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Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik.

https://arctichealth.org/en/permalink/ahliterature4455
Source
Environ Health Perspect. 2004 Oct;112(14):1359-65
Publication Type
Article
Date
Oct-2004
Author
Frédéric Dallaire
Eric Dewailly
Gina Muckle
Carole Vézina
Sandra W Jacobson
Joseph L Jacobson
Pierre Ayotte
Author Affiliation
Department of Social and Preventive Medicine, Laval University, and Public Health Research Unit, CHUQ-Laval University Medical Center, 945 Wolfe Street, Sainte-Foy, Québec G1V 5B3, Canada.
Source
Environ Health Perspect. 2004 Oct;112(14):1359-65
Date
Oct-2004
Language
English
Publication Type
Article
Keywords
Acute Disease
Adult
Cohort Studies
Dichlorodiphenyl Dichloroethylene - analysis - poisoning
Environmental Exposure
Environmental Pollutants - analysis - poisoning
Female
Gastrointestinal Diseases - epidemiology - etiology - microbiology
Humans
Infant
Infant, Newborn
Insecticides - analysis - poisoning
Inuits
Male
Otitis Media - epidemiology - etiology
Polychlorinated Biphenyls - analysis - poisoning
Pregnancy
Prenatal Exposure Delayed Effects
Quebec - epidemiology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Respiratory Tract Infections - epidemiology - etiology
Retrospective Studies
Abstract
The Inuit population of Nunavik (Canada) is exposed to immunotoxic organochlorines (OCs) mainly through the consumption of fish and marine mammal fat. We investigated the effect of perinatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) on the incidence of acute infections in Inuit infants. We reviewed the medical charts of a cohort of 199 Inuit infants during the first 12 months of life and evaluated the incidence rates of upper and lower respiratory tract infections (URTI and LRTIs, respectively), otitis media, and gastrointestinal (GI) infections. Maternal plasma during delivery and infant plasma at 7 months of age were sampled and assayed for PCBs and DDE. Compared to rates for infants in the first quartile of exposure to PCBs (least exposed), adjusted rate ratios for infants in higher quartiles ranged between 1.09 and 1.32 for URTIs, 0.99 and 1.39 for otitis, 1.52 and 1.89 for GI infections, and 1.16 and 1.68 for LRTIs during the first 6 months of follow-up. For all infections combined, the rate ratios ranged from 1.17 to 1.27. The effect size was similar for DDE exposure but was lower for the full 12-month follow-up. Globally, most rate ratios were > 1.0, but few were statistically significant (p
PubMed ID
15471725 View in PubMed
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An examination of traditional foods and cigarette smoking as cadmium sources among the nine First Nations of Eeyou Istchee, Northern Quebec, Canada.

https://arctichealth.org/en/permalink/ahliterature104372
Source
Environ Sci Process Impacts. 2014 May 28;16(6):1422-33
Publication Type
Article
Date
May-28-2014
Author
Nadia A Charania
Leonard J S Tsuji
Ian D Martin
Eric N Liberda
Suzanne Coté
Pierre Ayotte
Eric Dewailly
Evert Nieboer
Author Affiliation
Environment and Resource Studies, University of Waterloo, Waterloo, ON, Canada.
Source
Environ Sci Process Impacts. 2014 May 28;16(6):1422-33
Date
May-28-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cadmium - blood
Child
Environmental Exposure - analysis - statistics & numerical data
Environmental monitoring
Environmental pollutants - blood
Food Contamination - analysis - statistics & numerical data
Humans
Indians, North American
Male
Middle Aged
Quebec - epidemiology
Smoking - epidemiology
Young Adult
Abstract
Cadmium (Cd), a nonessential toxic metal present in the environment, accumulates in the organs of herbivorous mammals which typically are consumed by Aboriginal populations. The relative contribution of this potential exposure source to concentrations of blood Cd was investigated in 1429 participants (age >7 years) residing in the nine Cree First Nations communities of Eeyou Istchee, northern Quebec, Canada. Analysis of variance identified significant Cd concentration differences between communities, sex, and age groups, although these were complicated by significant 2-way interactions. The percentage of participants with Cd concentrations within the adopted health-based guideline categories of 'acceptable', 'concern' and 'action' pertaining to kidney damage was 56.2%, 38.3%, and 5.5%, respectively. Partial correlations (controlling for age as a continuous variable) did not show a significant association between consumption of traditional foods and Cd concentrations (r = 0.014, df = 105, p = 0.883). A significant and positive partial correlation (r = 0.390, df = 105, p
PubMed ID
24781002 View in PubMed
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Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort Study.

https://arctichealth.org/en/permalink/ahliterature4473
Source
Environ Health Perspect. 2003 Jul;111(9):1253-8
Publication Type
Article
Date
Jul-2003
Author
Pierre Ayotte
Gina Muckle
Joseph L Jacobson
Sandra W Jacobson
Eric Dewailly
Author Affiliation
Department of Social and Preventive Medicine, Laval University and Public Health Research Unit, CHUQ-Laval University Medical Centre, Québec, Québec, Canada. pierre.ayotte@inspq.qc.ca
Source
Environ Health Perspect. 2003 Jul;111(9):1253-8
Date
Jul-2003
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Biological Markers - analysis
Breast Feeding
Chromatography, Gas
Cohort Studies
Environmental Exposure
Environmental Pollutants - analysis - blood
Epidemiologic Studies
Female
Fetal Blood - chemistry
Forecasting
Humans
Indians, North American
Infant
Infant, Newborn
Maternal-Fetal Exchange
Milk, human - chemistry
Models, Theoretical
Polychlorinated Biphenyls - analysis - blood
Pregnancy
Quebec - epidemiology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Abstract
Polychlorinated biphenyls (PCBs) are food-chain contaminants that have been shown to induce adverse developmental effects in humans. In the course of an epidemiologic study established to investigate neurodevelopmental deficits induced by environmental PCB exposure in the Inuit population of northern Québec (Nunavik, Canada), we compared three biomarkers of prenatal exposure and models to predict PCB plasma concentration at 6 months postpartum. Concentrations of 14 PCB congeners were measured by high-resolution gas chromatography with electron capture detection in lipids extracted from maternal plasma, cord plasma, breast milk (collected at approximately 1 month postpartum), and 6-month-old infant plasma samples. Similar congener profiles were observed in all biologic samples, and PCB-153, the most abundant and persistent PCB congener, was strongly correlated with other frequently detected PCB congeners in all biologic media. When expressed on a lipid basis, maternal plasma, cord plasma, and milk concentrations of this congener were strongly intercorrelated, indicating that PCB concentration in any of these biologic media is a good indicator of prenatal exposure to PCBs. A multivariate model that included maternal PCB-153 plasma lipid concentration, breast-feeding duration, and the sum of two skin-fold thicknesses (an index of infant body fat mass) explained 72% of PCB-153 plasma concentration variance at 6 months postpartum (p
PubMed ID
12842782 View in PubMed
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Association between methylmercury and cardiovascular risk factors in a native population of Quebec (Canada): a retrospective evaluation.

