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Adherence of pregnant women to Nordic dietary guidelines in relation to postpartum weight retention: results from the Norwegian Mother and Child Cohort Study.

https://arctichealth.org/en/permalink/ahliterature256846
Source
BMC Public Health. 2014;14:75
Publication Type
Article
Date
2014
Author
Anne von Ruesten
Anne Lise Brantsæter
Margaretha Haugen
Helle Margrete Meltzer
Kirsten Mehlig
Anna Winkvist
Lauren Lissner
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. Anne.Lise.Brantsaeter@fhi.no.
Source
BMC Public Health. 2014;14:75
Date
2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Body Weight
Diet Surveys
Diet, Reducing - psychology
Female
Humans
Norway - epidemiology
Nutrition Policy
Patient Compliance - statistics & numerical data
Postpartum Period - psychology
Pregnancy
Weight Gain
Young Adult
Abstract
Pregnancy is a major life event for women and often connected with changes in diet and lifestyle and natural gestational weight gain. However, excessive weight gain during pregnancy may lead to postpartum weight retention and add to the burden of increasing obesity prevalence. Therefore, it is of interest to examine whether adherence to nutrient recommendations or food-based guidelines is associated with postpartum weight retention 6 months after birth.
This analysis is based on data from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Diet during the first 4-5 months of pregnancy was assessed by a food-frequency questionnaire and maternal weight before pregnancy as well as in the postpartum period was assessed by questionnaires. Two Healthy Eating Index (HEI) scores were applied to measure compliance with either the official Norwegian food-based guidelines (HEI-NFG) or the Nordic Nutrition Recommendations (HEI-NNR) during pregnancy. The considered outcome, i.e. weight retention 6 months after birth, was modelled in two ways: continuously (in kg) and categorically (risk of substantial postpartum weight retention, i.e. =?5% gain to pre-pregnancy weight). Associations between the HEI-NFG and HEI-NNR score with postpartum weight retention on the continuous scale were estimated by linear regression models. Relationships of both HEI scores with the categorical outcome variable were evaluated using logistic regression.
In the continuous model without adjustment for gestational weight gain (GWG), the HEI-NFG score but not the HEI-NNR score was inversely related to postpartum weight retention. However, after additional adjustment for GWG as potential intermediate the HEI-NFG score was marginally inversely and the HEI-NNR score was inversely associated with postpartum weight retention. In the categorical model, both HEI scores were inversely related with risk of substantial postpartum weight retention, independent of adjustment for GWG.
Higher adherence to either the official Norwegian food guidelines or possibly also to Nordic Nutrition Recommendations during pregnancy appears to be associated with lower postpartum weight retention.
Notes
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PubMed ID
24456804 View in PubMed
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Assessing sources of human methylmercury exposure using stable mercury isotopes.

https://arctichealth.org/en/permalink/ahliterature268003
Source
Environ Sci Technol. 2014;48(15):8800-6
Publication Type
Article
Date
2014
Author
Miling Li
Laura S Sherman
Joel D Blum
Philippe Grandjean
Bjarni Mikkelsen
Pál Weihe
Elsie M Sunderland
James P Shine
Source
Environ Sci Technol. 2014;48(15):8800-6
Date
2014
Language
English
Publication Type
Article
Keywords
Animals
Chemical Fractionation
Denmark
Environmental monitoring
Fishes
Gulf of Mexico
Hair - chemistry
Humans
Mercury - analysis
Mercury Isotopes - analysis
Methylmercury compounds - analysis
Seafood - analysis
Whales, Pilot
Abstract
Seafood consumption is the primary route of methylmercury (MeHg) exposure for most populations. Inherent uncertainties in dietary survey data point to the need for an empirical tool to confirm exposure sources. We therefore explore the utility of Hg stable isotope ratios in human hair as a new method for discerning MeHg exposure sources. We characterized Hg isotope fractionation between humans and their diets using hair samples from Faroese whalers exposed to MeHg predominantly from pilot whales. We observed an increase of 1.75‰ in d(202)Hg values between pilot whale muscle tissue and Faroese whalers' hair but no mass-independent fractionation. We found a similar offset in d(202)Hg between consumed seafood and hair samples from Gulf of Mexico recreational anglers who are exposed to lower levels of MeHg from a variety of seafood sources. An isotope mixing model was used to estimate individual MeHg exposure sources and confirmed that both ?(199)Hg and d(202)Hg values in human hair can help identify dietary MeHg sources. Variability in isotopic signatures among coastal fish consumers in the Gulf of Mexico likely reflects both differences in environmental sources of MeHg to coastal fish and uncertainty in dietary recall data. Additional data are needed to fully refine this approach for individuals with complex seafood consumption patterns.
Notes
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PubMed ID
24967674 View in PubMed
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Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands.

