Skip header and navigation

Refine By

12 records – page 1 of 2.

2008 Niday Perinatal Database quality audit: report of a quality assurance project.

https://arctichealth.org/en/permalink/ahliterature128969
Source
Chronic Dis Inj Can. 2011 Dec;32(1):32-42
Publication Type
Article
Date
Dec-2011
Author
S. Dunn
J. Bottomley
A. Ali
M. Walker
Author Affiliation
Better Outcomes Registry and Network (BORN Ontario), Ottawa, Ontario, Canada. sadunn@ohri.ca
Source
Chronic Dis Inj Can. 2011 Dec;32(1):32-42
Date
Dec-2011
Language
English
Publication Type
Article
Keywords
Canada
Data Collection - standards
Databases, Factual - standards
Humans
Medical Records
Perinatal care
Quality Control
Abstract
This quality assurance project was designed to determine the reliability, completeness and comprehensiveness of the data entered into Niday Perinatal Database.
Quality of the data was measured by comparing data re-abstracted from the patient record to the original data entered into the Niday Perinatal Database. A representative sample of hospitals in Ontario was selected and a random sample of 100 linked mother and newborn charts were audited for each site. A subset of 33 variables (representing 96 data fields) from the Niday dataset was chosen for re-abstraction.
Of the data fields for which Cohen's kappa statistic or intraclass correlation coefficient (ICC) was calculated, 44% showed substantial or almost perfect agreement (beyond chance). However, about 17% showed less than 95% agreement and a kappa or ICC value of less than 60% indicating only slight, fair or moderate agreement (beyond chance).
Recommendations to improve the quality of these data fields are presented.
PubMed ID
22153174 View in PubMed
Less detail

The Finnish founder mutation c.70 A>G in RMRP causes cartilage-hair hypoplasia in a Pakistani family.

https://arctichealth.org/en/permalink/ahliterature294744
Source
Clin Dysmorphol. 2017 Apr; 26(2):121-123
Publication Type
Case Reports
Journal Article
Date
Apr-2017

Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells.

https://arctichealth.org/en/permalink/ahliterature47904
Source
Transplantation. 2000 Jan 27;69(2):221-6
Publication Type
Article
Date
Jan-27-2000
Author
A. Ali
M. Garrovillo
M X Jin
M A Hardy
S F Oluwole
Author Affiliation
Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
Source
Transplantation. 2000 Jan 27;69(2):221-6
Date
Jan-27-2000
Language
English
Publication Type
Article
Keywords
Animals
Antibody Affinity
Dendritic Cells - immunology
Epitopes
Graft Survival
Heart Transplantation
Histocompatibility Antigens Class I
Immune Tolerance
Islets of Langerhans - cytology
Islets of Langerhans Transplantation - immunology
Lymphocyte Culture Test, Mixed
Rats
Rats, Inbred ACI
Rats, Inbred BN
Rats, Inbred WF
Research Support, U.S. Gov't, P.H.S.
Thymus Gland - immunology
Abstract
BACKGROUND: As T-cell receptor-major histocompatibility complex (MHC) class I/self peptide interaction regulates T-cell development in the thymus, we reasoned that presentation of peptides by self dendritic cells (DC) to developing T cells in the thymus might induce acquired thymic tolerance. This hypothesis is based on the finding that intrathymic injection of allopeptides in the adult animal induces acquired tolerance. To examine this hypothesis, we studied the effects of intrathymic (IT) injection of a single immunodominant Wistar-Furth (WF) MHC class I (RT1.Au) peptide-pulsed host DC on islet allograft survival in the WF-to-ACI rat combination. METHODS: Bone marrow-derived ACI DC expressing MHC class I and II, OX62, and ED2 present allopeptides to naive and specifically peptide-primed syngeneic T cells in mixed lymphocyte reaction. Host DC pulsed with RT1.Au peptide 5 (residues 93-109) were injected into the thymus of streptozotocin-induced diabetic ACI that were transplanted 7 days later with donor-type (WF) or third-party (Brown Norway [BN]) islets. RESULTS: Whereas IT injection of 300 microg of peptide 5 alone led to normoglycemia and permanent islet survival in three of six diabetic ACI recipients, similar treatment combined with simultaneous intraperitoneal injection of 0.5 ml of anti-lymphocyte serum (ALS) on day -7 led to 100% permanent islet allograft survival (>200 days) compared to a mean survival time of 15.0+/-2.3 days in controls treated with ALS alone. In contrast, similarly prepared animals rejected the third-party (BN) islets in an acute fashion. To address the question of indirect allorecognition in acquired thymic tolerance, we examined the effect of peptide-pulsed host DC on graft survival. Whereas IT injection of peptide-pulsed host DC alone resulted in permanent islet survival in two of five animals, IT injection of peptide-pulsed host DC combined with 0.5 ml of ALS induced 100% donor-specific permanent islet allograft survival in the WF-to-ACI rat combination. These results suggest that thymic DC take up, process, and present the administered peptide to the developing T cells by the indirect allorecognition pathway in the induction of acquired thymic tolerance. CONCLUSION: We have demonstrated a novel approach to inducing transplant tolerance to islet allografts with IT injection of allopeptide-pulsed host DC. This finding suggests that immunization strategies using DC expressing MHC allopeptides or peptide analogue might be potentially useful in the treatment of autoimmune diabetes mellitus.
PubMed ID
10670630 View in PubMed
Less detail

