Skip header and navigation

Refine By

4 records – page 1 of 1.

Baseline patterns of adipose tissue fatty acids and long-term risk of breast cancer: a case-cohort study in the Danish cohort Diet, Cancer and Health.

https://arctichealth.org/en/permalink/ahliterature264936
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Publication Type
Article
Date
Oct-2014
Author
J A Schmidt
A. Gorst-Rasmussen
P W Nyström
J H Christensen
E B Schmidt
C. Dethlefsen
A. Tjønneland
K. Overvad
C C Dahm
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology - pathology
Cohort Studies
Denmark - epidemiology
Fatty Acids - analysis
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk
Risk factors
Subcutaneous Fat - chemistry
Abstract
The evidence regarding fatty acids and breast cancer risk is inconclusive. Adipose tissue fatty acids can be used as biomarkers of fatty acid intake and of endogenous fatty acid exposure. Fatty acids in adipose tissue are correlated owing to common dietary sources and shared metabolic pathways, which group fatty acids into naturally occurring patterns. We aimed to prospectively investigate associations between adipose tissue fatty acid patterns and long-term risk of total breast cancer and breast cancer subtypes characterised by oestrogen and progesterone receptor status (ER and PR).
This case-cohort study was based on data from the Danish cohort Diet, Cancer and Health. At baseline, a fat biopsy and information on lifestyle and reproductive factors were collected. From the 31 original fatty acids measured, patterns of fatty acids were identified using the treelet transform. During a median follow-up of 5.3 years, 474 breast cancer cases were identified. Hazard ratios and 95% confidence intervals of risk of total breast cancer and of subtypes according to quintiles of factor score were determined by weighted Cox proportional hazards regression.
After adjustment for potential confounders, factor scores for the seven patterns identified by the treelet transform were not associated with risk of total breast cancer, nor with risk of ER+, ER-, PR+ or PR- tumours.
No clear associations between the patterns of fatty acids at baseline and long-term risk of total breast cancer or ER+, ER-, PR+ or PR- tumours were observed.
PubMed ID
24642780 View in PubMed
Less detail

Blood reinfusion combined with femoral nerve block in total knee replacement for patients with increased risk of bleeding.

https://arctichealth.org/en/permalink/ahliterature134986
Source
J Orthop Surg (Hong Kong). 2011 Apr;19(1):64-8
Publication Type
Article
Date
Apr-2011
Author
O H Simonsen
A. Gorst-Rasmussen
A B Simonsen
M B Jorgensen
Michael Skovdal Rathleff
S. Lundbye-Christensen
Author Affiliation
Orthopaedic Division, North Denmark Region, Aalborg Hospital, Aarhus University, Denmark.
Source
J Orthop Surg (Hong Kong). 2011 Apr;19(1):64-8
Date
Apr-2011
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Arthroplasty, Replacement, Knee - adverse effects
Blood Transfusion, Autologous - methods
Denmark - epidemiology
Female
Femoral Nerve
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Nerve Block - methods
Osteoarthritis, Knee - complications - surgery
Pain Measurement
Pain, Postoperative - epidemiology - prevention & control
Patient satisfaction
Postoperative Hemorrhage - epidemiology - prevention & control
Retrospective Studies
Risk factors
Treatment Outcome
Abstract
To compare patients with increased risk of bleeding who received combined blood reinfusion and femoral nerve block in total knee replacement (TKR) to regular patients treated routinely with respect to pain relief, blood loss, and knee function.
In a consecutive series of 67 patients who underwent unilateral TKR, 12 patients with increased risk of bleeding owing to cardiac disease or previous thromboembolic events received continuous femoral nerve block and blood reinfusion, without tranexamic acid (TA) injection. The remaining 55 patients were controls who received standard postoperative treatment (TA injection, local injection of analgesics, and suction drainage without reinfusion). The volume of blood loss (drained or reinfused), pain score (using a visual analogue scale) and knee function (using the Knee Society Score [KSS]) in the 2 groups were compared.
In the study group, patients were 5 years older and tended to have a lower preoperative KSS function score (35 vs. 45, p=0.08) and a higher function-related pain score (6.5 vs. 6, p=0.10). The mean volume of drained blood wasted in the study group did not differ significantly from the mean total volume of drained blood in the control group (235 vs. 300 ml, p=0.14). Similarly, the mean decrease in postoperative haemoglobin concentration did not differ significantly between the respective groups (2.1 vs. 2.1 mmol/l, p=0.97). A significantly greater proportion of patients received allogenic blood transfusion in the study group than in controls (3/12 vs. 2/55, p
PubMed ID
21519080 View in PubMed
Less detail

