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Genetic susceptibility to MS: a second stage analysis in Canadian MS families.
Neurogenetics. 2001 Jul;3(3):145-51
Publication Type
D A Dyment
C J Willer
B. Scott
H. Armstrong
A. Ligers
J. Hillert
D W Paty
S. Hashimoto
V. Devonshire
J. Hooge
L. Kastrukoff
J. Oger
L. Metz
S. Warren
W. Hader
C. Power
A. Auty
A. Nath
R. Nelson
M. Freedman
D. Brunet
J E Paulseth
G. Rice
P. O'Connor
P. Duquette
Y. Lapierre
G. Francis
J P Bouchard
T J Murray
V. Bhan
C. Maxner
W. Pryse-Phillips
M. Stefanelli
A D Sadovnick
N. Risch
G C Ebers
Author Affiliation
The Wellcome Trust Center for Human Genetics, Oxford, UK.
Neurogenetics. 2001 Jul;3(3):145-51
Publication Type
Genetic Linkage
Genetic markers
Genetic Predisposition to Disease
Genome, Human
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Linkage Disequilibrium
Multiple Sclerosis - genetics
Nuclear Family
Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P
PubMed ID
11523565 View in PubMed
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A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22.
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):585-90
Publication Type
J R Kelsoe
M A Spence
E. Loetscher
M. Foguet
A D Sadovnick
R A Remick
P. Flodman
J. Khristich
Z. Mroczkowski-Parker
J L Brown
D. Masser
S. Ungerleider
M H Rapaport
W L Wishart
H. Luebbert
Author Affiliation
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093, USA,
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):585-90
Publication Type
Bipolar Disorder - classification - epidemiology - genetics
British Columbia - epidemiology
California - epidemiology
Chromosome Mapping
Chromosomes, Human, Pair 10 - genetics
Chromosomes, Human, Pair 13 - genetics
Chromosomes, Human, Pair 21 - genetics
Chromosomes, Human, Pair 22 - genetics
Chromosomes, Human, Pair 3 - genetics
Chromosomes, Human, Pair 5 - genetics
Genetic Predisposition to Disease
Genome, Human
Lod Score
Microsatellite Repeats
Polymerase Chain Reaction
Schizophrenia - epidemiology - genetics
Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.
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PubMed ID
11149935 View in PubMed
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