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Active aging - resilience and external support as modifiers of the disablement outcome: AGNES cohort study protocol.

https://arctichealth.org/en/permalink/ahliterature299192
Source
BMC Public Health. 2018 05 02; 18(1):565
Publication Type
Journal Article
Date
05-02-2018
Author
Taina Rantanen
Milla Saajanaho
Laura Karavirta
Sini Siltanen
Merja Rantakokko
Anne Viljanen
Timo Rantalainen
Katja Pynnönen
Anu Karvonen
Inna Lisko
Lotta Palmberg
Johanna Eronen
Eeva-Maija Palonen
Timo Hinrichs
Markku Kauppinen
Katja Kokko
Erja Portegijs
Author Affiliation
Gerontology Research Center, Faculty of Sport and Health Sciences, Univerisity of Jyvaskyla, P.O. Box 35 (viv 149), 40014, Jyväskylä, Finland. taina.rantanen@jyu.fi.
Source
BMC Public Health. 2018 05 02; 18(1):565
Date
05-02-2018
Language
English
Publication Type
Journal Article
Keywords
Aged
Aged, 80 and over
Aging - psychology
Cohort Studies
Disabled persons - statistics & numerical data
Exercise
Female
Finland
Health Behavior
Health Literacy
Humans
Male
Resilience, Psychological
Social Support
Abstract
Population aging increases the need for knowledge on positive aspects of aging, and contributions of older people to their own wellbeing and that of others. We defined active aging as an individual's striving for elements of wellbeing with activities as per their goals, abilities and opportunities. This study examines associations of health, health behaviors, health literacy and functional abilities, environmental and social support with active aging and wellbeing. We will develop and validate assessment methods for physical activity and physical resilience suitable for research on older people, and examine their associations with active aging and wellbeing. We will examine cohort effects on functional phenotypes underlying active aging and disability.
For this population-based study, we plan to recruit 1000 participants aged 75, 80 or 85 years living in central Finland, by drawing personal details from the population register. Participants are interviewed on active aging, wellbeing, disability, environmental and social support, mobility, health behavior and health literacy. Physical activity and heart rate are monitored for 7 days with wearable sensors. Functional tests include hearing, vision, muscle strength, reaction time, exercise tolerance, mobility, and cognitive performance. Clinical examination by a nurse and physician includes an electrocardiogram, tests of blood pressure, orthostatic regulation, arterial stiffness, and lung function, as well as a review of chronic and acute conditions and prescribed medications. C-reactive protein, small blood count, cholesterol and vitamin D are analyzed from blood samples. Associations of factors potentially underlying active aging and wellbeing will be studied using multivariate methods. Cohort effects will be studied by comparing test results of physical and cognitive functioning with results of a cohort examined in 1989-90.
The current study will renew research on positive gerontology through the novel approach to active aging and by suggesting new biomarkers of resilience and active aging. Therefore, high interdisciplinary impact is expected. This cross-sectional study will not provide knowledge on temporal order of events or causality, but an innovative cross-sectional dataset provides opportunities for emergence of novel creative hypotheses and theories.
PubMed ID
29716566 View in PubMed
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Assortative mating by body height and BMI: Finnish twins and their spouses.

https://arctichealth.org/en/permalink/ahliterature183812
Source
Am J Hum Biol. 2003 Sep-Oct;15(5):620-7
Publication Type
Article
Author
Karri Silventoinen
Jaakko Kaprio
Eero Lahelma
Richard J Viken
Richard J Rose
Author Affiliation
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA. silventoinen@epi.umn.edu
Source
Am J Hum Biol. 2003 Sep-Oct;15(5):620-7
Language
English
Publication Type
Article
Keywords
Aged
Body Height - genetics
Body mass index
Body Weight - genetics
Cohort Studies
Female
Finland
Humans
Longitudinal Studies
Male
Middle Aged
Phenotype
Social Behavior
Spouses - psychology
Twins, Dizygotic
Twins, Monozygotic
Abstract
Assortative mating by body height and weight is well established in various populations, but its causal mechanisms remain poorly understood. We analyzed the effect of phenotypic assortment and social homogamy on spousal correlations for body height and body mass index (BMI, kg/m(2)). Our data derived from a questionnaire administered to the adult Finnish Twin Cohort in 1990 (response rate 77%) yielding results from 922 monozygotic and 1697 dizygotic adult twin pairs who reported information about their body height and weight and that of their spouses. Assortative mating was evident for body height and BMI. For body height, the effects of social homogamy (0.24 in men and 0.29 in women) and phenotypic assortment (0.27 and 0.28, respectively) were about the same. For BMI, the effect of social homogamy was stronger (0.31 in men and 0.28 in women) than the effect of phenotypic assortment (0.13 in both men and women). When assortative mating was taken into account, shared environmental factors had no effect on phenotypic variation in body height or BMI. Our results show that assortative mating needs to be considered in population genetic studies of body height and weight.
PubMed ID
12953173 View in PubMed
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Barriers to outdoor physical activity and unmet physical activity need in older adults.

