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Alcohol consumption among patients with diabetes: a survey-based cross-sectional study of Danish adults with diabetes.

https://arctichealth.org/en/permalink/ahliterature280674
Source
Scand J Public Health. 2016 Jul;44(5):517-24
Publication Type
Article
Date
Jul-2016
Author
Mathilde L Jakobsen
Julie R Larsen
Charlotte Glümer
Knud Juel
Ola Ekholm
Tina Vilsbøll
Ulrik Becker
Anders Fink-Jensen
Source
Scand J Public Health. 2016 Jul;44(5):517-24
Date
Jul-2016
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alcohol drinking - epidemiology
Comorbidity
Cross-Sectional Studies
Denmark - epidemiology
Diabetes Mellitus - epidemiology - therapy
Female
Health Surveys
Humans
Male
Middle Aged
Sex Distribution
Abstract
To estimate alcohol consumption among Danish adults with diabetes and to investigate whether certain comorbidities are related to a high alcohol intake.
A total of 162,283 participants responded to the Danish National Health Survey 2013 (questionnaire study, response rate 54.0%). Variables on the participants were extracted from the survey and 6.5% of respondents reported having diabetes. High alcohol consumption was defined as >21 (men) or >14 (women) standard drinks per week.
High alcohol consumption was reported by 11.2 % of men and 4.3% of women with diabetes. In the women, this was fewer than among women without diabetes (odds ratio (OR) 0.65, 95% confidence interval (CI) 0.56-0.77, p
PubMed ID
27113964 View in PubMed
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Antipsychotic polypharmacy and risk of death from natural causes in patients with schizophrenia: a population-based nested case-control study.

https://arctichealth.org/en/permalink/ahliterature98770
Source
J Clin Psychiatry. 2010 Feb;71(2):103-8
Publication Type
Article
Date
Feb-2010
Author
Lone Baandrup
Christiane Gasse
Vibeke D Jensen
Birte Y Glenthoj
Merete Nordentoft
Henrik Lublin
Anders Fink-Jensen
Anne Lindhardt
Preben B Mortensen
Author Affiliation
Centre for Neuropsychiatric Schizophrenia Research, Psychiatric Centre Glostrup, Copenhagen University Hospital, Glostrup, Nordre Ringvej 29-67, DK-2600 Glostrup, Denmark. lone.baandrup@cnsr.dk
Source
J Clin Psychiatry. 2010 Feb;71(2):103-8
Date
Feb-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Antipsychotic Agents - administration & dosage - adverse effects
Benzodiazepines - adverse effects
Case-Control Studies
Cause of Death - trends
Denmark
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Odds Ratio
Risk factors
Schizophrenia - drug therapy - mortality
Abstract
OBJECTIVE: Concomitant prescription of more than 1 antipsychotic agent (antipsychotic polypharmacy) in the treatment of schizophrenia is prevalent, although monotherapy is generally recommended. Mortality from natural causes is markedly increased in schizophrenia, and the role of polypharmacy remains controversial. The objective was to investigate if antipsychotic polypharmacy is associated with the excess mortality from natural causes among patients with schizophrenia. METHOD: A population-based nested case-control study was conducted using patient data from January 1, 1996, to December 31, 2005, obtained from central Danish registers. From the study population of 27,633 patients with ICD-8- and ICD-10-diagnosed schizophrenia or other mainly nonaffective psychoses, aged 18-53 years, we identified 193 cases who died of natural causes within a 2-year period and 1,937 age- and sex-matched controls. Current drug use was defined as at least 1 prescription filled within 90 days before the date of death or the index date. The data were analyzed by conditional logistic regression. RESULTS: Risk of natural death did not increase with the number of concurrently used antipsychotic agents compared with antipsychotic monotherapy (no antipsychotics: adjusted odds ratio [OR] = 1.48 [95% CI, 0.89-2.46]; 2 antipsychotics: OR = 0.91 [95% CI, 0.61-1.36]; 3 or more antipsychotics: OR = 1.16 [95% CI, 0.68-2.00]). Current use of benzodiazepine derivatives with long elimination half-lives (more than 24 hours) was associated with increased risk of natural death in patients with schizophrenia treated with antipsychotics (OR = 1.78 [95% CI, 1.25-2.52]). CONCLUSIONS: Antipsychotic polypharmacy did not contribute to the excess mortality from natural causes in middle-aged patients with schizophrenia. The detected increased risk of death associated with benzodiazepines with long elimination half-lives calls for further clarification.
PubMed ID
19895781 View in PubMed
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Source
Ugeskr Laeger. 2009 Mar 23;171(13):1082
Publication Type
Article
Date
Mar-23-2009
Author
Anders Fink-Jensen
Marianne Kastrup
Author Affiliation
Psykiatrisk Center Rigshospitalet, Psykiatrien i Region Hovedstaden. a.fink-jensen@dadlnet.dk
Source
Ugeskr Laeger. 2009 Mar 23;171(13):1082
Date
Mar-23-2009
Language
Danish
Publication Type
Article
Keywords
Denmark
Humans
Mental Disorders - diagnosis - therapy
Mental Health Services - trends
Psychiatry - trends
PubMed ID
19321077 View in PubMed
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Source
Ugeskr Laeger. 2008 Apr 21;170(17):1458-60
Publication Type
Article
Date
Apr-21-2008
Author
Jeanett Bauer
Anders Fink-Jensen
Author Affiliation
Rigshospitalet, Psykiatrisk Center, København Ø. jeanett.bauer@mail.dk
Source
Ugeskr Laeger. 2008 Apr 21;170(17):1458-60
Date
Apr-21-2008
Language
Danish
Publication Type
Article
Keywords
Commitment of Mentally Ill - legislation & jurisprudence
Denmark
Humans
Patient Admission - legislation & jurisprudence
Psychotic Disorders - diagnosis - therapy
PubMed ID
18462625 View in PubMed
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Neurological, Metabolic, and Psychiatric Adverse Events in Children and Adolescents Treated With Aripiprazole.