https://arctichealth.org/en/permalink/ahliterature120888
Source
Environ Res. 2013 Jan;120:102-8
Publication Type
Article
Date
Jan-2013
Author
Beatriz Valera
Eric Dewailly
Paul Poirier
Author Affiliation
Axe santé des populations et environnementale, Centre de recherche du CHUQ, Édifice Delta 2, 2875, boulevard Laurier, 6e étage, Sainte-Foy, Québec, Canada G1V 2M2. beatriz.valera@crchul.ulaval.ca
Source
Environ Res. 2013 Jan;120:102-8
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Blood pressure
Environmental Exposure - adverse effects
Female
Heart rate
Humans
Hypertension - chemically induced
Male
Methylmercury Compounds - adverse effects - blood
Middle Aged
Quebec
Retrospective Studies
Risk factors
Young Adult
Abstract
Epidemiological evidence suggests a negative impact of methylmercury (MeHg) on cardiovascular risk factors such as blood pressure (BP) and heart rate (HR). This issue is of concern in Arctic populations such as in the Inuit of Nunavik since this contaminant is accumulated in fish and marine mammals, which still represent the subsistence diet of this population.
We examined the associations between MeHg and BP and resting HR among Inuit adults.
The "Santé Quebec" health survey was conducted in 1992 in the 14 villages of Nunavik and a complete set of data was obtained for 313 Inuit adults=18 years. Blood samples were collected in order to determine total mercury, lead, total polychlorinated biphenyls (PCBs), n-3 polyunsaturated fatty acids (PUFAs), fasting glucose and lipid profile while socio-demographic variables were obtained through questionnaires. Anthropometric measurements as well as BP and resting HR were obtained using standardised protocols. Pulse pressure (PP: systolic BP minus diastolic BP) was also calculated. Multiple linear regression was used in order to determine the change in the dependent variables associated with the quartiles of MeHg concentration, taking the quartile 1 as reference.
The mean age of the participants was 38±14 years and the sample was composed of 132 men (42.2%) and 181 women (57.8%). MeHg geometric mean was 15.4 µg/L (95%CI: 13.9-17.0) and levels ranged from 0.8 to 112.0 µg/L. Resting HR increased linearly across quartiles of blood MeHg concentration after adjusting for confounders (p for trend=0.02). An increase of 6.9 beats per minute (bpm) between the 4th and 1st quartile was observed after adjusting for confounders. No significant association was observed between blood MeHg and systolic BP, diastolic BP or PP.
MeHg was associated with increasing resting HR after considering traditional risk factors as well as other contaminants (lead and total PCBs) and n-3 PUFAs. In contrast, no significant association with blood pressure was observed in this study.
PubMed ID
22959488 View in PubMed
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Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik.

https://arctichealth.org/en/permalink/ahliterature108571
Source
Environ Int. 2013 Sep;59:282-9
Publication Type
Article
Date
Sep-2013
Author
Beatriz Valera
Pierre Ayotte
Paul Poirier
Eric Dewailly
Author Affiliation
Axe santé publique et pratiques optimales en santé, Centre de recherche du CHU de Québec, Canada. beatriz.valera@crchul.ulaval.ca
Source
Environ Int. 2013 Sep;59:282-9
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Animals
Arctic Regions
Blood Pressure - drug effects
Dichlorodiphenyl Dichloroethylene - blood
Diet
Dioxins - blood
Environmental Exposure
Environmental pollutants - blood
Fatty Acids, Omega-3 - blood
Female
Fishes
Humans
Hydrocarbons, Chlorinated - blood
Hypertension - chemically induced - epidemiology
Inuits
Lindane - blood
Male
Mercury - blood
Middle Aged
Pesticides - blood
Polychlorinated biphenyls - blood
Quebec - epidemiology
Tetrachlorodibenzodioxin - blood
Young Adult
Abstract
Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, which represent the traditional diet of these populations.
We examined the associations between polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides and hypertension among Inuit from Nunavik (Quebec, Canada).
A complete set of data was obtained for 315 Inuit=18years who participated in the "Santé Québec" health survey that was conducted in the 14 villages of Nunavik in 1992. Fourteen polychlorinated biphenyls (PCBs) and 8 OC pesticides or their metabolites were measured in plasma samples using gas chromatography with electron capture detection. Blood pressure (BP) was measured using a standardized protocol and information regarding anti-hypertensive medication was obtained through questionnaires. The associations between log-transformed POPs and hypertension (systolic BP=140mmHg, diastolic BP=90mmHg or anti-hypertensive medication) were analyzed using multiple logistic regressions.
Total PCBs as well as the sum of non-dioxin-like PCBs were significantly associated with higher risk of hypertension. Furthermore, the risk of hypertension increased with higher plasma concentrations of congeners 101, 105, 138 and 187. Models adjusted for BP risk factors became significant after including n-3 polyunsaturated fatty acids (PUFAs) and further adjustment for lead and mercury did not change the results. Regarding OC pesticides, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was associated with increased risk of hypertension while inverse associations were observed with p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT), ß-hexachlorocyclohexane (HCH) and oxychlordane.
Some PCB congeners were associated with higher risk of hypertension in this highly exposed population. Most associations became significant after including n-3 PUFAs in the models. However, the analyses of OC pesticides revealed divergent results, which need to be confirmed in further cohort and experimental studies.
PubMed ID
23872387 View in PubMed
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Associations between prenatal cigarette smoke exposure and externalized behaviors at school age among Inuit children exposed to environmental contaminants.

