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Multiple sclerosis in stepsiblings: recurrence risk and ascertainment.

https://arctichealth.org/en/permalink/ahliterature171122
Source
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):258-9
Publication Type
Article
Date
Feb-2006
Author
D A Dyment
I M L Yee
G C Ebers
A D Sadovnick
Author Affiliation
The Wellcome Trust Center for Human Genetics, Oxford, UK.
Source
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):258-9
Date
Feb-2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Canada
Child
Child, Preschool
Cross-Sectional Studies
Family
Female
Genetics, Population
Humans
Male
Multiple Sclerosis - epidemiology - etiology - genetics
Recurrence
Risk
Siblings
Social Environment
Abstract
Reports implicating specific transmissible agents in multiple sclerosis (MS) susceptibility continue to appear. We therefore re-evaluated MS risk in 687 step-siblings of 19 746 MS index cases. We found the risk of MS to be indistinguishable from that of the general population after diagnostic verification. These results are coherent with studies of adopted children, half siblings and conjugals, showing no risk attributable to the familial microenvironment. This family based genetic epidemiological approach found no trace of transmissibility other than genetic from one affected individual to another in the high prevalence area of Canada. This adds to existing data showing that the action of environment in influencing MS risk is operative at a population level.
Notes
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PubMed ID
16421134 View in PubMed
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A timing-of-birth effect on multiple sclerosis clinical phenotype.

https://arctichealth.org/en/permalink/ahliterature162699
Source
Neurology. 2007 Jul 3;69(1):60-2
Publication Type
Article
Date
Jul-3-2007
Author
A D Sadovnick
P. Duquette
B. Herrera
I M L Yee
G C Ebers
Author Affiliation
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. sadovnik@infinet.net
Source
Neurology. 2007 Jul 3;69(1):60-2
Date
Jul-3-2007
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Disease Susceptibility
Female
Humans
Male
Multiple Sclerosis, Chronic Progressive - epidemiology
Multiple Sclerosis, Relapsing-Remitting - epidemiology
Parturition
Phenotype
Pregnancy
Prenatal Exposure Delayed Effects
Seasons
Sex ratio
Siblings
Abstract
A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS).
Our chi(2) analyses looked at whether this MOB effect differed by MS phenotype ("bout onset," "primary progressive").
The MOB effect was derived from "bout onset" MS patients (May/November ratio = 1.43; chi(2) = 17.32, df = 1, p = 0.000032).
An unspecified environmental effect in early development can influence both multiple sclerosis susceptibility and phenotype.
PubMed ID
17606881 View in PubMed
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Twin concordance and sibling recurrence rates in multiple sclerosis.

https://arctichealth.org/en/permalink/ahliterature183216
Source
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12877-82
Publication Type
Article
Date
Oct-28-2003
Author
C J Willer
D A Dyment
N J Risch
A D Sadovnick
G C Ebers
Author Affiliation
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
Source
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12877-82
Date
Oct-28-2003
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Databases, Factual
Diseases in Twins - genetics
Female
Genetic Predisposition to Disease
Heterozygote
Homozygote
Humans
Male
Multiple Sclerosis - epidemiology - genetics - physiopathology
Recurrence
Registries
Siblings
Twins - statistics & numerical data
Twins, Dizygotic
Twins, Monozygotic
Abstract
Size and ascertainment constraints often limit twin studies to concordance comparisons between identical and fraternal twins. Here we report the final results of a longitudinal, population-based study of twins with multiple sclerosis (MS) in Canada. Bias was demonstrably minimized, and an estimated 75% of all Canadian MS twin pairs were ascertained, giving a sample sufficiently large (n = 370) to permit additional informative comparisons. Twinning was not found to affect prevalence, and twins with MS did not differ from nontwins for DR15 allele frequency nor for MS risk to their siblings. Probandwise concordance rates of 25.3% (SE +/- 4.4) for monozygotic (MZ), 5.4% (+/-2.8) for dizygotic (DZ), and 2.9% (+/-0.6) for their nontwin siblings were found. MZ twin concordance was in excess of DZ twin concordance. The excess concordance in MZ was derived primarily from like-sexed female pairs with a probandwise concordance rate of 34 of 100 (34 +/- 5.7%) compared with 3 of 79 (3.8 +/- 2.8%) for female DZ pairs. We did not demonstrate an MZ/DZ difference in males, although the sample size was small. We observed a 2-fold increase in risk to DZ twins over nontwin siblings of twins, but the difference was not significant.
Notes
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PubMed ID
14569025 View in PubMed
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