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[Meta-analysis of association between pentachlorophenol exposure and cancer risk].

https://arctichealth.org/en/permalink/ahliterature156427
Source
Wei Sheng Yan Jiu. 2008 Mar;37(2):151-4
Publication Type
Article
Date
Mar-2008
Author
Weiwei Zheng
Ying Zhou
Weidong Qu
Hao Zhang
et al
Author Affiliation
Key Laboratory of the Public Health and Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Source
Wei Sheng Yan Jiu. 2008 Mar;37(2):151-4
Date
Mar-2008
Language
Chinese
Publication Type
Article
Keywords
Canada - epidemiology
Colorectal Neoplasms - epidemiology - mortality
Environmental Exposure - adverse effects
Humans
Kidney Neoplasms - epidemiology - mortality
Neoplasms - epidemiology - mortality
Pentachlorophenol - toxicity
Risk factors
United States - epidemiology
Abstract
The epidemiological data based on the exposure of pentachlorophenol (PCP) and cancer incidence and mortality were analyzed to study the relationship between PCP exposure and cancer risk.
According to the online search of relevant literatures, Poisson regression was used to analyze mortality rates for major cancer sites and fixed-effect model was employed to assess cancer SMR. The dose-response relationship between PCP exposure and cancer risk was also analyzed.
Major cancer mortality rates of exposure populations researched in American and Canadian studies were approximate to or lower than national male cancer mortality rates respectively. The incidence rate of colorectal cancer in occupational exposure population was over 16.4 times in comparison with the population exposed from to drinking water and food. The pooled SMR value of kidney cancer was 1.34 (95% CI 1.02-1.77). The pooled RR for major cancer mortality increased with the rise of PCP exposure level.
A potential dose-response relationship between PCP exposure and cancer risk could exist. In comparison with to the population to exposed from the drinking water and food, the risk of colorectal cancer in occupational exposure population was higher. PCP may be one of the risk factors of the kidney cancer in occupational exposure population.
PubMed ID
18589595 View in PubMed
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