https://arctichealth.org/en/permalink/ahliterature258359
Source
Neurotoxicol Teratol. 2013 Sep-Oct;39:84-90
Publication Type
Article
Author
Caroline Desrosiers
Olivier Boucher
Nadine Forget-Dubois
Eric Dewailly
Pierre Ayotte
Sandra W Jacobson
Joseph L Jacobson
Gina Muckle
Author Affiliation
Université Laval, Québec City, Québec, Canada; Centre de recherche du Centre Hospitalier Universitaire de Québec, Québec City, Québec, Canada.
Source
Neurotoxicol Teratol. 2013 Sep-Oct;39:84-90
Language
English
Publication Type
Article
Keywords
Attention - drug effects
Attention Deficit Disorder with Hyperactivity - chemically induced - epidemiology - psychology
Attention Deficit and Disruptive Behavior Disorders - chemically induced - psychology
Child
Drug Interactions
Environmental Pollutants - analysis - toxicity
Female
Fetal Blood - chemistry
Humans
Inuits - psychology
Lead Poisoning, Nervous System, Childhood - blood - psychology
Male
Mercury Poisoning, Nervous System - blood - psychology
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - psychology
Prevalence
Quebec - epidemiology
Tobacco Smoke Pollution - adverse effects
Abstract
Smoking during pregnancy is common among Inuit women from the Canadian Arctic. Yet prenatal cigarette smoke exposure (PCSE) is seen as a major risk factor for childhood behavior problems. Recent data also suggest that co-exposure to neurotoxic environmental contaminants can exacerbate the effects of PCSE on behavior. This study examined the association between PCSE and behavior at school age in a sample of Inuit children from Nunavik, Qu?bec, where co-exposure to environmental contaminants is also an important issue. Interactions with lead (Pb) and mercury (Hg), two contaminants associated with behavioral problems, were also explored.
Participants were 271 children (mean age=11.3years) involved in a prospective birth-cohort study. PCSE was assessed through maternal recall. Assessment of child behavior was obtained from the child's classroom teacher on the Teacher Report Form (TRF) and the Disruptive Behavior Disorders Rating Scale (DBD). Exposure to contaminants was assessed from umbilical cord and child blood samples. Other confounders were documented by maternal interview.
After control for contaminants and confounders, PCSE was associated with increased externalizing behaviors and attention problems on the TRF and higher prevalence of attention deficit hyperactivity disorder (ADHD) assessed on the DBD. No interactions were found with contaminants.
This study extends the existing empirical evidence linking PCSE to behavioral problems in school-aged children by reporting these effects in a population where tobacco use is normative rather than marginal. Co-exposure to Pb and Hg do not appear to exacerbate tobacco effects, suggesting that these substances act independently.
Notes
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PubMed ID
23916943 View in PubMed
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Cancer risk associated with household exposure to chloroform.

https://arctichealth.org/en/permalink/ahliterature190667
Source
J Toxicol Environ Health A. 2002 Apr 12;65(7):489-502
Publication Type
Article
Date
Apr-12-2002
Author
Benoît Lévesque
Pierre Ayotte
Robert Tardif
Liliane Ferron
Suzanne Gingras
Emmanuelle Schlouch
Guy Gingras
Patrick Levallois
Eric Dewailly
Author Affiliation
Unité de recherche en santé publique, Centre Hospitalier Universitaire de Québec, Beauport, Canada. benoit.levesque@crchul.ulaval.ca
Source
J Toxicol Environ Health A. 2002 Apr 12;65(7):489-502
Date
Apr-12-2002
Language
English
Publication Type
Article
Keywords
Adult
Air Pollutants - adverse effects - analysis
Air Pollution, Indoor - adverse effects
Baths - adverse effects
Chloroform - adverse effects - analysis
Environmental Exposure - adverse effects - statistics & numerical data
Humans
Linear Models
Male
Middle Aged
Neoplasms - chemically induced
Quebec - epidemiology
Risk assessment
Skin Absorption
Volatilization
Water Pollutants, Chemical - adverse effects - analysis
Water supply
Abstract
Chloroform (CHCl3) the trihalomethane most prevalent in drinking water, is a proven animal carcinogen and a suspected human carcinogen. Consequently, standards have been issued by health authorities to limit its concentration in drinking water. These limits are based solely on ingestion, without taking into account inhalation and skin contact. Exposure to CHCl3 was assessed for 18 men (age: mean 38 years; range 23-51) following a 10-min shower in their respective residences located in the Quebec City region (Canada). CHCl3 concentration was measured in alveolar air samples collected before, immediately after, and 15 min and 30 min following the shower. Indoor air and water concentrations were determined concomitantly. Mean CHCl3 concentrations in the air of the shower stall and in water were respectively 147 microg/m3 (SD = 56.2 microg/m3) and 20.1 microg/L (SD = 9.0 microg/L). Water concentrations were comparable to those documented in a large proportion of distribution networks in Canada. The mean increase in alveolar air CHCl3 concentration (deltaCHCIALV) at the end of the shower was 33 microg/m3 (SD = 14.7 microg/m3). A multiple-regression analysis revealed that deltaCHCl3ALV values were only associated with chloroform concentration in air of the shower stall. DeltaCHCl3ALV were described using a physiologically based pharmacokinetic (PBPK) model. This model was then used to estimate concentrations of CHCl3 metabolites bound to liver and kidney macromolecules following a shower, and also according to exposure scenarios that integrate drinking-water ingestion and air inhalation. The concentration predicted in the liver following a worst-case exposure scenario was 0.41 microg CHCl3 equivalents/kg of tissue, some 6,000 times lower than the lowest concentration that did not increase the incidence of hepatic tumors in laboratory animals. Data indicate that for this range of exposure the safety margin appears therefore considerable with respect to the potential carcinogenic effect of household exposure to CHCl3.
PubMed ID
11939707 View in PubMed
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Cohort profile: the maternal-infant research on environmental chemicals research platform.