Dabigatran adherence in atrial fibrillation patients during the first year after diagnosis: a nationwide cohort study.

https://arctichealth.org/en/permalink/ahliterature270279
Source
J Thromb Haemost. 2015 Apr;13(4):495-504
Publication Type
Article
Date
Apr-2015
Author
A. Gorst-Rasmussen
F. Skjøth
T B Larsen
L H Rasmussen
G Y H Lip
D A Lane
Source
J Thromb Haemost. 2015 Apr;13(4):495-504
Date
Apr-2015
Language
English
Publication Type
Article
Keywords
Administration, Oral
Aged
Aged, 80 and over
Antithrombins - administration & dosage - adverse effects
Atrial Fibrillation - diagnosis - drug therapy - epidemiology
Cohort Studies
Comorbidity
Dabigatran - administration & dosage - adverse effects
Denmark - epidemiology
Drug Prescriptions
Female
Health Knowledge, Attitudes, Practice
Hemorrhage - chemically induced
Humans
Male
Medication Adherence
Middle Aged
Registries
Risk factors
Stroke - diagnosis - epidemiology - prevention & control
Time Factors
Treatment Outcome
Abstract
There is a perception among physicians that lack of routine monitoring with non-vitamin K antagonist oral anticoagulants (NOACs) may lead to poor adherence to medication. We studied adherence during the first year of usage in a cohort of patients with newly diagnosed non-valvular atrial fibrillation (AF) started on the NOAC, dabigatran etexilate.
Nationwide Danish patient and prescription purchase registries were used to identify newly diagnosed AF patients taking dabigatran, comorbidities, and refill patterns under a twice-daily, one pill regimen. Adherence was characterized among remaining users (N = 2960) after 1 year using the proportion of days covered (PDC), gap rates and restart rates. The overall 1-year PDC was 83.9%, with 76.8% of patients having a 1-year PDC in excess of 80%. Patients with a CHA2 DS2 -VASc score = 2 were more adherent to medication regimes than patients with a CHA2 DS2 -VASc score of 1 (PDC ratio, 1.12; 95% confidence interval [CI], 1.08-1.17) and generally patients with higher morbidity showed more adherence. Patients with prior bleeding were not less adherent to medication regimes than patients with no prior bleeding (PDC ratio, 1.02; 95% CI, 0.98-1.06). The overall gap rate was 1.4 gaps per year. There were no clear tendencies in gap rates among subgroups, although patients with higher morbidity tended to have slightly more, but shorter, gap periods.
More than 75% of patients were showed > 80% adherence to medication regimes during the first year. Patients with higher morbidity, including patients with a higher risk of stroke or bleeding, exhibited better adherence. This improvement may be attributable to more regular contact with the healthcare system.
PubMed ID
25594442 View in PubMed
Less detail

Parity and risk of diabetes in a Danish nationwide birth cohort.

https://arctichealth.org/en/permalink/ahliterature138548
Source
Diabet Med. 2011 Jan;28(1):43-7
Publication Type
Article
Date
Jan-2011
Author
K V Naver
S. Lundbye-Christensen
A. Gorst-Rasmussen
L. Nilas
N J Secher
S. Rasmussen
P. Ovesen
Author Affiliation
Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Hvidovre, Denmark. kvnaver@gmail.com
Source
Diabet Med. 2011 Jan;28(1):43-7
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Adult
Denmark - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Female
Humans
Infant, Newborn
Male
Parity
Pregnancy
Pregnancy in Diabetics - epidemiology
Proportional Hazards Models
Registries - statistics & numerical data
Risk factors
Abstract
The purpose was to elucidate the association between parity and the incidence of diabetes using national register data.
The study population consisted of all Danish women with a singleton delivery in 1982/1983 (n = 100,669), who subsequently had 74,966 deliveries. The included women were followed up via registries until the end of 2006 for subsequent deliveries, diagnosis of diabetes and death/emigration.
A total of 2021 cases (2.0%) were diagnosed with diabetes in connection with hospitalization or outpatient treatment during follow-up. Analyses were adjusted for fetal weight and duration of gestation, both at index pregnancy. Cox regression analysis with parity as a time-varying exposure, stratified in two age groups, showed an association between parity and risk of a diagnosis of diabetes. In women 33 years of age, parity 2 was associated with a significantly lower risk of diabetes diagnosis compared with parity 1, whereas parity 4 + was associated with a significantly higher risk of diabetes diagnosis compared with parity 1.
The study shows that the risk of diabetes diagnosis increases with parity in young Danish women. This may support a causal association between diabetes and parity.
PubMed ID
21166844 View in PubMed
Less detail