https://arctichealth.org/en/permalink/ahliterature266937
Source
Prev Med. 2014 Oct;67:106-11
Publication Type
Article
Date
Oct-2014
Author
Johanna Eronen
Mikaela B von Bonsdorff
Timo Törmäkangas
Merja Rantakokko
Erja Portegijs
Anne Viljanen
Taina Rantanen
Source
Prev Med. 2014 Oct;67:106-11
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Aging
Cohort Studies
Cross-Sectional Studies
Environment
Environment Design
Exercise
Female
Finland
Geriatric Assessment
Health status
Humans
Male
Mobility Limitation
Questionnaires
Walking
Abstract
To profile participants based on reported outdoor physical activity barriers using a data-driven approach, describe the profiles and study their association with unmet physical activity need.
Cross-sectional analyses of 848 community-dwelling men and women aged 75-90 living in Central Finland in 2012. Barriers to outdoor physical activity and unmet physical activity need were enquired with a questionnaire. The latent profiles were identified by profiling participants into latent groups using a mixture modeling technique on the multivariate set of indicators of outdoor physical activity barriers. A path model was used to study the associations of the profiles with unmet physical activity need.
Five barrier profiles were identified. Profile A was characterized with minor barriers, profile B with weather barriers, profile C with health and weather barriers, profile D with barriers concerning insecurity, health and weather; and profile E with mobility and health barriers. The participants in the profiles differed in the proportion of individual and environmental barriers. The risk for unmet physical activity need was highest among people whose severe mobility difficulties restricted their outdoor physical activity.
Outdoor physical activity barriers reflect the imbalance in person-environment fit among older people, manifested as unmet physical activity need.
PubMed ID
25045839 View in PubMed
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Body dissatisfaction and drive for thinness in young adult twins.

https://arctichealth.org/en/permalink/ahliterature175339
Source
Int J Eat Disord. 2005 Apr;37(3):188-99
Publication Type
Article
Date
Apr-2005
Author
Anna Keski-Rahkonen
Cynthia M Bulik
Benjamin M Neale
Richard J Rose
Aila Rissanen
Jaakko Kaprio
Author Affiliation
Department of Public Health, University of Helsinki, Helsinki, Finland. anna.keski-rahkonen@helsinki.fi
Source
Int J Eat Disord. 2005 Apr;37(3):188-99
Date
Apr-2005
Language
English
Publication Type
Article
Keywords
Adult
Body Image
Drive
Eating Disorders - genetics - psychology
Female
Finland
Humans
Logistic Models
Longitudinal Studies
Male
Multivariate Analysis
Risk factors
Sex Factors
Thinness - psychology
Abstract
We explored correlates of the Eating Disorder Inventory subscales Body Dissatisfaction (BD) and Drive for Thinness (DT) and genetic and environmental influences on these traits.
In a population-based sample of 4,667 Finnish twins aged 22-27 years, we conducted twin modeling to explore genetic and environmental contributions to body dissatisfaction and drive for thinness. Logistic regression was used for the correlational analysis.
Various eating and body size-related factors and psychosomatic symptoms were significantly associated with high body dissatisfaction and drive for thinness in both genders. In women, early puberty onset, early initiation of sexual activity, and multiple sex partners were statistically significant risk factors of body dissatisfaction. In gender-specific univariate twin models, additive genes accounted for 59.4% (95% confidence interval [CI] = 53.2-64.7%) of the variance in body dissatisfaction and for 51.0% (95% CI = 43.7-57.5%) of the variance in drive for thinness among females, but for none of the variance among males.
There are very distinct gender differences in the heritability patterns of body dissatisfaction and drive for thinness in young adults.
PubMed ID
15822080 View in PubMed
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Body fat and mobility are explained by common genetic and environmental influences in older women.

https://arctichealth.org/en/permalink/ahliterature157662
Source
Obesity (Silver Spring). 2008 Jul;16(7):1616-21
Publication Type
Article
Date
Jul-2008
Author
Alfredo Ortega-Alonso
Sarianna Sipilä
Urho M Kujala
Jaakko Kaprio
Taina Rantanen
Author Affiliation
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland. alfredo.ortega@sport.jyu.fi
Source
Obesity (Silver Spring). 2008 Jul;16(7):1616-21
Date
Jul-2008
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Adiposity - genetics
Age Factors
Aged
Aging - genetics
Electric Impedance
Environment
Female
Finland
Genetic Predisposition to Disease
Humans
Locomotion - genetics
Middle Aged
Mobility Limitation
Models, Genetic
Obesity - genetics - physiopathology
Physical Endurance - genetics
Risk factors
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Walking
Abstract
In older adults, mobility limitations often coexist with overweight or obesity, suggesting that similar factors may underlie both traits. This study examined the extent to which genetic and environmental influences explain the association between adiposity and mobility in older women. Body fat percentage (bioimpedance test), walking speed over 10 m, and distance walked in a 6-min test were evaluated in 92 monozygotic (MZ) and 104 dizygotic (DZ) pairs of twin sisters reared together, aged 63-76 years. Genetic and environmental influences on each trait were estimated using age-adjusted multivariate genetic modeling. The analyses showed that the means (and s.d.) for body fat percentage, walking speed, and walking endurance were 33.2+/-7.3%, 1.7+/-0.3 m/s and 529.7+/-75.4 m, respectively. The phenotypic correlation between adiposity and walking speed was -0.32 and between adiposity and endurance it was -0.33. Genetic influences explained 80% of the association between adiposity and speed, and 65% of adiposity and walking endurance. Cross-trait genetic influences accounted for 12% of the variability in adiposity, 56% in walking speed, and 34% in endurance. Trait-specific genetic influences were also detected for adiposity (54%) and walking endurance (13%), but not speed. In conclusion, among community-living older women, an inverse association was found between adiposity and mobility that was mostly due to the effect of shared genes. This result suggests that the identification of genetic variants for body fat metabolism may also provide understanding of the development of mobility limitations in older women.
PubMed ID
18421266 View in PubMed
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Changing environmental influences on substance use across development.