https://arctichealth.org/en/permalink/ahliterature113014
Source
Paediatr Perinat Epidemiol. 2013 Jul;27(4):415-25
Publication Type
Article
Date
Jul-2013
Author
Tye E Arbuckle
William D Fraser
Mandy Fisher
Karelyn Davis
Chun Lei Liang
Nicole Lupien
Stéphanie Bastien
Maria P Velez
Peter von Dadelszen
Denise G Hemmings
Jingwei Wang
Michael Helewa
Shayne Taback
Mathew Sermer
Warren Foster
Greg Ross
Paul Fredette
Graeme Smith
Mark Walker
Roberta Shear
Linda Dodds
Adrienne S Ettinger
Jean-Philippe Weber
Monique D'Amour
Melissa Legrand
Premkumari Kumarathasan
Renaud Vincent
Zhong-Cheng Luo
Robert W Platt
Grant Mitchell
Nick Hidiroglou
Kevin Cockell
Maya Villeneuve
Dorothea F K Rawn
Robert Dabeka
Xu-Liang Cao
Adam Becalski
Nimal Ratnayake
Genevieve Bondy
Xiaolei Jin
Zhongwen Wang
Sheryl Tittlemier
Pierre Julien
Denise Avard
Hope Weiler
Alain Leblanc
Gina Muckle
Michel Boivin
Ginette Dionne
Pierre Ayotte
Bruce Lanphear
Jean R Séguin
Dave Saint-Amour
Eric Dewailly
Patricia Monnier
Gideon Koren
Emmanuel Ouellet
Author Affiliation
Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa. tye.arbuckle@hc-sc.gc.ca
Source
Paediatr Perinat Epidemiol. 2013 Jul;27(4):415-25
Date
Jul-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Biological Markers
Canada
Cohort Studies
Environmental Exposure - adverse effects
Environmental Monitoring - methods
Environmental Pollutants - adverse effects
Female
Humans
Infant
Infant Welfare
Male
Maternal Exposure - adverse effects
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Questionnaires
Young Adult
Abstract
The Maternal-Infant Research on Environmental Chemicals (MIREC) Study was established to obtain Canadian biomonitoring data for pregnant women and their infants, and to examine potential adverse health effects of prenatal exposure to priority environmental chemicals on pregnancy and infant health.
Women were recruited during the first trimester from 10 sites across Canada and were followed through delivery. Questionnaires were administered during pregnancy and post-delivery to collect information on demographics, occupation, life style, medical history, environmental exposures and diet. Information on the pregnancy and the infant was abstracted from medical charts. Maternal blood, urine, hair and breast milk, as well as cord blood and infant meconium, were collected and analysed for an extensive list of environmental biomarkers and nutrients. Additional biospecimens were stored in the study's Biobank. The MIREC Research Platform encompasses the main cohort study, the Biobank and follow-up studies.
Of the 8716 women approached at early prenatal clinics, 5108 were eligible and 2001 agreed to participate (39%). MIREC participants tended to smoke less (5.9% vs. 10.5%), be older (mean 32.2 vs. 29.4 years) and have a higher education (62.3% vs. 35.1% with a university degree) than women giving birth in Canada.
The MIREC Study, while smaller in number of participants than several of the international cohort studies, has one of the most comprehensive datasets on prenatal exposure to multiple environmental chemicals. The biomonitoring data and biological specimen bank will make this research platform a significant resource for examining potential adverse health effects of prenatal exposure to environmental chemicals.
PubMed ID
23772943 View in PubMed
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Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment.

https://arctichealth.org/en/permalink/ahliterature49183
Source
Environ Health Perspect. 2003 Jan;111(1):65-70
Publication Type
Article
Date
Jan-2003
Author
Matthew P Longnecker
Mary S Wolff
Beth C Gladen
John W Brock
Philippe Grandjean
Joseph L Jacobson
Susan A Korrick
Walter J Rogan
Nynke Weisglas-Kuperus
Irva Hertz-Picciotto
Pierre Ayotte
Paul Stewart
Gerhard Winneke
M Judith Charles
Sandra W Jacobson
Eric Dewailly
E Rudy Boersma
Larisa M Altshul
Birger Heinzow
James J Pagano
Allan A Jensen
Author Affiliation
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. longnecker@niehs.nih.gov
Source
Environ Health Perspect. 2003 Jan;111(1):65-70
Date
Jan-2003
Language
English
Publication Type
Article
Keywords
Chromatography, Gas - methods
Comparative Study
Environmental pollutants - blood
Europe
Female
Food Contamination
Humans
Maternal Exposure - adverse effects
Milk, Human - chemistry - drug effects
Nervous System - drug effects - embryology
Polychlorinated biphenyls - blood
Pregnancy
Quebec
Sensitivity and specificity
United States
Abstract
Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence from animal studies shows that PCBs are neurotoxins, even at low doses. Interpretation of human data regarding low-level, early-life PCB exposure and subsequent neurodevelopment is problematic because levels of exposure were not similarly quantified across studies. We expressed the exposure levels from 10 studies of PCB and neurodevelopment in a uniform manner using a combination of data from original investigators, laboratory reanalyses, calculations based on published data, and expert opinion. The mainstay of our comparison was the median level of PCB 153 in maternal pregnancy serum. The median concentration of PCB 153 in the 10 studies ranged from 30 to 450 ng/g serum lipid, and the median of the 10 medians was 110 ng/g. We found that (a)) the distribution of PCB 153 exposure in most studies overlapped substantially, (b)) exposure levels in the Faroe Islands study were about 3-4-fold higher than in most other studies, and (c)) the exposure levels in the two recent U.S. studies were about one-third of those in the four earlier U.S. studies or recent Dutch, German, and northern Qu?bec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies.
PubMed ID
12515680 View in PubMed
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Cord blood lymphocyte functions in newborns from a remote maritime population exposed to organochlorines and methylmercury.