https://arctichealth.org/en/permalink/ahliterature106521
Source
Am J Clin Nutr. 2014 Jan;99(1):5-13
Publication Type
Article
Date
Jan-2014
Author
Jeanett L Tang-Péronard
Berit L Heitmann
Helle R Andersen
Ulrike Steuerwald
Philippe Grandjean
Pál Weihe
Tina K Jensen
Author Affiliation
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark (JLT-P, HRA, PG, and TKJ); the Research Unit for Dietary Studies, Institute of Preventive Medicine, Copenhagen University Hospitals, Frederiksberg, Denmark (JLT-P and BLH); the National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark (BLH); the Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Sydney, Australia (BLH); the Department of Occupational Medicine and Public Health, Tórshavn, Faroe Islands (US); and the Department of Environmental Medicine, Faroese Hospital System, Tórshavn, Faroe Islands (PW).
Source
Am J Clin Nutr. 2014 Jan;99(1):5-13
Date
Jan-2014
Language
English
Publication Type
Article
Keywords
Body mass index
Body Weight - drug effects
Child
Child, Preschool
Denmark
Dichlorodiphenyl Dichloroethylene - blood - toxicity
Female
Humans
Linear Models
Male
Maternal Exposure
Milk, human - chemistry
Obesity - chemically induced
Overweight - blood - metabolism
Polychlorinated Biphenyls - blood - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Prospective Studies
Waist Circumference - drug effects
Abstract
Chemicals with endocrine-disrupting abilities may act as obesogens and interfere with the body's natural weight-control mechanisms, especially if exposure occurs during prenatal life.
We examined the association between prenatal exposure to polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age.
From 1997 to 2000, 656 pregnant Faroese women were recruited. PCB and DDE were measured in maternal serum and breast milk, and children's weight, height, and waist circumference (WC) were measured at clinical examinations at 5 and 7 y of age. The change in body mass index (BMI) from 5 to 7 y of age was calculated. Analyses were performed by using multiple linear regression models for girls and boys separately, taking into account maternal prepregnancy BMI.
For 7-y-old girls who had overweight mothers, PCB was associated with increased BMI (ß = 2.07, P = 0.007), and PCB and DDE were associated with an increased change in BMI from 5 to 7 y of age (PCB: ß = 1.23, P = 0.003; DDE: ß = 1.11, P = 0.008). No association was observed with BMI in girls with normal-weight mothers. PCB was associated with increased WC in girls with overweight mothers (ß = 2.48, P = 0.001) and normal-weight mothers (ß = 1.25, P = 0.04); DDE was associated with increased WC only in girls with overweight mothers (ß = 2.21, P = 0.002). No associations were observed between PCB or DDE and BMI in 5-y-old girls. For boys, no associations were observed.
Results suggest that prenatal exposure to PCB and DDE may play a role for subsequent obesity development. Girls whose mothers have a high prepregnancy BMI seem most affected.
PubMed ID
24153349 View in PubMed
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Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls.

https://arctichealth.org/en/permalink/ahliterature186651
Source
FASEB J. 2003 Apr;17(6):699-701
Publication Type
Article
Date
Apr-2003
Author
Philippe Grandjean
Esben Budtz-Jørgensen
Ulrike Steuerwald
Birger Heinzow
Larry L Needham
Poul J Jørgensen
Pál Weihe
Author Affiliation
Department of Environmental Health, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA. pgrand@health.sdu.dk
Source
FASEB J. 2003 Apr;17(6):699-701
Date
Apr-2003
Language
English
Publication Type
Article
Keywords
Body Height - drug effects
Body Weight - drug effects
Breast Feeding
Child, Preschool
Cohort Studies
Environmental Exposure - adverse effects
Environmental Pollutants - adverse effects
Female
Growth - drug effects
Humans
Infant
Infant, Newborn
Male
Methylmercury Compounds - adverse effects
Polychlorinated biphenyls - adverse effects - blood
Predictive value of tests
Pregnancy
Prenatal Exposure Delayed Effects
Prospective Studies
Abstract
Breast-feeding has been linked to slowed postnatal growth. Although the basis for this "weanling's dilemma" is unclear, environmental contaminants in human milk may be of relevance. We studied a Faroese birth cohort of 182 singleton children, born at term in 1994-95. Concentrations of mercury in cord blood and of polychlorinated biphenyls in maternal milk were measured, and duration of breast-feeding was recorded. At 18 months, children who had been exclusively breast-fed for at least 6 months weighed 0.59 kg less [95% confidence interval (CI) = 0.03, 1.16 kg] and were 1.50 cm [95% CI = 0.52, 2.47 cm] shorter than those not breast-fed. However, calculated transfer of contaminants from human milk fully explained the attenuated growth. Irrespective of duration of breast-feeding, a doubling of the mercury concentration in cord blood was associated with a decrease in weight at 18 months by 0.19 kg (95% CI = 0.03, 0.35 kg) and in height by 0.26 cm (95% CI = -0.02, 0.55 cm). Weight and height at 42 months showed the same tendencies, but the main effect occurred before 18 months of age. Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding.
PubMed ID
12586743 View in PubMed
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Autoantibodies associated with prenatal and childhood exposure to environmental chemicals in Faroese children.

https://arctichealth.org/en/permalink/ahliterature264893
Source
Toxicol Sci. 2014 Nov;142(1):158-66
Publication Type
Article
Date
Nov-2014
Author
Christa E Osuna
Philippe Grandjean
Pál Weihe
Hassan A N El-Fawal
Source
Toxicol Sci. 2014 Nov;142(1):158-66
Date
Nov-2014
Language
English
Publication Type
Article
Keywords
Autoantibodies - blood
Autoantigens - immunology
Child
Denmark
Environmental monitoring
Environmental Pollutants - blood - toxicity
Female
Fetal Blood - chemistry
Fluorocarbons - blood - toxicity
Hair - chemistry
Humans
Infant, Newborn
Male
Methylmercury Compounds - blood - toxicity
Pilot Projects
Polychlorinated Biphenyls - blood - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - blood - chemically induced - immunology
Abstract
Methylmercury, polychlorinated biphenyls (PCBs), and perfluorinated compounds (PFCs) are ubiquitous and persistent environmental chemicals with known or suspected toxic effects on the nervous system and the immune system. Animal studies have shown that tissue damage can elicit production of autoantibodies. However, it is not known if autoantibodies similarly will be generated and detectable in humans following toxicant exposures. Therefore, we conducted a pilot study to investigate if autoantibodies specific for neural and non-neural antigens could be detected in children at age 7 years who have been exposed to environmental chemicals. Both prenatal and age-7 exposures to mercury, PCBs, and PFCs were measured in 38 children in the Faroe Islands who were exposed to widely different levels of these chemicals due to their seafood-based diet. Concentrations of IgM and IgG autoantibodies specific to both neural (neurofilaments, cholineacetyltransferase, astrocyte glial fibrillary acidic protein, and myelin basic protein) and non-neural (actin, desmin, and keratin) antigens were measured and the associations of these autoantibody concentrations with chemical exposures were assessed using linear regression. Age-7 blood-mercury concentrations were positively associated with titers of multiple neural- and non-neural-specific antibodies, mostly of the IgM isotype. Additionally, prenatal blood-mercury and -PCBs were negatively associated with anti-keratin IgG and prenatal PFOS was negatively associated with anti-actin IgG. These exploratory findings demonstrate that autoantibodies can be detected in the peripheral blood following exposure to environmental chemicals. The unexpected association of exposures with antibodies specific for non-neural antigens suggests that these chemicals may have toxicities that have not yet been recognized.
Notes
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PubMed ID
25124724 View in PubMed
Less detail

Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls.

https://arctichealth.org/en/permalink/ahliterature166669
Source
Eur J Clin Pharmacol. 2006 Dec;62(12):1041-8
Publication Type
Article
Date
Dec-2006
Author
Maria Skaalum Petersen
Jónrit Halling
Per Damkier
Flemming Nielsen
Philippe Grandjean
Pál Weihe
Kim Brøsen
Author Affiliation
Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Winslovparken 17, 5000 Odense C, Denmark. mskaalum@health.sdu.dk
Source
Eur J Clin Pharmacol. 2006 Dec;62(12):1041-8
Date
Dec-2006
Language
English
Publication Type
Article
Keywords
Administration, Oral
Adolescent
Adult
Biometry
Caffeine - administration & dosage - metabolism
Cohort Studies
Cytochrome P-450 CYP1A2 - genetics - metabolism
Environmental Pollutants - chemistry - metabolism - poisoning
Female
Genotype
Humans
Male
Methylation
Middle Aged
Polychlorinated Biphenyls - chemistry - metabolism - poisoning
Sex Factors
Smoking - metabolism
Uracil - analogs & derivatives - metabolism
Uric Acid - analogs & derivatives - metabolism
Xanthines - metabolism
Abstract
To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Further, to investigate the effect of sex, smoking, and oral contraceptive use on the CYP1A2 activity.
In 305 randomly selected Faroese residents aged 18-60 years, the CYP1A2 activity was determined following oral intake of a caffeine dose and subsequent determination of the urinary metabolites and calculation of the caffeine metabolic ratio (CMR). PCB exposure was assessed by measuring the serum concentration of major congeners.
The CYP1A2 phenotype distribution was unimodal. The CMR was significantly higher both in smoking men and in smoking women, independent of oral contraceptive use, as compared with non-smokers. Among non-smokers, the CMR was significantly higher in women not using oral contraceptives than in those using oral contraceptives; a similar difference could not be established among smokers. The CMR appeared higher in men than in women, but stratified analyses confirmed a significant sex-related difference only among smokers not using oral contraceptives. Overall, the mean CMR in Faroese was significantly higher compared with the mean CMR in Danish historical controls. No association was found with PCB exposure and individual PCB congeners, except for one of three dioxin-like congeners, in confounder-adjusted multiple regression analyses.
The CYP1A2 phenotype in Faroese residents was unimodally distributed and showed the inducing effect of smoking and the inhibiting effect of use of oral contraceptives, but a sex-related difference was not apparent after confounder adjustment. There was no statistically significant association between CMR and PCB exposure.
PubMed ID
17089110 View in PubMed
Less detail

Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources?

https://arctichealth.org/en/permalink/ahliterature289389
Source
Environ Health. 2018 Feb 01; 17(1):11
Publication Type
Journal Article
Date
Feb-01-2018
Author
Xindi C Hu
Clifton Dassuncao
Xianming Zhang
Philippe Grandjean
Pál Weihe
Glenys M Webster
Flemming Nielsen
Elsie M Sunderland
Author Affiliation
Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA. xhu@mail.harvard.edu.
Source
Environ Health. 2018 Feb 01; 17(1):11
Date
Feb-01-2018
Language
English
Publication Type
Journal Article
Abstract
Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination. Common PFASs, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) and their precursors are ubiquitous in multiple exposure sources. However, their composition varies among sources, which may impact associated adverse health effects.
We use available PFAS concentrations from several demographic groups in a North Atlantic seafood consuming population (Faroe Islands) to explore whether chemical fingerprints in human sera provide insights into predominant exposure sources. We compare serum PFAS profiles from Faroese individuals to other North American populations to investigate commonalities in potential exposure sources. We compare individuals with similar demographic and physiological characteristics and samples from the same years to reduce confounding by toxicokinetic differences and changing environmental releases.
Using principal components analysis (PCA) confirmed by hierarchical clustering, we assess variability in serum PFAS concentrations across three Faroese groups. The first principal component (PC)/cluster consists of C9-C12 perfluoroalkyl carboxylates (PFCAs) and is consistent with measured PFAS profiles in consumed seafood. The second PC/cluster includes perfluorohexanesulfonic acid (PFHxS) and the PFOS precursor N-ethyl perfluorooctane sulfonamidoacetate (N-EtFOSAA), which are directly used or metabolized from fluorochemicals in consumer products such as carpet and food packaging. We find that the same compounds are associated with the same exposure sources in two North American populations, suggesting generalizability of results from the Faroese population.
We conclude that PFAS homologue profiles in serum provide valuable information on major exposure sources. It is essential to compare samples collected at similar time periods and to correct for demographic groups that are highly affected by differences in physiological processes (e.g., pregnancy). Information on PFAS homologue profiles is crucial for attributing adverse health effects to the proper mixtures or individual PFASs.
Notes
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PubMed ID
29391068 View in PubMed
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Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources?

