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Active aging - resilience and external support as modifiers of the disablement outcome: AGNES cohort study protocol.

https://arctichealth.org/en/permalink/ahliterature299192
Source
BMC Public Health. 2018 05 02; 18(1):565
Publication Type
Journal Article
Date
05-02-2018
Author
Taina Rantanen
Milla Saajanaho
Laura Karavirta
Sini Siltanen
Merja Rantakokko
Anne Viljanen
Timo Rantalainen
Katja Pynnönen
Anu Karvonen
Inna Lisko
Lotta Palmberg
Johanna Eronen
Eeva-Maija Palonen
Timo Hinrichs
Markku Kauppinen
Katja Kokko
Erja Portegijs
Author Affiliation
Gerontology Research Center, Faculty of Sport and Health Sciences, Univerisity of Jyvaskyla, P.O. Box 35 (viv 149), 40014, Jyväskylä, Finland. taina.rantanen@jyu.fi.
Source
BMC Public Health. 2018 05 02; 18(1):565
Date
05-02-2018
Language
English
Publication Type
Journal Article
Keywords
Aged
Aged, 80 and over
Aging - psychology
Cohort Studies
Disabled persons - statistics & numerical data
Exercise
Female
Finland
Health Behavior
Health Literacy
Humans
Male
Resilience, Psychological
Social Support
Abstract
Population aging increases the need for knowledge on positive aspects of aging, and contributions of older people to their own wellbeing and that of others. We defined active aging as an individual's striving for elements of wellbeing with activities as per their goals, abilities and opportunities. This study examines associations of health, health behaviors, health literacy and functional abilities, environmental and social support with active aging and wellbeing. We will develop and validate assessment methods for physical activity and physical resilience suitable for research on older people, and examine their associations with active aging and wellbeing. We will examine cohort effects on functional phenotypes underlying active aging and disability.
For this population-based study, we plan to recruit 1000 participants aged 75, 80 or 85 years living in central Finland, by drawing personal details from the population register. Participants are interviewed on active aging, wellbeing, disability, environmental and social support, mobility, health behavior and health literacy. Physical activity and heart rate are monitored for 7 days with wearable sensors. Functional tests include hearing, vision, muscle strength, reaction time, exercise tolerance, mobility, and cognitive performance. Clinical examination by a nurse and physician includes an electrocardiogram, tests of blood pressure, orthostatic regulation, arterial stiffness, and lung function, as well as a review of chronic and acute conditions and prescribed medications. C-reactive protein, small blood count, cholesterol and vitamin D are analyzed from blood samples. Associations of factors potentially underlying active aging and wellbeing will be studied using multivariate methods. Cohort effects will be studied by comparing test results of physical and cognitive functioning with results of a cohort examined in 1989-90.
The current study will renew research on positive gerontology through the novel approach to active aging and by suggesting new biomarkers of resilience and active aging. Therefore, high interdisciplinary impact is expected. This cross-sectional study will not provide knowledge on temporal order of events or causality, but an innovative cross-sectional dataset provides opportunities for emergence of novel creative hypotheses and theories.
PubMed ID
29716566 View in PubMed
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Associations between sports participation, cardiorespiratory fitness, and adiposity in young adult twins.

https://arctichealth.org/en/permalink/ahliterature138202
Source
J Appl Physiol (1985). 2011 Mar;110(3):681-6
Publication Type
Article
Date
Mar-2011
Author
L. Mustelin
A. Latvala
K H Pietiläinen
P. Piirilä
A R Sovijärvi
U M Kujala
A. Rissanen
J. Kaprio
Author Affiliation
Hjelt Institute, Dept. of Public Health, Twin Research Unit, PB 41, 00014 Univ. of Helsinki, Finland. linda.mustelin@helsinki.fi
Source
J Appl Physiol (1985). 2011 Mar;110(3):681-6
Date
Mar-2011
Language
English
Publication Type
Article
Keywords
Adiposity - genetics
Adult
Body Size - genetics
Female
Finland - epidemiology
Genetic Association Studies
Heart
Humans
Motor Activity - genetics
Physical Fitness - physiology
Sports
Statistics as Topic
Twins - genetics - physiology
Young Adult
Abstract
Exercise behavior, cardiorespiratory fitness, and obesity are strongly influenced by genetic factors. By studying young adult twins, we examined to what extent these interrelated traits have shared genetic and environmental etiologies. We studied 304 twin individuals selected from the population-based FinnTwin16 study. Physical activity was assessed with the Baecke questionnaire, yielding three indexes: sport index, leisure-time index, and work index. In this study, we focused on sport index, which describes sports participation. Body composition was determined using dual-energy X-ray absorptiometry and cardiorespiratory fitness using a bicycle ergometer exercise test with gas exchange analysis. The Baecke sport index was associated with high maximal oxygen uptake adjusted for lean body mass (Vo(2max)[adj]) (r = 0.40), with low body fat percentage (BF%) (r = -0.44) and low waist circumference (WC) (r = -0.29). Heritability estimates for the key traits were as follows: 56% for sport index, 71% for Vo(2max)[adj], 77% for body mass index, 66% for WC, and 68% for BF%. The association between sport index and Vo(2max) was mostly explained by genetic factors (70%), as were both the association between sport index and BF% (71%) and that between sport index and WC (59%). Our results suggest that genetic factors explain a considerable part of the associations between sports participation, cardiorespiratory fitness, and obesity.
PubMed ID
21193564 View in PubMed
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Barriers to outdoor physical activity and unmet physical activity need in older adults.