A new case of the unstable haemoglobin Genova (alpha 2 beta 2 28 (beta 10) leu leads to pro) in Canada: as a result of sporadic mutation and causing Heinz body haemolytic anaemia.

https://arctichealth.org/en/permalink/ahliterature246435
Source
Acta Haematol. 1980;63(4):222-5
Publication Type
Article
Date
1980
Author
S C Wong
M A Ali
M. Pai
R D Barr
Source
Acta Haematol. 1980;63(4):222-5
Date
1980
Language
English
Publication Type
Article
Keywords
Amino Acids - blood
Anemia, Hemolytic, Congenital - etiology
Blood Group Antigens
Canada
Child, Preschool
Heinz Bodies
Hemoglobins - genetics
Hemoglobins, Abnormal - analysis - isolation & purification
Humans
Male
Mutation
Abstract
The first case of the unstable Hb Genova as a result of sporadic mutation is described. It is found in a 3-year-old Canadian boy of East Indian extraction with chronic Heinz body haemolytic anaemia.
PubMed ID
6771953 View in PubMed
Less detail

Outbreak of Escherichia coli O157:H7 leading to the recall of retail ground beef--Winnipeg, Manitoba, May 1999.

https://arctichealth.org/en/permalink/ahliterature197666
Source
Can Commun Dis Rep. 2000 Jul 1;26(13):109-11
Publication Type
Article
Date
Jul-1-2000

Proficiency testing of hemoglobinopathy techniques in Ontario laboratories.

https://arctichealth.org/en/permalink/ahliterature208640
Source
Am J Clin Pathol. 1997 May;107(5):567-75
Publication Type
Article
Date
May-1997
Author
J. Lafferty
M A Ali
K. Carstairs
L. Crawford
Author Affiliation
St. Joseph's Hospital, Hamilton, Ontario, Canada.
Source
Am J Clin Pathol. 1997 May;107(5):567-75
Date
May-1997
Language
English
Publication Type
Article
Keywords
Certification
Chemistry, Analytic - standards
Clinical Competence
Diagnostic Errors
Electrophoresis - methods
Hematology - standards
Hemoglobin H - analysis
Hemoglobin SC Disease - diagnosis
Hemoglobin, Sickle - analysis
Humans
Ontario
Pathology, Clinical - standards
Sickle Cell Trait - diagnosis
Societies, Medical
Thalassemia - diagnosis
Abstract
The Laboratory Proficiency Testing Program has been in effect for 20 years. During the past 6 years, samples were distributed for screening, investigation, and identification of hemoglobinopathies to test laboratory proficiency. Six samples for hemoglobin (Hb) S screening were distributed to from 37 to 163 laboratories that perform screening tests for sickle cell disease, and 10 samples were distributed to from 52 to 71 laboratories that perform Hb electrophoresis. Assessment of unacceptable results was based on clinical significance of the errors; educational follow-up was implemented to address these results. Most participants demonstrated acceptable performance. The error rates for sickle cell screening were 2.7% to 19.7%; the poorest performance was noted for Hb SC disease. The error rates for Hb electrophoresis were 1.4% to 36.8%; the poorest performance was noted in the investigation of Hb H disease and alpha-thalassemia trait. Improved survey performance was observed in the screening for Hb S trait and in the investigation of Hb H disease, which illustrates the benefits of proficiency testing and its positive effect on laboratory services.
Notes
Comment In: Am J Clin Pathol. 1998 May;109(5):651-29576588
PubMed ID
9128270 View in PubMed
Less detail

A prospective study evaluating the lowering of hemoglobin standards for blood donors.

https://arctichealth.org/en/permalink/ahliterature231114
Source
Transfusion. 1989 Mar-Apr;29(3):268-72
Publication Type
Article
Author
A M Ali
C H Goldsmith
A T McAvoy
M A Ali
M A Blajchman
Author Affiliation
Canadian Red Cross Blood Transfusion Service, St. Joseph's Hospital, Hamilton, Ontario, Canada.
Source
Transfusion. 1989 Mar-Apr;29(3):268-72
Language
English
Publication Type
Article
Keywords
Anemia, Hypochromic - epidemiology - etiology
Blood Donors - psychology
Blood Transfusion - standards
Bloodletting - adverse effects - statistics & numerical data
Canada
Female
Hemoglobins - standards
Humans
Male
Prospective Studies
Questionnaires
Sex Factors
Time Factors
Abstract
Strict regulations exist for the selection of blood donors. These include minimum hemoglobin (Hb) standards of 13.5 and 12.5 g/dL for males and females respectively. In Canada 2% of all blood donors, or approximately 25,000 individuals annually attempt to make a blood donation but are deferred because their Hb level does not meet these minimum accepted standards. In a previous study we provided a biostatistical approach to ascertain objectively the optimal minimum Hb standards for blood donors to best discriminate between iron deficient and non iron deficient individuals. The derived values were lower than the existing minimum Hb standards and because of concern that blood donors accepted using these lower Hb standards might have asymptomatic disease, the proposed new levels were not adopted. This present prospective study was undertaken to assess the impact on the blood donors of the new Hb standards. Over 26 months we evaluated 1,558 donors (695 males and 863 females). On entry into the study they were screened for a variety of medical conditions which could result in asymptomatic anemia and 6 months later they answered a health questionnaire. Blood donors were entered into 1 of 3 groups. Group I were donors accepted by the existing criteria. Group II were donors who did not meet the existing Hb criteria but satisfied the newly derived standards. Group III were donors deferred even by the new Hb standards.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
2922794 View in PubMed
Less detail

