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Antidiabetic effects of Justicia spicigera Schltdl (Acanthaceae).

https://arctichealth.org/en/permalink/ahliterature122422
Source
J Ethnopharmacol. 2012 Sep 28;143(2):455-62
Publication Type
Article
Date
Sep-28-2012
Author
Rolffy Ortiz-Andrade
Angel Cabañas-Wuan
Víctor E Arana-Argáez
Angel Josabad Alonso-Castro
Rocio Zapata-Bustos
Luis A Salazar-Olivo
Fabiola Domínguez
Marco Chávez
Candy Carranza-Álvarez
Alejandro García-Carrancá
Author Affiliation
Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México. rolffy@uady.mx
Source
J Ethnopharmacol. 2012 Sep 28;143(2):455-62
Date
Sep-28-2012
Language
English
Publication Type
Article
Keywords
3T3 Cells
4-Chloro-7-nitrobenzofurazan - analogs & derivatives - metabolism
Acanthaceae
Adipocytes - drug effects - metabolism
Animals
Antioxidants - pharmacology - therapeutic use
Benzothiazoles - metabolism
Cell Survival - drug effects
Cells, Cultured
Deoxyglucose - analogs & derivatives - metabolism
Diabetes Mellitus, Experimental - drug therapy - metabolism
Ethanol - chemistry
Glucose - metabolism
Glucose Tolerance Test
Humans
Hypoglycemic Agents - pharmacology - therapeutic use
Kaempferols - analysis
Male
Mice
Phytotherapy
Plant Extracts - pharmacology - therapeutic use
Plant Leaves
Rats
Rats, Wistar
Solvents - chemistry
Sulfonic Acids - metabolism
Abstract
Justicia spicigera is a plant species used for the Teenak (Huesteca Potosina) and Mayan (Yucatan peninsula) indigenous for the empirical treatment of diabetes, infections and as stimulant.
To evaluate the cytotoxicity, antioxidant and antidiabetic properties of J. spicigera.
The effects of ethanolic extracts of J. spicigera (JSE) on the glucose uptake in insulin-sensitive and insulin-resistant murine 3T3-F442A and human subcutaneous adipocytes was evaluated. The antioxidant activities of the extract of JSE was determined by ABTS and DPPH methods. Additionally, it was evaluated the antidiabetic properties of JSE on T2DM model.
JSE stimulated 2-NBDG uptake by insulin-sensitive and insulin-resistant human and murine adipocytes in a concentration-dependent manner with higher potency than rosiglitazone 1mM. JSE showed antioxidant effects in vitro and induced glucose lowering effects in normoglycemic and STZ-induced diabetic rats.
The antidiabetic effects of administration of J. spicigera are related to the stimulation of glucose uptake in both insulin-sensitive and insulin-resistant murine and human adipocytes and this evidence justify its empirical use in Traditional Medicine. In addition, J. spicigera exerts glucose lowering effects in normoglycemic and STZ-induced diabetic rats.
PubMed ID
22819688 View in PubMed
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