https://arctichealth.org/en/permalink/ahliterature266937
Source
Prev Med. 2014 Oct;67:106-11
Publication Type
Article
Date
Oct-2014
Author
Johanna Eronen
Mikaela B von Bonsdorff
Timo Törmäkangas
Merja Rantakokko
Erja Portegijs
Anne Viljanen
Taina Rantanen
Source
Prev Med. 2014 Oct;67:106-11
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Aging
Cohort Studies
Cross-Sectional Studies
Environment
Environment Design
Exercise
Female
Finland
Geriatric Assessment
Health status
Humans
Male
Mobility Limitation
Questionnaires
Walking
Abstract
To profile participants based on reported outdoor physical activity barriers using a data-driven approach, describe the profiles and study their association with unmet physical activity need.
Cross-sectional analyses of 848 community-dwelling men and women aged 75-90 living in Central Finland in 2012. Barriers to outdoor physical activity and unmet physical activity need were enquired with a questionnaire. The latent profiles were identified by profiling participants into latent groups using a mixture modeling technique on the multivariate set of indicators of outdoor physical activity barriers. A path model was used to study the associations of the profiles with unmet physical activity need.
Five barrier profiles were identified. Profile A was characterized with minor barriers, profile B with weather barriers, profile C with health and weather barriers, profile D with barriers concerning insecurity, health and weather; and profile E with mobility and health barriers. The participants in the profiles differed in the proportion of individual and environmental barriers. The risk for unmet physical activity need was highest among people whose severe mobility difficulties restricted their outdoor physical activity.
Outdoor physical activity barriers reflect the imbalance in person-environment fit among older people, manifested as unmet physical activity need.
PubMed ID
25045839 View in PubMed
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Body fat and mobility are explained by common genetic and environmental influences in older women.

https://arctichealth.org/en/permalink/ahliterature157662
Source
Obesity (Silver Spring). 2008 Jul;16(7):1616-21
Publication Type
Article
Date
Jul-2008
Author
Alfredo Ortega-Alonso
Sarianna Sipilä
Urho M Kujala
Jaakko Kaprio
Taina Rantanen
Author Affiliation
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland. alfredo.ortega@sport.jyu.fi
Source
Obesity (Silver Spring). 2008 Jul;16(7):1616-21
Date
Jul-2008
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Adiposity - genetics
Age Factors
Aged
Aging - genetics
Electric Impedance
Environment
Female
Finland
Genetic Predisposition to Disease
Humans
Locomotion - genetics
Middle Aged
Mobility Limitation
Models, Genetic
Obesity - genetics - physiopathology
Physical Endurance - genetics
Risk factors
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Walking
Abstract
In older adults, mobility limitations often coexist with overweight or obesity, suggesting that similar factors may underlie both traits. This study examined the extent to which genetic and environmental influences explain the association between adiposity and mobility in older women. Body fat percentage (bioimpedance test), walking speed over 10 m, and distance walked in a 6-min test were evaluated in 92 monozygotic (MZ) and 104 dizygotic (DZ) pairs of twin sisters reared together, aged 63-76 years. Genetic and environmental influences on each trait were estimated using age-adjusted multivariate genetic modeling. The analyses showed that the means (and s.d.) for body fat percentage, walking speed, and walking endurance were 33.2+/-7.3%, 1.7+/-0.3 m/s and 529.7+/-75.4 m, respectively. The phenotypic correlation between adiposity and walking speed was -0.32 and between adiposity and endurance it was -0.33. Genetic influences explained 80% of the association between adiposity and speed, and 65% of adiposity and walking endurance. Cross-trait genetic influences accounted for 12% of the variability in adiposity, 56% in walking speed, and 34% in endurance. Trait-specific genetic influences were also detected for adiposity (54%) and walking endurance (13%), but not speed. In conclusion, among community-living older women, an inverse association was found between adiposity and mobility that was mostly due to the effect of shared genes. This result suggests that the identification of genetic variants for body fat metabolism may also provide understanding of the development of mobility limitations in older women.
PubMed ID
18421266 View in PubMed
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Body weight in the Finnish Twin Cohort.

https://arctichealth.org/en/permalink/ahliterature103520
Source
Diabetes Res Clin Pract. 1990;10 Suppl 1:S33-6
Publication Type
Article
Date
1990
Author
M. Turula
J. Kaprio
A. Rissanen
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Diabetes Res Clin Pract. 1990;10 Suppl 1:S33-6
Date
1990
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Body mass index
Body Weight - genetics
Cohort Studies
Environment
Female
Finland - epidemiology
Humans
Male
Middle Aged
Obesity - epidemiology - genetics - physiopathology
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Abstract
We estimated genetic and environmental variance of BMI among 7245 non-pregnant MZ and DZ pairs of the same sex from the population-based Finnish Twin Cohort. The contributions of additive genetic effects, shared and non-shared environmental effects on age-adjusted BMI-variance were estimated by LISREL structural equation models. Genetic effects contribute 72% in men and 66.4% in non-pregnant women of total variance, while 27.8% of variance among men and 33.6% among women is due to non-shared environmental effects. Shared environmental effects were nonsignificant (0% for women and 0.2% for men). Similar values were obtained for hereditary and non-shared environmental effects, when shared environmental effects were not included in the model. The inclusion of pregnant women did not substantially change heritability estimates.
PubMed ID
2286148 View in PubMed
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Cardiovascular reflexes in monozygotic twins discordant for exposure to organic solvents.