https://arctichealth.org/en/permalink/ahliterature163053
Source
Twin Res Hum Genet. 2007 Apr;10(2):315-26
Publication Type
Article
Date
Apr-2007
Author
Danielle M Dick
Jason L Pagan
Richard Viken
Shaun Purcell
Jaakko Kaprio
Lea Pulkkinen
Richard J Rose
Author Affiliation
Washington University, Department of Psychiatry, St Louis, MO 63110, USA. dickd@wustl.edu
Source
Twin Res Hum Genet. 2007 Apr;10(2):315-26
Date
Apr-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adolescent Behavior
Adolescent Psychology
Alcohol Drinking - genetics - psychology
Child
Cohort Studies
Environment
Female
Finland
Genetic Predisposition to Disease
Humans
Male
Parenting
Peer Group
Phenotype
Questionnaires
Smoking - genetics - psychology
Twins, Dizygotic - genetics - psychology
Twins, Monozygotic - genetics - psychology
Abstract
In contrast to many phenotypes that have been studied using twin designs, substance use shows considerable evidence of environmental influence. Accordingly, specifying the relevant environments and understanding the nature of their effects is an important research priority. Twin studies also have demonstrated that the importance of genetic and environmental influences varies across development for a variety of behavioral outcomes, including substance use. Here, we report analyses exploring moderating effects associated with parenting and peer characteristics on adolescent smoking and drinking, measured at ages 14 and 17. We find significant evidence of moderating effects associated with two dimensions of parenting (parental monitoring and time spent in activities with parents) on adolescent smoking, measured at two time points across development, but no moderating effects on adolescent drinking. Genetic influences on smoking increased, and common environmental effects decreased, as adolescents reported less parental monitoring and spending more time with their parents. Conversely, we find evidence that adolescent drinking is more strongly influenced by peer characteristics. The importance of genetic predispositions was increased among adolescents who reported more friends who used alcohol. These analyses illustrate the importance of incorporating measured aspects of the environment into genetically informative twin models to begin to understand how specific environments are related to various outcomes. Furthermore, they illustrate the importance of using a developmental perspective to understand how specific influences may vary across different ages, and across different phenotypes.
Notes
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PubMed ID
17564520 View in PubMed
Less detail

Co-twin dependence modifies heritability of abstinence and alcohol use: a population-based study of Finnish twins.

https://arctichealth.org/en/permalink/ahliterature9182
Source
Twin Res Hum Genet. 2005 Jun;8(3):232-44
Publication Type
Article
Date
Jun-2005
Author
Varpu Penninkilampi-Kerola
Jaakko Kaprio
Irma Moilanen
Richard J Rose
Author Affiliation
Department of Public Health, University of Helsinki, Helsinki, Finland. varpu.penninkilampi@oulu.fi
Source
Twin Res Hum Genet. 2005 Jun;8(3):232-44
Date
Jun-2005
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alcohol Drinking - epidemiology - genetics - psychology
Alcoholism - epidemiology - genetics
Chi-Square Distribution
Codependency (Psychology)
Diseases in Twins - epidemiology - genetics - psychology
Female
Finland - epidemiology
Humans
Longitudinal Studies
Male
Registries
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Temperance - psychology
Abstract
The role of co-twin dependence (twins' closeness or reliance on the co-twin) was examined as a moderator of genetic and environmental influences on alcohol use in adolescence and early adulthood in a large longitudinal population-based study of Finnish twins (FinnTwin16). The associations between co-twin dependence and alcohol use were studied first at an individual level in adolescence (n = 3362) and early adulthood (n = 2912). Then, maximum likelihood models were fit to the two waves of data from same-sex twin pairs to assess the differences and changes in genetic and environmental influences on alcohol use (abstinence, drinking frequency, intoxication frequency); N = 1342 pairs in adolescence, and N = 1078 pairs in early adulthood. Overall, no significant associations were found between co-twin dependence and individual alcohol use. However, co-twin dependence importantly modulated genetic effects on drinking habits, especially in adolescence, but also in early adulthood. Co-twin-dependent twins reported greater similarity in their alcohol-related behavior across all alcohol-use measures at both time points, and the role of genes and environments varied according to co-twin dependence. Shared environmental factors explained most of the variation in drinking among co-twin-dependent twins in adolescence and contributed to drinking to intoxication during early adulthood. In contrast, among co-twin-independent twin pairs, genetic variance contributed significantly to all alcohol-use measures at both time-points. An interdependent sibling relationship is an important modifier of drinking habits, and it appears to reduce the impact of inherited liabilities on alcohol-related behavior especially in adolescence.
PubMed ID
15989750 View in PubMed
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Do Associations Between Perceived Environmental and Individual Characteristics and Walking Limitations Depend on Lower Extremity Performance Level?

