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26 records – page 1 of 3.

[Analysis of linkage and association of alleles of proinflammatory cytokines genes IL-6, IFNg and TNF with multiple sclerosis using transmission disequilibrium test (TDT)].

https://arctichealth.org/en/permalink/ahliterature139177
Source
Mol Biol (Mosk). 2010 Sep-Oct;44(5):824-30
Publication Type
Article
Author
O Iu Makarycheva
E Iu Tsareva
M A Sudomoina
O G Kulakova
O V Bykova
N V Gol'tsova
L M Kuzenkova
A N Boiko
O O Favorova
Source
Mol Biol (Mosk). 2010 Sep-Oct;44(5):824-30
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Alleles
Child
Female
Genetic Predisposition to Disease - ethnology - genetics
Humans
Interferon-gamma - genetics
Interleukin-6 - genetics
Linkage Disequilibrium
Male
Multiple Sclerosis - ethnology - genetics
Polymorphism, Single Nucleotide
Russia
Tumor Necrosis Factor-alpha - genetics
Abstract
Proinflammatory cytokines Interleukin-6 (IL-6), Interferon-gamma (IFNg) and Tumor necrosis factor (TNF) are known as participants of inflammation and play an important role in pathogenesis of multiple sclerosis (MS). Based on literature data about influence of SNPs G(-308)A of TNF gene, A(+874)T of IFNG gene and G(-174)C of IL-6 gene on production of these cytokines, we investigated association of these polymorphic sites with MS. Linkage and association of alleles of these genes with MS was analyzed by transmission disequilibrium test (TDT). In investigated group of 104 nuclear families of Russian ethnicity it was found that TNF* (-308)A allele transmitted from healthy heterozygous parents to affected children more frequently (p = 0.01). Linkage/association of IFNG and IL-6 alleles with MS was not revealed. Thus, data obtained indicate the participation of TNF gene in MS susceptibility in Russians.
PubMed ID
21090238 View in PubMed
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Association and linkage of juvenile MS with HLA-DR2(15) in Russians.

https://arctichealth.org/en/permalink/ahliterature191378
Source
Neurology. 2002 Feb 26;58(4):658-60
Publication Type
Article
Date
Feb-26-2002
Author
A N Boiko
E I Gusev
M A Sudomoina
A D Alekseenkov
O G Kulakova
O V Bikova
O I Maslova
M R Guseva
S Y Boiko
M E Guseva
O O Favorova
Author Affiliation
Department of Neurology and Neurosurgery, Russian State Medical University, Moscow.
Source
Neurology. 2002 Feb 26;58(4):658-60
Date
Feb-26-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alleles
Child
Child, Preschool
Female
Genetic Linkage
Genotype
HLA-DR2 Antigen - genetics
Humans
Male
Multiple Sclerosis - epidemiology - genetics
Russia - epidemiology
Abstract
The aim of this study was to determine the role of the HLA-DRB1 gene [6p21] in susceptibility to juvenile MS (JMS) (age at onset or =16 years.
PubMed ID
11865153 View in PubMed
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[Changes in quality of life in patients with remitted multiple sclerosis during the specific treatment with disease-modifying drugs: a comparative study of populations of Moscow and Novosibirsk].

https://arctichealth.org/en/permalink/ahliterature137041
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(5 Pt 1):67-70
Publication Type
Article
Date
2010

The chemokine receptor CCR5 deletion mutation is associated with MS in HLA-DR4-positive Russians.

https://arctichealth.org/en/permalink/ahliterature187600
Source
Neurology. 2002 Nov 26;59(10):1652-5
Publication Type
Article
Date
Nov-26-2002
Author
O O Favorova
T V Andreewski
A N Boiko
M A Sudomoina
A D Alekseenkov
O G Kulakova
A V Slanova
E I Gusev
Author Affiliation
Department of Molecular Biology and Medical Biotechnology, Russian State Medical University, Moscow, Russia. olga_Favorova@mail.ru
Source
Neurology. 2002 Nov 26;59(10):1652-5
Date
Nov-26-2002
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
Alleles
DNA - genetics
Female
Gene Deletion
Gene Frequency
Genotype
HLA-DR4 Antigen - analysis
Humans
Male
Multiple Sclerosis - epidemiology - genetics - immunology
Mutation - genetics - physiology
Phenotype
Receptors, CCR5 - genetics
Russia - epidemiology
Abstract
The authors studied the possible association between the presence of a 32-base pair deletion allele in CC chemokine receptor 5 gene [3p21] (CCR5 Delta 32 allele) and the occurrence of MS. The presence of CCR5 Delta 32 homozygotes among patients with MS indicates that the absence of CCR5 did not protect against MS. Moreover, the CCR5 Delta 32 mutation was associated with MS in HLA-DR4-positive Russians (p(corr)
PubMed ID
12451219 View in PubMed
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[Clinical and epidemiological study of multiple sclerosis in Volgograd city].