https://arctichealth.org/en/permalink/ahliterature235974
Source
Acta Genet Med Gemellol (Roma). 1987;36(4):503-7
Publication Type
Article
Date
1987
Author
E. Matikainen
J. Juntunen
M. Koskenvuo
M. Antti-Poika
J. Kaprio
Author Affiliation
Institute of Occupation Health, Helsinki, Finland.
Source
Acta Genet Med Gemellol (Roma). 1987;36(4):503-7
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Aged
Autonomic Nervous System - physiology
Blood pressure
Environmental Exposure
Female
Finland
Heart - physiology
Heart rate
Humans
Male
Middle Aged
Pulse
Solvents - adverse effects
Twins
Twins, Monozygotic
Valsalva Maneuver
Abstract
Eighteen pairs of monozygotic twins discordant for long-term occupational exposure to organic solvents were examined for disturbances of cardiovascular reflexes. All of the subjects were asymptomatic, and considered themselves healthy. No significant differences were observed between the exposed and the nonexposed twins. The finding suggests that occupational solvent exposure at these particular levels is unlikely to cause disturbances of the autonomic nervous function.
PubMed ID
3454512 View in PubMed
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Changes in residential proximity to road traffic and the risk of death from coronary heart disease.

https://arctichealth.org/en/permalink/ahliterature142555
Source
Epidemiology. 2010 Sep;21(5):642-9
Publication Type
Article
Date
Sep-2010
Author
Wen Qi Gan
Lillian Tamburic
Hugh W Davies
Paul A Demers
Mieke Koehoorn
Michael Brauer
Author Affiliation
School of Environmental Health, The University of British Columbia, Vancouver, BC, Canada.
Source
Epidemiology. 2010 Sep;21(5):642-9
Date
Sep-2010
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Aged, 80 and over
Air Pollution - adverse effects
British Columbia - epidemiology
Cohort Studies
Coronary Disease - etiology - mortality
Dibutyl Phthalate
Environmental Exposure - adverse effects
Female
Humans
Logistic Models
Male
Middle Aged
Motor Vehicles - statistics & numerical data
Risk factors
Sex Factors
Socioeconomic Factors
Abstract
Residential proximity to road traffic is associated with increased coronary heart disease (CHD) morbidity and mortality. It is unknown, however, whether changes in residential proximity to traffic could alter the risk of CHD mortality.
We used a population-based cohort study with a 5-year exposure period and a 4-year follow-up period to explore the association between changes in residential proximity to road traffic and the risk of CHD mortality. The cohort comprised all residents aged 45-85 years who resided in metropolitan Vancouver during the exposure period and without known CHD at baseline (n = 450,283). Residential proximity to traffic was estimated using a geographic information system. CHD deaths during the follow-up period were identified using provincial death registration database. The data were analyzed using logistic regression.
Compared with the subjects consistently living away from road traffic (>150 m from a highway or >50 m from a major road) during the 9-year study period, those consistently living close to traffic (
PubMed ID
20585255 View in PubMed
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Common genetic influences on BMI and age at menarche.

https://arctichealth.org/en/permalink/ahliterature214205
Source
Hum Biol. 1995 Oct;67(5):739-53
Publication Type
Article
Date
Oct-1995
Author
J. Kaprio
A. Rimpelä
T. Winter
R J Viken
M. Rimpelä
R J Rose
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Hum Biol. 1995 Oct;67(5):739-53
Date
Oct-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Aging - physiology
Body mass index
Body Weight
Child
Confidence Intervals
Female
Finland
Humans
Menarche - genetics - physiology
Reproducibility of Results
Twins - genetics
Abstract
Genetic influences on variability of body weight and onset of menarche are well known. To investigate the genetic and environmental contributions to the association of body weight with onset of menarche, we studied Finnish twins from consecutive birth cohorts (the FinnTwin16 study) ascertained from the national population registry, which identifies nearly 100% of all living twins. Baseline questionnaires were mailed to the twins within 60 days of their sixteenth birthday and later to older sibs of the twins. Pairwise response rates (approximately 85% across gender and zygosity) and 30 months of data collection yielded results from 1283 twin pairs. The questionnaires included a survey of health habits and attitudes, a symptom checklist, MMPI personality scales, and a survey of relationships with parents, peers, and the co-twin. Age at menarche was reported by 468 monozygotic (MZ) girls, 378 girls from like-sex dizygotic (FDZ) pairs, 434 girls from opposite-sex (OSDZ) pairs, and 141 older female sibs of the twins. The one-month test-retest reliability of age at menarche in an independent sample (N = 136) of 16-year-olds from a national survey was 0.96. Girls from OSDZ pairs had a significantly higher mean age at menarche (13.33 yr) than FDZ girls (13.13 yr) (difference, 0.20 yr; 95% confidence interval, 0.05-0.35). The MZ correlation for age at menarche was 0.75, the DZ correlation was 0.31, and the sib-twin correlation was 0.32. A bivariate twin analysis of age at menarche and body mass index (wt/ht2) indicated that 37% of the variance in age at menarche can be attributed to additive genetic effects, 37% to dominance effects, and 26% to unique environmental effects. The correlation between additive genetic effects on age at menarche and body mass index was 0.57, indicating a substantial proportion of genetic effects in common.
PubMed ID
8543288 View in PubMed
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Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland.