https://arctichealth.org/en/permalink/ahliterature291084
Source
J Aging Health. 2017 Jun; 29(4):640-656
Publication Type
Comparative Study
Journal Article
Date
Jun-2017
Author
Ritva Sakari
Merja Rantakokko
Erja Portegijs
Susanne Iwarsson
Sarianna Sipilä
Anne Viljanen
Taina Rantanen
Author Affiliation
1 University of Jyvaskyla, Finland.
Source
J Aging Health. 2017 Jun; 29(4):640-656
Date
Jun-2017
Language
English
Publication Type
Comparative Study
Journal Article
Keywords
Activities of Daily Living
Aged
Aged, 80 and over
Cross-Sectional Studies
Disability Evaluation
Environment
Female
Geriatric Assessment - methods
Humans
Independent living
Interviews as Topic
Lower Extremity - physiopathology
Male
Mobility Limitation
Perception
Physical Fitness - physiology
Sweden
Task Performance and Analysis
Walking - physiology
Abstract
The aim of this study was to analyze whether the associations between perceived environmental and individual characteristics and perceived walking limitations in older people differ between those with intact and those with poorer lower extremity performance.
Persons aged 75 to 90 ( N = 834) participated in interviews and performance tests in their homes. Standard questionnaires were used to obtain walking difficulties; environmental barriers to and, facilitators of, mobility; and perceived individual hindrances to outdoor mobility. Lower extremity performance was tested using Short Physical Performance Battery (SPPB).
Among those with poorer lower extremity performance, the likelihood for advanced walking limitations was, in particular, related to perceived poor safety in the environment, and among those with intact performance to perceived social issues, such as lack of company, as well as to long distances.
The environmental correlates of walking limitations seem to depend on the level of lower extremity performance.
PubMed ID
27056910 View in PubMed
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Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins.

https://arctichealth.org/en/permalink/ahliterature295201
Source
Dev Psychopathol. 2018 02; 30(1):79-92
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Date
02-2018
Author
Jeanne E Savage
Richard J Rose
Lea Pulkkinen
Karri Silventoinen
Tellervo Korhonen
Jaakko Kaprio
Nathan Gillespie
Danielle M Dick
Author Affiliation
Virginia Commonwealth University.
Source
Dev Psychopathol. 2018 02; 30(1):79-92
Date
02-2018
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Keywords
Adolescent
Alcohol Drinking - genetics - psychology
Child
Diseases in Twins
Female
Finland
Humans
Longitudinal Studies
Male
Parenting
Peer Group
Social Environment
Substance-Related Disorders - etiology - genetics - psychology
Twins
Young Adult
Abstract
Early maturation, indexed by pubertal development (PD), has been associated with earlier initiation and greater frequency of adolescent substance use, but this relationship may be biased by confounding factors and effects that change across development. Using a population-based Finnish twin sample (N = 3,632 individuals), we conducted twin modeling and multilevel structural equation modeling of the relationship between PD and substance use at ages 12-22. Shared environmental factors contributed to early PD and heavier substance use for females. Biological father absence was associated with early PD for boys but not girls, and did not account for the relationship between PD and substance use. The association between early PD and heavier substance use was partially due to between-family confounds, although early PD appeared to qualitatively alter long-term trajectories for some substances (nicotine), but not others (alcohol). Mediation by peer and parental factors did not explain this relationship within families. However, higher peer substance use and lower parental monitoring were themselves associated with heavier substance use, strengthening the existing evidence for these factors as targets for prevention/intervention efforts. Early maturation was not supported as a robust determinant of alcohol use trajectories in adolescence and young adulthood, but may require longer term follow-up. Subtle effects of early PD on nicotine and illicit drug use trajectories throughout adolescence and adulthood merit further investigation.
Notes
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PubMed ID
28424107 View in PubMed
Less detail

Education and alcohol use: A study of gene-environment interaction in young adulthood.

https://arctichealth.org/en/permalink/ahliterature287869
Source
Soc Sci Med. 2016 08;162:158-67
Publication Type
Article
Date
08-2016
Author
Peter B Barr
Jessica E Salvatore
Hermine Maes
Fazil Aliev
Antti Latvala
Richard Viken
Richard J Rose
Jaakko Kaprio
Danielle M Dick
Source
Soc Sci Med. 2016 08;162:158-67
Date
08-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Alcoholism - epidemiology - genetics - psychology
Cohort Studies
Educational Status
Female
Finland - epidemiology
Gene-Environment Interaction
Humans
Male
Twin Studies as Topic - methods
Young Adult
Abstract
The consequences of heavy alcohol use remain a serious public health problem. Consistent evidence has demonstrated that both genetic and social influences contribute to alcohol use. Research on gene-environment interaction (GxE) has also demonstrated that these social and genetic influences do not act independently. Instead, certain environmental contexts may limit or exacerbate an underlying genetic predisposition. However, much of the work on GxE and alcohol use has focused on adolescence and less is known about the important environmental contexts in young adulthood. Using data from the young adult wave of the Finnish Twin Study, FinnTwin12 (N?=?3402), we used biometric twin modeling to test whether education moderated genetic risk for alcohol use as assessed by drinking frequency and intoxication frequency. Education is important because it offers greater access to personal resources and helps determine one's position in the broader stratification system. Results from the twin models show that education did not moderate genetic variance components and that genetic risk was constant across levels of education. Instead, education moderated environmental variance so that under conditions of low education, environmental influences explained more of the variation in alcohol use outcomes. The implications and limitations of these results are discussed.
Notes
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PubMed ID
27367897 View in PubMed
Less detail