https://arctichealth.org/en/permalink/ahliterature296906
Source
Environ Health. 2018 02 01; 17(1):11
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Date
02-01-2018
Author
Xindi C Hu
Clifton Dassuncao
Xianming Zhang
Philippe Grandjean
Pál Weihe
Glenys M Webster
Flemming Nielsen
Elsie M Sunderland
Author Affiliation
Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA. xhu@mail.harvard.edu.
Source
Environ Health. 2018 02 01; 17(1):11
Date
02-01-2018
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Keywords
Adolescent
Adult
Aged
Alkanesulfonic Acids - blood
Child
Denmark
Environmental Exposure
Environmental monitoring
Environmental pollutants - blood
Female
Fluorocarbons - blood
Humans
Male
Middle Aged
Nutrition Surveys
Prospective Studies
United States
Young Adult
Abstract
Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination. Common PFASs, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) and their precursors are ubiquitous in multiple exposure sources. However, their composition varies among sources, which may impact associated adverse health effects.
We use available PFAS concentrations from several demographic groups in a North Atlantic seafood consuming population (Faroe Islands) to explore whether chemical fingerprints in human sera provide insights into predominant exposure sources. We compare serum PFAS profiles from Faroese individuals to other North American populations to investigate commonalities in potential exposure sources. We compare individuals with similar demographic and physiological characteristics and samples from the same years to reduce confounding by toxicokinetic differences and changing environmental releases.
Using principal components analysis (PCA) confirmed by hierarchical clustering, we assess variability in serum PFAS concentrations across three Faroese groups. The first principal component (PC)/cluster consists of C9-C12 perfluoroalkyl carboxylates (PFCAs) and is consistent with measured PFAS profiles in consumed seafood. The second PC/cluster includes perfluorohexanesulfonic acid (PFHxS) and the PFOS precursor N-ethyl perfluorooctane sulfonamidoacetate (N-EtFOSAA), which are directly used or metabolized from fluorochemicals in consumer products such as carpet and food packaging. We find that the same compounds are associated with the same exposure sources in two North American populations, suggesting generalizability of results from the Faroese population.
We conclude that PFAS homologue profiles in serum provide valuable information on major exposure sources. It is essential to compare samples collected at similar time periods and to correct for demographic groups that are highly affected by differences in physiological processes (e.g., pregnancy). Information on PFAS homologue profiles is crucial for attributing adverse health effects to the proper mixtures or individual PFASs.
PubMed ID
29391068 View in PubMed
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Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort.

https://arctichealth.org/en/permalink/ahliterature30533
Source
J Pediatr. 2004 Feb;144(2):169-76
Publication Type
Article
Date
Feb-2004
Author
Philippe Grandjean
Katsuyuki Murata
Esben Budtz-Jørgensen
Pál Weihe
Author Affiliation
Institute of Public Health, University of Southern Denmark, Odense, Denmark. pgrand@hsph.harvard.edu
Source
J Pediatr. 2004 Feb;144(2):169-76
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Blood Pressure - physiology
Child
Cohort Studies
Denmark
Environmental Exposure - adverse effects
Evoked Potentials, Auditory, Brain Stem - drug effects - physiology
Female
Follow-Up Studies
Food Contamination
Heart - drug effects - physiology
Heart Rate - physiology
Humans
Male
Methylmercury Compounds - toxicity
Parasympathetic Nervous System - drug effects - physiopathology
Pregnancy
Prenatal Exposure Delayed Effects
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Seafood - adverse effects
Sex Factors
Sympathetic Nervous System - drug effects - physiopathology
Abstract
OBJECTIVE: To determine whether heart function in childhood is affected by exposure to methylmercury (MeHg) from seafood. STUDY DESIGN: Prospective study of a Faroese birth cohort (N=1022). Examinations at ages 7 and 14 years included blood pressure, heart rate variability (HRV) and its frequency components of autonomic origin, and brainstem auditory evoked potentials (BAEPs). Mercury concentrations were determined in cord blood and in the child's hair. RESULTS: Both low-frequency (LF) and high-frequency (HF) activities decreased by about 25% from 7 to 14 years; they correlated well with the blood pressures. A doubling of prenatal MeHg exposure was associated with a decrease in LF and HF powers of about 6.7% (P=.04) and in the coefficient of variation of the electrocardiographic R-R interval of 2.7% (P=.04) at age 14 years. No discernible effect on blood pressure was apparent. Decreased LF variability was associated with increased latency of BAEP peak III, but adjustment for MeHg exposure substantially attenuated this correlation. CONCLUSIONS: Methylmercury exposure was associated with decreased sympathetic (LF) and parasympathetic (HF) modulation of the HRV. Parallel MeHg-related delays of BAEP latencies may be caused by underlying MeHg neurotoxicity to brainstem nuclei.
PubMed ID
14760255 View in PubMed
Less detail

Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury.