https://arctichealth.org/en/permalink/ahliterature191730
Source
J Toxicol Environ Health A. 2002 Jan 25;65(2):165-82
Publication Type
Article
Date
Jan-25-2002
Author
Marthe Belles-Isles
Pierre Ayotte
Eric Dewailly
Jean-Philippe Weber
Raynald Roy
Author Affiliation
Unité de recherche en rhumatologie-immunologie, Centre hospitalier universitaire de Quebec-CHUL, Ste-Foy, Canada.
Source
J Toxicol Environ Health A. 2002 Jan 25;65(2):165-82
Date
Jan-25-2002
Language
English
Publication Type
Article
Keywords
Adult
Environmental Exposure
Female
Fetal Blood - chemistry - immunology
Food Contamination
Humans
Infant, Newborn
Killer Cells, Natural - immunology
Lead - blood
Lymphocyte Count
Male
Maternal-Fetal Exchange
Mercury - blood
Polychlorinated biphenyls - analysis
Pregnancy
Quebec
Abstract
The consumption of fish and sea mammals can be an important source of exposure to organochlorine compounds (OCs) and heavy metals in populations relying on seafood for subsistence. Exposure to these substances, especially during the prenatal period, has been shown to induce immunotoxic effects in mammals. Immunological status was assessed in 48 newborns from a remote maritime population living on the Lower and Mid North Shore of the St. Lawrence River (subsistence fishing group) and 60 newborns from the coastal urban center of Sept-Iles (reference group). Women were recruited upon arrival at Sept-Iles regional hospital to give birth. Cord blood samples were collected for organochlorine and heavy metal analyses and to isolate lymphocytes for immunological assays (proportions and functional responses of the main cellular subsets T, B, and NK (natural killer) cells. Concentrations of polychlorinated biphenyls (PCBs) and mercury were respectively three- and twofold higher, significantly greater, in the subsistence fishing group than in the reference group. Compared to the reference group, the subsistence fishing group showed significant decreases in the proportion of the naive helper T-cell subset CD4+CD45RA, T-cell proliferation following an in vitro mitogenic stimulation, and plasma immunoglobulin M (IgM) level, while plasma IgC level was increased. NK cytolytic activities were similar in both groups. The proportion of CD4+CD45RA cells was inversely correlated to mercury and PCBs, while T-cell clonal expansion was negatively associated with PCBs and p,p'-DDE. Mercury was inversely correlated to plasma IgM. Data show that subtle functional alterations of the developing human immune system may result from in utero exposure to OCs and mercury. Epidemiological studies are needed to determine the relevance of these alterations in predicting detrimental health effects in the developing child.
PubMed ID
11820504 View in PubMed
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Determinants of plasma concentrations of perfluorooctanesulfonate and brominated organic compounds in Nunavik Inuit adults (Canada).

https://arctichealth.org/en/permalink/ahliterature149165
Source
Environ Sci Technol. 2009 Jul 1;43(13):5130-6
Publication Type
Article
Date
Jul-1-2009
Author
Renée Dallaire
Pierre Ayotte
Daria Pereg
Serge Déry
Pierre Dumas
Eric Langlois
Eric Dewailly
Author Affiliation
Public Health Research Unit, Centre hospitalier universitaire de Québec-CHUL, Québec, Québec, Canada.
Source
Environ Sci Technol. 2009 Jul 1;43(13):5130-6
Date
Jul-1-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Alkanesulfonic Acids - blood
Animals
Bromine Compounds - blood
Canada
Environmental Exposure
Environmental Monitoring - methods
Female
Fishes
Fluorocarbons - blood
Halogenation
Humans
Inuits
Male
Middle Aged
Abstract
Perfluorooctanesulfonate (PFOS) and brominated organic compounds (BOCs) have been found in biota and humans worldwide with levels of BOCs being the highest in North America. PFOS and BOC exposure of remote populations that consume species of a marine food web for their subsistence has seldom been investigated. In 2004, we determined the concentrations of these contaminants in 883 Nunavik Inuit adults from the Canadian Arctic and investigated the demographic and dietary factors associated with them. Demographic and dietary information were collected by questionnaires. Multiple linear regressions were conducted to investigate predictors of exposure to those contaminants. Polychlorinated biphenyl (PCB) congener 153 concentrations are presented for comparative purposes. PFOS and PCB 153 were detected in all samples, with plasma concentrations several times higher than BOCs. The consumption of fish and marine mammals appears to be an important contributor to PFOS exposure among Nunavik Inuit. While PBDE 153 also appears as a persistent PBDE congener, exposure to PBDE 47 seems to be more recent in this population. Adoption of a westernized lifestyle seems to be related to an increased exposure to PBDE 47, but specific sources remain to be elucidated. In conclusion, we found that the remote geographical location and traditional lifestyle of the Nunavik Inuit population do not protect them against exposure to emerging POPs, particularly PFOS.
PubMed ID
19673318 View in PubMed
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Dioxin-like compounds and bone quality in Cree women of Eastern James Bay (Canada): a cross-sectional study.