Environmental barriers, person-environment fit and mortality among community-dwelling very old people.

https://arctichealth.org/en/permalink/ahliterature265500
Source
BMC Public Health. 2013;13:783
Publication Type
Article
Date
2013
Author
Merja Rantakokko
Timo Törmäkangas
Taina Rantanen
Maria Haak
Susanne Iwarsson
Source
BMC Public Health. 2013;13:783
Date
2013
Language
English
Publication Type
Article
Keywords
Aged, 80 and over
Architectural Accessibility
Environment
Female
Frail Elderly
Housing for the Elderly
Humans
Male
Mobility Limitation
Mortality - trends
Proportional Hazards Models
Sweden - epidemiology
Abstract
Environmental barriers are associated with disability-related outcomes in older people but little is known of the effect of environmental barriers on mortality. The aim of this study was to examine whether objectively measured barriers in the outdoor, entrance and indoor environments are associated with mortality among community-dwelling 80- to 89-year-old single-living people.
This longitudinal study is based on a sample of 397 people who were single-living in ordinary housing in Sweden. Participants were interviewed during 2002-2003, and 393 were followed up for mortality until May 15, 2012.Environmental barriers and functional limitations were assessed with the Housing Enabler instrument, which is intended for objective assessments of Person-Environment (P-E) fit problems in housing and the immediate outdoor environment. Mortality data were gathered from the public national register. Cox regression models were used for the analyses.
A total of 264 (67%) participants died during follow-up. Functional limitations increased mortality risk. Among the specific environmental barriers that generate the most P-E fit problems, lack of handrails in stairs at entrances was associated with the highest mortality risk (adjusted RR 1.55, 95% CI 1.14-2.10), whereas the total number of environmental barriers at entrances and outdoors was not associated with mortality. A higher number of environmental barriers indoors showed a slight protective effect against mortality even after adjustment for functional limitations (RR 0.98, 95% CI 0.96-1.00).
Specific environmental problems may increase mortality risk among very-old single-living people. However, the association may be confounded by individuals' health status which is difficult to fully control for. Further studies are called for.
Notes
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PubMed ID
23981906 View in PubMed
Less detail

Fear of moving outdoors and development of outdoor walking difficulty in older people.

https://arctichealth.org/en/permalink/ahliterature151341
Source
J Am Geriatr Soc. 2009 Apr;57(4):634-40
Publication Type
Article
Date
Apr-2009
Author
Merja Rantakokko
Minna Mänty
Susanne Iwarsson
Timo Törmäkangas
Raija Leinonen
Eino Heikkinen
Taina Rantanen
Author Affiliation
Department of Health Sciences, Finnish Centre for Interdisciplinary Gerontology, University of Jyväskylä, Jyväskylä, Finland. merja.rantakokko@sport.jyu.fi
Source
J Am Geriatr Soc. 2009 Apr;57(4):634-40
Date
Apr-2009
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Aged
Aged, 80 and over
Chi-Square Distribution
Cross-Sectional Studies
Environment
Fear
Female
Finland
Geriatric Assessment
Humans
Interviews as Topic
Logistic Models
Male
Mobility Limitation
Musculoskeletal Diseases - complications
Prospective Studies
Residence Characteristics
Risk factors
Socioeconomic Factors
Abstract
To study which individual characteristics and environmental factors correlate with fear of moving outdoors and whether fear of moving outdoors predicts development of mobility limitation.
Observational prospective cohort study and cross-sectional analyses.
Community and research center.
Seven hundred twenty-seven community-living people aged 75 to 81 were interviewed at baseline, of whom 314 took part in a 3.5-year follow-up.
Fear of moving outdoors and its potential individual and environmental correlates were assessed at baseline. Perceived difficulties in walking 0.5 km and 2 km were assessed twice a year over a 3.5-year period.
At baseline, 65% of the women and 29% of the men reported fear of moving outdoors. Poor socioeconomic status; musculoskeletal diseases; slow walking speed; and the presence of poor street conditions, hills in the nearby environment, and noisy traffic correlated with fear of moving outdoors. At the first 6-month follow-up, participants with fear of moving outdoors had more than four times the adjusted risk (odds ratio (OR)=4.6, 95% confidence interval (CI)=1.92-11.00) of developing difficulties in walking 0.5 km and a three times greater adjusted risk (OR=3.10, 95% CI=1.49-6.46) for developing difficulty in walking 2 km compared with those without fear. The difference in the prevalence of walking difficulties remained statistically significant over the 3.5-year follow-up (P=.02 and P=.009, respectively).
Fear of moving outdoors is common in older adults and increases the risk of developing self-reported difficulties in walking 0.5 km and 2 km. Knowledge about individual and environmental factors underlying fear of moving outdoors and finding ways to alleviate fear of moving outdoors are important for community planning and prevention of disability.
PubMed ID
19392955 View in PubMed
Less detail

Gender differences in friends' influences on adolescent drinking: a genetic epidemiological study.