https://arctichealth.org/en/permalink/ahliterature222787
Source
Diabetologia. 1992 Nov;35(11):1060-7
Publication Type
Article
Date
Nov-1992
Author
J. Kaprio
J. Tuomilehto
M. Koskenvuo
K. Romanov
A. Reunanen
J. Eriksson
J. Stengård
Y A Kesäniemi
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Diabetologia. 1992 Nov;35(11):1060-7
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cohort Studies
Diabetes Mellitus, Type 1 - epidemiology - genetics
Diabetes Mellitus, Type 2 - epidemiology - genetics
Diseases in Twins - epidemiology - genetics
Female
Finland - epidemiology
Humans
Male
Middle Aged
Population
Registries
Twins, Dizygotic
Twins, Monozygotic
Abstract
We studied the cumulative incidence, concordance rate and heritability for diabetes mellitus in a nationwide cohort of 13,888 Finnish twin pairs of the same sex. The twins were born before 1958 and both co-twins were alive in 1967. Data on diabetes were derived through computerized record linkage from death certificates, the National Hospital Discharge Register and the National Drug Register. Records were reviewed in order to assign a diagnostic category to the 738 diabetic patients identified. Of these patients 109 had Type 1 (insulin-dependent) diabetes, 505 Type 2 (non-insulin-dependent) diabetes, 46 gestational diabetes, 24 secondary diabetes, 38 impaired glucose tolerance and 16 remained unclassified. The cumulative incidence of diabetes was 1.4% in men and 1.3% in women aged 28-59 years and 9.3% and 7.0% in men and women aged 60 years and over, respectively. The cumulative incidence did not differ between monozygotic and dizygotic twins. The concordance rate for Type 1 diabetes was higher among monozygotic (23% probandwise and 13% pairwise) than dizygotic twins (5% probandwise and 3% pairwise). The probandwise and pairwise concordance rates for Type 2 diabetes were 34% and 20% among monozygotic twins and 16% and 9% in dizygotic twins, respectively. Heritability for Type 1 diabetes was greater than that for Type 2 where both genetic and environmental effects seemed to play a significant role.
Notes
Comment In: Diabetologia. 1993 May;36(5):471-28314454
PubMed ID
1473616 View in PubMed
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Consistency and change in patterns of social drinking: a 6-year follow-up of the Finnish Twin Cohort.

https://arctichealth.org/en/permalink/ahliterature224022
Source
Alcohol Clin Exp Res. 1992 Apr;16(2):234-40
Publication Type
Article
Date
Apr-1992
Author
J. Kaprio
R. Viken
M. Koskenvuo
K. Romanov
R J Rose
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Alcohol Clin Exp Res. 1992 Apr;16(2):234-40
Date
Apr-1992
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - genetics - psychology
Alcoholism - genetics - psychology
Cohort Studies
Diseases in Twins - genetics - psychology
Female
Finland
Follow-Up Studies
Humans
Individuality
Longitudinal Studies
Male
Models, Genetic
Phenotype
Risk factors
Social Environment
Twins, Dizygotic - genetics - psychology
Twins, Monozygotic - genetics - psychology
Abstract
In 1975 and again in 1981, all adult twins in the population-based Finnish Twin Cohort were administered postal questionnaires yielding data on self-reported frequency and quantity of alcohol use. The longitudinal results provide information on the age-to-age stability of social drinking patterns among 13,404 (twin) individuals aged 18 to 43 at baseline; model-fitting the cross-temporal consistency of the twins' reported alcohol use yields unique estimates of the contribution of genetic and environmental factors to their individual age-to-age stabilities. Mean consumption levels did not change between 1975 and 1981. Patterns of social drinking were more stable in older (aged 24-43 at baseline) than younger (aged 18-23 at baseline) adult twins, and were more stable among men than women. Heritabilities were significant at both baseline and follow-up for all three alcohol measures in both genders and both age groups, with a median magnitude of 0.48. Both longitudinal genetic and environmental covariances were significant, and both were generally higher among older pairs. Genetic covariances (median magnitude = 0.68) were significantly higher than environmental covariances (median = 0.36). Analyses of absolute changes in alcohol use revealed heritable influences on the disposition to change. We conclude that genes contribute to both consistency and change in patterns of alcohol use from early to midadulthood.
PubMed ID
1590545 View in PubMed
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Consistency and change of body mass index and weight. A study on 5967 adult Finnish twin pairs.