https://arctichealth.org/en/permalink/ahliterature30532
Source
J Pediatr. 2004 Feb;144(2):177-83
Publication Type
Article
Date
Feb-2004
Author
Katsuyuki Murata
Pál Weihe
Esben Budtz-Jørgensen
Poul J Jørgensen
Philippe Grandjean
Author Affiliation
Division of Environmental Health Sciences, Akita University School of Medicine, Akita, Japan.
Source
J Pediatr. 2004 Feb;144(2):177-83
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Audiometry
Child
Cohort Studies
Denmark
Environmental Exposure - adverse effects
Evoked Potentials, Auditory, Brain Stem - drug effects - physiology
Female
Fetal Blood - chemistry
Food Contamination
Hair - chemistry
Humans
Male
Mercury Poisoning, Nervous System - physiopathology
Methylmercury Compounds - analysis - toxicity
Pregnancy
Prenatal Exposure Delayed Effects
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Seafood - adverse effects
Abstract
OBJECTIVE: To determine possible exposure-associated delays in auditory brainstem evoked potential latencies as an objective measure of neurobehavioral toxicity in 14-year-old children with developmental exposure to methylmercury (MeHg) from seafood. STUDY DESIGN: Prospective study of a birth cohort in the Faroe Islands, where 878 of eligible children (87%) were examined at age 14 years. Latencies of brainstem evoked potential peaks I, III, and V at 20 and 40 Hz constituted the outcome variables. Mercury concentrations were determined in cord blood and maternal hair, and in the child's hair at ages 7 and 14. RESULTS: Latencies of peaks III and V increased by about 0.012 ms when the cord blood mercury concentration doubled. As seen at age 7 years, this effect appeared mainly within the I-III interpeak interval. Despite lower postnatal exposures, the child's hair mercury level at age 14 years was associated with prolonged III-V interpeak latencies. All benchmark dose results were similar to those obtained for dose-response relationships at age 7 years. CONCLUSIONS: The persistence of prolonged I-III interpeak intervals indicates that some neurotoxic effects from intrauterine MeHg exposure are irreversible. A change in vulnerability to MeHg toxicity is suggested by the apparent sensitivity of the peak III-V component to recent MeHg exposure.
PubMed ID
14760257 View in PubMed
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Determinants of plasma PCB, brominated flame retardants, and organochlorine pesticides in pregnant women and 3 year old children in The Norwegian Mother and Child Cohort Study.

https://arctichealth.org/en/permalink/ahliterature273849
Source
Environ Res. 2016 Apr;146:136-44
Publication Type
Article
Date
Apr-2016
Author
Ida Henriette Caspersen
Helen Engelstad Kvalem
Margaretha Haugen
Anne Lise Brantsæter
Helle Margrete Meltzer
Jan Alexander
Cathrine Thomsen
May Frøshaug
Nanna Margrethe Bruun Bremnes
Sharon Lynn Broadwell
Berit Granum
Manolis Kogevinas
Helle Katrine Knutsen
Source
Environ Res. 2016 Apr;146:136-44
Date
Apr-2016
Language
English
Publication Type
Article
Keywords
Child, Preschool
Cohort Studies
Demography
Diet
Environmental Exposure
Environmental monitoring
Environmental pollutants - blood
Female
Flame Retardants - metabolism
Humans
Hydrocarbons, Brominated - blood
Hydrocarbons, Chlorinated - blood
Life Style
Norway
Pesticides - blood
Polybrominated Biphenyls - blood
Polychlorinated biphenyls - blood
Pregnancy
Abstract
Exposure to persistent organic pollutants (POPs) during prenatal and postnatal life has been extensively studied in relation to adverse health effects in children.
The aim was to identify determinants of the concentrations of polychlorinated biphenyls (PCBs), brominated flame retardants (polybrominated diphenyl ethers, PBDEs; polybrominated biphenyl, PBB), and organochlorine pesticides (OCPs) in blood samples from pregnant women and children in The Norwegian Mother and Child Cohort Study (MoBa).
Blood samples were collected from two independent subsamples within MoBa; a group of women (n=96) enrolled in mid-pregnancy during the years 2002-2008 and a group of 3 year old children (n=99) participating during 2010-2011. PCB congeners (74, 99, 138, 153, 180, 170, 194, 209, 105, 114, 118, 156, 157, 167, and 189), brominated flame retardants (PBDE-28, 47, 99, 100, 153, 154, and PBB-153), as well as the OCPs hexachlorobenzene (HCB), oxychlordane, 4,4'dichlorodiphenyltrichloroethane (DDT), and 4,4'dichlorodiphenyldichloroethylene (DDE) were measured in both pregnant women and children.
Age, low parity, and low pre-pregnant BMI were the most important determinants of increased plasma concentrations of POPs in pregnant women. In 3 year old children, prolonged breastfeeding duration was a major determinant of increased POP concentrations. Estimated dietary exposure to PCBs during pregnancy was positively associated with plasma concentrations in 3 year old children, but not in pregnant women. Plasma concentrations were approximately 40% higher in children compared to pregnant women.
Several factors associated with exposure and toxicokinetics, i.e. accumulation, excretion and transfer via breastmilk of POPs were the main predictors of POP levels in pregnant women and children. Diet, which is the main exposure source for these compounds in the general population, was found to predict PCB levels only among children. For the PBDEs, for which non-dietary sources are more important, toxicokinetic factors appeared to have less predictive impact.
PubMed ID
26749444 View in PubMed
Less detail

Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa).

https://arctichealth.org/en/permalink/ahliterature118477
Source
Environ Health Perspect. 2013 Mar;121(3):374-9
Publication Type
Article
Date
Mar-2013
Author
Talita Duarte-Salles
Hans von Stedingk
Berit Granum
Kristine B Gützkow
Per Rydberg
Margareta Törnqvist
Michelle A Mendez
Gunnar Brunborg
Anne Lise Brantsæter
Helle Margrete Meltzer
Jan Alexander
Margaretha Haugen
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.
Source
Environ Health Perspect. 2013 Mar;121(3):374-9
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Acrylamide - administration & dosage - pharmacology
Cohort Studies
Diet
Environmental Exposure
Female
Fetal Development - drug effects
Hemoglobins - chemistry
Humans
Norway
Pregnancy
Questionnaires
Abstract
Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans.
We assessed associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birth weight.
This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ), which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n = 79). Data on infant birth weight and gestational age were obtained from the Medical Birth Registry of Norway. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes.
Acrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95% CI: 1.02, 1.21) and the coefficient for birth weight was -25.7 g (95% CI: -35.9, -15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide- and glycidamide-Hb adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95% CI: 0.02, 0.44; and 0.48; 95% CI: 0.29, 0.63, respectively).
Lowering dietary acrylamide intake during pregnancy may improve fetal growth.
Notes
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PubMed ID
23204292 View in PubMed
Less detail

