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[Dna repair activity in children exposed to small doses of ionizing radiation as a result of the accident at the Chernobyl nuclear power station]

https://arctichealth.org/en/permalink/ahliterature35148
Source
Genetika. 1995 Oct;31(10):1433-7
Publication Type
Article
Date
Oct-1995
Author
S V Unizhakov
G N L'vova
V V Chekova
A N Semiachkina
L S Baleva
G D Zasukhina
L Z Kazantseva
Source
Genetika. 1995 Oct;31(10):1433-7
Date
Oct-1995
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Case-Control Studies
Child
DNA Repair
English Abstract
Gamma Rays
Humans
Lymphocytes - radiation effects
Mental retardation
Mutagenicity Tests
Power Plants
Radiation, Ionizing
Reference Values
Ukraine
Ultraviolet Rays
Variola virus - genetics - radiation effects
Abstract
The repair activity of DNA was studied by variola vaccine virus reactivation and induced mutagenesis tests in the peripheral blood lymphocytes of children living in areas with an increased level of ionizing radiation due to breakdown at the Chernobyl' nuclear power station. A more profound repair disturbance was revealed in children living on strictly controlled territories and born after the disaster, compared to those born before it, and children living in areas where the radiation level does not exceed background values. The disturbances were characterized by increased induced mutagenesis and decreased reactivation of the variola vaccine virus. No changes in the degree of DNA repair synthesis were registered in any of the groups studied.
PubMed ID
8543145 View in PubMed
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[Radioadaptive response in lymphocytes of children living in territories polluted by radionuclides as a result of the accident at the Chernobyl power plant]

https://arctichealth.org/en/permalink/ahliterature34200
Source
Radiats Biol Radioecol. 1997 Jul-Aug;37(4):640-4
Publication Type
Article
Author
G P Makedonov
L V Tskhovrebova
S V Unzhakov
A N Semiachkina
I M Vasil'eva
G D Zasukhina
Author Affiliation
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow.
Source
Radiats Biol Radioecol. 1997 Jul-Aug;37(4):640-4
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adaptation, Physiological
Antimutagenic Agents - therapeutic use
Case-Control Studies
Child
Chromosome Aberrations
DNA Repair
English Abstract
Gamma Rays
Humans
Interferons - therapeutic use
Lymphocytes - radiation effects
Power Plants
Radioactive Pollutants - adverse effects
Ukraine
Abstract
The radioadaptive response and antimutagenic action of lymphoblastoid interferon in the human blood lymphocytes of the children from polluted after Chernobyl accident Bryansk region were studied. Cells pretreated with tritiated thymidine with 2 Gy of gamma-rays at 20 h of culture after PHA-stimulation on seven of the ten donors result in lack of radioadaptive response. On testing some of them (4 donors) no protective adaptive response was found, others (3 donors) pretreated with tritiated thymidine gave sensibilization. Significant decrease in interferon antimutagenic activity in lymphocytes with disturbed adaptive response was also found. It has been proposed that there is similarity or identity of mechanism of radioadaptive response and of non-repair component of interferons antimutagenic action.
PubMed ID
9599623 View in PubMed
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[The adaptive response in the lymphocytes of children from an area with an elevated background of ionizing radiation]

https://arctichealth.org/en/permalink/ahliterature35193
Source
Radiats Biol Radioecol. 1995 Sep-Oct;35(5):662-5
Publication Type
Article
Author
I M Vasil'eva
S V Unzhakov
I A Meliksetova
G D Zasukhina
A N Semiachkina
L Z Kazantseva
Source
Radiats Biol Radioecol. 1995 Sep-Oct;35(5):662-5
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adaptation, Physiological - radiation effects
Background Radiation - adverse effects
Child
DNA - radiation effects
Disease Susceptibility
Dose-Response Relationship, Radiation
English Abstract
Environmental Exposure - adverse effects - statistics & numerical data
Humans
Lymphocytes - physiology - radiation effects
Power Plants
Ukraine
Abstract
The ability to form the adaptive response in lymphocytes of 23 children, exposed to small radiation doses as the result of Chernobyl accident was studied by hydroxylapatite chromatography of cell lysates. No correlation was found between the ability to form adaptive response and received radiation dose.
PubMed ID
7489099 View in PubMed
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[The formation of an adaptive response in children exposed to the effect of low doses of radiation as a result of the accident at the Chernobyl Atomic Electric Power Station]

https://arctichealth.org/en/permalink/ahliterature35614
Source
Radiats Biol Radioecol. 1994 Nov-Dec;34(6):827-31
Publication Type
Article
Author
S V Unzhakov
I M Vasil'eva
I A Meliksetova
A N Semiachkina
L S Baleva
L Z Kazantseva
G D Zasukhina
Source
Radiats Biol Radioecol. 1994 Nov-Dec;34(6):827-31
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adaptation, Physiological - radiation effects
Air Pollution, Radioactive - adverse effects
Cells, Cultured
Child
Comparative Study
DNA - radiation effects
DNA Damage
Dose-Response Relationship, Radiation
English Abstract
Environmental Exposure - adverse effects
Humans
Lymphocytes - physiology - radiation effects
Power Plants
Russia
Ukraine
Abstract
The ability of lymphocytes to form an adaptive response in cells of the children which were exposed to small radiation doses during the Chernobyl accident was studied by hydroxyapatite chromatography of cell lysates. Ten children living in the area with high radiation level (Bryansk region) and seventeen children living in the area with natural radiation level (Bryansk region too) were examined. No difference in cell ability to form adaptive response was found in both children group.
PubMed ID
7827683 View in PubMed
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