https://arctichealth.org/en/permalink/ahliterature160735
Source
Alcohol Clin Exp Res. 2007 Dec;31(12):2012-9
Publication Type
Article
Date
Dec-2007
Author
Danielle M Dick
Jason L Pagan
Candice Holliday
Richard Viken
Lea Pulkkinen
Jaakko Kaprio
Richard J Rose
Author Affiliation
Washington University, St. Louis, Missouri, USA. ddick@vcu.edu
Source
Alcohol Clin Exp Res. 2007 Dec;31(12):2012-9
Date
Dec-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Alcohol Drinking - epidemiology - genetics - psychology
Analysis of Variance
Cross-Sectional Studies
Female
Finland
Friends - psychology
Genetic Predisposition to Disease - genetics
Genotype
Health Surveys
Humans
Leadership
Longitudinal Studies
Male
Peer Group
Phenotype
Questionnaires
Risk factors
Sex Factors
Smoking - epidemiology - genetics - psychology
Social Environment
Social Facilitation
Social Identification
Twins, Dizygotic - genetics - psychology
Twins, Monozygotic - genetics - psychology
Abstract
We use data from a population-based twin study to examine the association between characteristics of the friendship group and adolescents' own alcohol use at age 14, with focus on gender differences, both with respect to the adolescent's own gender and the gender composition of his/her friendship group.
(1) We conducted analyses on the full epidemiological sample of individuals to determine the magnitude of association between friendship characteristics and alcohol use, and to test for interaction with gender and gender of friends. (2) We used the twin structure of the dataset to study the extent to which similarity in drinking behaviors between adolescents and their friends was due to shared genetic and/or environmental pathways.
Friends' drinking, smoking, and delinquency were more strongly related to alcohol use in girls, compared to boys, and in adolescents with opposite-sex friends, compared to adolescents with only same-sex friends. Friends' alcohol use showed modest evidence of genetic influence in girls, suggesting peer selection; however, there was no evidence of genetic influence on friends' alcohol use in boys. The correlation between adolescent and friend drinking was largely attributable to shared environmental effects across genders.
Gender and gender of friends moderate the associations between friends' behavior and adolescents' alcohol use, with evidence that girls, and those with opposite-sex friends, may be more susceptible to friends' influence. Genetically informative analyses suggest that similarity in alcohol use between adolescents and their friends is mediated, at least partially, through environmental pathways.
PubMed ID
17949469 View in PubMed
Less detail

The genetic and environmental effects on depressive symptoms among older female twins.

https://arctichealth.org/en/permalink/ahliterature176906
Source
Twin Res. 2004 Dec;7(6):626-36
Publication Type
Article
Date
Dec-2004
Author
Sanna Takkinen
Asko Tolvanen
Jaakko Kaprio
Stig Berg
Markku Koskenvuo
Taina Rantanen
Author Affiliation
Institute of Gerontology, School of Health Sciences, Jönköping, Sweden.
Source
Twin Res. 2004 Dec;7(6):626-36
Date
Dec-2004
Language
English
Publication Type
Article
Keywords
Aged
Cross-Sectional Studies
Depression - epidemiology - genetics - psychology
Environment
Female
Finland - epidemiology
Humans
Models, Biological
Risk factors
Twins - genetics - psychology
Twins, Dizygotic - genetics - psychology
Twins, Monozygotic - genetics - psychology
Abstract
The aim of the present study was to examine the contribution of genetic and environmental factors to depressive symptoms among older women. The participants were 102 monozygotic and 115 dizygotic female twin pairs aged 64 to 76 years. Depressive symptoms were assessed by the Center for the Epidemiologic Studies Depression Scale. The contribution of genetic and environmental effects was estimated for the constructed depressiveness factor and for the subscales which were depressed mood, psychomotor retardation, lack of wellbeing and interpersonal difficulties. Of the variance in depressiveness, shared environmental influences accounted for 39% and nonshared environmental influences 61%. For the subscales, 24% to 62% of the variance was explained by individual, and 13% to 23% by shared, environmental factors. Lack of wellbeing had its own moderate additive genetic effect explaining 30% of the variance. This study showed that in older women predominantly environmental factors underlay individual differences in depressiveness; however, the factors varied to some extent between dimensions measured by the subscales.
PubMed ID
15607014 View in PubMed
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Genetic and environmental factors affecting self-esteem from age 14 to 17: a longitudinal study of Finnish twins.