https://arctichealth.org/en/permalink/ahliterature215253
Source
Int J Obes Relat Metab Disord. 1995 May;19(5):310-7
Publication Type
Article
Date
May-1995
Author
M. Korkeila
J. Kaprio
A. Rissanen
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Int J Obes Relat Metab Disord. 1995 May;19(5):310-7
Date
May-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Animals
Body mass index
Body Weight - genetics
Cohort Studies
Female
Finland
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Questionnaires
Twins, Dizygotic
Twins, Monozygotic
Abstract
To study twin resemblance for weight change (delta wt) and to assess the consistency of body mass index (BMI) over 6 years.
6 year follow-up based on identical mailed questionnaires in 1975 (baseline) and in 1981 (follow-up).
5967 same-sexed non-pregnant Finnish twin pairs aged 18-54 in 1975 (1106 male and 862 female monozygotic (MZ) and 2430 male and 1569 female dizygotic (DZ) pairs).
Intra-pair correlations of delta wt and BMI, estimates of genetic and environmental components of variance of delta wt and BMI.
Unadjusted mean delta wt was +2.0 (s.d. = 4.6) kg among MZ and 2.1 (4.9) kg among DZ male individuals. Corresponding values among MZ and DZ female individuals were +1.5 (4.4) kg and +1.7 (4.4) kg, respectively. Age and initial BMI together explained 8.0% of the male and 2.3% of the female phenotypic variance of delta wt. The intraclass correlations for delta wt (adjusted for age and initial BMI) for all pairs were 0.29 and 0.07 for MZ and DZ men and 0.25 and 0.05 for MZ and DZ women, respectively. The BMI of the twins increased slightly during the follow-up compared to the baseline values (23.9 (2.7) for MZ and 24.1 for DZ men and 23.0 (3.3) for MZ and 23.2 (3.42) for DZ women). The intra-class correlations for BMI at baseline (0.69 for MZ and 0.34 for DZ men and 0.67 for MZ and 0.29 for DZ women) were almost identical with the correlations at follow-up (0.67 for MZ and 0.32 for DZ men and 0.69 for MZ and 0.29 for DZ women). The intra-class correlations for both BMI and delta wt were consistently higher among pairs living together than among pairs living apart at baseline and at follow-up in both zygosity groups (MZ and DZ). Among pairs living apart at baseline, the longitudinal model for BMI showed that the correlation between genetic effects at baseline and at follow-up was very high (> 0.9 in all age groups among both genders). The correlations for environmental effects ranged from 0.50 to 0.67 during the follow-up period.
Weight changes in adults over a 6-year period appear to be determined by environmental effects rather than genetic factors. However, the genetic component in BMI is considerable and stable over time. Shared environment is likely to contribute to the resemblance of both delta wt and BMI among adult twin pairs, especially among MZ pairs.
PubMed ID
7647822 View in PubMed
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Descriptive epidemiological features of bronchiolitis in a population-based cohort.

https://arctichealth.org/en/permalink/ahliterature153946
Source
Pediatrics. 2008 Dec;122(6):1196-203
Publication Type
Article
Date
Dec-2008
Author
Mieke Koehoorn
Catherine J Karr
Paul A Demers
Cornel Lencar
Lillian Tamburic
Michael Brauer
Author Affiliation
School of Environmental Health, Centre for Health Services and Policy Research, University of British Columbia, 5804 Fairview Ave, Vancouver, British Columbia, Canada V6T 1Z3. mieke.koehoorn@ubc.ca
Source
Pediatrics. 2008 Dec;122(6):1196-203
Date
Dec-2008
Language
English
Publication Type
Article
Keywords
Age Distribution
Breast Feeding
British Columbia - epidemiology
Bronchiolitis - diagnosis - epidemiology
Cohort Studies
Female
Hospitalization - statistics & numerical data
Humans
Incidence
Infant
Male
Multivariate Analysis
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk assessment
Severity of Illness Index
Sex Distribution
Tobacco Smoke Pollution - statistics & numerical data
Abstract
The goal was to investigate the epidemiological features of incident bronchiolitis by using a population-based infant cohort.
Outpatient and inpatient health records were used to identify incident bronchiolitis cases among 93,058 singleton infants born in the Georgia Air Basin between 1999 and 2002. Additional health-related databases were linked to provide data on sociodemographic variables, maternal characteristics, and birth outcome measures.
From 1999 to 2002, bronchiolitis accounted for 12,474 incident health care encounters (inpatient or outpatient contacts) during the first year of life (134.2 cases per 1000 person-years). A total of 1588 hospitalized bronchiolitis cases were identified (17.1 cases per 1000 person-years). Adjusted Cox proportional-hazard analyses for both case definitions indicated an increased risk of incident bronchiolitis in the first year of life (follow-up period: 2-12 months) for boys, infants of First Nations status, infants with older siblings, and infants living in neighborhoods with smaller proportions of maternal postsecondary education. The risk also was elevated for infants born to young mothers (
PubMed ID
19047234 View in PubMed
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Determinants of plasma PCB, brominated flame retardants, and organochlorine pesticides in pregnant women and 3 year old children in The Norwegian Mother and Child Cohort Study.

https://arctichealth.org/en/permalink/ahliterature273849
Source
Environ Res. 2016 Apr;146:136-44
Publication Type
Article
Date
Apr-2016
Author
Ida Henriette Caspersen
Helen Engelstad Kvalem
Margaretha Haugen
Anne Lise Brantsæter
Helle Margrete Meltzer
Jan Alexander
Cathrine Thomsen
May Frøshaug
Nanna Margrethe Bruun Bremnes
Sharon Lynn Broadwell
Berit Granum
Manolis Kogevinas
Helle Katrine Knutsen
Source
Environ Res. 2016 Apr;146:136-44
Date
Apr-2016
Language
English
Publication Type
Article
Keywords
Child, Preschool
Cohort Studies
Demography
Diet
Environmental Exposure
Environmental monitoring
Environmental pollutants - blood
Female
Flame Retardants - metabolism
Humans
Hydrocarbons, Brominated - blood
Hydrocarbons, Chlorinated - blood
Life Style
Norway
Pesticides - blood
Polybrominated Biphenyls - blood
Polychlorinated biphenyls - blood
Pregnancy
Abstract
Exposure to persistent organic pollutants (POPs) during prenatal and postnatal life has been extensively studied in relation to adverse health effects in children.
The aim was to identify determinants of the concentrations of polychlorinated biphenyls (PCBs), brominated flame retardants (polybrominated diphenyl ethers, PBDEs; polybrominated biphenyl, PBB), and organochlorine pesticides (OCPs) in blood samples from pregnant women and children in The Norwegian Mother and Child Cohort Study (MoBa).
Blood samples were collected from two independent subsamples within MoBa; a group of women (n=96) enrolled in mid-pregnancy during the years 2002-2008 and a group of 3 year old children (n=99) participating during 2010-2011. PCB congeners (74, 99, 138, 153, 180, 170, 194, 209, 105, 114, 118, 156, 157, 167, and 189), brominated flame retardants (PBDE-28, 47, 99, 100, 153, 154, and PBB-153), as well as the OCPs hexachlorobenzene (HCB), oxychlordane, 4,4'dichlorodiphenyltrichloroethane (DDT), and 4,4'dichlorodiphenyldichloroethylene (DDE) were measured in both pregnant women and children.
Age, low parity, and low pre-pregnant BMI were the most important determinants of increased plasma concentrations of POPs in pregnant women. In 3 year old children, prolonged breastfeeding duration was a major determinant of increased POP concentrations. Estimated dietary exposure to PCBs during pregnancy was positively associated with plasma concentrations in 3 year old children, but not in pregnant women. Plasma concentrations were approximately 40% higher in children compared to pregnant women.
Several factors associated with exposure and toxicokinetics, i.e. accumulation, excretion and transfer via breastmilk of POPs were the main predictors of POP levels in pregnant women and children. Diet, which is the main exposure source for these compounds in the general population, was found to predict PCB levels only among children. For the PBDEs, for which non-dietary sources are more important, toxicokinetic factors appeared to have less predictive impact.
PubMed ID
26749444 View in PubMed
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Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa).