https://arctichealth.org/en/permalink/ahliterature260305
Source
Environ Health. 2013;12(1):54
Publication Type
Article
Date
2013
Author
Alexandra-Cristina Paunescu
Eric Dewailly
Sylvie Dodin
Evert Nieboer
Pierre Ayotte
Source
Environ Health. 2013;12(1):54
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
American Native Continental Ancestry Group
Bone and Bones - drug effects - physiology
Cross-Sectional Studies
Dioxins - blood
Environmental monitoring
Environmental Pollutants - blood - toxicity
Female
Humans
Metals, Heavy - blood
Middle Aged
Polychlorinated Biphenyls - blood - toxicity
Quebec
Abstract
Aboriginal populations living in Canada's northern regions are exposed to a number of persistent organic pollutants through their traditional diet which includes substantial amounts of predator fish species. Exposure to dioxin-like compounds (DLCs) can cause a variety of toxic effects including adverse effects on bone tissue. This descriptive cross-sectional study was conducted to investigate the relationship between plasma concentrations of DLCs and bone quality parameters in Cree women of Eastern James Bay (Canada).
Two hundred and forty-nine Cree women from seven communities in Eastern James Bay (Canada), aged 35 to 74 years old, participated in the study. In order to determine the total DLC concentration in plasma samples of participants, we measured the aryl hydrocarbon receptor-mediated transcriptional activity elicited by plasma sample extracts using a luciferase reporter gene assay. Plasma concentrations of mono-ortho-substituted dioxin-like polychlorinated biphenyls (DL-PCBs) 105, 118 and 156 were measured by gas chromatography-mass spectrometry. Bone quality parameters (speed of sound, m/s; broadband ultrasound attenuation, dB/MHz; stiffness index, %) were assessed by quantitative ultrasound at the right calcaneus with the Achilles InSight system. Several factors known to be associated with osteoporosis were documented by questionnaire. Multiple linear regression models were constructed for the three ultrasound parameters.
DL-PCBs 105 and 118 concentrations, but not the global DLC concentration, were inversely associated with the stiffness index, even after adjusting for several confounding factors. The stiffness index (log) decreased by -0.22% (p=0.0414) and -0.04% (p=0.0483) with an increase of one µg/L in plasma concentrations of DL-PCB 105 and DL-PCB 118, respectively. Other factors, including age, height, smoking status, menopausal status and the percentage of omega-6 polyunsaturated fatty acids (PUFAs) in erythrocyte membranes were negatively associated with one of the ultrasound parameters, while the percentage of omega-3 PUFAs in these membranes and levels of physical activity and education were positively associated with them.
Our results show that an increase in plasma concentrations of DL-PCBs 105 and 118 was negatively associated with stiffness index, a measure of bone quality/strength, in women of this population. In addition to environmental contaminants, future studies should also consider PUFA intake as a factor influencing bone quality.
Notes
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PubMed ID
23816203 View in PubMed
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Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study.

https://arctichealth.org/en/permalink/ahliterature113413
Source
Int J Circumpolar Health. 2013;72
Publication Type
Article
Date
2013
Author
Alexandra-Cristina Paunescu
Pierre Ayotte
Eric Dewailly
Sylvie Dodin
Author Affiliation
Axe santé publique et pratiques optimales en santé, Centre de recherche du CHU de Québec, Québec, Canada.
Source
Int J Circumpolar Health. 2013;72
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Arctic Regions - epidemiology
Bone Diseases - chemically induced
Bone and Bones - physiopathology - ultrasonography
Calcaneus - physiopathology - ultrasonography
Canada - epidemiology
Cross-Sectional Studies
Diet
Dioxins - adverse effects - blood
Environmental Exposure - analysis
Environmental pollutants - blood
Female
Humans
Inuits
Middle Aged
Polychlorinated biphenyls - adverse effects - blood
Abstract
Bone strength in Inuit people appears lower than that of non-Aboriginals. Inuit are exposed to persistent organic pollutants including dioxin-like compounds (DLCs) through their traditional diet that comprises predatory fish and marine mammal fat. Results from experimental and population studies suggest that some DLCs can alter bone metabolism and increase bone fragility.
This cross-sectional descriptive study was conducted to examine the relationship between the stiffness index (SI) and plasma concentrations of total DLCs or specific dioxin-like polychlorinated biphenyls (DL-PCBs) in Inuit women of Nunavik (Northern Quebec, Canada).
SI was determined by ultrasonography at the right calcaneus of 194 Inuit women aged 35-72 years who participated to Qanuippitaa? How Are We? Nunavik Inuit Health Survey in 2004. Plasma total DLC levels were quantified by measuring the aryl hydrocarbon receptor-mediated transcriptional activity elicited by plasma sample extracts in a cell-based reporter gene assay. Plasma concentrations of DL-PCBs nos. 105, 118, 156, 157, 167 and 189 were measured by gas chromatography-mass spectrometry. We used multiple linear regression analyses to investigate relations between total DLCs or specific DL-PCBs and SI, taking into consideration several potential confounders.
Neither total plasma DLCs nor specific DL-PCBs were associated with SI after adjustment for several confounders and covariates.
Our results do not support a relation between exposure to DLCs and bone strength measured by ultrasonography in Inuit women of Nunavik.
Notes
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PubMed ID
23730628 View in PubMed
Less detail

Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (Northern Quebec).

https://arctichealth.org/en/permalink/ahliterature99280
Source
Environ Res. 2010 Aug 7;
Publication Type
Article
Date
Aug-7-2010
Author
Marie-Ludivine Château-Degat
Daria Pereg
Renée Dallaire
Pierre Ayotte
Serge Dery
Eric Dewailly
Author Affiliation
Axe santé des populations et environnementale, Research center of the Centre hospitalier universitaire de Québec and Université Laval, Québec, QC, Canada G1V 2M2.
Source
Environ Res. 2010 Aug 7;
Date
Aug-7-2010
Language
English
Publication Type
Article
Abstract
BACKGROUND: Perfluorooctanesulfonate (PFOS) was used as a surfactant in various commercial products. In rodents, exposure to this compound induced various health effects, including hypolipidemia. In human populations, the potential toxicity of PFOS is not yet fully characterized, but indications of effects on lipids are reported. A recent study reported an increase in plasma cholesterol associated with exposure to perfluorinated compounds in humans exposed through drinking water, but similar effects were not reported in all exposed human populations. PFOS is widely distributed in the environment, including the arctic biota. The Inuit of Nunavik are exposed to environmental contaminants through the consumption of fish and game. This diet is also a source of omega3-polyunsaturated fatty acids (n-3 PUFAs) that are known to lower plasma triacylglycerols. OBJECTIVE: This cross-sectional epidemiologic study aims at assessing the relationship between PFOS exposure and plasma lipids, while taking account of the concomitant hypolipidemic effect exerted by n-3 PUFAs. METHODS: Plasma concentrations of PFOS and lipids were assessed in Nunavik Inuit adults (n=723) in the framework of a large-scale environmental health study. Associations of exposure levels to age, gender and selected wild food consumption associated with n-3 PUFAs intake, as well as the exposure on lipid levels were investigated by multivariate linear modeling. RESULTS: In the Inuit population, PFOS exposure and n-3 PUFAs intake are related to traditional food consumption. Triacylglycerol and ratio of total cholesterol to high density lipoprotein cholesterol (HDL-C) levels were negatively associated with PFOS plasma levels, while HDL-C levels were positively associated, after adjustment for circulating levels of n-3 PUFAs and for the interaction between gender and PFOS plasma levels. Other plasma lipids, such as low density lipoprotein-cholesterol and non-HDL-C were not related to PFOS plasma concentrations. CONCLUSION: The results of this study show a relationship between PFOS and plasma lipid levels in an environmentally exposed human population, and this effect appears distinct from that of n-3 PUFAs.
PubMed ID
20696425 View in PubMed
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Effects of prenatal exposure to organochlorines on thyroid hormone status in newborns from two remote coastal regions in Québec, Canada.