https://arctichealth.org/en/permalink/ahliterature163269
Source
Psychol Med. 2007 Nov;37(11):1625-33
Publication Type
Article
Date
Nov-2007
Author
Anu Raevuori
Danielle M Dick
Anna Keski-Rahkonen
Lea Pulkkinen
Richard J Rose
Aila Rissanen
Jaakko Kaprio
Richard J Viken
Karri Silventoinen
Author Affiliation
Department of Public Health, University of Helsinki, Finland. anu.raevuori@helsinki.fi
Source
Psychol Med. 2007 Nov;37(11):1625-33
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adolescent Psychology
Age Factors
Family
Female
Finland
Humans
Longitudinal Studies
Male
Personality - genetics
Personality Assessment
Questionnaires
Self Concept
Sex Factors
Social Environment
Twins - genetics - psychology
Abstract
We analysed genetic and environmental influences on self-esteem and its stability in adolescence.
Finnish twins born in 1983-1987 were assessed by questionnaire at ages 14 (n = 4132 twin individuals) and 17 years (n = 3841 twin individuals). Self-esteem was measured using the Rosenberg global self-esteem scale and analyzed using quantitative genetic methods for twin data in the Mx statistical package.
The heritability of self-esteem was 0.62 [95% confidence interval (CI) 0.56-0.68] in 14-year-old boys and 0.40 (95% CI 0.26-0.54) in 14-year-old girls, while the corresponding estimates at age 17 were 0.48 (95% CI 0.39-0.56) and 0.29 (95% CI 0.11-0.45). Rosenberg self-esteem scores at ages 14 and 17 were modestly correlated (r = 0.44 in boys, r = 0.46 in girls). In boys, the correlation was mainly (82%) due to genetic factors, with residual co-variation due to unique environment. In girls, genetic (31%) and common environmental (61%) factors largely explained the correlation.
In adolescence, self-esteem seems to be differently regulated in boys versus girls. A key challenge for future research is to identify environmental influences contributing to self-esteem during adolescence and determine how these factors interact with genetic influences.
Notes
Cites: Child Dev. 1999 Nov-Dec;70(6):1283-9610621957
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PubMed ID
17537282 View in PubMed
Less detail

Genetic and environmental factors affecting self-rated health from age 16-25: a longitudinal study of Finnish twins.

https://arctichealth.org/en/permalink/ahliterature167932
Source
Behav Genet. 2007 Mar;37(2):326-33
Publication Type
Article
Date
Mar-2007
Author
Karri Silventoinen
Danielle Posthuma
Eero Lahelma
Richard J Rose
Jaakko Kaprio
Author Affiliation
Department of Public Health, University of Helsinki, P.O. Box 41, Mannerheimintie 172, FIN-00014, Helsinki, Finland. karri.silventoinen@helsinki.fi
Source
Behav Genet. 2007 Mar;37(2):326-33
Date
Mar-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Environment
Female
Finland
Genetics, Medical
Health status
Humans
Longitudinal Studies
Male
Models, Genetic
Questionnaires
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Abstract
We analyzed genetic and environmental determinants of self-rated health and its change from adolescence to early adulthood. Questionnaires were mailed to Finnish twins born 1975-1979 at ages 16, 17, 18 1/2 and, on average, 25 years of age (N=2465 complete twin pairs). The data were analyzed using quantitative genetic methods for twin data by the Mx statistical package. Heritability of self-rated health was greatest at age 16 (63%, 95% confidence intervals (CI) 56-67%, men and women together) and declined steadily to age 25 (33%, 95% CI 25-41%). The residual variation was due to unshared environments. Health ratings at different ages were modestly correlated (r=0.33-0.61). These correlations were mainly due to genetic factors, but unshared environment also contributed to them. An important challenge for further research is to identify environmental influences contributing to self-rated health independently of, or in interaction with, genetic factors.
PubMed ID
16906466 View in PubMed
Less detail

Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families.

https://arctichealth.org/en/permalink/ahliterature186967
Source
Twin Res. 2002 Oct;5(5):366-71
Publication Type
Article
Date
Oct-2002
Author
Jaakko Kaprio
Lea Pulkkinen
Richard J Rose
Author Affiliation
Dept. of Public Health, University of Helsinki, National Public Health Institute, Helsinki, Finland. jaakko.kaprio@helsinki.fi
Source
Twin Res. 2002 Oct;5(5):366-71
Date
Oct-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alcoholism - epidemiology - genetics - psychology
Child
Cohort Studies
Databases, Factual
Diseases in Twins - epidemiology - genetics
Eating Disorders - epidemiology - genetics - psychology
Environment
Family - psychology
Finland - epidemiology
Genetic Predisposition to Disease - epidemiology - genetics - psychology
Health Behavior
Humans
Morbidity
Obesity - epidemiology - genetics - psychology
Population Surveillance
Registries
Risk assessment
Risk factors
Twin Studies as Topic
Twins - genetics - psychology
Abstract
Family, twin and adoption studies have provided evidence for familial and genetic influences on individual differences in disease risk and in human behavior. Attempts to identify individual genes accounting for these differences have not been outstandingly successful to date, and at best, known genes account for only a fraction of the familiality of most traits or diseases. More detailed knowledge of the dynamics of gene action and of specific environmental conditions are needed. Twin and twin-family studies with multiple measurements of risk factors and morbidity over time can permit a much more detailed assessment of the developmental dynamics of disease risk and the unfolding of behavioral risk factors.
PubMed ID
12537860 View in PubMed
Less detail

Genetic and environmental influences on BMI from late childhood to adolescence are modified by parental education.

