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Genetic susceptibility to MS: a second stage analysis in Canadian MS families.

https://arctichealth.org/en/permalink/ahliterature193481
Source
Neurogenetics. 2001 Jul;3(3):145-51
Publication Type
Article
Date
Jul-2001
Author
D A Dyment
C J Willer
B. Scott
H. Armstrong
A. Ligers
J. Hillert
D W Paty
S. Hashimoto
V. Devonshire
J. Hooge
L. Kastrukoff
J. Oger
L. Metz
S. Warren
W. Hader
C. Power
A. Auty
A. Nath
R. Nelson
M. Freedman
D. Brunet
J E Paulseth
G. Rice
P. O'Connor
P. Duquette
Y. Lapierre
G. Francis
J P Bouchard
T J Murray
V. Bhan
C. Maxner
W. Pryse-Phillips
M. Stefanelli
A D Sadovnick
N. Risch
G C Ebers
Author Affiliation
The Wellcome Trust Center for Human Genetics, Oxford, UK.
Source
Neurogenetics. 2001 Jul;3(3):145-51
Date
Jul-2001
Language
English
Publication Type
Article
Keywords
Canada
Family
Female
Genetic Linkage
Genetic markers
Genetic Predisposition to Disease
Genome, Human
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Linkage Disequilibrium
Male
Multiple Sclerosis - genetics
Nuclear Family
Software
Abstract
Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P
PubMed ID
11523565 View in PubMed
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A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22.

https://arctichealth.org/en/permalink/ahliterature196145
Source
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):585-90
Publication Type
Article
Date
Jan-16-2001
Author
J R Kelsoe
M A Spence
E. Loetscher
M. Foguet
A D Sadovnick
R A Remick
P. Flodman
J. Khristich
Z. Mroczkowski-Parker
J L Brown
D. Masser
S. Ungerleider
M H Rapaport
W L Wishart
H. Luebbert
Author Affiliation
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093, USA,
Source
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):585-90
Date
Jan-16-2001
Language
English
Publication Type
Article
Keywords
Bipolar Disorder - classification - epidemiology - genetics
British Columbia - epidemiology
California - epidemiology
Chromosome Mapping
Chromosomes, Human, Pair 10 - genetics
Chromosomes, Human, Pair 13 - genetics
Chromosomes, Human, Pair 21 - genetics
Chromosomes, Human, Pair 22 - genetics
Chromosomes, Human, Pair 3 - genetics
Chromosomes, Human, Pair 5 - genetics
Female
Genetic Predisposition to Disease
Genome, Human
Genotype
Humans
Lod Score
Male
Microsatellite Repeats
Polymerase Chain Reaction
Schizophrenia - epidemiology - genetics
Abstract
Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.
Notes
Cites: Nature. 1999 Dec 2;402(6761):489-9510591208
Cites: Am J Med Genet. 1995 Oct 9;60(5):370-68546148
Cites: Am J Hum Genet. 1974 Sep;26(5):588-974422075
Cites: Arch Gen Psychiatry. 1978 Jul;35(7):837-44678037
Cites: Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-66587361
Cites: Nature. 1987 Feb 26-Mar 4;325(6107):783-72881209
Cites: Nature. 1987 Mar 19-25;326(6110):289-923493438
Cites: Arch Gen Psychiatry. 1987 May;44(5):441-73579495
Cites: Genet Epidemiol. 1988;5(6):471-23061869
Cites: Am J Hum Genet. 1989 Apr;44(4):543-512929597
Cites: Nature. 1989 Nov 16;342(6247):238-432682265
Cites: Nucleic Acids Res. 1991 Jul 25;19(14):40081861999
Cites: Soc Biol. 1991 Fall-Winter;38(3-4):179-881801199
Cites: Am J Hum Genet. 1993 Jul;53(1):252-638317490
Cites: Am J Med Genet. 1994 Mar 15;54(1):36-438178837
Cites: Am J Med Genet. 1994 Mar 15;54(1):59-717909992
Cites: Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5918-218016089
Cites: Science. 1994 Sep 30;265(5181):2049-548091227
Cites: Nat Genet. 1994 Nov;8(3):291-67874172
Cites: Nat Genet. 1995 Nov;11(3):241-77581446
Cites: Am J Med Genet. 1995 Oct 9;60(5):465-78546164
Cites: Nature. 1996 Mar 14;380(6570):152-48600387
Cites: Nat Genet. 1996 Apr;12(4):427-308630499
Cites: Nat Genet. 1996 Apr;12(4):436-418630501
Cites: Genome Res. 1995 Sep;5(2):105-159132265
Cites: Psychiatr Genet. 1995 Fall;5(3):127-308746411
Cites: Am J Med Genet. 1996 Nov 22;67(6):533-408950410
Cites: Am J Med Genet. 1997 Apr 18;74(2):121-89129709
Cites: Am J Med Genet. 1997 May 31;74(3):238-469184305
Cites: Am J Hum Genet. 1997 Aug;61(2):430-89311749
Cites: Arch Gen Psychiatry. 1997 Dec;54(12):1096-1029400345
Cites: Schizophr Res. 1998 Jul 27;32(2):115-219713907
Cites: Am J Hum Genet. 1998 Sep;63(3):861-99718341
Cites: Nat Genet. 1998 Sep;20(1):70-39731535
Cites: Proc Natl Acad Sci U S A. 1999 May 11;96(10):5604-910318931
Cites: Am J Med Genet. 1999 Jun 18;88(3):239-4310374738
Cites: Am J Med Genet. 1999 Oct 15;88(5):544-5010490714
Cites: Am J Med Genet. 1995 Apr 24;60(2):94-1027485258
Cites: Biol Psychiatry. 2000 Feb 1;47(3):245-5110682222
PubMed ID
11149935 View in PubMed
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