https://arctichealth.org/en/permalink/ahliterature118477
Source
Environ Health Perspect. 2013 Mar;121(3):374-9
Publication Type
Article
Date
Mar-2013
Author
Talita Duarte-Salles
Hans von Stedingk
Berit Granum
Kristine B Gützkow
Per Rydberg
Margareta Törnqvist
Michelle A Mendez
Gunnar Brunborg
Anne Lise Brantsæter
Helle Margrete Meltzer
Jan Alexander
Margaretha Haugen
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.
Source
Environ Health Perspect. 2013 Mar;121(3):374-9
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Acrylamide - administration & dosage - pharmacology
Cohort Studies
Diet
Environmental Exposure
Female
Fetal Development - drug effects
Hemoglobins - chemistry
Humans
Norway
Pregnancy
Questionnaires
Abstract
Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans.
We assessed associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birth weight.
This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ), which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n = 79). Data on infant birth weight and gestational age were obtained from the Medical Birth Registry of Norway. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes.
Acrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95% CI: 1.02, 1.21) and the coefficient for birth weight was -25.7 g (95% CI: -35.9, -15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide- and glycidamide-Hb adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95% CI: 0.02, 0.44; and 0.48; 95% CI: 0.29, 0.63, respectively).
Lowering dietary acrylamide intake during pregnancy may improve fetal growth.
Notes
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PubMed ID
23204292 View in PubMed
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Dietary benzo(a)pyrene intake during pregnancy and birth weight: associations modified by vitamin C intakes in the Norwegian Mother and Child Cohort Study (MoBa).

https://arctichealth.org/en/permalink/ahliterature107027
Source
Environ Int. 2013 Oct;60:217-23
Publication Type
Article
Date
Oct-2013
Author
Talita Duarte-Salles
Michelle A Mendez
Helle Margrete Meltzer
Jan Alexander
Margaretha Haugen
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. Electronic address: duartesallest@fellows.iarc.fr.
Source
Environ Int. 2013 Oct;60:217-23
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Adult
Ascorbic Acid - pharmacology
Benzo(a)pyrene - administration & dosage - analysis - toxicity
Birth Weight - drug effects
Child
Cohort Studies
Diet - statistics & numerical data
Female
Fetal Development - drug effects
Food - classification
Food Contamination - analysis - statistics & numerical data
Heredodegenerative Disorders, Nervous System - chemically induced
Humans
Infant
Maternal Exposure - statistics & numerical data
Microphthalmos - chemically induced
Multivariate Analysis
Mutagenicity Tests
Norway - epidemiology
Parity
Polycyclic Hydrocarbons, Aromatic - toxicity
Pregnancy
Pregnancy Outcome - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Abstract
Maternal exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy has been associated with reduced fetal growth. However, the role of diet, the main source of PAH exposure among non-smokers, remains uncertain.
To assess associations between maternal exposure to dietary intake of the genotoxic PAH benzo(a)pyrene [B(a)P] during pregnancy and birth weight, exploring potential effect modification by dietary intakes of vitamins C, E and A, hypothesized to influence PAH metabolism.
This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Dietary B(a)P and nutrient intakes were estimated based on total consumption obtained from a food frequency questionnaire (FFQ) and estimated based on food composition data. Data on infant birth weight were obtained from the Medical Birth Registry of Norway (MBRN). Multivariate regression was used to assess associations between dietary B(a)P and birth weight, evaluating potential interactions with candidate nutrients.
The multivariate-adjusted coefficient (95%CI) for birth weight associated with maternal energy-adjusted B(a)P intake was -20.5g (-31.1, -10.0) in women in the third compared with the first tertile of B(a)P intake. Results were similar after excluding smokers. Significant interactions were found between elevated intakes of vitamin C (>85mg/day) and dietary B(a)P during pregnancy for birth weight (P
PubMed ID
24071023 View in PubMed
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Dietary exposure to dioxins and PCBs in a large cohort of pregnant women: results from the Norwegian Mother and Child Cohort Study (MoBa).