https://arctichealth.org/en/permalink/ahliterature166052
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2006;Spec No 3:4-10
Publication Type
Article
Date
2006
Author
N N Dokuchaeva
A N Boiko
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2006;Spec No 3:4-10
Date
2006
Language
Russian
Publication Type
Article
Keywords
Adult
Catchment Area (Health)
Environmental Exposure - adverse effects
Female
Hazardous Substances - adverse effects
Humans
Industry
Male
Multiple Sclerosis - epidemiology
Prevalence
Risk factors
Russia - epidemiology
Stress, Psychological - epidemiology
Tonsillitis - epidemiology
Abstract
Descriptive and analytical study of multiple sclerosis (MS) has been first-ever carried out in population of Volgograd city, South region of Russian Federation. At the period of the study (1996-2000) the population was estimated as 814 100 adult persons. An average age-adjusted level of MS prevalence was 31.9 per 100,000, MS incidence--9.8, mortality 1,8. Thus, the city is at a moderate risk for MS, however the incidence of the disease appeared to be rather high that indicates a further increase of MS patients number in this population. The highest level of MS prevalence was registered in two districts with poor ecological characteristics and numerous industries: Krasnoarmeysky (52.4 per 100,000 persons) and Krasnooktiabrsky (46.4). An analytical case-control study included data collected from 178 pairs (73.6% female) of MS patients and controls matched for age, sex and ethnic origin. Significant differences between patients and controls were detected as follows: patients more often had blue eyes as compared to dark ones; in the patient group mother's age at birth was above 30 years; patients more often lived near chemical and/or oil factories at age before 15 years; they more often reported a presence of stress factors in the family and chronic tonsillitis. Association with other factors, including infections, nutrition, acute and chronic diseases, poisoning, traumas, family history of different diseases, contact with animals etc, has not been found. A possible association between environmental factors and features of MS course were analyzed. Living near chemical factories at age before 15 was associated with more active MS course, i.e. high frequency of progressive course, short period from MS onset to confirmed EDSS=3, short duration of first remission. The same, though less significant, influence may exert the presence of herpes infection and chronic tonsillitis at age under 15.
PubMed ID
17172228 View in PubMed
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[Clinical epidemiology of multiple sclerosis in Moscow. Descriptive epidemiology in population of one region of Moscow].

https://arctichealth.org/en/permalink/ahliterature105841
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(10 Pt 2):8-14
Publication Type
Article
Date
2013
Author
A N Boiko
T M Kukel'
M A Lysenko
T V Vdovichenko
E I Gusev
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(10 Pt 2):8-14
Date
2013
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Morbidity - trends
Moscow - epidemiology
Multiple Sclerosis - epidemiology
Retrospective Studies
Sex Distribution
Urban Population
Young Adult
Abstract
The epidemiological study of multiple sclerosis (MS) has been done in the population (927 400 people) of the North-Western Administrative District (SZAO) of Moscow for the period of 2008-2012. In average for the 5 years the prevalence of MS was amounted to 53.38 cases per 100 000 population, incidence was 2.16 cases per 100 000 population and the mortality rate was 0.23 cases per 100 000 population. Thus, the population of SZAO belongs to high-incidence area. An increase in the prevalence of MS as well as a reduction of incidence and mortality were observed during a comparative analysis with the epidemiological indicators of MS in Moscow in the period of 1991-1996. Such dynamics of epidemiological indicators is due to the accumulation of patients in population that, in the first place, is related with the quality improvement of diagnostic and therapeutic-rehabilitative measures which increased the frequency of early diagnosis and patient's life expectancy together with the implementation of disease-modifying therapy (DMT) and modern methods of symptomatic treatment.
PubMed ID
24300812 View in PubMed
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Clinico-immunogenetic characteristics of multiple sclerosis with optic neuritis in children.