https://arctichealth.org/en/permalink/ahliterature130499
Source
Obesity (Silver Spring). 2012 Mar;20(3):583-9
Publication Type
Article
Date
Mar-2012
Author
Hanna-Reetta Lajunen
Jaakko Kaprio
Richard J Rose
Lea Pulkkinen
Karri Silventoinen
Author Affiliation
Department of Public Health, University of Helsinki, Helsinki, Finland. hanna-reetta.lajunen@helsinki.fi
Source
Obesity (Silver Spring). 2012 Mar;20(3):583-9
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Body mass index
Child
Educational Status
Female
Finland - epidemiology
Genetic Variation
Humans
Male
Obesity - epidemiology - etiology - genetics - prevention & control
Parenting
Parents - education
Prospective Studies
Self Report
Social Environment
Twins
Abstract
To investigate how parental education modifies genetic and environmental influences on variation in BMI during adolescence, self-reported BMI at 11-12, 14, and 17 years of age was collected from a population sample of 2,432 complete Finnish twin pairs born in 1983-1987. Based on parental report, twins were divided to those with high (both parents high school graduates), mixed level (one parent a graduate, the other not), and limited (neither parent a graduate) parental education. Genetic and environmental influences on variation in BMI in different education classes were modeled using twin analysis. Heritability of BMI among 11-12-year-olds with high parental education was 85-87% whereas it was 61-68% if parental education was limited or mixed level. Common environmental effect, i.e., effect of environmental factors shared by family members, was found (17-22%) if parental education was limited or mixed level but not if it was high. With increasing parental education, common environmental variance in BMI decreased at age 14 among boys (from 22 to 3%) and girls (from 17 to 10%); heritability increased among boys from 63 to 78%, but did not change among girls. The common environmental component disappeared and heritability of BMI was larger at the age of 17 in all parental education classes. To conclude, common environment did not affect variation of adolescent BMI in high-educated families but did so in families with limited parental education. This suggests that intervention and prevention campaigns could effectively target families identified by limited parental education.
PubMed ID
21996670 View in PubMed
Less detail

Genetic and environmental influences on hearing at different frequencies separately for the better and worse hearing ear in older women.

https://arctichealth.org/en/permalink/ahliterature160056
Source
Int J Audiol. 2007 Dec;46(12):772-9
Publication Type
Article
Date
Dec-2007
Author
Anne Viljanen
Jaakko Kaprio
Ilmari Pyykkö
Martti Sorri
Markku Kauppinen
Markku Koskenvuo
Taina Rantanen
Author Affiliation
Finnish Centre for Interdisciplinary Gerontology, Department of Health Sciences, University of Jyväskylä, Finland. anne.viljanen@sport.jyu.fi
Source
Int J Audiol. 2007 Dec;46(12):772-9
Date
Dec-2007
Language
English
Publication Type
Article
Keywords
Aged
Aging - physiology
Auditory Threshold - physiology
Diseases in Twins - epidemiology
Environmental Exposure - adverse effects
Female
Finland - epidemiology
Hearing Disorders - epidemiology - etiology - genetics
Humans
Middle Aged
Registries
Severity of Illness Index
Twins, Dizygotic
Abstract
The purpose of the present study was to examine the relative contribution of genetic and environmental effects on the air-conducted hearing threshold levels at low (0.125-0.5 kHz), mid (1-2 kHz), and high (4-8 kHz) frequencies separately for the better and worse hearing ear in older women. We also examined the distribution of audiogram configurations. Data was analysed using quantitative genetic modelling. As part of the Finnish twin study on aging (FITSA), hearing was measured in 103 monozygotic and 114 dizygotic female twin pairs aged 63-76 years. Approximately every third subject had a flat type, and two-thirds a descending type of audiogram configuration. No significant difference was observed in the distribution of audiogram configurations between zygosity groups. In the better ear, additive genetic effects accounted for 64%-74% of the total variance at different frequencies. For the worse ear, environmental effects were larger. Although overall heritability is rather constant across the frequency spectrum, it is noteworthy that at low and high frequencies frequency-specific genetic and environmental effects together accounted for the majority of the total variance.
PubMed ID
18049966 View in PubMed
Less detail

Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood.

https://arctichealth.org/en/permalink/ahliterature169926
Source
Behav Genet. 2006 Jul;36(4):483-97
Publication Type
Article
Date
Jul-2006
Author
Jason L Pagan
Richard J Rose
Richard J Viken
Lea Pulkkinen
Jaakko Kaprio
Danielle M Dick
Author Affiliation
Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
Source
Behav Genet. 2006 Jul;36(4):483-97
Date
Jul-2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alcohol Drinking - epidemiology - genetics - physiopathology
Alcoholism - epidemiology - etiology - genetics
Environment
Finland - epidemiology
Humans
Models, Biological
Prevalence
Registries
Abstract
The progression to alcohol dependence unfolds across multiple stages, including the decision to initiate use, the development of regular patterns of use, and (for some individuals) the subsequent development of problems associated with alcohol use. Using data from two population-based, longitudinal twin studies, FinnTwin16 (FT16) and FinnTwin12 (FT12), we applied multiple stage genetic models (Heath et al., Twin Res. 5 (2002) 113) to better understand the extent to which genetic and environmental influences impact the initiation of alcohol use, frequency of use in adolescence and young adulthood, and alcohol problems in young adulthood. Shared environmental factors played a large role in initiation, and a more moderate role on frequency of use, and it was largely the same influences acting across these stages of use. However, there was no significant evidence of shared environmental influences on alcohol problems in early adulthood. Problems were largely influenced by genetic factors that overlapped with genetic influences on frequency of use. Unique environmental factors were largely specific to each stage, with some overlap between alcohol problems and frequency of use at age 25.
Notes
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PubMed ID
16586152 View in PubMed
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