https://arctichealth.org/en/permalink/ahliterature108262
Source
Environ Int. 2013 Sep;59:398-407
Publication Type
Article
Date
Sep-2013
Author
Ida H Caspersen
Helle K Knutsen
Anne Lise Brantsæter
Margaretha Haugen
Jan Alexander
Helle Margrete Meltzer
Helen E Kvalem
Author Affiliation
Norwegian Institute of Public Health, Oslo, Norway. ida.henriette.caspersen@fhi.no
Source
Environ Int. 2013 Sep;59:398-407
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Adult
Body Burden
Cohort Studies
Diet - adverse effects
Dioxins - administration & dosage - blood
Environmental Exposure
Environmental Pollutants - administration & dosage - analysis - blood
Female
Fish Products - adverse effects - analysis
Food Contamination
Humans
Norway
Polychlorinated Biphenyls - administration & dosage - blood
Tetrachlorodibenzodioxin - blood
Young Adult
Abstract
Exposure to dioxins and polychlorinated biphenyls (PCBs) during pregnancy and breastfeeding may result in adverse health effects in children. Prenatal exposure is determined by the concentrations of dioxins and PCBs in maternal blood, which reflect the body burden obtained by long term dietary exposure. The aims of this study were (1) to describe dietary exposure and important dietary sources to dioxins and PCBs in a large group of pregnant women and (2) to identify maternal characteristics associated with high dietary exposure to dioxins and PCBs. Dietary exposure to dioxins (sum of toxic equivalents (TEQs) from dioxin-like (dl) compounds) and PCB-153 in 83,524 pregnant women (gestational weeks 17-22) who participated in the Norwegian Mother and Child Cohort Study (MoBa) during the years 2002-2009 was calculated based on a food frequency questionnaire (FFQ) and a database of dioxin and PCB concentrations in Norwegian food. The median (interquartile range, IQR) intake of PCB-153 (marker of ndl-PCBs) was 0.81 (0.77) ng/kg bw/day. For dioxins and dioxin-like PCBs, the median (IQR) intake was 0.56 (0.37) pg TEQ/kg bw/day. Moreover, 2.3% of the participants had intakes exceeding the tolerable weekly intake (TWI) of 14pg TEQ/kg bw/week. Multiple regression analysis showed that dietary exposure was positively associated with maternal age, maternal education, weight gain during pregnancy, being a student, and alcohol consumption during pregnancy and negatively associated with pre-pregnancy BMI and smoking. A high dietary exposure to PCB-153 or dl-compounds (TEQ) was mainly explained by the consumption of seagull eggs and/or pate with fish liver and roe. Women who according to Norwegian recommendations avoid these food items generally do not have dietary exposure above the tolerable intake of dioxins and dl-PCBs.
PubMed ID
23911340 View in PubMed
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Do Associations Between Perceived Environmental and Individual Characteristics and Walking Limitations Depend on Lower Extremity Performance Level?

https://arctichealth.org/en/permalink/ahliterature291084
Source
J Aging Health. 2017 Jun; 29(4):640-656
Publication Type
Comparative Study
Journal Article
Date
Jun-2017
Author
Ritva Sakari
Merja Rantakokko
Erja Portegijs
Susanne Iwarsson
Sarianna Sipilä
Anne Viljanen
Taina Rantanen
Author Affiliation
1 University of Jyvaskyla, Finland.
Source
J Aging Health. 2017 Jun; 29(4):640-656
Date
Jun-2017
Language
English
Publication Type
Comparative Study
Journal Article
Keywords
Activities of Daily Living
Aged
Aged, 80 and over
Cross-Sectional Studies
Disability Evaluation
Environment
Female
Geriatric Assessment - methods
Humans
Independent living
Interviews as Topic
Lower Extremity - physiopathology
Male
Mobility Limitation
Perception
Physical Fitness - physiology
Sweden
Task Performance and Analysis
Walking - physiology
Abstract
The aim of this study was to analyze whether the associations between perceived environmental and individual characteristics and perceived walking limitations in older people differ between those with intact and those with poorer lower extremity performance.
Persons aged 75 to 90 ( N = 834) participated in interviews and performance tests in their homes. Standard questionnaires were used to obtain walking difficulties; environmental barriers to and, facilitators of, mobility; and perceived individual hindrances to outdoor mobility. Lower extremity performance was tested using Short Physical Performance Battery (SPPB).
Among those with poorer lower extremity performance, the likelihood for advanced walking limitations was, in particular, related to perceived poor safety in the environment, and among those with intact performance to perceived social issues, such as lack of company, as well as to long distances.
The environmental correlates of walking limitations seem to depend on the level of lower extremity performance.
PubMed ID
27056910 View in PubMed
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Effect of dietary factors in pregnancy on risk of pregnancy complications: results from the Norwegian Mother and Child Cohort Study.

