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Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study.

https://arctichealth.org/en/permalink/ahliterature152983
Source
Clin Ther. 2008 Dec;30(12):2298-313
Publication Type
Article
Date
Dec-2008
Author
Jacques Bonnet
R. McPherson
A. Tedgui
D. Simoneau
A. Nozza
P. Martineau
Jean Davignon
Author Affiliation
Hôpital du Haut-Lévèque, Pessac, France.
Source
Clin Ther. 2008 Dec;30(12):2298-313
Date
Dec-2008
Language
English
Publication Type
Article
Keywords
Adult
Anticholesteremic Agents - adverse effects - therapeutic use
C-Reactive Protein - metabolism
Canada
Cholestasis, Intrahepatic - etiology
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Artery Disease - blood - drug therapy
Dose-Response Relationship, Drug
Double-Blind Method
Drug-Induced Liver Injury - etiology
Europe
Female
Heptanoic Acids - adverse effects - therapeutic use
Humans
Male
Prospective Studies
Pyrroles - adverse effects - therapeutic use
Time Factors
Treatment Outcome
Triglycerides - blood
Abstract
The major beneficial effect of statins- reducing the risk for coronary events-has primarily been ascribed to reductions in low-density lipoprotein cholesterol (LDL-C) but may in part be related to a direct antiinflammatory action (ie, decreased high-sensitivity C-reactive protein [hs-CRP] concentration).
The objectives of this CAP (Comparative Atorvastatin Pleiotropic Effects) study were to compare the effects of low- versus high-dose atorvastatin on hs-CRP concentrations and to determine the relationship between changes in LDL-C and hs-CRP concentrations in patients with coronary artery disease (CAD), low-grade inflammation, and normal lipoprotein concentrations.
This multicenter, prospective, randomized, double-blind, double-dummy study was conducted at 65 centers across Canada and Europe. Patients with documented CAD, low-grade inflammation (hs-CRP concentration, 1.5-15.0 mg/L), and a normal-range lipid profile (LDL-C concentration, 1.29-3.87 mmol/L [50-150 mg/dL]; triglyceride [TG] concentration,
PubMed ID
19167589 View in PubMed
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Fibre and nutrient intakes of chronic care elderly patients.

https://arctichealth.org/en/permalink/ahliterature216157
Source
J Nutr Elder. 1995;15(1):13-30
Publication Type
Article
Date
1995
Author
L J McCargar
B L Hotson
A. Nozza
Source
J Nutr Elder. 1995;15(1):13-30
Date
1995
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Chronic Disease
Dietary Fiber
Energy intake
Female
Humans
Inpatients
Male
Manitoba
Nutrition Surveys
Quebec
Abstract
It has been previously suggested that chronic care elderly patients are at increased nutritional risk. However dietary intake studies have not completely supported this statement. To determine usual dietary intakes, 32 elderly patients, mean (+/- SEM) age 84 +/- 1 years, from two hospitals, had 3-day dietary intakes estimated or weighed and analyzed for nutrient composition. The group as a whole had low intakes of dietary fibre but intakes of other nutrients were equal to or greater than the Canadian recommendations. The distribution of macronutrients also met recommended guidelines. In general, this group of elderly patients appeared to be eating well, however, some individuals results suggest nutritional risk.
PubMed ID
8715451 View in PubMed
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