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[Association of polymorphisms in glutathione-S-transferase and DNA repair genes with ovarian cancer risk in the Russian population].

https://arctichealth.org/en/permalink/ahliterature120602
Source
Genetika. 2012 Jul;48(7):901-4
Publication Type
Article
Date
Jul-2012
Author
D V Khokhrin
A V Khrunin
A A Moiseev
V A Gorbunov
S A Limborskaia
Source
Genetika. 2012 Jul;48(7):901-4
Date
Jul-2012
Language
Russian
Publication Type
Article
Keywords
DNA Repair Enzymes - genetics
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Glutathione Transferase - genetics
Humans
Ovarian Neoplasms - genetics
Polymorphism, Single Nucleotide
Risk factors
Russia
Xeroderma Pigmentosum Group D Protein - genetics
Abstract
Polymorphism ofglutathione-S-transferase (GSTA1, GSTM1, GSTM3, GSTP1, and GSTT1) and DNA repair (ERCC1, ERCC2, and XRCC1) genes in samples of ovarian cancer patients and healthy women of the Russian ethnic group was studied. A trend in the allele frequency variation of ERCC2 gene single nucleotide polymorphism (rs13181, A > C) was revealed. The A allele frequency was higher in the sample of patients (60,6% versus 52,9%, P = 0.058).
PubMed ID
22988779 View in PubMed
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[CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population].

https://arctichealth.org/en/permalink/ahliterature126508
Source
Genetika. 2011 Dec;47(12):1686-8
Publication Type
Article
Date
Dec-2011
Author
A V Khrunin
F G Ivanova
A A Moiseev
V A Gorbunova
S A Limborskaia
Source
Genetika. 2011 Dec;47(12):1686-8
Date
Dec-2011
Language
Russian
Publication Type
Article
Keywords
Alleles
Cytochrome P-450 CYP2E1 - genetics
Female
Humans
Mutagenesis, Insertional
Ovarian Neoplasms - epidemiology - ethnology - genetics
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Risk factors
Siberia - epidemiology - ethnology
Abstract
The CYP2E1 gene polymorphism has been studied in Yakut women with ovarian cancer and without cancer. The two groups have been found to substantially differ in the frequency of the CYP2E1* 1D allele (with a 96-bp insertion in the promoter region of the gene): it is more frequent in healthy women (16.3 versus 7.4%, P = 0.007).
PubMed ID
22384697 View in PubMed
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[Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients from Yakutia].

https://arctichealth.org/en/permalink/ahliterature117737
Source
Mol Gen Mikrobiol Virusol. 2013;(4):6-9
Publication Type
Article
Date
2013
Author
D V ?hokhrin
A V Khrunin
F G Ivanova
A A Moiseev
V A Gorbunova
S A Limborskaia
Source
Mol Gen Mikrobiol Virusol. 2013;(4):6-9
Date
2013
Language
Russian
Publication Type
Article
Keywords
Apoptosis - genetics
Cell Cycle - genetics
Cisplatin - administration & dosage
Cyclin-Dependent Kinase Inhibitor p27 - genetics
DNA Repair - genetics
Disease-Free Survival
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Neoplasm Staging
Ovarian Neoplasms - drug therapy - genetics - pathology
Pharmacogenetics
Polymorphism, Single Nucleotide
Russia
Xenobiotics - metabolism
Abstract
DNA polymorphism is an important component of the interindividual variation in reactions of patients to the same drugs. In this work, evaluation of the association between polymorphisms in 106 genes involved in key processes of cellular activity (xenobiotic metabolism, DNA repair, the cell cycle, and apoptosis), and outcomes in a cohort of Yakut ovarian cancer patients receiving cisplatin-based chemotherapy was carried out. The polymorphism in the CDKN1B gene (rs34330) was found to be associated with complete tumor response and progression-free survival. SNPs in EPXH1 gene (rs2234922 and rs2260863) were correlated with hearing impairment. A SNP in NBN gene (rs1063045) was associated with severe emesis.
PubMed ID
24645271 View in PubMed
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[Polymorphisms of DNA repair genes ERCC2 and XRCC1 in populations of Russia].

https://arctichealth.org/en/permalink/ahliterature127012
Source
Genetika. 2011 Nov;47(11):1565-8
Publication Type
Article
Date
Nov-2011
Author
A V Khrunin
S Iu Firsov
S A Limborskaia
Source
Genetika. 2011 Nov;47(11):1565-8
Date
Nov-2011
Language
Russian
Publication Type
Article
Keywords
Case-Control Studies
DNA Repair - genetics
DNA-Binding Proteins - genetics
European Continental Ancestry Group - genetics
Gene Frequency
Genotype
Humans
Polymorphism, Genetic
Population - genetics
Russia
Xeroderma Pigmentosum Group D Protein - genetics
Abstract
We have conducted a comparative study of allele frequencies of single nucleotide polymorphisms (SNPs) rs1799793 and rs13181 of the ERCC2 gene as well as rs1799782 and rs25487 of the XRCC1 gene in population samples from European regions of Russia as well as in populations of Izhemsk and Priluzsk Komi and Yakuts. Significant differences in the distribution of polymorphic variants of the ERCC2 gene were demonstrated between populations of Yakuts and populations of Russians and Komi. In case of XRCC1 gene Izhemsk Komi population exhibited dissimilar allele frequencies compared to other populations.
PubMed ID
22332413 View in PubMed
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