https://arctichealth.org/en/permalink/ahliterature134772
Source
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1970S-1974S
Publication Type
Article
Date
Dec-2011
Author
Helle Margrete Meltzer
Anne Lise Brantsæter
Roy M Nilsen
Per Magnus
Jan Alexander
Margareta Haugen
Author Affiliation
Divisions of Environmental Medicine and Epidemiology, Norwegian Institute of Public Health, Oslo, Norway. helle.margrete.meltzer@fhi.no
Source
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1970S-1974S
Date
Dec-2011
Language
English
Publication Type
Article
Keywords
Birth weight
Diet, Mediterranean
European Continental Ancestry Group
Female
Folic Acid - administration & dosage
Food Habits
Humans
Norway - epidemiology
Nutrition Assessment
Nutritional Status
Pre-Eclampsia - epidemiology - etiology - pathology
Pregnancy
Pregnancy Complications - epidemiology - etiology
Premature Birth - metabolism
Prospective Studies
Questionnaires
Risk factors
Vitamin D - administration & dosage
Abstract
There has been a thrilling development , as well as profound changes, in our understanding of the effect of fetal nutrition on the development and health of the child. The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing nationwide population-based pregnancy cohort study that between 1999 and 2008 recruited 90,723 women with 106,981 pregnancies and 108,487 children. The objective of MoBa is to test specific etiologic hypotheses by estimating the association between exposures and diseases with a special focus on disorders that may originate in early life. An important aspect in this regard is maternal diet and nutritional status during pregnancy. Nutritional factors have long been considered to be important determinants of maternal and fetal health, and dietary information is currently being collected in a number of pregnancy cohorts in Europe and the United States. Thus far, pregnancy complications studied in MoBa are preterm birth, preeclampsia, and fetal growth; and the aim of this article is to report results of recently published studies of dietary factors in relation to these outcomes. Numerous studies are planned using MoBa data, and the aim is to add to the knowledge of the interplay between dietary factors, nonnutrients, and toxic dietary substances and epigenetic modulation on fetal development and health later in life.
Notes
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PubMed ID
21543541 View in PubMed
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Effect of early life exposure to air pollution on development of childhood asthma.

https://arctichealth.org/en/permalink/ahliterature145670
Source
Environ Health Perspect. 2010 Feb;118(2):284-90
Publication Type
Article
Date
Feb-2010
Author
Nina Annika Clark
Paul A Demers
Catherine J Karr
Mieke Koehoorn
Cornel Lencar
Lillian Tamburic
Michael Brauer
Author Affiliation
School of Population and Public Health, University of British Columbia, British Columbia, Canada.
Source
Environ Health Perspect. 2010 Feb;118(2):284-90
Date
Feb-2010
Language
English
Publication Type
Article
Keywords
Air Pollution - adverse effects
Asthma - chemically induced
British Columbia
Carbon Monoxide - adverse effects
Case-Control Studies
Child, Preschool
Environmental Exposure - adverse effects
Female
Humans
Logistic Models
Male
Nitrogen Dioxide - adverse effects
Nitrogen Oxides - adverse effects
Particulate Matter - adverse effects
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Time Factors
United States
Abstract
There is increasing recognition of the importance of early environmental exposures in the development of childhood asthma. Outdoor air pollution is a recognized asthma trigger, but it is unclear whether exposure influences incident disease. We investigated the effect of exposure to ambient air pollution in utero and during the first year of life on risk of subsequent asthma diagnosis in a population-based nested case-control study.
We assessed all children born in southwestern British Columbia in 1999 and 2000 (n = 37,401) for incidence of asthma diagnosis up to 34 years of age using outpatient and hospitalization records. Asthma cases were age- and sex-matched to five randomly chosen controls from the eligible cohort. We estimated each individual's exposure to ambient air pollution for the gestational period and first year of life using high-resolution pollution surfaces derived from regulatory monitoring data as well as land use regression models adjusted for temporal variation. We used logistic regression analyses to estimate effects of carbon monoxide, nitric oxide, nitrogen dioxide, particulate matter
Notes
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PubMed ID
20123607 View in PubMed
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Environmental barriers, person-environment fit and mortality among community-dwelling very old people.

https://arctichealth.org/en/permalink/ahliterature265500
Source
BMC Public Health. 2013;13:783
Publication Type
Article
Date
2013
Author
Merja Rantakokko
Timo Törmäkangas
Taina Rantanen
Maria Haak
Susanne Iwarsson
Source
BMC Public Health. 2013;13:783
Date
2013
Language
English
Publication Type
Article
Keywords
Aged, 80 and over
Architectural Accessibility
Environment
Female
Frail Elderly
Housing for the Elderly
Humans
Male
Mobility Limitation
Mortality - trends
Proportional Hazards Models
Sweden - epidemiology
Abstract
Environmental barriers are associated with disability-related outcomes in older people but little is known of the effect of environmental barriers on mortality. The aim of this study was to examine whether objectively measured barriers in the outdoor, entrance and indoor environments are associated with mortality among community-dwelling 80- to 89-year-old single-living people.
This longitudinal study is based on a sample of 397 people who were single-living in ordinary housing in Sweden. Participants were interviewed during 2002-2003, and 393 were followed up for mortality until May 15, 2012.Environmental barriers and functional limitations were assessed with the Housing Enabler instrument, which is intended for objective assessments of Person-Environment (P-E) fit problems in housing and the immediate outdoor environment. Mortality data were gathered from the public national register. Cox regression models were used for the analyses.
A total of 264 (67%) participants died during follow-up. Functional limitations increased mortality risk. Among the specific environmental barriers that generate the most P-E fit problems, lack of handrails in stairs at entrances was associated with the highest mortality risk (adjusted RR 1.55, 95% CI 1.14-2.10), whereas the total number of environmental barriers at entrances and outdoors was not associated with mortality. A higher number of environmental barriers indoors showed a slight protective effect against mortality even after adjustment for functional limitations (RR 0.98, 95% CI 0.96-1.00).
Specific environmental problems may increase mortality risk among very-old single-living people. However, the association may be confounded by individuals' health status which is difficult to fully control for. Further studies are called for.
Notes
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PubMed ID
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