https://arctichealth.org/en/permalink/ahliterature155027
Source
Environ Res. 2008 Nov;108(3):387-92
Publication Type
Article
Date
Nov-2008
Author
Renée Dallaire
Eric Dewailly
Pierre Ayotte
Gina Muckle
Claire Laliberté
Suzanne Bruneau
Author Affiliation
Public Health Research Unit, Laval University Medical Research Centre-Centre Hospitalier, Universitaire de Québec, Québec City, Québec, Canada.
Source
Environ Res. 2008 Nov;108(3):387-92
Date
Nov-2008
Language
English
Publication Type
Article
Keywords
Environmental Pollutants - blood - metabolism
Female
Humans
Hydrocarbons, Chlorinated - blood - metabolism
Infant, Newborn
Maternal Exposure - statistics & numerical data
Models, Biological
Quebec
Thyroid Hormones - blood - metabolism
Abstract
Several prospective studies have revealed that prenatal exposure to polychlorinated biphenyls (PCBs) and other organochlorine compounds (OCs) affect neurodevelopment during infancy. One of the mechanisms by which PCBs might interfere with neurodevelopment is a deficit in thyroid hormone (TH) concentrations.
We investigated the potential impact of transplacental exposure to PCBs and hexachlorobenzene (HCB) on TH concentrations in neonates from two remote coastal populations exposed to OCs through the consumption of seafood products.
Blood samples were collected at birth from the umbilical cord of neonates from Nunavik (n=410) and the Lower North Shore of the St. Lawrence River (n=260) (Québec, Canada) for thyroid parameters [thyroid-stimulating hormone (TSH), free T4 (fT4), total T3 (tT3), and thyroxine-binding globuline (TBG)] and contaminants analyses.
In multivariate models, umbilical cord plasma concentrations of PCB 153, the predominant PCB congener, were not associated with TH and TSH levels in both populations. Prenatal exposure to HCB was positively associated with fT4 levels at birth in both populations (Nunavik, beta=0.12, p=0.04; St. Lawrence, beta=0.19, p
PubMed ID
18814871 View in PubMed
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Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec.

https://arctichealth.org/en/permalink/ahliterature3462
Source
Environ Health Perspect. 2002 Jun;110(6):607-12
Publication Type
Article
Date
Jun-2002
Author
Daria Pereg
Eric Dewailly
Guy G Poirier
Pierre Ayotte
Author Affiliation
Département de Biologie Médicale, Faculté de Médecine, Université Laval et Unité de recherche en santé et environnement, Ste-Foy, Québec, Canada.
Source
Environ Health Perspect. 2002 Jun;110(6):607-12
Date
Jun-2002
Language
English
Publication Type
Article
Keywords
Adult
Body Burden
Cytochrome P-450 CYP1A1 - analysis - biosynthesis
Diet
Environmental Exposure
Environmental Pollutants - adverse effects - pharmacokinetics
Enzyme Induction
Epidemiologic Studies
Female
Fetal Blood - chemistry
Humans
Indians, North American
Placenta - drug effects - enzymology
Polychlorinated Biphenyls - adverse effects - pharmacokinetics
Pregnancy
Quebec - epidemiology
Research Support, Non-U.S. Gov't
Smoking - adverse effects
Abstract
Some polychlorinated biphenyl (PCB) congeners are CYP1A1 inducers, and induction of this enzyme in the placenta has been linked to adverse effects on fetal development. The objective of this study was to determine if the body burden of PCBs is related to placental CYP1A1 activity in Inuit women from Nunavik (northern Québec), a population highly exposed to organochlorines. Placenta and cord blood samples were obtained from 35 Inuit women and 30 women from a southern Québec community exposed to background levels of organochlorines. We measured PCB concentrations in all cord plasma samples and in a subset of placenta samples from the Nunavik group and assessed CYP1A1 activity (ethoxyresorufin-O-deethylase; EROD) in placental microsomes from all participants. Concentrations of PCBs in cord plasma were strongly correlated to those in placenta (Pearson's r) = 0.77-0.97, p
PubMed ID
12055053 View in PubMed
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Epidemiological portrait of behavior problems within an Inuit sample of school-aged Nunavik children: preliminary report

https://arctichealth.org/en/permalink/ahliterature284421
Source
Pages 254-255 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):254-255
Publication Type
Article
Date
2013
polyunsaturated- fatty acid on infant development: evidence from the Inuit of A rctic Que bee. J Pediatr. 2008;152: 356- 62. 4 . Muckle G, Ayotte P, Dewailly E, Jacobson SW, Jacobson JL. Prenatal exposure of the northern Quebec inuit infants to environmental contaminants. Environ Health Perspect. 2001; 109
  1 document  
Author
Gabrielle Begin
Sandra W. Jacobson
Nadine Forget-Dubois
Jocelyne Gagnon
Eric Dewailly
Pierre Ayotte
Joseph L. Jacobson
Gina Muckle
Author Affiliation
Universite Laval, Quebec, QC, Canada
Centre de recherche du Centre Hospitalier Universitaire de Quebec (CHUO), Quebec, QC, Canada
Departement of Psychiatry and Behavioural Neurosciences, The Wayne State University School of Medicine, Detroit, MI, USA
Source
Pages 254-255 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):254-255
Date
2013
Language
English
Geographic Location
Canada
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
University of Alaska Anchorage
Abstract
The Inuit of Nunavik experience a variety of psycho-social problems that tend to compromise optimal child development. Among these problems are teenage pregnancy, domestic violence, alcohol abuse, as well as a suicide rate that is among the highest in the world. Both internalising behavioral problems (IBP) and externalising behavioral problems (EBP) can appear very early in development and can lead to sustained trajectories of delinquency, criminality, rejection by peers, depression and anxiety. IBP include symptoms of anxiety, depression and social withdrawal or rejection, whereas EBP take the form of impulsive, delinquent or aggressive behaviors. Objective This research project seeks to document the presence of behavior problems (BP) among school-aged Inuit in Nunavik and to examine their link with psycho-social risk factors to which the children are exposed.
Documents
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In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury.