Dietary benzo(a)pyrene intake during pregnancy and birth weight: associations modified by vitamin C intakes in the Norwegian Mother and Child Cohort Study (MoBa).

https://arctichealth.org/en/permalink/ahliterature107027
Source
Environ Int. 2013 Oct;60:217-23
Publication Type
Article
Date
Oct-2013
Author
Talita Duarte-Salles
Michelle A Mendez
Helle Margrete Meltzer
Jan Alexander
Margaretha Haugen
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. Electronic address: duartesallest@fellows.iarc.fr.
Source
Environ Int. 2013 Oct;60:217-23
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Adult
Ascorbic Acid - pharmacology
Benzo(a)pyrene - administration & dosage - analysis - toxicity
Birth Weight - drug effects
Child
Cohort Studies
Diet - statistics & numerical data
Female
Fetal Development - drug effects
Food - classification
Food Contamination - analysis - statistics & numerical data
Heredodegenerative Disorders, Nervous System - chemically induced
Humans
Infant
Maternal Exposure - statistics & numerical data
Microphthalmos - chemically induced
Multivariate Analysis
Mutagenicity Tests
Norway - epidemiology
Parity
Polycyclic Hydrocarbons, Aromatic - toxicity
Pregnancy
Pregnancy Outcome - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Abstract
Maternal exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy has been associated with reduced fetal growth. However, the role of diet, the main source of PAH exposure among non-smokers, remains uncertain.
To assess associations between maternal exposure to dietary intake of the genotoxic PAH benzo(a)pyrene [B(a)P] during pregnancy and birth weight, exploring potential effect modification by dietary intakes of vitamins C, E and A, hypothesized to influence PAH metabolism.
This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Dietary B(a)P and nutrient intakes were estimated based on total consumption obtained from a food frequency questionnaire (FFQ) and estimated based on food composition data. Data on infant birth weight were obtained from the Medical Birth Registry of Norway (MBRN). Multivariate regression was used to assess associations between dietary B(a)P and birth weight, evaluating potential interactions with candidate nutrients.
The multivariate-adjusted coefficient (95%CI) for birth weight associated with maternal energy-adjusted B(a)P intake was -20.5g (-31.1, -10.0) in women in the third compared with the first tertile of B(a)P intake. Results were similar after excluding smokers. Significant interactions were found between elevated intakes of vitamin C (>85mg/day) and dietary B(a)P during pregnancy for birth weight (P
PubMed ID
24071023 View in PubMed
Less detail

Dietary exposure to dioxins and PCBs in a large cohort of pregnant women: results from the Norwegian Mother and Child Cohort Study (MoBa).

https://arctichealth.org/en/permalink/ahliterature108262
Source
Environ Int. 2013 Sep;59:398-407
Publication Type
Article
Date
Sep-2013
Author
Ida H Caspersen
Helle K Knutsen
Anne Lise Brantsæter
Margaretha Haugen
Jan Alexander
Helle Margrete Meltzer
Helen E Kvalem
Author Affiliation
Norwegian Institute of Public Health, Oslo, Norway. ida.henriette.caspersen@fhi.no
Source
Environ Int. 2013 Sep;59:398-407
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Adult
Body Burden
Cohort Studies
Diet - adverse effects
Dioxins - administration & dosage - blood
Environmental Exposure
Environmental Pollutants - administration & dosage - analysis - blood
Female
Fish Products - adverse effects - analysis
Food Contamination
Humans
Norway
Polychlorinated Biphenyls - administration & dosage - blood
Tetrachlorodibenzodioxin - blood
Young Adult
Abstract
Exposure to dioxins and polychlorinated biphenyls (PCBs) during pregnancy and breastfeeding may result in adverse health effects in children. Prenatal exposure is determined by the concentrations of dioxins and PCBs in maternal blood, which reflect the body burden obtained by long term dietary exposure. The aims of this study were (1) to describe dietary exposure and important dietary sources to dioxins and PCBs in a large group of pregnant women and (2) to identify maternal characteristics associated with high dietary exposure to dioxins and PCBs. Dietary exposure to dioxins (sum of toxic equivalents (TEQs) from dioxin-like (dl) compounds) and PCB-153 in 83,524 pregnant women (gestational weeks 17-22) who participated in the Norwegian Mother and Child Cohort Study (MoBa) during the years 2002-2009 was calculated based on a food frequency questionnaire (FFQ) and a database of dioxin and PCB concentrations in Norwegian food. The median (interquartile range, IQR) intake of PCB-153 (marker of ndl-PCBs) was 0.81 (0.77) ng/kg bw/day. For dioxins and dioxin-like PCBs, the median (IQR) intake was 0.56 (0.37) pg TEQ/kg bw/day. Moreover, 2.3% of the participants had intakes exceeding the tolerable weekly intake (TWI) of 14pg TEQ/kg bw/week. Multiple regression analysis showed that dietary exposure was positively associated with maternal age, maternal education, weight gain during pregnancy, being a student, and alcohol consumption during pregnancy and negatively associated with pre-pregnancy BMI and smoking. A high dietary exposure to PCB-153 or dl-compounds (TEQ) was mainly explained by the consumption of seagull eggs and/or pate with fish liver and roe. Women who according to Norwegian recommendations avoid these food items generally do not have dietary exposure above the tolerable intake of dioxins and dl-PCBs.
PubMed ID
23911340 View in PubMed
Less detail

Diet before pregnancy and the risk of hyperemesis gravidarum.

