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TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system.

https://arctichealth.org/en/permalink/ahliterature167548
Source
Virchows Arch. 2006 Oct;449(4):395-401
Publication Type
Conference/Meeting Material
Article
Date
Oct-2006
Author
G. Rindi
G. Klöppel
H. Alhman
M. Caplin
A. Couvelard
W W de Herder
B. Erikssson
A. Falchetti
M. Falconi
P. Komminoth
M. Körner
J M Lopes
A-M McNicol
O. Nilsson
A. Perren
A. Scarpa
J-Y Scoazec
B. Wiedenmann
Author Affiliation
Dipartimento di Patologia e, Medicina di Laboratorio, Sezione di Anatomia Patologica, Università di Parma, Via Gramsci, 14, 43100, Parma, Italy, and Department of Internal Medicine, Royal Free Hospital, London, UK. guido.rindi@unipr.it
Source
Virchows Arch. 2006 Oct;449(4):395-401
Date
Oct-2006
Language
English
Publication Type
Conference/Meeting Material
Article
Keywords
Digestive System Neoplasms - chemistry - classification - diagnosis
Humans
Lymph Nodes - chemistry - pathology
Mitotic Index
Neoplasm Metastasis - diagnosis
Neoplasm Staging - methods - standards
Neuroendocrine Tumors - chemistry - classification - diagnosis
Tumor Markers, Biological - analysis
Abstract
The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.
Notes
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PubMed ID
16967267 View in PubMed
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TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system.

https://arctichealth.org/en/permalink/ahliterature162101
Source
Virchows Arch. 2007 Oct;451(4):757-62
Publication Type
Conference/Meeting Material
Article
Date
Oct-2007
Author
G. Rindi
G. Klöppel
A. Couvelard
P. Komminoth
M. Körner
J M Lopes
A-M McNicol
O. Nilsson
A. Perren
A. Scarpa
J-Y Scoazec
B. Wiedenmann
Author Affiliation
Department of Pathology, University of Parma, Parma, Italy. guido.rindi@unipr.it
Source
Virchows Arch. 2007 Oct;451(4):757-62
Date
Oct-2007
Language
English
Publication Type
Conference/Meeting Material
Article
Keywords
Appendiceal Neoplasms - diagnosis - pathology
Carcinoma, Neuroendocrine - diagnosis - pathology
Cell Proliferation
Colonic Neoplasms - diagnosis - pathology
Europe
Guidelines as Topic
Humans
Ileal Neoplasms - diagnosis - pathology
Lymph Nodes - pathology
Lymphatic Metastasis
Neoplasm Staging - methods
Rectal Neoplasms - diagnosis - pathology
Abstract
Criteria for the staging and grading of neuroendocrine tumors (NETs) of midgut and hindgut origin were established at the second Consensus Conference in Frascati (Rome) organized by the European Neuroendocrine Tumor Society (ENETS). The proposed tumor-node-metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow our previous proposal for foregut tumors. The new TNM classifications for NETs of the ileum, appendix, colon, and rectum, and the grading system were designed, discussed, and consensually approved by all conference participants. These proposals need to be validated and are meant to help clinicians in the stratification, treatment and follow-up of patients.
PubMed ID
17674042 View in PubMed
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TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study.

https://arctichealth.org/en/permalink/ahliterature125020
Source
J Natl Cancer Inst. 2012 May 16;104(10):764-77
Publication Type
Article
Date
May-16-2012
Author
G. Rindi
M. Falconi
C. Klersy
L. Albarello
L. Boninsegna
M W Buchler
C. Capella
M. Caplin
A. Couvelard
C. Doglioni
G. Delle Fave
L. Fischer
G. Fusai
W W de Herder
H. Jann
P. Komminoth
R R de Krijger
S. La Rosa
T V Luong
U. Pape
A. Perren
P. Ruszniewski
A. Scarpa
A. Schmitt
E. Solcia
B. Wiedenmann
Author Affiliation
Institute of Anatomic Pathology, Università Cattolica del Sacro Cuore, Histopathology and Cytodiagnosis Unit, Policlinico Gemelli, Largo A. Gemelli, 8, Roma I-00168, Italy. guido.rindi@rm.unicatt.it
Source
J Natl Cancer Inst. 2012 May 16;104(10):764-77
Date
May-16-2012
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Cohort Studies
Confounding Factors (Epidemiology)
Europe - epidemiology
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Neuroendocrine Tumors - epidemiology - mortality - pathology
Observer Variation
Odds Ratio
Pancreatic Neoplasms - epidemiology - mortality - pathology
Predictive value of tests
Proportional Hazards Models
Retrospective Studies
Sex Distribution
United States - epidemiology
Abstract
Both the European Neuroendocrine Tumor Society (ENETS) and the International Union for Cancer Control/American Joint Cancer Committee/World Health Organization (UICC/AJCC/WHO) have proposed TNM staging systems for pancreatic neuroendocrine neoplasms. This study aims to identify the most accurate and useful TNM system for pancreatic neuroendocrine neoplasms.
The study included 1072 patients who had undergone previous surgery for their cancer and for which at least 2 years of follow-up from 1990 to 2007 was available. Data on 28 variables were collected, and the performance of the two TNM staging systems was compared by Cox regression analysis and multivariable analyses. All statistical tests were two-sided.
Differences in distribution of sex and age were observed for the ENETS TNM staging system. At Cox regression analysis, only the ENETS TNM staging system perfectly allocated patients into four statistically significantly different and equally populated risk groups (with stage I as the reference; stage II hazard ratio [HR] of death = 16.23, 95% confidence interval [CI] = 2.14 to 123, P = .007; stage III HR of death = 51.81, 95% CI = 7.11 to 377, P
PubMed ID
22525418 View in PubMed
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