https://arctichealth.org/en/permalink/ahliterature182590
Source
Environ Health Perspect. 2003 Dec;111(16):1952-7
Publication Type
Article
Date
Dec-2003
Author
Houda Bilrha
Raynald Roy
Brigitte Moreau
Marthe Belles-Isles
Eric Dewailly
Pierre Ayotte
Author Affiliation
Rheumatology-Immunology Research Unit, CHUQ-Laval University Medical Center, Québec City, Québec, Canada.
Source
Environ Health Perspect. 2003 Dec;111(16):1952-7
Date
Dec-2003
Language
English
Publication Type
Article
Keywords
Adult
Body Weight
Cytokines - metabolism
Environmental Monitoring - methods
Epidemiological Monitoring
European Continental Ancestry Group - statistics & numerical data
Female
Fetal Blood - metabolism
Food contamination - analysis
Humans
Immune System - metabolism
Indians, North American - statistics & numerical data
Infant, Newborn
Insecticides - blood
Leukocytes, Mononuclear - metabolism
Male
Maternal Exposure - statistics & numerical data
Methylmercury Compounds - blood
Population Surveillance
Pregnancy
Quebec - epidemiology
Rural Population - statistics & numerical data
Seafood - analysis
Smoking - epidemiology
Abstract
Remote coastal populations that rely on seafood for subsistence often receive unusually high doses of organochlorines and methyl mercury. Immunosuppression resulting from prenatal exposure to organochlorines has been reported in wildlife species and humans. In this study, we assessed lymphocyte activation and associated cytokine secretion in 47 newborns from a remote maritime population living on the Mid and Lower North Shore regions of the St. Lawrence River (Québec, Canada; subsistence fishing group) and 65 newborns from nearby urban settings (reference group). Cord blood samples were collected for organochlorine and mercury analyses and also to isolate cord blood mononuclear cells (CBMCs) for the in vitro assessment of cytokine production and expression of surface markers after mitogenic stimulation (CD4(+)CD45RO(+), CD8(+)CD45RO(+), CD3(+)CD25(+), and CD8(+)HLA-DR(+)). Blood mercury and plasma concentrations of polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE), and hexachlorobenzene (HCB) were significantly higher in the subsistence fishing group than in the reference group (p
Notes
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PubMed ID
14644672 View in PubMed
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Knowledge translation in Arctic environmental health.

https://arctichealth.org/en/permalink/ahliterature120744
Source
Int J Circumpolar Health. 2012;71
Publication Type
Article
Date
2012
Author
Eric Dewailly
Chris Furgal
Source
Int J Circumpolar Health. 2012;71
Date
2012
Language
English
Publication Type
Article
Keywords
Arctic Regions
Environmental health
Humans
Translational Medical Research
Notes
Cites: Int J Environ Res Public Health. 2010 Feb;7(2):651-7420616996
Cites: J Public Health (Oxf). 2006 Dec;28(4):384-917082462
PubMed ID
22973571 View in PubMed
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Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Québec.

https://arctichealth.org/en/permalink/ahliterature4805
Source
Environ Health Perspect. 2002 Apr;110(4):411-7
Publication Type
Article
Date
Apr-2002
Author
Courtney D Sandau
Pierre Ayotte
Eric Dewailly
Jason Duffe
Ross J Norstrom
Author Affiliation
Centre for Analytical and Environmental Chemistry, Department of Chemistry, Carleton University, Ottawa, Ontario, Canada. csandau@cdc.gov
Source
Environ Health Perspect. 2002 Apr;110(4):411-7
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Diet
Environmental Exposure
Environmental Pollutants - analysis - metabolism
Female
Fetal Blood - chemistry
Humans
Indians, North American
Infant, Newborn
Male
Pentachlorophenol - analysis - metabolism
Polychlorinated Biphenyls - analysis - metabolism
Quebec
Research Support, Non-U.S. Gov't
Thyroid Hormones - blood
Abstract
Concentrations of polychlorinated biphenyls (PCBs), hydroxylated metabolites of PCBs (HO-PCBs) and octachlorostyrene (4-HO-HpCS), and pentachlorophenol (PCP) were determined in umbilical cord plasma samples from three different regions of Québec. The regions studied included two coastal areas where exposure to PCBs is high because of marine-food-based diets--Nunavik (Inuit people) and the Lower North Shore of the Gulf of St. Lawrence (subsistence fishermen)--and a southern Québec urban center where PCB exposure is at background levels (Québec City). The main chlorinated phenolic compound in all regions was PCP. Concentrations of PCP were not significantly different among regions (geometric mean concentration 1,670 pg/g, range 628-7,680 pg/g wet weight in plasma). The ratio of PCP to polychlorinated biphenyl congener number 153 (CB153) concentration ranged from 0.72 to 42.3. Sum HO-PCB (sigma HO-PCBs) concentrations were different among regions, with geometric mean concentrations of 553 (range 238-1,750), 286 (103-788), and 234 (147-464) pg/g wet weight plasma for the Lower North Shore, Nunavik, and the southern Québec groups, respectively. Lower North Shore samples also had the highest geometric mean concentration of sum PCBs (sum of 49 congeners; sigma PCBs), 2,710 (525-7,720) pg/g wet weight plasma. sigma PCB concentrations for Nunavik samples and southern samples were 1,510 (309-6,230) and 843 (290-1,650) pg/g wet weight plasma. Concentrations (log transformed) of sigma HO-PCBs and sigma PCBs were significantly correlated (r = 0.62, p
PubMed ID
11940460 View in PubMed
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