https://arctichealth.org/en/permalink/ahliterature282307
Source
J Clin Psychopharmacol. 2016 Oct;36(5):496-9
Publication Type
Article
Date
Oct-2016
Author
Klaus Damgaard Jakobsen
Christina Hedegaard Bruhn
Anne-Katrine Pagsberg
Anders Fink-Jensen
Jimmi Nielsen
Source
J Clin Psychopharmacol. 2016 Oct;36(5):496-9
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Antipsychotic Agents - adverse effects
Aripiprazole - adverse effects
Attention Deficit Disorder with Hyperactivity - drug therapy
Autism Spectrum Disorder - drug therapy
Child
Child, Preschool
Databases, Factual
Denmark
Drug-Related Side Effects and Adverse Reactions - physiopathology
Female
Humans
Male
Neurodevelopmental Disorders - drug therapy
Obsessive-Compulsive Disorder - drug therapy
Psychotic Disorders - drug therapy
Schizophrenia - drug therapy
Tourette Syndrome - drug therapy
Abstract
Aripiprazole is a partial dopamine agonist with only minor neurological and psychiatric adverse effects, making it a potential first-line drug for the treatment of psychiatric disorders. However, the evidence of its use in children and adolescents is rather sparse. The aim of this case study is to discuss adverse drug reaction (ADR) reports concerning aripiprazole-associated neurological and psychiatric events in children and adolescents. The ADR report database at Danish Medicines Agency was searched for all ADRs involving children and adolescents (
PubMed ID
27504593 View in PubMed
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No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample.

https://arctichealth.org/en/permalink/ahliterature170659
Source
Schizophr Res. 2006 Mar;83(1):1-5
Publication Type
Article
Date
Mar-2006
Author
Andrés Ingason
Karen Søeby
Sally Timm
August G Wang
Klaus D Jakobsen
Anders Fink-Jensen
Ralf Hemmingsen
Henrik Berg Rasmussen
Thomas Werge
Author Affiliation
Research Institute of Biological Psychiatry, Copenhagen University Hospital, H:S Sct. Hans Hospital, DK-4000 Roskilde, Denmark.
Source
Schizophr Res. 2006 Mar;83(1):1-5
Date
Mar-2006
Language
English
Publication Type
Article
Keywords
Case-Control Studies
Denmark
European Continental Ancestry Group - genetics
Genetic Predisposition to Disease - ethnology - genetics
Haplotypes
Humans
Nerve Tissue Proteins - genetics
Neuregulin-1
Polymorphism, Single Nucleotide
Schizophrenia - ethnology - genetics
Abstract
Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.
PubMed ID
16483744 View in PubMed
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Prevalence of the metabolic syndrome in Danish psychiatric outpatients treated with antipsychotics.