https://arctichealth.org/en/permalink/ahliterature198069
Source
J Neurovirol. 2000 May;6 Suppl 2:S152-5
Publication Type
Article
Date
May-2000
Author
A N Boiko
M E Guseva
M R Guseva
S Y Boiko
M A Sudomoina
O V Bikova
O I Maslova
O O Favorova
E I Gusev
Author Affiliation
Department of Neurology and Neurosurgery of the Russian State Medical University, Ostrovitianova 1, Moscow, Russia.
Source
J Neurovirol. 2000 May;6 Suppl 2:S152-5
Date
May-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Alleles
Child
Female
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Haplotypes
Humans
Male
Multiple Sclerosis, Relapsing-Remitting - complications - genetics - immunology
Optic Neuritis - etiology - genetics - immunology
Phenotype
Polymorphism, Single-Stranded Conformational
Russia
Tumor Necrosis Factor-alpha - genetics
Abstract
The frequency of multiple sclerosis (MS) with clinical onset before 16 years of age in different regions of Russia fluctuates from 2 to 10% of all MS patients. One of the most frequent signs of MS manifestation and/or exacerbation at this age is optic neuritis (ON). Forty-seven children with MS were observed in Moscow. Diagnosis of MS in every case was clinically definite and proved by serial MRI. Clinico-tomographic dissociation was noticed: numerous large lesions, typical for MS on T2 images were often seen in children with mild or moderate residual neurological symptoms. All patients had relapsing/remitting MS course, mean EDSS was 2.24+/-0.26. Thirty-eight children (80%) had ON at least once, ten (21.3%) - twice or more times. In several cases ON had subclinical course or might be missed and the damage of the optic nerve with partial atrophy was found only after complex ophthalmological investigation including visual evoked potentials. Thus, the clinical course of MS and ON have some peculiarities in children and may be genetically based. Analyses of allelic polymorphisms of HLA-DR and TNF loci on chromosome 6 was performed. Data from children with MS were compared with data from their parents, healthy controls and other MS patients from the same ethnic group. Children with MS had increased frequency of DR2(15) and TNF-a11, but not TNF-a9 as adult MS patients from the same ethnic group. The presence of TNF-a7, rare in adult patients, could be proposed as a marker of early MS onset.
PubMed ID
10871804 View in PubMed
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[Epidemiological characteristics of multiple sclerosis in the Kabardino-Balkaria Republic].

https://arctichealth.org/en/permalink/ahliterature105842
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(10 Pt 2):5-7
Publication Type
Article
Date
2013
Author
A R Zikhova
L M Berezgova
L B Tlapshokova
A N Boiko
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(10 Pt 2):5-7
Date
2013
Language
Russian
Publication Type
Article
Keywords
Adult
Female
Humans
Male
Morbidity - trends
Multiple Sclerosis - epidemiology
Retrospective Studies
Rural Population
Russia - epidemiology
Abstract
Prevalence of multiple sclerosis (MS) in two populations of the Kabardino-Balkaria Republic (Nalchik and Prokhladnensky region) was studied. In Nalchik, the prevalence of MS was 13.0 cases per 100 000 in 2006 and 13.7 cases - in 2010. It was lower among Circassians (8.0) compared to Slavs (31.3). The 5-year morbidity was low (0.15 per 100 000 population). In 2010, the prevalence of MS in Nalchik was 34.3 per 100 000. In the rural Prokhladnensky region with mainly Slav population, the prevalence was 11.0 cases per 100 000 in 2006 and 19.8 (all patients were Slavs) - in 2010. The morbidity was 1.76 for the period analyzed. At the same time, the prevalence of MS in the Slav population in 2010 was lower by a factor of 1.73 in the rural region compared to Nalchik (19.8 and 34.3, respectively). The higher prevalence of MS in Nalchik may be explained by adverse environmental factors increasing the risk of MS. A case-control study revealed the higher risk for people under 15 years old living very close to chemical and biological plants.
PubMed ID
24300811 View in PubMed
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[Epidemiology of multiple sclerosis in the Primosky Krai and Far East regions].

https://arctichealth.org/en/permalink/ahliterature123675
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2 Pt 2):5-8
Publication Type
Article
Date
2012
Author
A A Gavrilenko
Z S Evdokimova
G A Vasikovskaia
A N Boiko
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2 Pt 2):5-8
Date
2012
Language
Russian
Publication Type
Article
Keywords
Adult
Female
Humans
Incidence
Male
Middle Aged
Multiple Sclerosis - diagnosis - drug therapy - epidemiology
Prevalence
Russia - epidemiology
Abstract
The first results of a clinical and epidemiological survey on prevalence, incidence, clinical characteristics, diagnosis of multiple sclerosis (MS) and medical assistance to patients in Primosky Krai, Vladivostok and the Far East regions (Sakhalin, Magadan oblasts and Kamchatka Krai) during 2005-2010 are presented. The prevalence of MS was 1.12 cases per 100000 population in the Primosky Krai in whole and from 1.61 cases in 2005 in Vladivostok to 11.45 and 16.2 cases in Primosky Krai and Vladivostok in 2010, respectively. The incidence of MS was maximal in the Primosky Krai (2.61 cases per 100 000 population in 2007 and 3.95 cases in 2008). The increase in the prevalence may be explained by the improvement of MS diagnosis, introduction of neuroimaging methods for brain structure visualization (MRI etc) and the organization of a regional MS center. The relative decrease in the MS incidence to 2.49 cases per 100 000 in 2010 was noted. Epidemiological characteristics of MS in separate oblasts of the Far East are presented. In whole, all indices indicate the moderate risk for MS in the region studied.
PubMed ID
22677672 View in PubMed
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26 records – page 1 of 3.