https://arctichealth.org/en/permalink/ahliterature134673
Source
Br J Nutr. 2011 Aug;106(4):596-602
Publication Type
Article
Date
Aug-2011
Author
Margaretha Haugen
Ase Vikanes
Anne Lise Brantsaeter
Helle Margrete Meltzer
Andrej M Grjibovski
Per Magnus
Author Affiliation
Division of Environmental Medicine, Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway. margaretha.haugen@fhi.no
Source
Br J Nutr. 2011 Aug;106(4):596-602
Date
Aug-2011
Language
English
Publication Type
Article
Keywords
Adult
Allium
Cohort Studies
Diet - adverse effects
Female
Hospitalization
Humans
Hyperemesis Gravidarum - epidemiology - prevention & control - therapy
Maternal Nutritional Physiological Phenomena
Norway - epidemiology
Pregnancy
Questionnaires
Risk factors
Seafood
Severity of Illness Index
Water - administration & dosage
Young Adult
Abstract
Hyperemesis gravidarum (hyperemesis), characterised by severe nausea and vomiting in early pregnancy, has an unknown aetiology. The aim of the present study was to investigate food and nutrient intake before pregnancy and the risk of developing hyperemesis in women participating in the Norwegian Mother and Child Cohort Study. From 1999 to 2002, a total of 7710 pregnant women answered a FFQ about their diet during the 12 months before becoming pregnant and a questionnaire about illnesses during pregnancy, including hyperemesis. Only women who were hospitalised for hyperemesis were included as cases. Nutrient intakes during the year before pregnancy did not differ between the ninety-nine women who developed hyperemesis and the 7611 who did not. However, the intake of seafood, allium vegetables and water was significantly lower among women who developed hyperemesis than among women in the non-hyperemesis group. Relative risks of hyperemesis were approximated as OR, and confounder control was performed with multiple logistic regression. Women in the upper tertile of seafood consumption had a lower risk of developing hyperemesis than those in the lower tertile (OR 0·56, 95 % CI 0·32, 0·98), and women in the second tertile of water intake had a lower risk of developing hyperemesis than those in the first tertile (OR 0·43, 95 % CI 0·25, 0·73). The findings suggest that a moderate intake of water and adherence to a healthy diet that includes vegetables and fish are associated with a lower risk of developing hyperemesis.
PubMed ID
21554820 View in PubMed
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Effects of breast feeding on neuropsychological development in a community with methylmercury exposure from seafood.

https://arctichealth.org/en/permalink/ahliterature29935
Source
J Expo Anal Environ Epidemiol. 2005 Sep;15(5):423-30
Publication Type
Article
Date
Sep-2005
Author
Tina Kold Jensen
Philippe Grandjean
Esben Budtz Jørgensen
Roberta F White
Frodi Debes
Pál Weihe
Author Affiliation
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense C, Denmark. tkjensen@health.sdu.dk
Source
J Expo Anal Environ Epidemiol. 2005 Sep;15(5):423-30
Date
Sep-2005
Language
English
Publication Type
Article
Keywords
Adult
Animals
Atlantic Ocean
Breast Feeding
Child
Child Development
Child, Preschool
Cognition Disorders - etiology - prevention & control
Environmental Exposure
Female
Fetal Blood - chemistry
Food Contamination
Geography
Hair - chemistry
Humans
Infant
Infant Welfare
Infant, Newborn
Intelligence Tests
Longitudinal Studies
Male
Methylmercury Compounds - pharmacokinetics
Neuropsychological Tests
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Seafood
Whales
Abstract
Breastfeeding has been associated with an advantage to infant neurobehavioral development, possibly in part due to essential nutrients in breast milk. However, breast milk may be contaminated by environmental neurotoxicants, such as methylmercury. In the Faroe Islands, where maternal consumption of pilot whale may cause transfer of marine toxicants into breast milk, a cohort of 1022 consecutive singleton births was generated during 1986-87. Methylmercury exposure was assessed from mercury concentrations in cord blood and in the hair of the child at age 12 months, and the duration of breastfeeding was recorded. At approximately 7 years of age, 917 (90%) of the children underwent detailed neurobehavioral examination. After adjustment for confounders, breastfeeding was associated with only marginally better neuropsychological performance on most tests. These associations were robust even after adjustment for cord-blood and hair mercury concentration at age 1 year. Thus, in this cohort of children with a relatively high prenatal toxicant exposure and potential exposure to neurotoxicants through breast milk, breastfeeding was associated with less benefits on neurobehavioral development than previously published studies though not associated with a deficit in neuropsychological performance at age 7. Although the advantage may be less, Faroese women can still safely breastfeed their children.
PubMed ID
15674318 View in PubMed
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Exploration of biomarkers for total fish intake in pregnant Norwegian women.

https://arctichealth.org/en/permalink/ahliterature98999
Source
Public Health Nutr. 2010 Jan;13(1):54-62
Publication Type
Article
Date
Jan-2010
Author
Anne Lise Brantsaeter
Margaretha Haugen
Yngvar Thomassen
Dag G Ellingsen
Trond A Ydersbond
Tor-Arne Hagve
Jan Alexander
Helle Margrete Meltzer
Author Affiliation
Division of Environmental Medicine, Department of Food Safety and Nutrition, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO-04030 Oslo, Norway. anne.lise.brantsaeter@fhi.no
Source
Public Health Nutr. 2010 Jan;13(1):54-62
Date
Jan-2010
Language
English
Geographic Location
Norway
Publication Type
Article
Keywords
Adult
Arsenic - administration & dosage - blood
Biological Markers - blood - urine
Cohort Studies
Diet Records
Erythrocytes - chemistry
Fatty Acids, Omega-3 - administration & dosage - analysis
Female
Food Habits
Humans
Iodine - administration & dosage - urine
Mercury - administration & dosage - blood
Norway
Pregnancy
Questionnaires
Seafood - analysis
Selenium - administration & dosage - blood
Young Adult
Abstract
OBJECTIVE: Few biomarkers for dietary intake of various food groups have been established. The aim of the present study was to explore whether selenium (Se), iodine, mercury (Hg) or arsenic may serve as a biomarker for total fish and seafood intake in addition to the traditionally used n-3 fatty acids EPA and DHA. DESIGN: Intake of fish and seafood estimated by an FFQ was compared with intake assessed by a 4 d weighed food diary and with biomarkers in blood and urine. SETTING: Validation study in the Norwegian Mother and Child Cohort Study (MoBa). SUBJECTS: One hundred and nineteen women. RESULTS: Total fish/seafood intake (median 39 g/d) calculated with the MoBa FFQ was comparable to intake calculated by the food diary (median 30 g/d, rS = 0.37, P
Notes
RefSource: Public Health Nutr. 2009 Dec;12(12):2536-7
PubMed ID
19490733 View in PubMed
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Fish liver and seagull eggs, vitamin D-rich foods with a shadow: results from the Norwegian Fish and Game Study.