Recognizing and investigating iron-deficiency anemia in hospitalized elderly people.

https://arctichealth.org/en/permalink/ahliterature211047
Source
CMAJ. 1996 Sep 15;155(6):691-6
Publication Type
Article
Date
Sep-15-1996
Author
M J Smieja
D J Cook
D L Hunt
M A Ali
G H Guyatt
Author Affiliation
Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ont.
Source
CMAJ. 1996 Sep 15;155(6):691-6
Date
Sep-15-1996
Language
English
Publication Type
Article
Keywords
Aged
Algorithms
Anemia, Iron-Deficiency - diagnosis - epidemiology
Biopsy, Needle
Bone Marrow - pathology
Endoscopy, Gastrointestinal
Ferritins - blood
Hospitalization
Humans
Middle Aged
Ontario - epidemiology
Prevalence
Retrospective Studies
Abstract
To determine whether anemia is documented and appropriately investigated for iron deficiency in hospitalized elderly people.
Retrospective chart review.
Medical clinical teaching unit (CTU) in secondary care hospital in Hamilton, Ont.
Consecutive patients 65 years of age or older admitted between April 1992 and March 1993.
Proportion of anemic patients for whom documentation was adequate (included in problem list in patient chart) and for whom adequate investigations were performed (measurement of serum ferritin level in anemic patients in whom iron deficiency was suspected, bone-marrow aspiration for those with intermediate probability of iron deficiency after determination of serum ferritin level, and endoscopy of upper or lower gastrointestinal tract, or both, in patients with iron deficiency).
Of 183 eligible patients admitted to the CTU 66 (36%) had anemia, in 47 cases (71%) the anemia was documented by house staff or attending physicians. Of the 66 anemic patients 49 had a non-macrocytic anemia of unknown cause: 26 had their serum ferritin level measured, 5 underwent bone-marrow aspiration, and 21 were referred for gastrointestinal endoscopy. Six of eight patients with probable iron deficiency (i.e., a serum ferritin level that was diagnostic [less than 18 micrograms/L] or suggestive [18 to 45 micrograms/L]) underwent endoscopy, two were found to have cancer of the stomach or cecum. Only 26 of the 49 patients had adequate investigation.
Anemia is common among elderly patients in hospital. However, iron deficiency is underrecognized and underinvestigated.
Notes
Cites: N Engl J Med. 1974 May 30;290(22):1213-64825851
Cites: J Fam Pract. 1989 May;28(5):524-82715768
Cites: J Gen Intern Med. 1992 Mar-Apr;7(2):145-531487761
Cites: CMAJ. 1991 Feb 15;144(4):435-401993290
Cites: Am J Med. 1990 Mar;88(3):205-92178409
PubMed ID
8823214 View in PubMed
Less detail

Self-esteem as a predictor of attitudes toward wife abuse among Muslim women and men in Canada.

https://arctichealth.org/en/permalink/ahliterature195082
Source
J Soc Psychol. 2001 Feb;141(1):23-30
Publication Type
Article
Date
Feb-2001
Author
A. Ali
B B Toner
Author Affiliation
Department of Psychiatry, University of Toronto, Canada. alisha_ali@camh.net
Source
J Soc Psychol. 2001 Feb;141(1):23-30
Date
Feb-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Attitude
Canada
Female
Gender Identity
Humans
Islam - psychology
Male
Middle Aged
Religion and Psychology
Self Concept
Spouse Abuse - psychology
Abstract
This study was designed (a) to assess attitudes toward wife abuse in a sample of Muslim women and men in Canada and (b) to assess whether those attitudes were influenced by self-esteem. Results suggested that, as in general North American samples, the Muslim women and men did not differ from each other on levels of self-esteem. Also consistent with general North American samples, the Muslim women's and men's attitudes toward wife abuse were related to their self-esteem, with higher self-esteem scores predicting stronger attitudes against wife abuse, independent of gender. However, the results also revealed that the Muslim men had significantly more lenient attitudes toward wife abuse compared with the Muslim women and with North American norms.
PubMed ID
11294163 View in PubMed
Less detail

12 records – page 1 of 2.