported in several studies in various body fluids and tissues, but results have been inconsistent. In order to examine trace element levels in the early phase of type 2 diabetes, we investigated the association between whole blood levels of 26 trace elements and the prevalence of previously undiagnosed, screening-detected type 2 diabetes. The study was conducted as a case-control study nested within the third survey of the population-based Nord-Trøndelag Health Study (HUNT3 Survey). Among participants without previously known diabetes, 128 cases of type 2 diabetes were diagnosed in people with a high diabetes risk score (FINDRISC=15), and frequency-matched for age and sex with 755 controls. Blood samples were analyzed by high resolution inductively coupled plasma mass spectrometry. Associations between trace element levels and the prevalence of previously undiagnosed type 2 diabetes were evaluated with multivariable conditional logistic regression controlling for age, sex, body mass index, waist-to-hip ratio, education, income, smoking and family history of diabetes. The prevalence of previously undiagnosed type 2 diabetes increased across tertiles/quartiles for cadmium, chromium, iron, nickel, silver and zinc, and decreased with increasing quartiles of bromine (Ptrend
PubMed ID
28159221 View in PubMed
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Trace element status in patients with type 2 diabetes in Norway: The HUNT3 Survey.

https://arctichealth.org/en/permalink/ahliterature283467
Source
J Trace Elem Med Biol. 2017 May;41:91-98
Publication Type
Article
Date
May-2017
Author
Anica Simic
Ailin Falkmo Hansen
Bjørn Olav Åsvold
Pål Richard Romundstad
Kristian Midthjell
Tore Syversen
Trond Peder Flaten
Source
J Trace Elem Med Biol. 2017 May;41:91-98
Date
May-2017
Language
English
Publication Type
Article
Keywords
Aged
Diabetes Mellitus, Type 2 - blood - diagnosis - epidemiology
Female
Health Surveys
Humans
Male
Middle Aged
Norway - epidemiology
Trace Elements - blood
Abstract
Several epidemiological studies have indicated that a number of trace elements may play a role in type 2 diabetes (T2D). We investigated the association between prevalent T2D and the concentrations of 25 trace elements in whole blood, and the relationships between T2D duration and blood levels of the trace elements that we found to be related to T2D prevalence. In this population based case-control study, 267 patients with self-reported T2D and 609 controls (frequency matched), were selected from the third Nord-Trøndelag Health Survey. Trace element blood levels were determined by high resolution inductively coupled plasma-mass spectrometry. Multivariable conditional logistic regression and multivariable linear regression were used to estimate associations. The prevalence of T2D was positively associated with boron, calcium and silver, and inversely associated with indium, lead and magnesium (Ptrend
PubMed ID
28347468 View in PubMed
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