https://arctichealth.org/en/permalink/ahliterature127159
Source
Mol Nutr Food Res. 2012 Mar;56(3):388-98
Publication Type
Article
Date
Mar-2012
Author
Bryndis E Birgisdottir
Anne L Brantsaeter
Helen E Kvalem
Helle K Knutsen
Margaretha Haugen
Jan Alexander
Ragna B Hetland
Lage Aksnes
Helle M Meltzer
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. bryndis.eva.birgisdottir@fhi.no
Source
Mol Nutr Food Res. 2012 Mar;56(3):388-98
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Animals
Charadriiformes
Databases, Factual
Diet
Dioxins - analysis - metabolism - toxicity
Eggs
Female
Fish Oils - administration & dosage
Fishes
Food contamination - analysis
Humans
Liver - chemistry
Male
Middle Aged
Norway
Polychlorinated Biphenyls - analysis - metabolism - toxicity
Questionnaires
Vitamin D - administration & dosage - analysis
Vitamins - administration & dosage - analysis
Abstract
Fish liver, fish liver oil, oily fish and seagull eggs have been major sources of vitamin D for the coastal population of Norway. They also provide dioxin and polychlorinated dioxin-like compounds (dl-compounds), which may interfere with vitamin D homeostasis. We investigated whether serum 25-hydroxyvitamin D (25(OH)D) might be compromised by concomitant intake of dl-compounds.
We studied 182 adults participating in the Norwegian Fish and Game Study. Participants who consumed fish liver and/or seagull eggs had higher dl-compound intake and blood concentrations than non-consumers (p
PubMed ID
22319024 View in PubMed
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Food patterns and dietary quality associated with organic food consumption during pregnancy; data from a large cohort of pregnant women in Norway.

https://arctichealth.org/en/permalink/ahliterature121954
Source
BMC Public Health. 2012;12:612
Publication Type
Article
Date
2012
Author
Hanne Torjusen
Geir Lieblein
Tormod Næs
Margaretha Haugen
Helle Margrete Meltzer
Anne Lise Brantsæter
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. hanne.torjusen@sifo.no
Source
BMC Public Health. 2012;12:612
Date
2012
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Cohort Studies
Diet
Female
Food Preferences
Food, Organic - utilization
Humans
Norway
Pregnancy
Questionnaires
Young Adult
Abstract
Little is known about the consumption of organic food during pregnancy. The aim of this study was to describe dietary characteristics associated with frequent consumption of organic food among pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa).
The present study includes 63 808 women who during the years 2002-2007 answered two questionnaires, a general health questionnaire at gestational weeks 15 and a food frequency questionnaire at weeks 17-22. The exploration of food patterns by Principal component analyses (PCA) was followed by ANOVA analyses investigating how these food patterns as well as intake of selected food groups were associated with consumption of organic food.
The first principal component (PC1) identified by PCA, accounting for 12% of the variation, was interpreted as a 'health and sustainability component', with high positive loadings for vegetables, fruit and berries, cooking oil, whole grain bread and cereal products and negative loadings for meat, including processed meat, white bread, and cakes and sweets. Frequent consumption of organic food, which was reported among 9.1% of participants (n?=?5786), was associated with increased scores on the 'health and sustainability component' (p?
Notes
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PubMed ID
22862737 View in PubMed
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Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands.

https://arctichealth.org/en/permalink/ahliterature158611
Source
Pharmacogenet Genomics. 2008 Mar;18(3):209-12
Publication Type
Article
Date
Mar-2008
Author
Jónrit Halling
Maria Skaalum Petersen
Philippe Grandjean
Pál Weihe
Kim Brosen
Author Affiliation
Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Winslowparken, Odense C, Denmark. jhalling@health.sdu.dk
Source
Pharmacogenet Genomics. 2008 Mar;18(3):209-12
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Alleles
Base Sequence
Case-Control Studies
Cytochrome P-450 CYP2D6 - genetics
DNA Primers - genetics
Denmark
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Histocompatibility Antigens Class I - genetics
Humans
Male
Membrane Proteins - genetics
Middle Aged
Parkinson Disease - genetics
Pharmacogenetics
Abstract
To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased.
Blood samples were collected from 79 PD patients and 154 controls in the Faroe Islands. Genotyping for the 'CYP2D6*3, *4, *6 and *9' alleles and for the C282Y and H63D mutations were performed by real-time polymerase chain reaction before Taqman assessment.
The frequency of CYP2D6 poor metabolizers among the patients was not higher compared with the frequency found in the control group (chi2 test, P=0.86). The odds ratio was 0.92 (95% confidence interval: 0.44-1.90). Neither was a difference in HFE genotype or allele frequencies found between the patients and the controls, and the C282Y and H63D mutation carrier frequencies did not reveal any difference (chi2 test, P=0.50 and 0.60, respectively).
This study does not support an association between PD and mutations of the CYP2D6 and HFE genes, although a weak association cannot be excluded. The high frequency of PD in the Faroes is most likely the result of interactions between multiple genetic and environmental factors, still to be identified.
PubMed ID
18300942 View in PubMed
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