https://arctichealth.org/en/permalink/ahliterature135953
Source
Nord J Psychiatry. 2011 Oct;65(5):345-52
Publication Type
Article
Date
Oct-2011
Author
Karoline Krane-Gartiser
Leif Breum
Charlotte Glümrr
Allan Linneberg
Maiken Madsen
Anne Køster
Peter W Jepsen
Anders Fink-Jensen
Author Affiliation
Psychiatric Centre Copenhagen, University of Copenhagen, Denmark.
Source
Nord J Psychiatry. 2011 Oct;65(5):345-52
Date
Oct-2011
Language
English
Publication Type
Article
Keywords
Adult
Antipsychotic Agents - adverse effects - therapeutic use
Case-Control Studies
Cross-Sectional Studies
Denmark - epidemiology
Diabetes Mellitus - chemically induced - drug therapy - epidemiology
Female
Humans
Incidence
Lipoproteins, HDL - therapeutic use
Male
Metabolic Syndrome X - chemically induced - drug therapy - epidemiology
Middle Aged
Outpatients
Prevalence
Risk factors
Schizophrenia - chemically induced - drug therapy - epidemiology
Triglycerides - therapeutic use
Abstract
The incidence of the metabolic syndrome, a major risk factor for diabetes and cardiovascular disease, is increasing worldwide and is suggested to be higher among psychiatric patients, especially those on antipsychotic treatment.
To assess the prevalence of the metabolic syndrome in Danish psychiatric outpatients and compare it with the general population.
In a cross-sectional, observational study in 2007-08, 170 Danish outpatients on antipsychotic drug treatment were monitored for the prevalence of the metabolic syndrome based on the International Diabetes Federation (IDF) definition and compared with a general population group of 3303 randomly selected Danes.
Of the antipsychotic-treated patients 48.2% fulfilled the IDF criteria for the metabolic syndrome, compared with 29.6% of the general population. The antipsychotic-treated patients had higher rates of increased waist circumference, triglyceride and glucose levels, and lower high-density lipoprotein cholesterol. Compared with the general population, the odds ratio (OR) of the metabolic syndrome among antipsychotic-treated patients was 2.2. After adjustment for age and sex, the OR increased to 2.7. In the antipsychotic-treated group, statistically different rates of the metabolic syndrome for patients in monopharmacy vs. polypharmacy, and for patients in monotherapy with first-generation vs. second-generation antipsychotics, could not be found.
The metabolic syndrome is highly prevalent among a Danish outpatient population treated with antipsychotics compared with the general population. Monitoring of lipid and glucose levels, blood pressure and waist circumference before start-up and during treatment with antipsychotic medication is of pivotal importance in order to prevent diabetes and cardiovascular disease in this patient population.
PubMed ID
21428861 View in PubMed
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Psychopharmacologic treatment and blood transfusion in fast-track total hip and knee arthroplasty.

https://arctichealth.org/en/permalink/ahliterature283526
Source
Transfusion. 2017 Apr;57(4):971-976
Publication Type
Article
Date
Apr-2017
Author
Silas Hinsch Gylvin
Christoffer Calov Jørgensen
Anders Fink-Jensen
Pär I Johansson
Henrik Kehlet
Source
Transfusion. 2017 Apr;57(4):971-976
Date
Apr-2017
Language
English
Publication Type
Article
Keywords
Aged
Arthroplasty, Replacement, Hip
Arthroplasty, Replacement, Knee
Blood Platelets
Blood Transfusion
Databases, Factual
Denmark
Hemorrhage - blood - etiology - prevention & control
Humans
Intraoperative Care
Postoperative Care
Prospective Studies
Risk factors
Serotonin Uptake Inhibitors - administration & dosage - adverse effects
Abstract
Selective serotonin reuptake inhibitors (SSRIs) and other psychotropics are receiving increasing attention due to reports on inhibition of thrombocyte function and an increased bleeding risk in surgical settings. Studies in total hip and total knee arthroplasty (THA and TKA, respectively) have shown conflicting results, questioning whether the potential increased bleeding risk is of clinical importance.
Prospective consecutive collection of data on preoperative comorbidity in patients undergoing primary unilateral THA or TKA was cross-referenced with regional transfusion databases and The Danish National Database of Reimbursed Prescriptions for information regarding blood transfusions and psychopharmacologic treatment. All participating orthopedic centers followed similar perioperative guidelines. Multiple logistic regression analysis was applied to calculate odds ratios (ORs) for transfusion between preoperative users and nonusers of psychotropics.
Of 8402 patients, 569 (6.8%) were SSRI users versus 7833 (93.2%) nonusers. A total of 109 (19,2%) patients in the SSRI group and 700 (8.9%) in the "no-SSRI" group received blood intra- or postoperatively. Preoperative SSRI treatment was a risk factor for perioperative transfusion (OR, 1.98; 95% confidence interval [CI], 1.44-2.70). Other antidepressants (OAs) were associated with an increased risk of transfusion (OR, 1.69; 95% CI, 1.17-2.44) as well as the combination of SSRIs and OAs (OR, 3.31; 95% CI, 1.79-6.13). Singular use of antipsychotics (APs) increased the transfusion risk (OR, 2.37; 95% CI, 1.04-2.41), while AP medicine in combination with antidepressants did not.
Preoperative treatment with SSRIs, OAs, or APs are independent risk factors for blood transfusion in elective fast-track THA and TKA.
PubMed ID
28145024 View in PubMed
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14 records – page 1 of 2.